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Type of membrane proteins
Mechanosensitive channels (MSCs), mechanosensitive ion channels or stretch-gated ion channels are membrane proteins capable of responding to mechanical
Mechanosensitive_channels
Group of transport proteins
Large conductance mechanosensitive ion channels (MscLs) (TC# 1.A.22) are a family of pore-forming membrane proteins that are responsible for translating
Large-conductance mechanosensitive channel
Large-conductance_mechanosensitive_channel
Cluster of neurons in a dorsal root of a spinal nerve
Two distinct types of mechanosensitive ion channels have been found in the posterior root ganglion neurons. The two channels are broadly classified as
Dorsal_root_ganglion
Protein-coding gene in the species Homo sapiens
Piezo-type mechanosensitive ion channel component 1 is a protein that in humans is encoded by the PIEZO1 gene. PIEZO1 is a large mechanosensitive ion channel protein
PIEZO1
Group of transport proteins
There are two families of mechanosensitive (MS) channels: large-conductance MS channels (MscL) and small-conductance MS channels (MscS or YGGB). The MscS
Small-conductance mechanosensitive channel
Small-conductance_mechanosensitive_channel
Mammalian protein found in Homo sapiens
Piezo-type mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene. The PIEZO2 protein has a role in mechanotransduction
PIEZO2
Grammostola mechanotoxin 4
peptide family. It reduces mechanical sensation by inhibiting mechanosensitive channels (MSCs). GsMTx-4 also serves as a cationic antimicrobial peptide
GsMTx-4
Type of ion channel transmembrane protein
ion channels. These channels include the bacterial channels MscL and MscS which open in response to lytic pressure. Many mechanosensitive channels require
Lipid-gated_ion_channels
Pressure receptor of the skin
independently mechanosensitive. The Merkel cell expresses the PIEZO2 mechanosensitive ion channels; mechanical activation of the channel causes depolarisation
Merkel_nerve_ending
Transduction of mechanical stimuli into neural signals
channel. FMI-43 is a dye which can be used to block mechanosensitive ion channels and therefore is a useful technique for studying mechanosensitive ion
Mechanosensation
Microbe with cell wall mostly removed
native mechanosensitive channels (MscL, MscS, and MscM) of E. coli. It has been extended to study other heterologously expressed ion channels and it has
Spheroplast
Species of creeping annual plant
nutrient maintenance, these parts have mechanoreceptors linked to mechanosensitive channels that can conduct calcium ions and indirectly relative anions upon
Mimosa_pudica
Type of mechanoreceptor cell in hairless mammals
through mechanosensitive channels which initiates the receptor potential. This initial receptor potential is potentiated by voltage-activated ion channels present
Pacinian_corpuscle
Pore-forming membrane protein
photons. Mechanosensitive ion channels open under the influence of stretch, pressure, shear, and displacement. Cyclic nucleotide-gated channels: This superfamily
Ion_channel
Topics referred to by the same term
the Mediterranean Sea dried up Meteorological Service of Canada Mechanosensitive channels Mesenchymal stem cell, a multipotent stromal cell MSC (gene),
MSC
Concept in chemistry and biology
membrane voltage (voltage-gated channels), ligand binding (ligand-gated channels), mechanical forces (mechanosensitive channels), or intracellular signaling
Activation
Biological membrane structure
F, Gottlieb PA (July 2004). "Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers". Nature. 430 (6996): 235–40
Lipid_bilayer
Family of transport proteins
Voltage Activating channels (HVA) and Low Voltage Activating channels (LVA). After further experimentation, it was found that HVA channels were blocked by
L-type_calcium_channel
Conversion of mechanical stimulus of a cell into electrochemical activity
structures in specialized ways to detect mechanical forces. Ion channels - mechanosensitive channels modulate their activity based on physical pressures. Extracellular
Mechanotransduction
