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peptides to form triple helix collagen, and replenish the collagen in the targeted site. Scientists believe that Alpha collagen can help to deliver specific
Alpha_collagen
Most abundant structural protein in animals
Collagen (/ˈkɒlədʒən/) is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein
Collagen
Type of connective tissue in animals
in size and shape. Type II collagen Collagen, type I, alpha 1 Collagen, type I, alpha 2 Collagen, type III, alpha 1 "Collagen: What It Is, Types, Function
Type_I_collagen
Mammalian protein
III Collagen is a homotrimer, or a protein composed of three identical peptide chains (monomers), each called an alpha 1 chain of type III collagen. Formally
Collagen,_type_III,_alpha_1
Mammalian protein found in humans
Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. COL1A1 encodes the major component
Collagen,_type_I,_alpha_1
Protein found in humans
Collagen alpha-2(I) chain is a protein that in humans is encoded by the COL1A2 gene. This gene encodes one of the chains for type I collagen, the fibrillar
Collagen,_type_I,_alpha_2
Protein found in humans
Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_1
Protein found in humans
Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene. It is composed of a triple helical, collagenous domain flanked by
Collagen,_type_VII,_alpha_1
Basis for articular and hyaline cartilage in animals
collagen, type II, alpha 1 chains. It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage. Type II collagen is organised
Type_II_collagen
Protein-coding gene in humans
Collagen alpha-5(IV) chain is a protein that in humans is encoded by the COL4A5 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_5
Protein found in humans
Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_2
Protein found in humans
Collagen alpha-1(XIX) chain is a protein that in humans is encoded by the COL19A1 gene. This gene encodes the alpha chain of type XIX collagen, a member
Collagen,_type_XIX,_alpha_1
Protein found in humans
Collagen alpha-5(VI) chain also known as von Willebrand factor A domain-containing protein 4 is a protein that in humans is encoded by the COL6A5 gene
Collagen,_type_VI,_alpha_5
Protein-coding gene in humans
Collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital), also known as COL2A1, is a human gene that provides instructions
Collagen,_type_II,_alpha_1
Protein found in humans
Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene. Type IV collagen, the major structural component of basement membranes
Collagen,_type_IV,_alpha_3
Mammalian protein found in humans
Collagen alpha-3(VI) chain is a protein that in humans is encoded by the COL6A3 gene. This protein is an alpha chain of type VI collagen that aids in microfibril
Collagen,_type_VI,_alpha_3
Protein found in humans
Collagen alpha-4(IV) chain is a protein that in humans is encoded by the COL4A4 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_4
Protein found in humans
Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues
Collagen,_type_IV,_alpha_1
Protein found in humans
Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1 gene. This gene encodes the alpha chain of type XII collagen, a member
Collagen,_type_XII,_alpha_1
Protein found in humans
Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. It likely plays a role in collagen binding and cell-cell adhesion
Collagen,_type_XIV,_alpha_1
Protein found in humans
Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene. This gene encodes the alpha chain of type XVI collagen, a member
Collagen,_type_XVI,_alpha_1
Protein found in humans
Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_3
Protein found in humans
Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. This gene encodes one of the three alpha chains of type IX collagen
Collagen,_type_IX,_alpha_1
Protein found in humans
Collagen alpha-1(XI) chain is a protein that in humans is encoded by the COL11A1 gene. The COL11A1 gene encodes one of the two alpha chains of type XI
Collagen,_type_XI,_alpha_1
Mammalian protein found in humans
Collagen alpha-6(IV) chain is a protein that in humans is encoded by the COL4A6 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_6
Protein found in humans
Collagen alpha-1(X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene. This gene encodes the alpha chain
Collagen,_type_X,_alpha_1
Protein found in humans
Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. The collagens are a superfamily of proteins that play a role in
Collagen,_type_VI,_alpha_1
Protein found in humans
