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Type of warning that appears on the package insert for certain prescription drugs
In the United States, a boxed warning (sometimes "black box warning", colloquially) is a warning that death or serious injury may result from the use of
Black_box_warning
Chemical compound
Tigecycline treatment, and thus prompted a black box warning by the FDA. The FDA issued a black box warning in September 2010, for tigecycline regarding
Tigecycline
Pharmaceutical drug
multifocal leukoencephalopathy, they were requiring the addition of a black box warning to the drug label regarding this potential risk. In August 2011, the
Brentuximab_vedotin
Topics referred to by the same term
France Black Box (Handcuff Cover) Blackboxing, a social process in science studies Black box warning, U.S. warning on a prescription drug Black Box Affair
Black_box_(disambiguation)
Opioid analgesic
Delusions Apathy Anorexia (symptom) Methadone has the following U.S. FDA black box warning: Risk of addiction and abuse Potentially fatal respiratory depression
Methadone
Medication used in asthma or COPD
neuropsychiatric side effects resulted in montelukast receiving a black box warning in the United Kingdom for behavioural changes, depression, and suicidality
Montelukast
Class of antidepressant medication
monitored for an increased risk of suicidality, as indicated by the FDA black box warning. SSRIs have the best outcomes when combined with cognitive-behavioral
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
2021 American drama miniseries
unsuccessfully, before learning McCloskey now represents Purdue. 7 "Black Box Warning" Danny Strong Danny Strong & Beth Macy November 10, 2021 (2021-11-10)
Dopesick_(miniseries)
Medication used for epilepsy, bipolar disorder and migraine
indicated a black box warning given the frequency and severity of the side effects and teratogenicity. Additionally, there is also a black box warning due to
Valproate
Medicine
constipation and chronic constipation with no known cause. It has a black box warning about the risk of serious dehydration in children in the US; the most
Linaclotide
"black box" suicide warning inclusion in the prescription. The authors discussed the suicide rates might increase also as a consequence of the warning
Antidepressants and suicide risk
Antidepressants_and_suicide_risk
Immunosuppressive drug
(FDA) announced that Elidel packaging would be required to carry a black box warning regarding the potential increased risk of lymph node or skin cancer
Pimecrolimus
Medical condition
pregnancy. The warnings against use of danazol were progressively strengthened in the 1980s. In 1991, the FDA required a black box warning that use of danazol
Progestin-induced virilization
Progestin-induced_virilization
Medication to treat symptoms of narcolepsy
program mandated by the FDA. The US label for sodium oxybate also has a black box warning because it is a central nervous system (CNS) depressant and may cause
Sodium_oxybate
Medication for hyperkinetic movement disorders
and nausea. It has also been reported to produce apathy. There is a boxed warning associated with the use of tetrabenazine: Increases the risk of depression
Tetrabenazine
American dermatologist (1945–2015)
the FDA. He was responsible for the FDA giving Allergan's Botox a black box warning. In 2004, Klein became the subject of national attention during a
Arnold_Klein
Blood pressure medication
October 2014, the US Food and Drug Administration (FDA) issued a black box warning that losartan can cause fetal toxicity and should be discontinued
Losartan
Antiandrogen and hormone replacement medication
the drug during the first few months of therapy. The FDA added a black-box warning to dutasteride in 2011 describing an increased risk of high-grade
Dutasteride
Antidopaminergic drug
changed the labeling requirements for droperidol injection to include a Black Box Warning, citing concerns of QT prolongation and torsades de pointes. The evidence
Droperidol
Class of antibacterial drugs, subgroup of quinolones
varying degrees of evidence for causation. In 2008, the U.S. FDA added black box warnings on all fluoroquinolones, advising of the increased risk of tendon
Quinolone_antibiotic
Thoughts, ideas, or ruminations about attempting suicide
Serena; Perna, Giampaolo; Martinotti, Giovanni (2019-05-03). "The FDA "Black Box" Warning on Antidepressant Suicide Risk in Young Adults: More Harm Than Benefits
Suicidal_ideation
Medical condition
The US Food and Drug Administration (FDA) has subsequently issued a black box warning regarding concurrent use of benzodiazepines and opioids. Benzodiazepines
Benzodiazepine_overdose
SSRI antidepressant
