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Group of voltage-gated ion channels permeable to Ca2+
Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ion channels found in the
Voltage-gated_calcium_channel
Family of transport proteins
calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium
L-type_calcium_channel
Drugs that disrupt movement of calcium across calcium channels
inside the lymphatic vessel supported by voltage-gated calcium channels, inhibition of voltage-gated calcium channel poses a threat towards lymphatic removal
Calcium_channel_blocker
Ion channel complex through which calcium ions pass
calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous with voltage-gated calcium channel,
Calcium_channel
Family of transport proteins
T-type calcium channels are low voltage activated calcium channels that become inactivated during cell membrane hyperpolarization but then open to depolarization
T-type_calcium_channel
Type of ion channel transmembrane protein
triggering voltage change. Found along the axon and at the synapse, voltage-gated ion channels directionally propagate electrical signals. Voltage-gated ion-channels
Voltage-gated_ion_channel
Family of transport proteins
Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the
Voltage-gated_sodium_channel
Family of transport proteins
The P-type calcium channel is a type of voltage-dependent calcium channel. Similar to many other high-voltage-gated calcium channels, the α1 subunit determines
P-type_calcium_channel
Protein family
N-type calcium channels, also called Cav2.2 channels, are voltage gated calcium channels that are localized primarily on the nerve terminals and dendrites
N-type_calcium_channel
Muscular contraction-related structure in tissue
contractions, Calcium (Ca2+) ions are required for polarization and depolarization through a voltage-gated calcium channel. The rapid influx of calcium into the
Diad
Protein family
R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters
R-type_calcium_channel
Transmembrane protein allowing sodium ions in and out
similar to both the EEEE motif of voltage-gated calcium channel and the DEKA motif of the voltage-gated sodium channel, possibly explaining its lack of
Sodium_channel
Class of transport proteins
voltage-gated potassium channels are grouped into 12 classes. These are labeled Kvα1-12. The following is a list of the 40 known human voltage-gated potassium
Voltage-gated potassium channel
Voltage-gated_potassium_channel
Pore-forming membrane protein
needed] Voltage-gated calcium channels: This family contains 10 members, though these are known to coassemble with α2δ, β, and γ subunits. These channels play
Ion_channel
Protein found in humans
Calcium channel, voltage-dependent, T type, alpha 1H subunit, also known as CACNA1H, is a protein which in humans is encoded by the CACNA1H gene. This
CACNA1H
Action potential generated in the dendrite of a neuron
voltage-gated sodium channels, voltage-gated calcium channels are also integral membrane proteins found in the plasma membrane. Voltage-gated calcium
Dendritic_spike
Protein-coding gene in humans
Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene. Voltage-dependent calcium channel GRCh38:
CACNB3
Protein-coding gene in humans
Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene. The CACNA2D1 gene is located on
CACNA2D1
Protein-coding gene in humans
XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacological Reviews. 57 (4): 411–425. doi:10.1124/pr.57
CACNA1B
Ion channel that conducts protons based on voltage and pH
Voltage-gated proton channels are ion channels that conduct protons in a voltage- and pH-dependent manner. Compared to most voltage-gated cation channels
Voltage-gated_proton_channel
Protein encoding gene in humans
known as Calcium channel, voltage-dependent, L type, alpha 1D subunit, is a protein that in humans is encoded by the CACNA1D gene. Cav1.3 channels belong
CACNA1D
Protein-coding gene in humans
Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene. This gene encodes a member of the beta
CACNB4
Mammalian protein found in humans
Cav1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, is a protein which in humans is encoded by the CACNA1S gene. It
CACNA1S
Protein encoding gene in humans
Cav1.4 also known as the calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F), is a human gene. This gene encodes a member of the alpha-1
CACNA1F
Protein-coding gene in humans
Voltage-dependent L-type calcium channel subunit alpha-1C (also known as Cav1.2) is a protein that in humans is encoded by the CACNA1C gene. Cav1.2 is
CACNA1C
Biological process in the heart
There are two voltage-gated calcium channels within cardiac muscle: L-type calcium channels ('L' for Long-lasting) and T-type calcium channels ('T' for Transient
Cardiac_action_potential