Topics referred to by the same term
Compound with the chemical formula CH3ClO2S. Large-conductance mechanosensitive channel, MscL, membrane proteins This disambiguation page lists articles
MSCL
Mechanosensing organelles of hair cells
the brain. The identity of the mechanosensitive channels in the stereocilia is still unknown. The transduction channels associated with stereocilia are
Stereocilia_(inner_ear)
American neuroscientist and professor emeritus
cardiovascular disease. At UCSF, his laboratory established mechanosensitive ion channels as a driver of pathological calcium loading in Duchenne muscular
Jeffry_Lansman
Chemical compound
Jedi2 is a chemical compound which acts as an agonist for the mechanosensitive ion channel PIEZO1, and is used in research into the function of touch perception
Jedi2
Cell from a primary tumor carried by blood circulation
is the RhoA-ROCK pathway. When the cell membrane is stretched, mechanosensitive channels will open, flooding the cell with calcium ions. These calcium
Circulating_tumor_cell
Family of transport proteins
voltage-gated ion channels, ligand-gated ion channels, mechanosensitive ion channels, and temperature-gated ion channels. Most light-gated ion channels have been
Light-gated_ion_channel
Plant growth in reaction to gravity and bending of leaves and roots
sedimentation transmits the gravitropic signal by activating mechanosensitive channels. The gravitropic signal then leads to the reorientation of auxin
Gravitropism
Biological response in plants
response integrates diverse molecular components, including mechanosensitive ion channels, receptor-like kinases, the cytoskeletal elements, phytohormones
Thigmomorphogenesis
Chemical compound
chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure
Yoda1
Transmembrane receptors involved in cellular adhesion and signalling
PMID 20694000. S2CID 20775305. Gullingsrud J, Sotomayor M. "Mechanosensitive channels". Theoretical and Computational Biophysics Group, Beckman Institute
Integrin
Protein spanning across a biological membrane
ion channel like, including potassium channels KcsA and KvAP, and inward-rectifier potassium ion channel Kirbac Large-conductance mechanosensitive channel
Transmembrane_protein
clustering behavior of syntaxin-1A, the simulations of the opening of mechanosensitive channels (MscL) and the simulation of the domain partitioning of membrane
MARTINI
Bulgarian physicist (1948–2024)
mechanotransduction (Invited Review), In: Current Topics in Membranes, vol. 58: Mechanosensitive channels, O.P. Hamil, Ed., Elsevier/Academic Press (2007), pp. 121–150
Alexander_G._Petrov
Order of fungi
1016/S1286-4579(00)01319-8. PMID 11113382. Zhou, X. L.; et al. (1991). "A Mechanosensitive Channel in Whole Cells and in Membrane Patches of the Fungus Uromyces"
Rust_(fungus)
Type of drug which modulates ion channels
Neuromuscular-blocking drug) Ion channels gated by other mechanisms (e.g. light gated and mechanosensitive ion channels). These types of channels can also be pharmacologically
Channel_modulator
Topic in membrane biology
fingerprint zones and void zones comprise all membrane lipids. The mechanosensitive channel Piezo2 has a complex lipid fingerprint that tends to include phosphoinositide
Lipid_fingerprint
Russian-American materials scientist
the Anikeeva laboratory then extended this concept to stimulate mechanosensitive channels. Anikeeva and her colleagues have also shown that these magnetic
Polina_Anikeeva
3390/ijms13044564. PMC 3344232. PMID 22605996. Gullingsrud J, Sotomayor M. "Mechanosensitive channels". Theoretical and Computational Biophysics Group, Beckman Institute
Role of cell adhesions in neural development
Role_of_cell_adhesions_in_neural_development
F, Gottlieb PA (July 2004). "Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers". Nature. 430 (6996): 235–40
Lipid_bilayer_mechanics
man-made analogues of natural ion channels, and are thus also known as artificial ion channels. Compared to biological channels, they usually allow fluxes of
Synthetic_ion_channels
Chemical compound
