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Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. When they are bound to surface antigen on target cell (e.g
Complement-dependent cytotoxicity
Complement-dependent_cytotoxicity
Cell-mediated killing of other cells mediated by antibodies
Antibody-dependent cellular cytotoxicity (ADCC), also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune
Antibody-dependent cellular cytotoxicity
Antibody-dependent_cellular_cytotoxicity
Type of immunotherapy
antagonistic and agonistic reaction, complement-dependent cytotoxicity (CDC), and antibody-dependent cellular cytotoxicity (ADCC). Passive antibody therapy
Passive_antibody_therapy
Quality of being toxic to cells
Lymphocyte-mediated cytotoxicity, on the other hand, does not have to be mediated by antibodies; nor does complement-dependent cytotoxicity (CDC), which is
Cytotoxicity
Measure of the percentage of human antibodies in a transplant candidate's blood
an extent other leukocytes in a complement dependent cytotoxicity test. From the extent and pattern of cytotoxicity an estimation of what percentage
Panel-reactive_antibody
Artificial stimulation of the immune system to treat cancer
enhancement of antibody-dependent cell-mediated cytotoxicity; and CR3-dependent cellular cytotoxicity. Complement-dependent cytotoxicity occurs when antibodies
Cancer_immunotherapy
Concept in transplantation medicine
transplant recipients who were positively tested for DSA using a complement-dependent cytotoxicity crossmatch assay had a higher risk of transplant rejection
Donor-specific_antibody
Topics referred to by the same term
cell-division cycle protein Cholesterol-dependent cytolysin, exotoxins secreted by bacteria Complement-dependent cytotoxicity Conventional dendritic cell, cDC
CDC_(disambiguation)
Biopharmaceutical drug
portion of rituximab mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Rituximab has a general regulatory
Rituximab
Antibodies rarely making an infection worse instead of better
Mitchell WM (April 1990). "Complement-mediated antibody-dependent enhancement of HIV-1 infection requires CD4 and complement receptors". Virology. 175
Antibody-dependent enhancement
Antibody-dependent_enhancement
proliferation of B cells, they are involved in enhancing complement-dependent cytotoxicity in NK cells. Immunomodulatory therapies often aim for an induced
Macrophage-1_antigen
Complement proteins protect against malignant cells- both by direct complement attack and through initiation of Complement-dependent cytotoxicity, which
Complement_control_protein
Protein found in humans
regulators of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system
Factor_H
Type of allergic reaction
through mechanisms such as complement activation via the classical complement pathway Antibody-dependent cellular cytotoxicity or anti-receptor activity
Type_II_hypersensitivity
Pharmaceutical drug
signal transduction inhibition, antibody-dependent cellular cytotoxicity, and complement-dependent cytotoxicity. Clinical trials have shown promising results
Sofituzumab_vedotin
Mammalian protein found in humans
effects include: Complement dependent cytotoxicity Anti-CD20 mAbs interact with C1q complement protein, leading to classical complement pathway activation
CD20
Monoclonal antibody
via antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, inhibition of mitochondrial transfer or antibody-dependent cellular phagocytosis
Daratumumab
Chemical compound
Wöppel A, Müller J, et al. (January 2005). "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast
Adecatumumab
Artificial protein
recognized by an Fc receptor, such as antibody-dependent cell-mediated cytotoxicity or complement-dependent cytotoxicity. The growth of tumor cells can be stimulated
Bispecific monoclonal antibody
Bispecific_monoclonal_antibody
Medication
causes cytotoxicity in the cells that express CD20 by means of complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC)
Ofatumumab
T cell that kills infected, damaged or cancerous cells
but may be due to complement activation through immune complex formation. Moreover, several animal studies suggest that cytotoxic T cells may have a
Cytotoxic_T_cell
Protein complex
"Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis". Nature. 322 (6082): 831–4. Bibcode:1986Natur
Complement membrane attack complex
Complement_membrane_attack_complex
Anti-inflammatory cytokine
enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. A study in mice has
Interleukin_10
Protein-coding gene in humans
phenotypes. However, while AIM from Kupffer macrophages triggers complement-dependent cytotoxicity, inducing tumor cell death, its heightened expression in hepatocellular
CD5L
Protein and coding gene in humans
others. It has been suggested that this fibrogenic program is critically dependent on direct IL-13 signaling through IL-4Rα on PDGFRβ+ fibroblasts. IL-13
Interleukin_13
Anti-CD20 monoclonal antibody