Collagen alpha-2(IX) chain is a protein that in humans is encoded by the COL9A2 gene. This gene encodes one of the three alpha chains of type IX collagen
Collagen,_type_IX,_alpha_2
Protein found in humans
Collagen alpha-2(XI) chain is a protein that in humans is encoded by the COL11A2 gene. The COL11A2 gene produces one component of this type of collagen
Collagen,_type_XI,_alpha_2
Protein found in humans
Collagen alpha-1(XXI) chain is a protein that in humans is encoded by the COL21A1 gene. It is the alpha chain of type XXI collagen, a collagen belonging
Collagen,_type_XXI,_alpha_1
Mammalian protein found in humans
It encodes the alpha chain of type XVII collagen. Collagen XVII is a transmembrane protein, like collagen XIII, XXIII and XXV. Collagen XVII is a structural
Collagen,_type_XVII,_alpha_1
Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_2
Protein found in humans
Collagen alpha-1(XV) chain is a protein that in humans is encoded by the COL15A1 gene. This gene encodes the alpha chain of type XV collagen, a member
Collagen,_type_XV,_alpha_1
Protein found in humans
Collagen alpha-2(VI) chain is a protein that in humans is encoded by the COL6A2 gene. This gene encodes one of the three alpha chains of type VI collagen
Collagen,_type_VI,_alpha_2
Protein found in humans
Biotechnology Information, U.S. National Library of Medicine. "COL22A1 collagen type XXII alpha 1 chain". NCBI. 25 May 2017. Retrieved 18 September 2017. v t e
Collagen,_type_XXII,_alpha_1
Protein found in humans
Collagen alpha-1(XIII) chain is a protein that in humans is encoded by the COL13A1 gene. This gene encodes the alpha chain of one of the nonfibrillar collagens
Collagen,_type_XIII,_alpha_1
Main protein structure of fibrous collagen
biology, the collagen triple helix or type-2 helix is the main secondary structure of various types of fibrous collagen, including type I collagen. In 1954
Collagen_helix
Protein found in humans
Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene. This gene encodes the alpha chain of type XVIII collagen. This
Collagen,_type_XVIII,_alpha_1
Protein found in humans
Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene. This gene encodes one of the two alpha chains of type VIII collagen
Collagen,_type_VIII,_alpha_1
Protein found in humans
Collagen, type XXVIII, alpha 1 also known as COL28A1 is a protein that in humans is encoded by the COL28A1 gene. This protein belongs to a class of collagens
Collagen, type XXVIII, alpha 1
Collagen,_type_XXVIII,_alpha_1
Protein found in humans
Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene. COL27A1 is a type XXVII collagen. It was discovered
Collagen,_type_XXVII,_alpha_1
Protein found in humans
Collagen alpha-3(IX) chain is a protein that in humans is encoded by the COL9A3 gene. This gene encodes one of the three alpha chains of type IX collagen
Collagen,_type_IX,_alpha_3
Protein found in humans
Collagen alpha-2(VIII) chain is a protein that in humans is encoded by the COL8A2 gene. Mutations of the gene are linked to posterior polymorphous dystrophy
Collagen,_type_VIII,_alpha_2
Non-fibrillar collagen found in the structure of basement membranes
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational
Type_IV_collagen
containing type I collagen. Type V collagen is a part of the family of collagen proteins consisting of Collagen I – Collagen XXVIII. Collagen proteins are
Type_V_collagen
Fibers obtained from natural sources
applications. Collagen is a structural protein, often referred to as "the steel of biological materials". There are multiple types of collagen: Type I (comprising
Natural_fiber
Mammalian protein found in Homo sapiens
α2β1 integrin receptor. This is a major collagen-binding integrin in vertebrates. Integrin α2 is an integrin alpha subunit, so it is made of a large extracellular
Integrin_alpha_2
Chemical compound
component of the protein collagen, comprising roughly 13.5% of mammalian collagen. Hydroxyproline and proline play key roles for collagen stability. They permit
Hydroxyproline
Protein found in humans
Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene. COL25A1 is a brain-specific membrane-bound collagen. Proteolytic
Collagen,_type_XXV,_alpha_1
IV, alpha 1 Collagen, type V, alpha 1 Collagen, type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Type of biological tissue in animals
types of connective tissue consists of three main components: elastic and collagen fibers, ground substance, and cells. It is one of the four primary types
Connective_tissue
Mammalian protein found in humans
nucleotide level, human and rat collagen XXIII alpha 1 show 76% identity. Furthermore, cellular localization of collagen XXIII was determined by immunofluorescence