"Structure, kinetic properties and biological function of mechanosensitive Piezo channels". Cell & Bioscience. 11 (1): 13. doi:10.1186/s13578-020-00522-z
Jedi1
Protein-coding gene in the species Homo sapiens
is caused by blood flow in normal endothelium. This activates mechanosensitive channels, which in turn activates two pathways; the MEK5/ERK5 pathway,
KLF2
Family of RNA-binding proteins
essential protein. The middle domain of the small conductance mechanosensitive channel MscS in Escherichia coli forms a homoheptameric ring. This LSm
LSm
Molecule able to block protein channels, frequently used as pharmaceutical
ligand-gated ion channel Ion channels mediated by the binding of a ligand to the channel protein mechanosensitive ion channels Ion channels that respond to
Channel_blocker
American biologist
Wikidata Q24546253. Elizabeth S Haswell; Rob Phillips; Douglas C Rees (2011). "Mechanosensitive channels: what can they do and how do they do it?". Structure. 19 (10):
Elizabeth_Haswell
Index of articles on biophysics
Mechanics of human sexuality Mechanome Mechanosensitive channels Mechanotaxis Membrane biology Membrane channel Membrane contact site Membrane curvature
Index_of_biophysics_articles
British biologist (born 1968)
7-halogenase and establishing the structure of an open Escherichia coli mechanosensitive channel. His contributions have been recognised by the Carbohydrate Chemistry
James_Naismith_(chemist)
American neuroscience academic (1945–2025)
bent and then open the channel. Although the precise identity of the proteins forming the tip link and the mechanosensitive channel is still controversial
A._James_Hudspeth
American biochemist, biophysicist, and structural biologist
fixation, and membrane proteins including ABC transporters and mechanosensitive ion channels including MscL and MscS. To do this, his group uses X-ray crystallography
Douglas_C._Rees
Chemical compound
Rog-Zielinska EA, Raja S, et al. (2020). "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE. 15 (10) e0240532
RN-9893
Biological membrane that separates the interior of a cell from its outside environment
Examples of integral proteins include ion channels, proton pumps, and g-protein coupled receptors. Ion channels allow inorganic ions such as sodium, potassium
Cell_membrane
Unexpected itching sensation
interneurons, to chemical pathways via the activation of the mechanosensitive ion channel PIEZO1; though both are poorly understood. Andersen, Hjalte Holm;
Alloknesis
Protein family
N-type calcium channels, also called Cav2.2 channels, are voltage gated calcium channels that are localized primarily on the nerve terminals and dendrites
N-type_calcium_channel
Manipulation of cells using magnetic fields
(2021-01-28). "Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals". Nature Materials. 20 (7): 1029–1036
Magnetogenetics
Genus of bacteria
obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock". Applied and Environmental
Salinispora
Chemical compound
Wahl-Schott C, et al. (November 2020). "TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles". Science Advances. 6 (46) eabb5064
ML2-SA1
Physiologist
ion channels in articular chondrocytes. Putative roles in mechanotransduction, metabolic regulation and cell proliferation. In: Mechanosensitive Ion Channels
Ali_Mobasheri
MCA1 has been identified as a candidate for a Ca2+ permeable mechanosensitive channel in Arabidopsis thaliana. Overexpression of plasma membrane protein
Hydraulic_signaling_in_plants
Species of bacterium
Obligate Marine Actinobacterium Salinispora tropica with the Large Mechanosensitive Channel Gene mscL Rescues Cells from Osmotic Downshock". Applied and Environmental
Salinispora_tropica
Protein family
Bao L, Locovei S, Dahl G (August 2004). "Pannexin membrane channels are mechanosensitive conduits for ATP". FEBS Letters. 572 (1–3): 65–8. Bibcode:2004FEBSL
Pannexin
Chemical compound
Rog-Zielinska EA, Raja S, et al. (2020). "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE. 15 (10) e0240532
GSK417651A
pressure. Fibroblasts synthesize structural proteins, some of which are mechanosensitive and form integral part of the extracellular Matrix (ECM) e.g. collagen