NKTR-171 – voltage-gated sodium channel blocker PF-05089771 – selective Nav1.7 and Nav1.8 blocker Ralfinamide (NW-1029) – non-selective voltage-gated sodium
List of investigational analgesics
List_of_investigational_analgesics
by genetic variants in the gene CACNA1C. CACNA1C encodes the voltage-gated calcium channel (CaV1.2), widely expressed throughout the body, subsequently
CACNA1C-Related_Disorders
channel, including changes in voltage across the cell membrane (voltage-gated ion channels), chemicals interacting with the ion channel (ligand-gated
Gating_(electrophysiology)
Protein-coding gene in humans
Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene. Mutation in the CACNB2 gene are associated
CACNB2
Diseases caused by dysfunction of ion channels or related proteins
Cristofori-Armstrong B, Miller D, et al. (January 2015). "Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy". Nature
Channelopathy
Protein-coding gene in humans
Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the CACNA1G gene
CACNA1G
Class of transport proteins
Calcium-activated potassium channels are potassium channels gated by calcium, or that are structurally or phylogenetically related to calcium gated channels
Calcium-activated potassium channel
Calcium-activated_potassium_channel
Protein-coding gene in humans
Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene. The protein encoded by this gene belongs
CACNB1
Protein-coding gene in humans
Calcium channel, voltage-dependent, alpha 2/delta subunit 4 is a protein that in humans is encoded by the CACNA2D4 gene. This gene encodes a member of
CACNA2D4
Protein-coding gene in humans
Calcium channel, voltage-dependent, alpha 2/delta subunit 3 is a protein that in humans is encoded by the CACNA2D3 gene on chromosome 3 (locus 3p21.1)
CACNA2D3
Family of transport proteins
or increase in calcium levels. Structurally, BK channels are homologous to voltage- and ligand-gated potassium channels, having a voltage sensor and pore
BK_channel
Class of medications
transaminase. Additional targets include voltage-gated calcium channels, SV2A, and α2δ. By blocking sodium or calcium channels, antiepileptic drugs reduce the
Anticonvulsant
Class of transport proteins
of voltage-gated channels and ligand-gated channels (e.g., the CaCC families) have been characterized in humans. Voltage-gated chloride channels perform
Chloride_channel
Protein encoding gene in humans
Cav2.1, also known as P/Q voltage-dependent calcium channel, is a calcium channel that in humans is encoded by the CACNA1A gene. Cav2.1 is highly expressed
CACNA1A
Type of membrane proteins
Mechanosensitive channels (MSCs), mechanosensitive ion channels or stretch-gated ion channels are membrane proteins capable of responding to mechanical
Mechanosensitive_channels
Protein-coding gene in humans
Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene
CACNA1I
Part of SR around T-tubules in muscle
dihydropyridine channel (DHP channel) is activated. This is similar to a voltage-gated calcium channel, but is not actually an ionotropic channel. Instead,
Terminal_cisternae
Autoimmune disorder causing muscular weakness
the body). It is the result of antibodies against presynaptic voltage-gated calcium channels, and likely other nerve terminal proteins, in the neuromuscular
Lambert–Eaton myasthenic syndrome
Lambert–Eaton_myasthenic_syndrome
Junction between motor neuron and muscle fiber
of a motor neuron, which activates voltage-gated calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmins)
Neuromuscular_junction
Protein-coding gene in humans
1999). "Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications". Mayo
CACNG3
Investigational generalized anxiety disorder drugs
(PD-0332334; PD-332334; PF-00195889) – α2δ subunit-containing voltage-gated calcium channel ligand [29] Naluzotan (PRX-00023) – serotonin 5-HT1A receptor
List of investigational generalized anxiety disorder drugs
List_of_investigational_generalized_anxiety_disorder_drugs
Protein found in humans
Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin, is a protein that in humans is encoded by the CACNG2 gene. L-type
CACNG2
Group of neurotoxic peptides
HWTX are described: those targeting voltage-gated calcium channels, and those targeting voltage-gated sodium channels. HWTX-I is the most abundant toxic
Huwentoxin
Anticonvulsant medication
(somewhat distant from the calcium conducting pore of the voltage-gated calcium channel α1 subunit) on the calcium channel and chemotaxis domain of α2δ-1
Gabapentin
Neuron communication by electric impulses
potentials. One type is generated by voltage-gated sodium channels, the other by voltage-gated calcium channels. Sodium-based action potentials usually
Action_potential
Investigational insomnia drugs
mechanism of action Atagabalin (PD-0200390) – gabapentinoid (α2δ voltage-gated calcium channel ligand) Eplivanserin (Ciltyri; Sliwens; SR–46349; SR–46349B;
