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Mammalian protein found in humans
Collagen alpha-3(VI) chain is a protein that in humans is encoded by the COL6A3 gene. This protein is an alpha chain of type VI collagen that aids in microfibril
Collagen,_type_VI,_alpha_3
Protein found in humans
Collagen alpha-5(VI) chain also known as von Willebrand factor A domain-containing protein 4 is a protein that in humans is encoded by the COL6A5 gene
Collagen,_type_VI,_alpha_5
Protein found in humans
Collagen alpha-2(VI) chain is a protein that in humans is encoded by the COL6A2 gene. This gene encodes one of the three alpha chains of type VI collagen
Collagen,_type_VI,_alpha_2
Protein found in humans
abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in
Collagen,_type_V,_alpha_1
Type of collagen protein
Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle function
Collagen_VI
II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, type VI, alpha 1 Collagen, type VII, alpha 1 Collagen
Alpha_collagen
Most abundant structural protein in animals
interruptions) (types XV, XVIII) MACIT (membrane-associated collagens with interrupted triple helices) (types XIII, XVII) Microfibril-forming (type VI) Anchoring
Collagen
Protein found in humans
Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. The collagens are a superfamily of proteins that play a role in
Collagen,_type_VI,_alpha_1
Group of genetic disorders resulting in fragile bones
problem with connective tissue due to a lack of, or poorly formed, type I collagen. In more than 90% of cases, OI occurs due to mutations in the COL1A1
Osteogenesis_imperfecta
Surface glycoproteins involved in hemostasis
Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. It is an important collagen receptor involved in collagen-induced
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein domain
complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the
Von Willebrand factor type C domain
Von_Willebrand_factor_type_C_domain
Protein factor that regulates the length of R-actin
(January 2005). "Spectrin, alpha-actinin, and dystrophin". Advances in Protein Chemistry. Fibrous Proteins: Coiled-Coils, Collagen and Elastomers. 70. Academic
Actinin
Mammalian protein involved in blood clotting
P-selectin. The A1 domain: Binds to the platelet GPIb-receptor, collagen types IV and VI, heparin, and osteoprotegerin. The A2 domain: Unfolds to expose
Von_Willebrand_factor
Medical condition
UCMD1 is associated with variants of type VI collagen, while UCMD2 is associated with variants of type XII collagen. UCMD is commonly associated with contractures
Ullrich congenital muscular dystrophy
Ullrich_congenital_muscular_dystrophy
Protein-coding gene in the species Homo sapiens
PMID 7780165. Arora PD, McCulloch CA (April 1994). "Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblasts". Journal of Cellular
ACTA2
Protein-coding gene in the species Homo sapiens
Platelet glycoprotein VI (GPVI) is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GP6
Platelet_glycoprotein_VI
Protein-coding gene in the species Homo sapiens
myofibrillar actin filaments. Alpha-actinin-1 has been shown to interact with: CDK5R1, CDK5R2, Collagen, type XVII, alpha 1, GIPC1, PDLIM1, Protein kinase
Alpha-actinin-1
Medical condition
inheritance of the disease points to the region of chromosome 3 near the collagen, type VII, alpha 1 gene (COL7A1). List of cutaneous conditions Bart-Pumphrey
Bart_syndrome
InterPro Domain
beta-protein; domains at the C-termini of the alpha-1 and alpha-3 chains of type VI and type VII collagens; tissue factor pathway inhibitor precursor; and
Kunitz_domain
II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, type VI, alpha 1 Collagen, type VII, alpha 1 Collagen
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Mammalian protein found in Homo sapiens
chemotherapies. Increased expression of ITGA1-associated collagen ligands including type IV and type VI collagen, is also associated with aggressive tumor features
Integrin_alpha-1
Human chromosome
encoding alpha-1 chain of collagen VI COL6A2: encoding alpha-2 chain of collagen VI COL18A1: encoding alpha-1 chain of collagen XVIII CRYAA: encoding alpha-crystallin
Chromosome_21
Protein-coding gene in the species Homo sapiens
glomerulosclerosis. Alpha-actinin-4 has been shown to interact with PDLIM1, Sodium-hydrogen exchange regulatory cofactor 2, Collagen, type XVII, alpha 1, CAMK2A