cells are deleted by antibody-dependent cell-mediated cytotoxicity and, to a lesser extent, complement-dependent cytotoxicity. Ocrelizumab is a humanized
Ocrelizumab
Monoclonal antibody
such as complement dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and antibody-dependent cell-mediated cytotoxicity (ADCC)
Isatuximab
Monoclonal antibody medication
such as opsonization, complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity and antibody-dependent phagocytosis. These effector
Ansuvimab
Mammalian protein found in Homo sapiens
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement
Decay-accelerating_factor
Form of immunotherapy
regions. The four known IgG subclasses are involved in antibody-dependent cellular cytotoxicity. Antibodies are a key component of the adaptive immune response
Monoclonal_antibody_therapy
Mammalian protein found in humans
lysing. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane
CD59
Chemical compound
following mechanisms of action: Antibody-dependent cellular cytotoxicity Complement-dependent cytotoxicity Inhibition of interaction between FRα and
Farletuzumab
Antibodies from clones of the same blood cell
enzyme prodrug therapy; ADCC: antibody dependent cell-mediated cytotoxicity; CDC: complement-dependent cytotoxicity; MAb: monoclonal antibody; scFv, single-chain
Monoclonal_antibody
Group of proteins
receptor-independent cytotoxicity. In patients with severe COVID-19, CD16-positive T cells may lead to exacerbated cytotoxicity, promote microvascular
CD16
Mammalian protein found in Homo sapiens
confirmed by reduced NK cell cytotoxicity, as healthy NK cells normally exhibit constitutive, pathogen-independent cytotoxicity, and by identifying mutations
Perforin-1
Mammalian protein found in Mus musculus
endothelial cell apoptotic process negative regulation of complement-dependent cytotoxicity regulation of phosphorylation negative regulation of apoptotic
Interleukin_4
Radioimmunotherapy treatment
may trigger cell death via antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and apoptosis. Together, these
Ibritumomab_tiuxetan
Large group of transport proteins
domain that is common to the membrane attack complex (MAC) proteins of the complement system (C6, C7, C8α, C8β and C9) and perforin (PF). Members of this protein
MACPF
Antibody isotype
neutralizes toxins; IgG also plays an important role in antibody-dependent cell-mediated cytotoxicity (ADCC) and intracellular antibody-mediated proteolysis, in
Immunoglobulin_G
Mammalian protein found in Homo sapiens
facilitate destruction of tumor cells by complement-dependent cytotoxicity (CDC) and cell-mediated cytotoxicity (ADCC). In CDC, mAbs bind to specific antigen
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Type of immune system molecule
antibody-dependent cellular cytotoxicity (ADCC). Both IgM and IgG undergo conformational change upon binding antigen that allows complement protein C1q
Opsonin
Protein-coding gene in the species Homo sapiens
other instances, in stromal cells, IL-11 activates non-canonical MAPK/ERK-dependent signalling to initiate the post-transcriptional upregulation of specific
Interleukin_11
Species of spider
(Loxosceles laeta). The venom is capable of causing complement-dependent hemolysis and cytotoxic activity against human skin fibroblasts in concentrations
Sicarius_thomisoides
Protein-coding gene in the species Homo sapiens
glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by
TGF_beta_2
Overreaction of the immune system to an antigen
opsonization. Fc-mediated effector functions (e.g., antibody-dependent cellular cytotoxicity, opsonization and phagocytosis, cytokine secretion, degranulation
Hypersensitivity
Pharmaceutical drug
has GD2, that cell is destroyed via cell-mediated cytotoxicity and complement-dependent cytotoxicity. In clinical trials of dinutuximab, the maximum plasma
Dinutuximab
Surface protein important to the immune system
phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some
Fc_receptor
Monoclonal antibody for autoimmune diseases
region in order to have antibody-dependent cellular cytotoxicity (ADCC) as well as complement-dependent cytotoxicity (CDC) properties. GSK licensed the
GSK2831781
Protein-coding gene in humans
constitutive secretory pathway synaptic vesicle transport complement-dependent cytotoxicity pigmentation cytotoxic T cell degranulation exosomal secretion positive
RAB27A
Medical condition
binding of eEF-1-dependent binding of aminoacyl tRNA to the 60S subunit of the ribosome, thus inhibiting protein synthesis. The cytotoxicity from the lack
Thrombotic_microangiopathy
Overview of and topical guide to immunology
hypersensitivity / Antibody-dependent cell-mediated cytotoxicity (ADCC) Foreign Pernicious anemia Hemolytic disease of the newborn Autoimmune Cytotoxic Autoimmune hemolytic
Outline_of_immunology
Type of cancer
cells to destroy the targeted cells Complement-dependent cytotoxicity (CDC) – Initiates the complement system which activates the membrane attack complex