List of investigational insomnia drugs
List_of_investigational_insomnia_drugs
Type of cell found in pancreatic islets
KATP channel closure, and the opening of voltage gated calcium channels causing insulin granule fusion and exocytosis. Voltage-gated calcium channels and
Beta_cell
Family of transport proteins
The Q-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most
Q-type_calcium_channel
Pharmaceutical compound
PD-0299685 is a gabapentinoid (α2δ subunit-containing voltage-gated calcium channel blocker) which was under development for the treatment of insomnia
PD-0299685
Anticonvulsant medication
protein that was first described as an auxiliary subunit of Voltage-gated calcium channels. Pregabalin was approved for medical use in the United States
Pregabalin
Anticonvulsant medication
release of excitatory neurotransmitters via voltage-sensitive sodium channels and voltage-gated calcium channels in neurons. Lamotrigine was first marketed
Lamotrigine
Conotoxin peptide under investigation as an analgesic drug
N-type voltage-gated calcium channel (Cav2.2) blocker and is highly selective for this channel over the related P/Q-type voltage-gated calcium channel (Cav2
Leconotide
Class of toxins
includes blockade of glutamate-gated ion channels, voltage-gated sodium channels, or voltage-dependent calcium channels. Agatoxin is named after the funnel
Agatoxin
Basic taste
in turn depolarizes the cell and opens voltage-gated calcium channels, flooding the cell with positive calcium ions and leading to neurotransmitter release
Saltiness
Protein-coding gene in humans
Calcium homeostasis modulator 1 (CALHM1) is a pore-forming subunit of a voltage-gated ion channel and a voltage-gated ATP channel that in humans is encoded
CALHM1
Investigational tinnitus drugs
(e.g., dexamethasone) Gabapentinoids (α2δ subunit-containing voltage-gated calcium channel ligands) (e.g., gabapentin) Others (e.g., acamprosate, melatonin)
List of investigational tinnitus drugs
List_of_investigational_tinnitus_drugs
Investigational fibromyalgia drugs
CR; Pregabalin ER) – gabapentinoid (α2δ subunit-containing voltage-gated calcium channel ligand) [2] Celecoxib/famciclovir (famciclovir/celecoxib; IMC-1)
List of investigational fibromyalgia drugs
List_of_investigational_fibromyalgia_drugs
Class of intracellular transport proteins
receptor (a voltage-dependent, L-type calcium channel), whereas in cardiac muscle, the primary mechanism of activation is calcium-induced calcium release
Ryanodine_receptor
Electric potential difference between interior and exterior of a biological cell
the ion channels that are potentially permeable to that ion, including leakage channels, ligand-gated channels, and voltage-gated ion channels. For fixed
Membrane_potential
Protein-coding gene in humans
Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene. L-type calcium channels are composed of five
CACNG1
Colombian-American neuroscientist and entrepreneur
excitation-transcription coupling, specifically the role of voltage-gated calcium channels in controlling the activation of transcription factors in neurons
Ricardo_Dolmetsch
Neuronal calcium sensory protein
(Kv4.3; Shal-related subfamily, member 3) voltage-gated potassium channels Nitric oxide synthase TRPC5 channel Ric8a Frq modulates Ca2+ entry through a
Neuronal_calcium_sensor-1
Several medications which disrupt the movement of Na+ ions
8 voltage-gated sodium channels, such as CNV1014802 and Funapide, are being investigated as novel analgesics. Sodium channel opener Sodium+Channel+Blockers
Sodium_channel_blocker
Protein-coding gene in humans
Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene. L-type calcium channels are composed of five
CACNG4
Ion channel that selectively passes K+
potassium channels" or "leak channels" that set the negative membrane potential of neurons. Voltage-gated potassium channel – are voltage-gated ion channels that
Potassium_channel
Biological process
action potential depolarizes the cell membrane, voltage-gated Ca2+ channels (e.g., L-type calcium channels) are activated. CICR occurs when the resulting
Calcium-induced calcium release
Calcium-induced_calcium_release
Substance that arouses sexual desires
GHB receptor agonists: 1,4-Butanediols α2δ subunit-containing voltage-gated calcium channel blockers: Gabapentinoids Opioids/μ-opioid receptor agonists:
Aphrodisiac
Medical condition
history, of ganglionic neuronal acetylcholine receptor and N-type voltage-gated calcium channel autoantibodies in the blood stream would result in a medically
Autoimmune gastrointestinal dysmotility
Autoimmune_gastrointestinal_dysmotility
Neural phenomenon
the dendritic voltage-gated calcium channels. As described in the first process, the triggering of dendritic voltage-gated calcium channels leads to the
Neural_backpropagation
Protein-coding gene in the species Homo sapiens
