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Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Mammalian protein found in Homo sapiens
is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family
Integrin_alpha_4
Mammalian protein found in Homo sapiens
known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein
Integrin_alpha_X
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Mammalian protein found in Homo sapiens
CD49b gene. The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane
Integrin_alpha_2
Protein-coding gene in the species Homo sapiens
Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_D
Protein
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins
Integrin_alpha_5
Mammalian protein found in Homo sapiens
CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains
Integrin_beta_2
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7
Integrin_alpha_7
Mammalian protein found in Homo sapiens
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans
Integrin_alpha_L
Mammalian protein found in Homo sapiens
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane
Integrin_alpha_V
Mammalian protein found in Homo sapiens
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are
Integrin_alpha_6
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Protein-coding gene in the species Homo sapiens
Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins
Integrin_alpha_9
Protein-coding gene in the species Homo sapiens
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103
Integrin_alpha_E
Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Protein-coding gene in the species Homo sapiens
Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins are heterodimeric integral
Integrin_alpha_11
Protein-coding gene in the species Homo sapiens
Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_8
Protein found in humans
Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of
Integrin_alpha_10
Protein complex
Integrin α4β7 (Lymphocyte Peyer’s patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently
LPAM-1
Integrin dimer
Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the
VLA-4
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed
Alpha-v_beta-3
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta subunits
Integrin_beta_4
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Mammalian protein found in Homo sapiens
with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to
Integrin_beta_1
Mammalian protein found in Homo sapiens
ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given
Integrin_beta_3
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Type of chemical bond
integrin alpha L beta 2 and intercellular adhesion molecule 1 (ICAM-1), integrin alpha 4 beta 1 with vascular adhesion molecule 1, integrin alpha M beta
Catch_bond
Topics referred to by the same term
MAC-1 may refer to: Macrophage-1 antigen Integrin alpha M Macintosh This disambiguation page lists articles associated with the same title formed as a
Mac1
Contrast agent for cancer imaging
targets (i.e., binds to) the cell surface receptor αvβ6-integrin and accumulates in αvβ6-integrin-abundant tissues after intravenous (i.v.) application
Ga-68-Trivehexin
not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein found in humans
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are
Integrin-linked_kinase
Protein found in humans
Ugarova TP, Ye RD, Lau LF, Lam SC (June 2002). "Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61
CCN_family_member_2
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
American immunologist
Briskin, M. J.; Andrew, D. P.; Kilshaw, P. J.; Holzmann, B.; Weissman, I. L.; Hamann, A.; Butcher, E. C. (16 July 1993). "Alpha 4 beta 7 integrin mediates
Timothy_A._Springer
(or integrin αMβ2 or macrophage integrin or Mac-1) is an integrin complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2)
Macrophage-1_antigen
Protein-coding gene in the species Homo sapiens
subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is
Integrin_beta_5
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
migration. Alpha-7 integrin pericytes (AIPs) express several types of integrin chains which generate heterodimers. Integrin chains allow integrin pericytes
Lymph_node_stromal_cell
Protein found in humans
Ruiz-Velasco N, Guerrero-Esteo M, Briskin MJ, Teixidó J (March 2000). "The alpha(4) integrin subunit Tyr(187) has a key role in alpha(4)beta(7)-dependent cell
Addressin
Protein domain
codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with
Talin_(protein)
Protein-coding gene in the species Homo sapiens
This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular
Integrin_beta_8
Mammalian protein found in humans
ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration
Collagen,_type_XVII,_alpha_1
Mammalian protein found in Homo sapiens
neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7).