Valchera A, Carano A, Orsolini L, Vellante F, et al. (2019). "The FDA "Black Box" Warning on Antidepressant Suicide Risk in Young Adults: More Harm Than Benefits
Sertraline
Chemical compound
February 2011, the Food and Drug Administration began requiring a black box warning on the drug's label. Pregnant women should not be given injections
Terbutaline
Antiviral drug
nausea, vomiting, and abdominal pain. It carries an FDA-mandated black box warning of an increased risk of death with extended use. Brincidofovir was
Brincidofovir
American psychiatrist (born 1936)
it to young adults. New general warnings were added along with the aforementioned black box warnings. These warnings confirmed many of the adverse effects
Peter_Breggin
British critical psychiatrist
the U. S. Food and Drug Administration held a panel to debate a black box warning for SSRI use during pregnancy, bringing a host of expert panelists
Joanna_Moncrieff
American author and menopause advocate
Food and Drug Administration's decision to remove the long-standing “black box” warning on many estrogen-containing hormone therapy products, describing the
Mary_Claire_Haver
Combination pain relief drug
paracetamol-containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic
Hydrocodone/paracetamol
Swelling of the eyelid due to infection of an oil gland
Chloramphenicol is used successfully in many parts of the world, but contains a black box warning in the United States due to concerns about aplastic anemia, which
Stye
Pediatric depressive disorders
the treatment of adolescent depression. This led the FDA to issue a black box warning regarding this risk. Once remission is achieved, the medications are
Depression in childhood and adolescence
Depression_in_childhood_and_adolescence
Effect of drug opposite to expectation
Behavioral Reactions Singh RR, Nayak R (June 2012). "PMH76 Impact of Fda Black Box Warning on the Prescribing of Atypical Antipsychotics in Non-Institutionalized
Paradoxical_reaction
on the results of a confirmatory trial. The drug label carries a black box warning due to the risk of potentially fatal or serious toxicities: infections
Verastem_Oncology
Antibiotic
Prominent among these are adverse effects that became the subject of a black box warning by the FDA in 2016. The FDA wrote: "An FDA safety review has shown
Levofloxacin
Harmful use of antipsychotic medications
abuse: Since 2005, Black Box Warnings established by the FDA that antipsychotic medications package requires to carry "black box" warnings, the most severe
Antipsychotic_abuse
Chemical compound
system adverse effects. In October 2008, the FDA added the following black box warning to the product insert for Maxaquin: "Lomefloxacin is unique in that
Lomefloxacin
2016 academic book by Frank Pasquale
The Black Box Society: The Secret Algorithms That Control Money and Information is a 2015 academic book authored by law professor Frank Pasquale that
The_Black_Box_Society
Fluoroquinolone antibiotic
UV-induced skin tumors as compared to vehicle control. The other black box warning is that ciprofloxacin should not be used in people with myasthenia
Ciprofloxacin
SNRI medication
duloxetine, carry a black box warning stating that antidepressants may increase the risk of suicide in persons younger than 25. This warning is based on statistical
Duloxetine
Anticonvulsant medication
or aseptic meningitis. Lamotrigine prescribing information has a black box warning about life-threatening skin reactions, including Stevens–Johnson syndrome
Lamotrigine
Sleep medication
implemented a boxed warning for the drug. In April 2019, the FDA strengthened the drug's warning labeling by adding a black box warning highlighting the
Zolpidem
Angiotensin II receptor antagonist
severe renal impairment has not been established. Valsartan includes a black box warning for fetal toxicity. Discontinuation of these agents is recommended
Valsartan
Anticonvulsant, which works as a potassium-channel opener
clinical use in 2017 due to declining use, after the addition of a black box warning regarding side effects was added to the drug in 2013. The adverse
Retigabine
Medication primarily used to treat severe acne
depression and is also within the top 10 for suicide attempts. A black box warning for suicide, depression, and psychosis has been present on isotretinoin's
Isotretinoin
American psychiatrist and researcher
decided to require a Black Box warning on suicidality for all antidepressant drugs. Goodman voted in favor of the Black Box warning for the pediatric population
Wayne_Goodman
Medical condition with rash and bleeding risk
(12%) chills (<2%) and fever (1%).[citation needed]. Following a black-box warning of possible uncontrolled hemolytic reactions, use of intravenous anti-D