Medicine. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci
CATSPER1
Protein-coding gene in humans
Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene. This gene encodes a member of the
CACNA2D2
Protein family
the opening of voltage-gated calcium channels (VGCCs) allowing the rapid influx of calcium down its electrochemical gradient. Calcium goes on to stimulate
SNARE_protein
Gamma-aminobutyric acid analogs
protein that was first described as an auxiliary subunit of voltage-gated calcium channels (VGCCs). Clinically used gabapentinoids include gabapentin,
Gabapentinoid
American neuroscientist and professor emeritus
co-authored the defining characterization of the L- and T-type voltage-gated calcium channels in cardiac muscle and determined the mechanism of action of
Jeffry_Lansman
Medical condition
primarily by mutations in the gene CACNA1F, which encodes a voltage-gated calcium channel important for neurotransmitter release. CSNB has been identified
Congenital stationary night blindness
Congenital_stationary_night_blindness
cell membrane via calcium channels (such as calcium-binding proteins or voltage-gated calcium channels), or from some internal calcium storages such as
Calcium_in_biology
Family of transport proteins
Two-pore channels (TPCs) are eukaryotic intracellular voltage-gated and ligand gated cation selective ion channels. There are two known paralogs in the
Two-pore_channel
GHB receptor agonists: 1,4-Butanediols α2δ subunit-containing voltage-gated calcium channel blockers: Gabapentinoids Opioids/μ-opioid receptor agonists:
Orphine
Category of drugs
variety of ion channels, and they are typically characterized by their gating mechanism, such as ligand-gated channels or voltage-gated channels, and the ion
Chloride_channel_opener
Medication used to treat absence seizures
thought to be due to antagonism of the postsynaptic T-type voltage-gated calcium channel. Ethosuximide was approved for medical use in the United States
Ethosuximide
Structure connecting neurons in the nervous system
the presynaptic neuron is converted (via the activation of voltage-gated calcium channels) into the release of a chemical called a neurotransmitter that
Synapse
Intermembrane proteins
cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes
HCN_channel
α2δ-1 subunit of voltage-gated calcium channels. This reduces calcium intake of this channel. Calcium intake reduction of the channels is associated with
Gap_junction_modulator
Chemical compound
As a gabapentinoid, mirogabalin binds to the α2δ subunit of voltage-gated calcium channel (1 and 2), but with significantly higher potency than pregabalin
Mirogabalin
Protein subfamily of calcium-activated potassium channels
channels are directly coupled to NMDA receptors. In addition to being activated by calcium flow through voltage-gated calcium channels, SK channels can
SK_channel
Toxin from the Chilean tarantula venom
Chilean tarantula venom that acts as both a voltage-gated calcium channel blocker and a voltage-gated sodium channel blocker. GTx1-15 is derived from the Chilean
GTx1-15
Primary cell of the nervous system
reaches the axon terminal, it opens voltage-gated calcium channels, allowing calcium ions to enter the terminal. Calcium causes synaptic vesicles filled with
Neuron
Species of arachnid
targets voltage-gated calcium channels and calcium-activated potassium channels, and Cn2 toxin, which targets the mammalian voltage-gated sodium channel (VGSC)
Centruroides_noxius
Biological response in plants
stress while maintaining structural integrity. FER can activate voltage-gated calcium channels, facilitating cytosolic Ca²⁺ influx in response to mechanical
Thigmomorphogenesis
Family of transport proteins
Light-gated ion channels are a family of ion channels regulated by electromagnetic radiation. Other gating mechanisms for ion channels include voltage-gated
Light-gated_ion_channel
Obsolete sedative–hypnotic drug
GHB receptor agonists: 1,4-Butanediols α2δ subunit-containing voltage-gated calcium channel blockers: Gabapentinoids Opioids/μ-opioid receptor agonists:
Methaqualone
Voltage-gated potassium channel protein
subfamily M, alpha member 1 (KCa1.1), or BK channel alpha subunit, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized
KCNMA1
Wadsworth, Teri L.; Woltjer, Randall L. (2011-01-01). "L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's
Ion channel hypothesis of Alzheimer's disease
Ion_channel_hypothesis_of_Alzheimer's_disease
Medical condition
intracellular calcium concentration by causing an increase in ion conductance through voltage gated calcium channels. This increase in calcium concentration
Neuromuscular junction disease
Neuromuscular_junction_disease
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VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
VOLTAGE GATED-CALCIUM-CHANNEL
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