Mechanobiology
Protein-coding gene in the species Homo sapiens
reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains
TMC8
Family of transport proteins
TRPN is a member of the transient receptor potential channel family of ion channels, which is a diverse group of proteins thought to be involved in mechanoreception
TRPN
Protein-coding gene in humans
C-terminal of TREK-1 channels plays a role in the mechanosensitivity of the channels. In the neurons of the central nervous system, TREK-1 channels are important
KCNK2
Species of spider
(Grammostola rosea Mechanotoxin 4), has been shown to inhibit mechanosensitive ion channels in living cells. In March 5, 2026, G. rosea was added to Appendix
Chilean_rose_tarantula
Sensory system in fish
parallel circuits to interpret mechanoreceptive information. The use of mechanosensitive hairs is homologous to the functioning of hair cells in the auditory
Lateral_line
Human protein and coding gene
in intracellular potassium (K+) levels caused by efflux from mechanosensitive ion channels located in the cell membrane. However, other triggers induce
NLRP3
Protein-coding gene in the species Homo sapiens
(TWIK-related Arachidonic Acid-Stimulated K+) subfamily of mechanosensitive potassium channels. Potassium channels play a role in many cellular processes including
KCNK4
Detectable change in the internal or external surroundings
generated forces. Mechanosensitive ion channels are found in many cell types and it has been shown that the permeability of these channels to cations is affected
Stimulus_(physiology)
Molecular biologist, neuroscientist, and Nobel laureate 2021
functional genomics techniques to identify and characterize mechanosensitive ion channels (mechanotransduction). Patapoutian has an h-index of 68 according
Ardem_Patapoutian
Protein-coding gene in the species Homo sapiens
Transmembrane channel-like protein 2 is a protein that in humans is encoded by the TMC2 gene. This gene is considered a member of a gene family predicted
TMC2
Principle and applications of MINFLUX microscopy
vitro and in vivo, and to monitor configurational changes of the mechanosensitive ion channel PIEZO1. Confocal microscopy Fluorescence Fluorescence microscope
Minflux
Protein and coding gene in humans
a transient receptor potential channel of the classical TRPC subfamily. TRPC6 channels are nonselective cation channels that respond directly to diacylglycerol
TRPC6
Class of enzymes
phosphatidylcholine phosphatidohydrolase) is an anesthetic-sensitive and mechanosensitive enzyme of the phospholipase protein superfamily that catalyzes the
Phospholipase_D
Amino acid
PMID 17929246. S2CID 45669104. Ma MC, Huang HS, Chen YS, Lee SH (Nov 2008). "Mechanosensitive N-methyl-D-aspartate receptors contribute to sensory activation in
Serine
Protein-coding gene in the species Homo sapiens
Transmembrane channel-like protein 6 is a protein that in humans is encoded by the TMC6 gene. In vivo, TMC6 and its homolog TMC8, interact and form a
TMC6
Medical condition
autosomal dominant mutations in PIEZO1, which encodes a cation channel whose mechanosensitive properties enable erythrocytes to deform as they pass through
Hereditary_stomatocytosis
Receptors in the skin of vertebrates
transmitted to the nervous system. Merkel cells express PIEZO2, a mechanosensitive ion channel that responds to mechanical forces. Mice in which Piezo2 is knocked-out
Merkel_cell
South Korean chemist
nanoparticles to generate mechanical forces or torque that activate mechanosensitive ion channels, such as Piezo1, enabling non-invasive and long-distance modulation
Cheon_Jinwoo
Sensory organ or cell
full of membrane proteins and ion channels. One type of ion channel are Mechanosensitive (MS) ion channels. MS channels are different from other membrane
Mechanoreceptors_(in_plants)
Medical condition
Pellegrini, Monica (2005), "Mechanosensitive Cation Channels of Leech Neurons", in Kamkin, Andre; Kiseleva, Irina (eds.), Mechanosensitivity in Cells and Tissues
McKusick–Kaufman_syndrome
Protein-coding gene in the species Homo sapiens