Immune thrombocytopenic purpura
Immune_thrombocytopenic_purpura
Medical intervention
can be serious and potentially fatal, and infliximab carries an FDA black-box warning on the label. Listed side effects include hypersensitivity and allergic
Management_of_Crohn's_disease
post-operative nausea and vomiting. Nonetheless, and without warning, in 2001 the FDA issued a black box warning regarding QTc prolongation (a dangerous finding on
Criticism of the Food and Drug Administration
Criticism_of_the_Food_and_Drug_Administration
Nonsteroidal anti-inflammatory medication
Like all NSAIDs on the US market, celecoxib carries an FDA-mandated "black box warning" for cardiovascular and gastrointestinal risk. In February 2007, the
Celecoxib
Opiate and prodrug of morphine used to treat pain
of paracetamol with codeine after tonsillectomy; this warning was upgraded to a black box warning in February 2013. As codeine is metabolized to morphine
Codeine
Class of pharmaceutical drugs
Administration requires that all atypical antipsychotics carry a black box warning that the medication has been associated with an increased risk of
Atypical_antipsychotic
Organochlorine chemical and an isomer of hexachlorocyclohexane
so-called black box warning on lindane products, which explains the risks of lindane products and their proper use. The black box warning emphasizes
Lindane
Nonspecific long-lasting anxiety
seizures, arrhythmia and unconsciousness. SNRIs like SSRIs carry a black box warning for suicidal ideation, but it is generally considered that the risk
Generalized_anxiety_disorder
Chemical compound
increases in total cholesterol and triglycerides. Aptivus labeling has a black box warning regarding hepatotoxicity and intracranial hemorrhage. Tipranavir is
Tipranavir
2020 film directed by Emmanuel Osei-Kuffour Jr.
Black Box is a 2020 American science fiction horror film directed by Emmanuel Osei-Kuffour Jr. (in his directorial debut) and written by Osei-Kuffour
Black_Box_(2020_film)
American pharmaceutical company
Orsolini, Laura; Vellante, Federica; et al. (May 3, 2019). "The FDA "Black Box" Warning on Antidepressant Suicide Risk in Young Adults: More Harm Than Benefits
Eli_Lilly_and_Company
Medication
the FDA required all manufacturers of metoclopramide to issue a black box warning regarding the risk of tardive dyskinesia with chronic or high-dose
Metoclopramide
Medical condition characterized by unintentional and purposeless motions and restlessness
Irritability in Alzheimer's Disease: Evidenced-Based Treatments and the Black-Box Warning". Current Psychiatry Reports. 18 (1) 3. doi:10.1007/s11920-015-0640-7
Psychomotor_agitation
Withdrawn anti-obesity drug combination
it and approve the drug with no black box warning for marketing in 1996. European regulators required a major warning of pulmonary hypertension risks
Fenfluramine/phentermine
SNRI antidepressant
all antidepressants, including venlafaxine, to carry a black box warning with a generic warning about a possible suicide risk. A 2014 meta-analysis of
Venlafaxine
Medication used to treat tuberculosis
were nausea, joint and chest pain, and headache. The drug also has a black-box warning for increased risk of death and arrhythmias, as it may prolong the
Bedaquiline
Label on a product identifying risk of its use
regulated by ISO 7010. Alcohol packaging warning messages California Proposition 65 (1986) Black box warnings mandated by the US Food and Drug Administration
Warning_label
Chemical compound
manufacturer to update the product labeling with a "black box warning," their strongest form of warning. Ketek's warning states that it should not be used in patients
Telithromycin
Nicotinic receptor agonist
one post-marketing surveillance study. In 2016, the FDA removed the black box warning. People are still advised to stop the medication if they "notice any
Varenicline
Pharmaceutical drug
blood cell (RBC) transfusions. In addition to those listed in the black box warning, use of darbepoetin alfa also increases the risk of cardiovascular
Darbepoetin_alfa
Atypical antipsychotic medication
immediately, usually leading to resolution. Clozapine carries a U.S. black box warning for agranulocytosis, but evidence suggests that CIN and CIA are not
Clozapine
Species of bacterium
system effects and other serious side effects detailed in the FDA black box warning. Moxifloxacin/Avelox should be reserved for use when patients have
Mycoplasma_genitalium
Antibiotic
warning of the risk of liver injury. The U.S. label does not contain restrictions similar to the European label, but it carries a "black box" warning
Moxifloxacin
Medication
Hepatitis B infection or reactivation Ofatumumab (Arzerra) has received a black box warning regarding the potential for it to cause progressive multifocal leukoencephalopathy