Alpha-actinin-4
Component of blood aiding in coagulation
into the blood. Platelets store vWF in their alpha granules. When the endothelial layer is disrupted, collagen and VWF anchor platelets to the subendothelium
Platelet
Protein Domain
complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the
Von Willebrand factor type A domain
Von_Willebrand_factor_type_A_domain
Structural fibrous protein
two types: the primitive, softer forms found in all vertebrates and the harder, derived forms found only among sauropsids (reptiles and birds). Alpha-keratins
Keratin
Group of eye diseases related to poor retinal and nerve perfusion
such as the Ologen collagen matrix, which has been clinically shown to increase the success rates of surgical treatment. Collagen matrix prevents scarring
Glaucoma
Protein-coding gene in the species Homo sapiens
keratinocytes and macrophages for induced IL-1α secretion induces pro-collagen type I and III synthesis causes proliferation of fibroblasts, induces collagenase
Interleukin_1-alpha
Protein in the extracellular matrix
place. Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. The proteins also
Laminin
Protein-coding gene in humans
Timpl R, Hook M (March 1992). "Binding of the proteoglycan decorin to collagen type VI". J. Biol. Chem. 267 (8): 5250–6. doi:10.1016/S0021-9258(18)42759-7
Biglycan
Medical condition
COL6A2 and COL6A3 genes that encode for three of the alpha chains making up Collagen VI. Collagen VI is important in muscle, tendon, and skin tissue, and
Congenital_muscular_dystrophy
Neurologically significant human protein
and neurodegeneration. Dystonin has been shown to interact with collagen, type XVII, alpha 1, DCTN1, MAP1B and erbin. Several Dst mutant mouse lines have
Dystonin
Type of protein
higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened levels of collagen helped facilitate adhesions
Catenin
Organic compounds containing amine and carboxylic groups
groups (alpha- (α-), beta- (β-), gamma- (γ-) amino acids, etc.); other categories relate to polarity, ionization, and side-chain group type (aliphatic
Amino_acid
Chemical compound
activity of Fli1, a nuclear transcription factor and a negative regulator of collagen 1 synthesis. Fli1 competes with another transcription factor, ETS-1, to
Marinobufagenin
Protein-coding gene in humans
to type I collagen fibrils, and plays a role in matrix assembly. Decorin's name is a derivative of both the fact that it "decorates" collagen type I,
Decorin
Medical condition neuromuscular disorders
Dystrophy Mimicking Emery-Dreifuss and Collagen VI related Diseases". Journal of Neuromuscular Diseases. 2 (3): 229–240. doi:10.3233/JND-150093. PMC 5240538
LAMA2 related congenital muscular dystrophy
LAMA2_related_congenital_muscular_dystrophy
Protein
"Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor". Cell. 77 (5): 675–686. doi:10.1016/0092-8674(94)90052-3. PMID 8205617
Dystroglycan
Amino acid
humans, most importantly proteinogenesis, but also in the crosslinking of collagen polypeptides, uptake of essential mineral nutrients, and in the production
Lysine
"Structure of cDNAs encoding the triple-helical domain of murine alpha 2 (VI) collagen chain and comparison to human and chick homologues. Use of polymerase
Decellularization
Medical condition
(thrombospondin-2), COL6A2 (collagen type VI alpha 2 chain), SEC31A, EIF5A (eukaryotic translation initiation factor 5A), COL1A1 (collagen type I alpha 1 chain), COL1A2
Nodular_fasciitis
Process of formation of blood clots
extracellular matrix promotes collagen interaction with platelet glycoprotein VI. Binding of collagen to glycoprotein VI triggers a signaling cascade that
Coagulation
Type III intermediate filament protein
vimentum, meaning an osier, withy (array of flexible rods). Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells
Vimentin
Protein-coding gene in humans
association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological
FCER1G
Specialised kidney cells
composed of glomerular matrix proteins such as collagen IV (α1 and α2 chains), collagen V, collagen VI, laminin A, B1, B2, fibronectin, and proteoglycans
Mesangial_cell
Protein-coding gene in humans
MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency". Molecular and Cellular Neurosciences. 30 (3): 408–17. doi:10.1016/j.mcn.2005.08.005.