Transmembrane channel like 3 is a protein that in humans is encoded by the TMC3 gene. GRCh38: Ensembl release 89: ENSG00000188869 – Ensembl, May 2017
TMC3
American biologist (1941–2023)
Department of Pharmacology. In this role, Sachs discovered mechanosensitive ion channels which are sensors for systems including the senses of hearing
Frederick_Sachs
Classification of membrane proteins including ion channels
Bcl-2 family 1.A.22 Large-conductance mechanosensitive ion channel 1.A.23 Small-conductance mechanosensitive ion channel 1.A.24 Gap-junction-forming connexin
Transporter Classification Database
Transporter_Classification_Database
Protein-coding gene in humans
Kir4.1 channel is expressed in the stria vascularis and is essential for formation of the endolymph, the fluid that surrounds the mechanosensitive stereocilia
KCNJ10
Velvet Ant toxin
Gating of these channels is still not entirely understood. While their activation upon harsh mechanical pressure may suggest a mechanosensitive nature of these
Do6a
Sense of position of one's own body parts
and zebrafish. PIEZO2, a nonselective cation channel, has been shown to underlie the mechanosensitivity of proprioceptors in mice. Humans with loss-of-function
Proprioception
Activation of a protein by exposure to its substrate
disruption also causes PLD2 to favor trafficking to PIP2 domains. The mechanosensitive ion channel TREK-1 is released from cholesterol dependent lipid rafts in
Substrate_presentation
Chemical compound and pharmaceutical drug
"Nongenomic effects of cisplatin: acute inhibition of mechanosensitive transporters and channels without actin remodeling". Cancer Research. 70 (19): 7514–22
Cisplatin
Protein-coding gene in humans
Tabarean IV, Juranka P, Morris CE (November 2002). "Mechanosensitivity of N-type calcium channel currents". Biophysical Journal. 83 (5): 2560–2574. Bibcode:2002BpJ
CACNA1B
Gut sensory epithelial cell that synapses with neurons
serotonergic enterochromaffin cells, is directly mechanosensitive: mechanical stimulation opens Piezo2 channels, producing a rapid inward current and a rise
Neuropod_cell
Protein-coding gene in the species Homo sapiens
and 5. This topology is similar to that of transient receptor potential channels (TRPs), a family of proteins involved in the perception of senses such
TMC1
Nuclear membrane surrounding the nucleus in eukaryotic cells
Sean; Bas, Guniz; Styner, Maya; Rubin, Clinton T. (2015-06-01). "Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus"
Nuclear_envelope
Protein-coding gene in the species Homo sapiens
Mangrum C, Wu YG, Elemento O, Tavazoie SF (July 2015). "Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival". Nature Cell
PANX1
German scientist
PMID 19197074. Kohl, P; Kamkin, AG; Kiseleva, I S.; Noble, D (1994). "Mechanosensitive fibroblasts in the sino-atrial node region of rat heart: interaction
Peter_Kohl_(physiologist)
Protein-coding gene in the species Homo sapiens
include six TRPV channels. The high Ca2+-selectivity of TRPV5 and TRPV6 makes these channels distinct from the other four TRPV channels (TRPV1-TRPV4). TRPV5
TRPV6
Protein-coding gene in humans
Doulazmi M, Hautefeuille M, Fouquet C, Sarde L, et al. (2025). "GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration". Science
GPR161
Species of virus
observed in a virus. It is also the first virus to be found with a mechanosensitive ion channel protein, which may protect the genome from osmotic damage. Mature
Cafeteria_roenbergensis_virus
Chemical compound
for NaV channels. The action of NSTX produces minimal effect on cardiac NaV channels, exhibiting around 20–60 fold less affinity than NaV channels in skeletal
Neosaxitoxin
Growth or movement of an organism in response to an electric field
and potassium levels. Pressure applied to our skin opens up mechanosensitive sodium channels. With the right amount of stimulus it can cause the action
Electrotropism
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MECHANOSENSITIVE CHANNELS
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MECHANOSENSITIVE CHANNELS
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