Ofatumumab
Drugs that lower neurotransmission levels, reducing brain activity
benzodiazepines, and Gamma-Hydroxybutyric acid (GHB). The FDA placed a black box warning on Neurontin (gabapentin) and Lyrica (pregabalin) for serious breathing
Depressant
Gene therapy
cells in lovotibeglogene autotemcel. The US FDA label contains a black box warning about hematologic malignancy (blood cancer). The safety and effectiveness
Lovotibeglogene_autotemcel
Chemical compound
is rarely observed but has caused occasional fatalities, and has black box warning status. Other reported serious adverse events are retinal changes
Didanosine
Managing symptoms of Tourette syndrome
associated with individual cases of liver damage, carries an FDA black box warning regarding suicidal ideation, and controlled studies show increases
Management of Tourette syndrome
Management_of_Tourette_syndrome
Tanning using an artificial source of ultraviolet light
(changed in 2014 from "low risk"). It requires that devices carry a black box warning that they should not be used by individuals under the age of 18. There
Indoor_tanning
Form of hormone therapy
warning information about the possibility of an increased risk of heart attacks and stroke. In February 2025, the FDA removed the black box warning on
Androgen_replacement_therapy
Pharmaceutical drug
and benefits of HES solution, the USFDA announced the addition of a black box warning to the prescribing information which includes the following recommendations
Hydroxyethyl_starch
Medication used to prevent RhD isoimmunization
manufactured, distributed and marketed by Cangene in the US. There is a black box warning on WinRho SDF due to the risk of potentially fatal intravascular hemolysis
Rho(D)_immune_globulin
Chemical compound
the Food and Drug Administration (FDA) to consider giving Tequin a black box warning. This editorial followed distribution of a letter dated February 15
Gatifloxacin
Oral iron chelator
Practices. Retrieved 28 June 2021. Pediatrics AA (19 February 2010). "Black box warning added to Exjade". AAP News. doi:10.1542/aapnews.20100219-1 (inactive
Deferasirox
Withdrawn opioid medication
strengthen the boxed warning for propoxyphene to reflect the risk of overdose. Dextropropoxyphene subsequently carried a black box warning in the U.S.,
Dextropropoxyphene
Medication
The approved form of the once weekly exenatide [Bydureon] has a black box warning discussing the thyroid issue. Eli Lilly has reported they have not
Exenatide
Independent record label
May The Plague Be With You, an anonymous work featuring 3 tracks (Black Box Warning I, II, III), each 23 minutes long, has ever since intrigued drone
Plague_Recordings
Robust aircraft electronic recording device
accidents and incidents. The device may be referred to colloquially as a "black box", an outdated name which has become a misnomer because they are required
Flight_recorder
Chemical compound
complications, the US Food and Drug Administration (FDA) issued a black box warning for tolcapone and label revisions that aimed to regulate the monitoring
Tolcapone
Biopharmaceutical for autoimmune diseases
On 2 May 2008, the US Food and Drug Administration (FDA) placed a black box warning on etanercept due to a number of serious infections associated with
Etanercept
Gene therapy medication
stabilizing the progression of CALD. Elivaldogene autotemcel has a black box warning for hematological cancers, as patients have developed myelodysplastic
Elivaldogene_autotemcel
Pharmaceutical drug
to adverse effects of ESA therapy in selected groups. In a revised black box warning, the FDA notes significant risks, advising that ESAs should be used
Epoetin_alfa
Chemical compound
In 2000, the U.S. Food and Drug Administration issued a black box warning on nevirapine, warning that it could cause life-threatening liver toxicity and
Nevirapine
Physician, author and public health advocate
officials to petition the Food and Drug Administration (FDA) on adding black box warnings to opioids and benzodiazepines. In March 2016, she was invited by
Leana_Wen
Pharmaceutical drug
approved. Within the first year after approval, the FDA required a black box warning be added to gemtuzumab packaging. The drug was noted to increase the
Gemtuzumab_ozogamicin
Anti-epileptic medication
on dialysis, should not take perampanel. Perampanel's label has a black box warning noting that some people taking the drug have undergone serious psychiatric
Perampanel
Chemical compound
risk of fetal toxicity. The U.S. Food and Drug Administration has a black box warning for valsartan/hydrochlorothiazide use during pregnancy. The use of
Valsartan/hydrochlorothiazide