Germinal center B-cell like diffuse large B-cell lymphoma
Germinal_center_B-cell_like_diffuse_large_B-cell_lymphoma
White blood cells of the immune system
conventional counterparts (CD4 T helper cells and CD8 cytotoxic T cells), which are dependent on the recognition of peptide antigens in the context of
T_cell
Protein-coding gene in the species Homo sapiens
downstream cytotoxic effects. Compared to in vitro studies of GrK cytotoxicity in rats and humans, in vitro mouse studies show no cytotoxic potential in
GZMK
Protein fragment
cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments. C5b is important in late events of the complement cascade, an
Complement_component_5a
Protein-coding gene in the species Homo sapiens
proteins that bind to other proteins, thereby stabilizing them in an ATP-dependent manner. Chaperones stabilize new proteins during translation, mature proteins
HSP90AB1
Cellular process
(cytotoxic T cells). Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8+ T cells into activated cytotoxic CD8+
Cross-presentation
Subsystem of the immune system
Activation of complement: Cause inflammation and cell lysis Opsonization: Coating antigen with antibody enhances phagocytosis Antibody-dependent cell-mediated
Adaptive_immune_system
Biological system protecting an organism against disease
antibody-dependent (or cytotoxic) hypersensitivity, and is mediated by IgG and IgM antibodies. Immune complexes (aggregations of antigens, complement proteins
Immune_system
British chemist
Moghimi, S. M. (2021). "Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking". Nature Communications
Moein_Moghimi
Mammalian protein found in Homo sapiens
cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component
Integrin_alpha_M
Autoimmune disease in which the immune system attacks healthy tissue
RNASEH2C, Complement component 1qA, Complement component 1qB, Complement component 1r, Complement component 1s, Complement component 2, Complement component
Lupus
Pharmaceutical drug
antibodies of the IgG1 isotype may activate the complement pathway and mediate antibody-dependent cellular cytotoxicity (ADCC). It is not clear at this time if
Panitumumab
Classifications of antibodies
on neutrophils which may be activated to mediate antibody-dependent cellular cytotoxicity. sIgA has also been shown to potentiate the immune response
Isotype_(immunology)
Branch of science combining immunology and parasitology
binding to the parasite surface in a mechanism known as antibody-dependent cellular cytotoxicity. Adaptive immune responses to parasites are broadly organized
Immunoparasitology
Drug that inhibits activity of immune system
antibodies inhibit T lymphocytes and cause their lysis, which is both complement-mediated cytolysis and cell-mediated opsonization followed by removal
Immunosuppressive_drug
Antibody that plays a crucial role in the immune function of mucous membranes
FcαRI by IgA containing immune complexes causes antibody-dependent cell-mediated cytotoxicity (ADCC), degranulation of eosinophils and basophils, phagocytosis
Immunoglobulin_A
Glial cell located throughout the brain and spinal cord
PMID 15695167. S2CID 25545853. Soteros BM, Sia GM (November 2021). "Complement and microglia dependent synapse elimination in brain development". WIREs Mechanisms
Microglia
Immunity strategy in living beings
PMID 28104818. Zarantonello, Alessandra (2023). "C3-dependent effector functions of complement". Immunological Reviews. 313 (1): 120–138. doi:10.1111/imr
Innate_immune_system
Type of programmed cell death
glutathione levels, an accumulation in intracellular peroxides, and cytotoxicity. Later work by Pamela Maher and David Schubert noted the distinction
Ferroptosis
Type of immune cell
Overactivation of THαβ against autoantigen will cause type 2 antibody-dependent cytotoxic hypersensitivity. Myasthenia gravis or Graves' disease belong to
T_helper_cell
Virus of the herpes family
membrane, allowing EBV to enter the B cell. Human CD35, also known as complement receptor 1 (CR1), is an additional attachment factor for gp350 / 220,
Epstein–Barr_virus
Cell surface proteins, part of the acquired immune system
activated by the donor tissue, causing damage via mechanisms such as direct cytotoxicity from CD8 cells. Acute humoral rejection and chronic disfunction occurs
Major histocompatibility complex
Major_histocompatibility_complex
Class of molecules found in the outer membrane of Gram-negative bacteria
LPS is directly cytotoxic[clarification needed] and is highly immunostimulatory – as host immune cells recognize LPS, the complement system is strongly
Lipopolysaccharide
Autoimmune disease affecting the peripheral nervous system
oligoclonal IgG bands in the cerebrospinal fluid and immunoglobulin as well as complement deposition on myelinated nerve fibers. Target antigens may also include
Chronic inflammatory demyelinating polyneuropathy
Chronic_inflammatory_demyelinating_polyneuropathy