Collagen,_type_XXIII,_alpha_1
Mammalian protein found in Homo sapiens
integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others. CD49a has been implicated as a marker of tissue resident
Integrin_alpha-1
Group of connective tissue conditions
on the type of collagen. Type II collagen is made by combining three copies of the alpha chain made by the COL2A1 gene. Type XI collagen, on the other
Collagenopathy, types II and XI
Collagenopathy,_types_II_and_XI
Rare autoimmune disease
glomerulonephritis, and kidney failure. It is thought to attack the alpha-3 subunit of type IV collagen, which has therefore been referred to as Goodpasture's antigen
Goodpasture_syndrome
Type of collagen protein
Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle
Collagen_VI
Protein-coding gene in the species Homo sapiens
COL20A1 is a collagen gene. GRCh38: Ensembl release 89: ENSG00000101203 – Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000016356 – Ensembl, May
Collagen,_type_XX,_alpha_1
Mammalian protein involved in blood clotting
this day. Von Willebrand Factor has been shown to interact with Collagen, type I, alpha 1. Recently, It has been reported that the cooperation and interactions
Von_Willebrand_factor
Type XXVII collagen is the protein predicted to be encoded by COL27A1. It was first described by Dr. James M. Pace and his colleagues at the University
Type_XXVII_collagen
Chemical compound
tumor necrosis factor alpha and elastin-degrading matrix metalloproteinases. Biotinylated GHK-Cu was incorporated into a collagen membrane, which was used
Copper_peptide_GHK-Cu
Organic compounds containing amine and carboxylic groups
classified according to the locations of the core structural functional groups (alpha- (α-), beta- (β-), gamma- (γ-) amino acids, etc.); other categories relate
Amino_acid
Group of genetic disorders resulting in fragile bones
problem with connective tissue due to a lack of, or poorly formed, type I collagen. In more than 90% of cases, OI occurs due to mutations in the COL1A1 or
Osteogenesis_imperfecta
Species of bacterium
this alpha-toxin. The beta-toxin of H. histolytica is a group of seven collagenases. Collagenases are zinc metalloproteases that cleave collagen and gelatin
Hathewaya_histolytica
Series of events that restore integrity to damaged tissue after an injury
oral collagen supplements for wound healing and skin aging. Oral collagen supplements also increase skin elasticity, hydration, and dermal collagen density
Wound_healing
Mammalian protein found in Homo sapiens
Collagen alpha-1(XXVI) chain is a protein that in humans is encoded by the EMID2 gene. GRCh38: Ensembl release 89: ENSG00000160963 – Ensembl, May 2017
EMID2
Ultraviolet light-induced biological development over time
that contributes to degradation of extracellular matrix proteins such as collagen and elastin. Prevention focuses on photoprotection, including shade, sun-protective
Photoaging
Class of enzymes
Rhoads RE, Udenfriend S (Aug 1968). "Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase". Proceedings of the National Academy
Lysyl_hydroxylase
Protein-coding gene in humans
Collagen, type XXIV, alpha 1 is a protein that in humans is encoded by the COL24A1 gene. GRCm38: Ensembl release 89: ENSMUSG00000028197 – Ensembl, May
COL24A1
Rigid organs of the skeleton of vertebrates
substance. These cells synthesise collagen alpha polypeptide chains and then secrete collagen molecules. The collagen molecules associate with their neighbors
Bone
Protein-coding gene in the species Homo sapiens
chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues"
Integrin_alpha_11
Protein-coding gene in the species Homo sapiens
subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis
P4HA1
Mammalian protein found in humans
Alpha-1 antitrypsin or α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1
Alpha-1_antitrypsin
Surface glycoproteins involved in hemostasis
GPVI and probably GPIV as well, function as collagen receptors, engaged in platelet adhesion to collagen. The leading role in the elimination of high-stress
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein domain
Brorin (VWC2) Collagen, type I, alpha 1 (COL1A1) Collagen, type II, alpha 1 (COL2A1) Collagen, type III, alpha 1 (COL3A1) Collagen, type V, alpha 2 (COL5A2)
Von Willebrand factor type C domain
Von_Willebrand_factor_type_C_domain
Dog breed
resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV". Proceedings of the National Academy of Sciences. 91
Samoyed_dog
Rare genetic disorder
"COL9A1 collagen type IX alpha 1 [ Homo sapiens (human) ]". "COL9A2 collagen type IX alpha 2 [ Homo sapiens (human) ]". "COL9A3 collagen type IX alpha 3".