Injectable form of birth control
November 2004, the United States Food and Drug Administration put a black box warning on the label, indicating that there were potential adverse effects
Medroxyprogesterone_acetate
Chemical compound
breast milk. In the US, the capsule formulation (Cometriq) carries a black box warning of the risk of holes forming in the stomach or intestines as well
Cabozantinib
Controversies surrounding the topic of ADHD's nature, diagnosis, and treatment
2006, the U.S. Food and Drug Administration voted to recommend a "black-box" warning describing the cardiovascular risks of stimulant drugs used to treat
Attention deficit hyperactivity disorder controversies
Attention_deficit_hyperactivity_disorder_controversies
Medication used to prevent formation of blood clots
similar for each drug. Clopidogrel, unlike prasugrel, was issued a black box warning from the FDA on 12 March 2010, as the estimated 2–14% of the US population
Prasugrel
Medication
abdominal pain. Up to 4% of patients showed anaphylaxis, which led to a black box warning in the US. As of 2011[update], no interaction studies have been conducted
Ecallantide
Medication
1943. In the US, the label for hydrocodone/homatropine contains a black box warning about addiction, abuse, and misuse. "Hycodan- hydrocodone bitartrate
Hydrocodone/homatropine
Medication used to treat multiple sclerosis and Crohn's disease
conclusion on the ability of natalizumab alone to induce PML, its black box warning states that the drug has only been linked to PML when combined with
Natalizumab
Medication
2014. In the US, the label for hydrocodone/guaifenesin contains a black box warning about addiction, abuse, and misuse. "Flowtuss (hydrocodone bitartrate
Hydrocodone/guaifenesin
travel, tourism, insurance
BLACK BOX-WARNING
BLACK BOX-WARNING
Male
Slovene
Short form of Slovene Sebastjan, BOÅ TJAN means "from Sebaste."
Surname or Lastname
English
English : variant of Lake.North German : variant of Laack.Hungarian : from a short form of the personal name László (see Laszlo).
Surname or Lastname
English
English : from Middle English bakke ‘back’ (Old English bæc), hence a nickname for someone with a hunched back or some other noticeable peculiarity of the back or spine, or a topographic name for someone who lived on a hill or ridge, or at the rear of a settlement.English : from the Old English personal name Bacca, which was still in use in the 12th century. It is of uncertain origin, but may have been a byname in the same sense as 1.English : nickname from Middle English bakke ‘bat’ (apparently of Scandinavian origin), from some fancied resemblance to the animal.Altered spelling of Bach 1, 2, or 6.North German : from Middle Low German back ‘kneading trough’, hence a metonymic occupational name for someone who made or used such vessels.Americanized spelling of Norwegian Bakk(e) (see Bakke).
Surname or Lastname
English
English : unexplained; possibly from Middle English bleik, blek(e) ‘pallid’, ‘sallow’ (from Old Norse bleikr ‘pale’) with alteration of the vowel, although Reaney suggests it may be a nickname derived from Middle English blikie(n) ‘to shine or gleam’ (from Old English blīcian).Jewish (Ashkenazic) : origin uncertain; possibly from German Blick or Yiddish blik ‘glance’, ‘look’, and based on some now irrecoverable anecdote.German : Prussian variant of Blek, a nickname from Middle High German blic ‘shine’.German : short form of the Low German occupational name Blickslager ‘tinsmith’. Compare Bleck.German : from a short form of the Germanic personal name Bligger, Blickhart, based on blic ‘gleam’, ‘shine’, later ‘pale’.
Boy/Male
American, Anglo, British, English
Dark; Dark Skinned
Boy/Male
English
Boy.
Male
English
Short form of English Robert, BOB means "bright fame."Â
Surname or Lastname
English
English : from a Middle English personal name Clac, which is from Old English Clacc or the Old Norse cognate Klakkr. As a personal name this is from a word meaning ‘lump’ and may have been used as a nickname for a large or thickset man. Reaney suggests that it could also be from clacker ‘chatterer’.
Surname or Lastname
English
English : from Middle English, Old English box ‘box tree’ (Latin buxus), in any of a number of possible applications. It may have been a topographic name for someone who lived by a box thicket, a habitational name from one of the places called Box, in Gloucestershire, Hertfordshire, and Wiltshire, or a metonymic occupational name for someone who worked box wood, which is very hard and for this reason was used to make a variety of tools. In some cases it may even have been a nickname for a person with pale or yellow skin, for example as the result of jaundice, a reference to the color of box wood.