Protein(s) forming a major part of an organism's immune system
killer cells by antibodies initiates a cytotoxic mechanism known as antibody-dependent cell-mediated cytotoxicity (ADCC) – this process may explain the
Antibody
concentrations of IgA which is noninflammatory. IgA does not usually activate the complement system and is not involved with phagocytosis. Th3 inhibits Th1 and Th2 cells
T_helper_3_cell
Protein-produced toxins that create pores in cell membrane
"Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis". Nature. 322 (6082): 831–834
Pore-forming_toxin
Antibodies targeted against the thyroid
bone marrow. They cause thyroid cell damage by complement activation and antibody dependent cell cytotoxicity. However, anti-TPO antibodies are not believed
Antithyroid_autoantibodies
Substances toxic to individual cells
membrane insertion mechanism of Perfringolysin O (PFO), a cholesterol-dependent pore-forming cytolysin produced by pathogenic Clostridium perfringens
Cytolysin
Cells that ingest harmful matter within the body
have been coated with immunoglobulin G (IgG) antibodies or with complement. "Complement" is the name given to a complex series of protein molecules found
Phagocyte
Class of animals
Varanids, and a few other lizard species, employ buccal pumping as a complement to their normal "axial breathing". This allows the animals to completely
Reptile
American immunologist
1984). "Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency"
Timothy_A._Springer
Subtype of leukocytes
also capable of killing infected host cells via antibody-dependent cell-mediated cytotoxicity. Vacuolization may be present in a cell that has recently
Monocyte
Mammalian protein found in humans
mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity". Mol Cell Biol. 13 (10): 6012–23. doi:10.1128/MCB.13.10.6012. PMC 364661
MTOR
Abnormally increased hemoglobin in urine
the morning. In G6PD deficiency, the lack of the G6PD enzyme enables complement mediated destruction against the RBCs, enhanced by certain exposures like
Hemoglobinuria
Use of baculovirus to deliver genes to mammalian cells
function. Cytotoxicity assays and transcriptome analyses on a human HEK cell line (HEK293) have revealed that baculovirus transduction is not cytotoxic and
BacMam
downstream effector functions such as complement lysis, phagocytosis and antibody-dependent cell-mediated cytotoxicity Symplex Technology is a process used
Symphogen
Medication
antibody, thought to work via the activation of antibody-dependent cell-mediated cytotoxicity.[unreliable medical source?] It is used for the relapsing
Alemtuzumab
Enzyme in glutathione biosynthesis
glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity". Toxicol Appl Pharmacol. 243 (1): 35–45. Bibcode:2010ToxAP.243...35B
Glutamate–cysteine_ligase
Type of white blood cell
their life. They can die eventually due to factors including pathogenic cytotoxicity, oxidative stress, and phagocytosis-induced apoptosis. Phagocytosis-induced
Macrophage
Rodent-borne viral infectious disease
from two different mouse strains, A and B. By the method of Cr-release cytotoxicity assay, thereby tagging the CTL with chromium-51 (Cr-51), the CTL destruction
Lymphocytic_choriomeningitis
Genes on human chromosome 6
improving. HLAs corresponding to MHC class III encode components of the complement system. HLAs have other roles. They are important in disease defense.
Human_leukocyte_antigen
American biochemist
proteins. By showing mitochondrial protein synthesis was the link to Zyvox cytotoxicity in human cells, this research led to important advances in antibiotic
Karen_Leach
Natural killer T cells genetically engineered to combat cancer
killing mechanisms, including antibody-dependent cellular cytotoxicity (ADCC) and cytokine release, complementing CAR-mediated lysis. This dual action enhances
CAR-NK
Human genotype
autoantibody production is characteristic of disease, whereas class I mediated cytotoxicity is not. MICA and MICB are intestinally expressed. There are many genes
HLA_A1-B8-DR3-DQ2
Breakdown of proteins into smaller polypeptides or amino acids
activation of many specific proteases, resulting in blood coagulation. The complement system of the immune response also involves a complex sequential proteolytic
Proteolysis
Autoimmune disease
cells, which protect against autoimmunity. IFN-γ promotes cell-mediated cytotoxicity against thyroid mutations causing increased production of IFN-γ were
Hashimoto's_thyroiditis
Particle with size less than 100 nm
on human immune cells has found varying levels of susceptibility to cytotoxicity. There are concerns that pharmaceutical companies, seeking regulatory
Nanoparticle
Language used to describe the human body
the complement system, a biochemical cascade that attacks the surfaces of foreign cells. This response is activated by the binding of complement proteins
Medical_terminology
COMPLEMENT DEPENDENT-CYTOTOXICITY
COMPLEMENT DEPENDENT-CYTOTOXICITY
Girl/Female
Indian
Competent.