CSPG4
Keratin protein in humans
tumor cells in blood. Keratin 18 has been shown to interact with Collagen, type XVII, alpha 1, DNAJB6, Pinin and TRADD. GRCh38: Ensembl release 89: ENSG00000111057
Keratin_18
type IV collagen, and fibronectin which is partially responsible for the hemorrhage caused by the toxin The cysteine-rich domain binds to the alpha-2/beta-1
Atrolysin_A
Human protein-coding gene
Timpl R, Stallcup WB (1996). "Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules". The Journal of Biological
Tenascin_C
Protein found in humans
(K1) is a Type II intermediate filament (IFs) of the intracytoplasmatic cytoskeleton. It is co-expressed with and binds to Keratin 10, a Type I keratin
Keratin_1
Protein found in humans
associate with transmembrane proteins α6β4 integrin, a type of cell adhesion molecule, and BP180/collagen XVII, linking K5/K14 filaments in the basal cells
Keratin_5
Cell type
settled in the stroma, keratocytes start synthesizing collagen molecules of different types (I, V, VI) and keratan sulfate. By the moment of eye opening
Corneal_keratocyte
400 – non-fibrillar collagens MeSH D12.776.860.300.250.400.100 – Type IV collagen MeSH D12.776.860.300.250.400.200 – Type VI collagen MeSH D12.776.860.300
List_of_MeSH_codes_(D12.776)
Polysaccharides found in animal tissue
binding protein, brain enriched hyaluronan binding protein, collagen VI, TSG-6, and inter-alpha-trypsin inhibitor. Cell surface interactions involving hyaluronan
Glycosaminoglycan
Medical condition
regular spacing and arrangement of the collagen fibrils within the stroma. Alterations in the spacing of collagen fibrils in a variety of conditions including
Corneal_opacity
Muscular degenerative disorder primarily of the hip and shoulders
descending order, are those due to mutation of 1) CAPN3 (calpain-3), 2) dysferlin, 3) collagen VI, 4) sarcoglycans, 5) anoctamin 5, and 6) FKRP (fukutin-related
Limb–girdle muscular dystrophy
Limb–girdle_muscular_dystrophy
Protein found in humans
Chen M, Marinkovich MP, Jones JC, et al. (1999). "NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within
Laminin_subunit_gamma-2
Mammalian protein found in humans
"Modulation of expression and assembly of vinculin during in vitro fibrillar collagen-induced angiogenesis and its reversal". Experimental Cell Research. 224
Vinculin
Protein-coding gene in the species Homo sapiens
catalytically active, magnesium(Mg)-ATPase. The C-terminal rod domain is an alpha helical coiled-coil that can multimerize with other myosin molecules to
MYH10
Protein found in humans
profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome
Filaggrin
through the basement membrane zone. Structural components of the dermis are collagen, elastic fibers, and ground substance. Within these components are the
List_of_skin_conditions
Chemical element with atomic number 14 (Si)
patients with osteoporosis. Silicon is needed for synthesis of elastin and collagen, of which the aorta contains the greatest quantity in the human body, and
Silicon
Chronic disease of the liver, characterized by fibrosis
liver, and portal hypertension. No fibrosis, but mild zone 3 steatosis, in which collagen fibres (pink–red, arrow) are confined to portal tracts (P) (Van
Cirrhosis
Protein-coding gene in the species Homo sapiens
gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets". Eur. J. Biochem. 263 (3): 612–23. doi:10.1046/j.1432-1327.1999
PLCG2
Human chromosome
associated protein 1 like 1 (6p22.3) COL11A2: collagen, type XI, alpha 2(6p21.3) CRIP3: encoding protein Cysteine rich protein 3 CYP21A2: cytochrome P450, family
Chromosome_6
to be added when the gentle cooking breaks down connective tissue and collagen, which lubricates and tenderizes fibers. Mussels and clams that do not
List of common misconceptions about arts and culture
List_of_common_misconceptions_about_arts_and_culture
Protein-coding gene in the species Homo sapiens
C, Cornelissen H (2003). "P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation"
MYLK2
Genetic changes in OA can lead to defects of a structural protein such as collagen, or changes in the metabolism of bone and cartilage. OA is rarely considered
Gene therapy for osteoarthritis
Gene_therapy_for_osteoarthritis
Superfamily of proteins with similar structures and diverse functions
plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming". The Journal of Experimental
Serpin
Extinct species of canine mammal
about the diet of the species found in the pits. Isotope analysis of bone collagen extracted from La Brea specimens provides evidence that the dire wolf,
Dire_wolf
Form of milk produced immediately following the delivery of newborn
maintain telomere length and boost fibroblast proliferation—a key element in collagen production and the maintenance of skin structure. A study argues that BC
Colostrum
Mammalian protein found in humans
vimentin, alpha smooth muscle actin (ACTA2), and fibroblast-specific protein 1 (FSP1). They also produce extracellular matrix components, such as type I collagen
Catenin_beta-1
e.g. collagen types I, III, IV, V VI, elastin, lamin etc. In addition to the structural proteins, fibroblasts make Tumor-Necrosis-Factor- alpha (TNF-α)
Mechanobiology