Boy/Male
English
Dark.
Surname or Lastname
English
English : patronymic from Back 2.German : from a short form of a Germanic personal name, related to Old High German bÄgan ‘to fight’.North German form of Backhaus.
Boy/Male
British, English
White
Surname or Lastname
Scottish and English
Scottish and English : from Middle English blak(e) ‘black’ (Old English blæc, blaca), a nickname given from the earliest times to a swarthy or dark-haired man.Scottish and English : from Old English blÄc ‘pale’, ‘fair’, i.e. precisely the opposite meaning to 1, and a variant of Blake 2. Blake and Black are found more or less interchangeably in several surnames and place names.English : variant of Blanc as a Norman name. The pronunciation of the nasalized vowel gave considerable difficulty to English speakers, and its quality was often ignored.Scottish and Irish : translation of various names from Gaelic dubh ‘black’ (see Duff).Danish and Swedish : generally, probably the English and Scottish name, but in some cases perhaps a variant spelling of Blak, a nickname from blak ‘black’.In some cases, a translation of various names meaning ‘black’, for example German and Jewish Schwarz.
Male
English
From an Old English byname, FOX means "fox."
Surname or Lastname
German and Dutch
German and Dutch : from Middle High German bloch, Middle Dutch blok ‘block of wood’, ‘stocks’. The surname probably originated as a nickname for a large, lumpish man, or perhaps as a nickname for a persistent lawbreaker who found himself often in the stocks.English : possibly a metonymic occupational name for someone who blocks, as in shoemaking and bookbinding, from Middle English blok ‘block’.Jewish (Ashkenazic) : Americanized spelling of Bloch (see Vlach).Adriaen Coertsz Block was a Dutch-born merchant-explorer who traded along the CT coast and Long Island shortly after Hudson’s voyage to the region in 1609. Block Island, between the north fork of Long Island and RI, which he used as a base of operations, is named after him.
Surname or Lastname
English
English : probably from Middle English flack, flak ‘turf’, ‘sod’ (as found in the place name Flatmoor, in Cambridgeshire), and hence perhaps a metonymic occupational name for a turf cutter.North German : topographic name probably derived from a lost word denoting stagnant water.
Male
Polish
Polish form of Slavic Bozidar, BOŻYDAR means "divine gift."
Female
Polish
Feminine form of Polish Bożydar, BOŻENA means "divine gift."
Girl/Female
Native American
Fox (Black Foot).
Surname or Lastname
English and Dutch
English and Dutch : nickname for an idle person, from Middle Dutch slac, Middle English slack, ‘lazy’, ‘careless’.English : topographic name from northern Middle English slack ‘shallow valley’ (Old Norse slakki), or a habitational name from one of the places named with this word, for example near Stainland and near Hebden Bridge in West Yorkshire.Scottish (Dumfriesshire) : habitational name, maybe from Slake or Slack in Roberton, Roxburghshire (now part of Borders region).It may also be an Americanized spelling of Slovenian Slak, a nickname from slak ‘bindweed’.
BLACK BOX-WARNING
BLACK BOX-WARNING
BLACK BOX-WARNING
BLACK BOX-WARNING
BLACK BOX-WARNING
BLACK BOX-WARNING
BLACK BOX-WARNING
a.
Black as jet; deep black.
n.
A chest or any receptacle for the deposit of money; as, a poor box; a contribution box.
n. pl.
Black garments, etc. See Black, n., 4.
n.
An axle box, journal box, journal bearing, or bushing.
n.
A black garment or dress; as, she wears black
v. t.
To inclose in a box.
a.
In a less literal sense: Enveloped or shrouded in darkness; very dark or gloomy; as, a black night; the heavens black with clouds.
n.
A boxlike shed for shelter; as, a sentry box.
a.
Having black eyes.
a.
To make black; to blacken; to soil; to sully.
n.
Mourning garments of a black color; funereal drapery.
a.
As black as coal; jet black; very black.
n.
A present in a box; a present; esp. a Christmas box or gift.
n.
The quantity that a box contain.
n.
A black pigment or dye.
n.
A negro; a person whose skin is of a black color, or shaded with black; esp. a member or descendant of certain African races.
v. t.
A piece of box or other wood for engravers' work.
travel, tourism, insurance