Multiple_epiphyseal_dysplasia
Histological staining method
of collagen may be estimated based on the staining method. Trichrome methods are now used for differentiating muscle from collagen, pituitary alpha cells
Trichrome_staining
Disorders of adaptive immune system
peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency". Journal of Immunology. 186 (1): 621–631. doi:10.4049/jimmunol
Autoimmune_disease
Group of eye diseases related to poor retinal and nerve perfusion
such as the Ologen collagen matrix, which has been clinically shown to increase the success rates of surgical treatment. Collagen matrix prevents scarring
Glaucoma
Medical condition
2021. Zhou J, Hertz JM, Tryggvason K (June 1992). "Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular
Alport_syndrome
Protein-coding gene in the species Homo sapiens
Interleukin-1 alpha (IL-1 alpha or IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that is encoded by the IL1A gene in
Interleukin_1-alpha
Protein in the extracellular matrix
extracellular proteins. For example, all laminin alpha-chains have five laminin G domains, all collagen family proteins have one laminin G domain, the CNTNAP
Laminin
Protein-coding gene in the species Homo sapiens
subunit alpha-2 is an enzyme that in humans is encoded by the P4HA2 gene. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis
P4HA2
Large plasma protein found in the blood
α2-Macroglobulin (α2M) or alpha-2-macroglobulin is a large (720 KDa) plasma protein found in the blood. It is mainly produced by the liver, and also locally
Alpha-2-Macroglobulin
Type of collagen
Type XVIII collagen is a type of collagen which can be cleaved to form endostatin. The endostatin is from the c terminus end of the collagen XVIII, and
Type_XVIII_collagen
Immune system messenger protein which induces inflammation
contributors of liver fibrosis. On the other hand, TNF suppresses alpha-1 type-1 collagen expression and HSC proliferation in vitro, which should inhibit
Tumor_necrosis_factor
Component of blood aiding in coagulation
into the blood. Platelets store vWF in their alpha granules. When the endothelial layer is disrupted, collagen and VWF anchor platelets to the subendothelium
Platelet
Protein complex
Ninomiya Y, Olsen BR (April 1991). "The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome
Complement_component_1q
Protein factor that regulates the length of R-actin
(January 2005). "Spectrin, alpha-actinin, and dystrophin". Advances in Protein Chemistry. Fibrous Proteins: Coiled-Coils, Collagen and Elastomers. 70. Academic
Actinin
Enzyme in humans
Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Prolyl endopeptidase
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Amino acid
most notably in collagen, where glycine makes up about 35% of the amino acid content and enables the tight coiling of the collagen triple helix. Glycine
Glycine
Vertebrate natural glucocorticoid hormone
Cortisol down-regulates the synthesis of collagen. Cortisol raises the free amino acids in the serum by inhibiting collagen formation, decreasing amino acid uptake
Cortisol
Topics referred to by the same term
CA54, CA-54, or CA 54 may refer to: Collagen, type IV, alpha 5, a human protein-coding gene Calcium-54, (Ca-54 or 54Ca), an isotope of calcium California
CA54
Protrusion of abdominal contents through the inguinal canal in the pelvis
HT, Erden G, Ozturk G, Düzgün AP, et al. (2014). "Association of Collagen Type I Alpha 1 Gene Polymorphism With Inguinal Hernia - PubMed". Hernia: The
Inguinal_hernia
Topics referred to by the same term
KNO may refer to: Kno, an American education software company Collagen, type XVIII, alpha 1, a protein Kno (musician) (Ryan Wisler), member of the hip
KNO
Protein-coding gene in the species Homo sapiens
PMID 7780165. Arora PD, McCulloch CA (April 1994). "Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblasts". Journal of Cellular
ACTA2
Mammalian protein found in Homo sapiens
promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin
Osteonectin
Mammalian protein found in Homo sapiens
expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol. 115 (1):
Integrin_alpha_3
Enzyme
Udenfriend S (July 1966). "Requirements for alpha-ketoglutarate, ferrous ion and ascorbate by collagen proline hydroxylase". Biochemical and Biophysical
Procollagen-proline dioxygenase
Procollagen-proline_dioxygenase
Protein-coding gene in the species Homo sapiens
Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is
Alpha_2-antiplasmin
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