Class of enzymes
2013). "Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling". The Journal of Biological Chemistry. 288 (11): 7430–7
Receptor_tyrosine_kinase
Deformation of the eye's cornea into a conelike shape
scleral contact lenses may be needed. In 2016, the FDA approved corneal collagen cross-linking to halt progression. If vision cannot be improved with contact
Keratoconus
Protein-coding gene in the species Homo sapiens
doi:10.1172/JCI115190. PMC 295277. PMID 2022742. Karathanasis SK, Zannis VI, Breslow JL (Apr 1985). "Isolation and characterization of cDNA clones corresponding
Apolipoprotein_C-III
Protein-coding gene in the species Homo sapiens
2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". The Journal of Biological Chemistry. 277 (15): 12874–12878
Phosphoinositide-dependent kinase-1
Phosphoinositide-dependent_kinase-1
Protein-coding gene in humans
2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". J. Biol. Chem. 277 (15): 12874–8. doi:10.1074/jbc.M200482200
AKT1
Removal of opacified lens from the eye
syndrome), small pupils, axial length greater than 26 mm, use of systemic alpha-1a antagonist medication (e.g., tamsulosin), previous trauma, inability
Cataract_surgery
Biological process of getting older
increase skin cell proliferation, and increase extracellular proteins such as collagen and fibronectin (important proteins for cell proliferation). Another substance
Ageing
Chemical element with atomic number 25 (Mn)
causes skeletal deformation in animals and inhibits the production of collagen in wound healing. Waterborne manganese has a greater bioavailability than
Manganese
responsible for significant age-associated dryness, wrinkling, elastin and collagen damage, freckling, IGH, age spots and other cosmetic changes. The American
Health effects of sunlight exposure
Health_effects_of_sunlight_exposure
Organism altered by genetic engineering
developed to be expressed by silkworms include; human serum albumin, human collagen α-chain, mouse monoclonal antibody and N-glycanase. Silkworms have been
Genetically_modified_organism
Inorganic, nonmetallic solid prepared by the action of heat
may be used as bone replacement, or with the incorporation of protein collagens, the manufacture of synthetic bones. Applications for actinide-containing
Ceramic
Order of reptiles
are hinge areas that consist mainly of alpha-keratin. Underneath the surface, the dermis is thick with collagen. Both the head and jaws lack scales and
Crocodylia
Drug developed by Novartis
with laminin-α2-deficient congenital muscular dystrophy (MDC1A) and collagen VI related myopathy. Santhera Pharmaceuticals will use the phase 1 clinical
Omigapil
Protein-coding gene in the species Homo sapiens
whereas a PRDX5 dimer is formed by close contact between an alpha-3-helix of one molecule and an alpha-5-helix from the other molecule. As a peroxiredoxin, PRDX5
PRDX5
Poisoning caused by lead in the body
metabolism of bones and teeth and alters the permeability of blood vessels and collagen synthesis. Lead may also be harmful to the developing immune system, causing
Lead_poisoning
Class of enzymes
their surfaces under specialized conditions may also lead to accelerated collagen and elastin degradation at sites of inflammation in diseases such as atherosclerosis
Cysteine_protease
Body hair removal
Khachemoune A (January 2007). "Hair removal with the 3-msec alexandrite laser in patients with skin types IV-VI: efficacy, safety, and the role of topical corticosteroids
Hair_removal
2013. Retrieved 3 April 2013.[permanent dead link] Aguilar, M.; et al. (AMS Collaboration) (3 April 2013). "First Result from the Alpha Magnetic Spectrometer
2013_in_science
Genetic engineering to produce pharmaceuticals
with PlantForm (see below) and Fraunhofer. Pharming – C1 inhibitor, human collagen 1, fibrinogen (with American Red Cross), and lactoferrin in cow milk The
Pharming_(genetics)
Antiandrogen medication
behavior in the rat: role of 3 alpha- and 3 beta-androstanediols". Biology of Reproduction. 51 (3): 562–571. doi:10.1095/biolreprod51.3.562. PMID 7803627. Sánchez
Bicalutamide
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
This structural motif twists two alpha helical protein domains into a "coiled coil," characterized by a periodicity of 3.5 residues per turn and repetitive
AP-1_transcription_factor
Chemical compound
(September 2007). "A new orally bioavailable synthetic androstene inhibits collagen-induced arthritis in the mouse: androstene hormones as regulators of regulatory
Dehydroepiandrosterone
Mammalian protein found in humans
protease-activated receptors. These characteristics include having seven transmembrane alpha helices, four extracellular loops and three intracellular loops. PAR1 specifically
Proteinase-activated receptor 1
Proteinase-activated_receptor_1
Chemical compound
doi:10.1016/S0090-4295(96)00117-3. PMID 8693644. Ayub M, Levell MJ (July 1987). "Inhibition of rat testicular 17 alpha-hydroxylase and 17,20-lyase activities
Flutamide
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COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
COLLAGEN TYPE-VI-ALPHA-3
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