Girl/Female
Hindu
Independent, Submissive, Willing, Dependent
Boy/Male
Arabic, Muslim
Competent
Girl/Female
Hindu
Independent, Submissive, Willing, Dependent
Girl/Female
Tamil
Independent, Submissive, Willing, Dependent
Boy/Male
Arabic, Muslim
Competent
Girl/Female
Tamil
Asritha | அஸà¯à®°à¯€à®¤à®¾
Dependent
Asritha | அஸà¯à®°à¯€à®¤à®¾
Girl/Female
Indian
Dependent
Boy/Male
Japanese
Complacent; satisfied.
Boy/Male
Indian, Sanskrit
Competent
Boy/Male
Muslim
Compliments, Happiness
Boy/Male
Indian
Compliments, Happiness
Boy/Male
Hindi
Competent.
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Muslim
Competent
Girl/Female
Indian
Competent
Girl/Female
Tamil
Independent, Submissive, Willing, Dependent
Boy/Male
Anglo Saxon
Competent.
Girl/Female
Indian
Self Dependent
COMPLEMENT DEPENDENT-CYTOTOXICITY
COMPLEMENT DEPENDENT-CYTOTOXICITY
Girl/Female
Indian, Tamil
Sindoor; Kumkum; River; Music
Girl/Female
Norse
Mother of Gudrun.
Boy/Male
Gujarati, Hindu, Indian, Marathi
Unbeatable
Girl/Female
Hindu, Indian
Goddess of the Sky
Girl/Female
Hindu
Art, Phases of Moon
Surname or Lastname
English
English : patronymic from Silver.
Female
Egyptian
, the sister of the officer Tutu.
Girl/Female
Muslim
Something beautiful
Surname or Lastname
English
English : habitational name from a place named Somerton, usually from Old English sumor ‘summer’ + tūn ‘farmstead’, notably Somerton in Oxfordshire, where the surname is still relatively common. There are also places so named in Somerset and Norfolk which may also have contributed to the surname.
Girl/Female
Hindu, Indian, Tamil
Nature
COMPLEMENT DEPENDENT-CYTOTOXICITY
COMPLEMENT DEPENDENT-CYTOTOXICITY
COMPLEMENT DEPENDENT-CYTOTOXICITY
COMPLEMENT DEPENDENT-CYTOTOXICITY
COMPLEMENT DEPENDENT-CYTOTOXICITY
a.
Self-satisfied; contented; kindly; as, a complacent temper; a complacent smile.
n.
State of being dependent; dependence; state of being subordinate; subordination; concatenation; connection; reliance; trust.
n.
One who depends; a dependent.
n.
A dependency; a dependent territory.
v. t.
A deponent verb.
adv.
In a dependent manner.
a.
Not dependent; free; not subject to control by others; not relying on others; not subordinate; as, few men are wholly independent.
n.
The act or state of depending; state of being dependent; a hanging down or from; suspension from a support.
a.
Relying on, or subject to, something else for support; not able to exist, or sustain itself, or to perform anything, without the will, power, or aid of something else; not self-sustaining; contingent or conditioned; subordinate; -- often with on or upon; as, dependent on God; dependent upon friends.
v. t.
To compliment.
a.
Marked by despondence; given to despondence; low-spirited; as, a despondent manner; a despondent prisoner.
n.
See Dependent, Dependence, Dependency.
a.
Depending on itself; independent.
v. t.
The interval wanting to complete the octave; -- the fourth is the complement of the fifth, the sixth of the third.
a.
Supported from above; suspended; depending; pendulous; hanging; as, a pendent leaf.
a.
Dependent on one's self; self-depending; self-reliant.
v. t.
A compliment.
n.
One who believes that an organized Christian church is complete in itself, competent to self-government, and independent of all ecclesiastical authority.
v. i.
To pass compliments; to use conventional expressions of respect.
a.
Hanging down; as, a dependent bough or leaf.