Alpha-actinin-3
Surface glycoproteins involved in hemostasis
Bhattacharyya-Pakrasi M, Roby J D, Santoro S A, Parks W C (2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Pharmaceutical compound
Vatelizumab is an immunomodulator. It binds to integrin alpha 2. It was withdrawn from Phase II trials for inflammatory bowel disease due to a lack of
Vatelizumab
Protein-coding gene in humans
protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). CIB1 is a small
CIB1
Subset of cell adhesion proteins
survival, and transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits
Cell_adhesion_molecule
Mammalian protein found in Homo sapiens
expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus
ICAM-1
Protein in the extracellular matrix
includes the brain and muscle fibers. In muscle, it binds to alpha-dystroglycan and integrin alpha7—beta1 via the G domain, and via the other end, it binds
Laminin
Protein-coding gene in humans
and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't
CD47
Protein-coding gene in the species Homo sapiens
Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. Cell Biol. 111 (2): 721–9. doi:10
Alpha-actinin-4
Human protein-encoding gene
Ueda M, Hirano T, Higuchi T, Maeda M, et al. (March 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6)
CD9
H.; Griffiths, M. J.; Dalton, S. L.; Wu, J.; Pittet, J. F.; Kaminski, N.; Garat, C.; Matthay, M. A.; et al. (1999). "The integrin alpha v beta 6 binds
TGF_beta_Activation
Cytokine
Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. (February 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating
Transforming growth factor beta
Transforming_growth_factor_beta
Protein found in humans
neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7):
Alpha-actinin-2
Medical treatment
proinflammatory cytokines. The alpha 4 integrin on inflammatory cells interacts with these adhesion molecules to allow for migration. Integrin receptor antagonists
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
Medication used to treat multiple sclerosis and Crohn's disease
a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing
Natalizumab
Protein found in humans
PMID 15165854. Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal
Collagen,_type_XVI,_alpha_1
Movement of white blood cells out of blood vessels and towards the inflamed site
juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. In the activated state, integrins bind tightly to complementary
Leukocyte_extravasation
Medical condition neuromuscular disorders
namely integrin-α7β1 and α-dystroglycan. In LAMA2-CMD the laminin alpha2 deficiency results in malfunctioning or down regulation of integrin-α7β1 and
LAMA2 related congenital muscular dystrophy
LAMA2_related_congenital_muscular_dystrophy
Protein-coding gene in humans
Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, et al. (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and
PTK2
Enzyme in humans
Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Prolyl endopeptidase
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Chemical compound
known as iRGD, is a cyclic peptide that homes to tumors via binding to integrin alpha V receptors. It also binds and activates neuropilin-1, leading to a
Arginylglycylaspartic_acid
Protein-coding gene in the species Homo sapiens
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse
Alpha-actinin-1
Protein-coding gene in the species Homo sapiens
inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200
Alpha-1B_adrenergic_receptor
Protein-coding gene in the species Homo sapiens
endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. VCAM-1 expression has also been observed in other
VCAM-1
Protein-coding gene in the species Homo sapiens
the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells
Periostin
Mammalian protein found in humans
β1 integrins. Collagen XXIII interacts in an ion-and conformation-dependent manner with integrin α2β1. Integrin α2β1 is a collagen-binding integrin present
Collagen,_type_XXIII,_alpha_1
Protein-coding gene in the species Homo sapiens
mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been
TLN1
Chemical compound
disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. Etrolizumab was developed by Genentech by engineering the
Etrolizumab
Protein-coding gene in the species Homo sapiens
Koretzky GA, Peterson EJ (Dec 2004). "PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function". Mol Cell Biol. 24 (24): 10923–32. doi:10
PRAM1
Mammalian protein found in Homo sapiens
immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through
ICAM3
Protein-coding gene in the species Homo sapiens
Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of serine- and threonine-specific
PKC_alpha
Protein found in humans
FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration
ANGPTL3
Protein-coding gene in the species Homo sapiens
Gonzales M, Haan K, Baker SE, Fitchmun M, Todorov I, Weitzman S, Jones JC (1999). "A Cell Signal Pathway Involving Laminin-5, α3β1 Integrin, and Mitogen-activated
Laminin,_alpha_3
Macrophage found in the lungs
thus inducing the expression of the αvβ6 integrin. Integrins are dimeric cell-surface receptors composed of alpha and beta subunits, which activates TGF-β
Alveolar_macrophage
Protein involved in cell adhesion, cell growth, cell migration and differentiation
extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as
Fibronectin
that walks along microtubules. Schaffner, F.; Ray, A.; Dontenwill, M. (2013). "Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target
Alpha-5_beta-1
Protein-coding gene in the species Homo sapiens
altering the molecule's conformation. Modification of integrin's conformation serves to dissociate alpha and beta subunits by disrupting their interactions
FERMT3
Protein found in humans
Fietzek PP, van der Rest M (1984). "Human placenta type V collagens. Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule"
Collagen,_type_V,_alpha_1
Protein-coding gene in the species Homo sapiens
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene. The cytoplasmic domains of integrins are essential for
ITGB1BP1
Medical condition
chromosome 21. This subunit is involved in the formation of the β-2 integrins (LFA-1, integrin alphaXbeta2/CR4/p150,95, and Mac-1/CR3) by dimerization with different
Leukocyte_adhesion_deficiency
Overview of and topical guide to immunology
/ CD18 Integrin alphaXbeta2 (CR4) - Heterodimer: CD11c / CD18 Very late antigen receptor: Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1
Outline_of_immunology
Protein-coding gene in the species Homo sapiens
possibly by limiting the expression of alpha-5 integrin. NISCH has been shown to interact with IRS4, Integrin alpha 5, and small GTPases Rac1, Rab4a, Rab9a
NISCH
Structures which transmit force and signals between a cell and the extracellular matrix
DGEA and GFOGER motifs found in collagen. Integrins are heterodimers which are formed from one beta and one alpha subunit. These subunits are present in
Focal_adhesion
Contact-based cell-cell signalling
cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the
Juxtacrine_signalling
Protein factor that regulates the length of R-actin
the connection between the actin cytoskeleton within the cell and the integrins that directly interact with the stromal ECM. Additionally, it can sense
Actinin
Mammalian protein found in Homo sapiens
Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D (1999). "cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I
EMID2
Human protein-coding gene
Weinacker A, Ferrando R, Elliott M, Hogg J, Balmes J, Sheppard D (May 1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands
Tenascin_C
Protein found in humans
H, Seki M, Itoh A, Miyanaka H, Yuube K, et al. (November 2003). "Galectin-8 modulates neutrophil function via interaction with integrin alphaM". Glycobiology
Galectin-8
Protein-coding gene in humans
"Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions"
ADAM2
Class of enzymes
In enzymology, a lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.9) is an enzyme that catalyzes the chemical reaction CMP-N-acetylneuraminate
Lactosylceramide alpha-2,3-sialyltransferase
Lactosylceramide_alpha-2,3-sialyltransferase
Component of striated muscle cells
dystrophin-glycoprotein complex (DGC) and the integrin-vinculin-talin complex. The sarcoglycans of the DGC and the integrins of the integrin-vinculin-talin complex attach
Costamere
Protein-coding gene in the species Homo sapiens
22719. PMID 9712903. Jiang P, Lagenaur CF, Narayanan V (January 1999). "Integrin-associated protein is a ligand for the P84 neural adhesion molecule". The
Signal-regulatory protein alpha
Signal-regulatory_protein_alpha
Human protein-coding gene
by regulating beta1 integrin function". J. Cell Sci. 116 (Pt 19): 3893–904. doi:10.1242/jcs.00699. PMID 12915587. Mori S, Tanaka M, Nanba D, Nishiwaki
ADAM12
Protein-coding gene in the species Homo sapiens
bone marrow stromal cells through matrices by bridging MMP-2 to alpha(v)beta3-integrin". J. Bone Miner. Res. 21 (10): 1627–36. doi:10.1359/jbmr.060710
Bone_sialoprotein
Mammalian protein found in humans
1016/S0022-2836(05)80110-X. PMID 7533217. Pfaff M, Aumailley M, Specks U, Knolle J, Zerwes HG, Timpl R (May 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion
Collagen,_type_VI,_alpha_3
Mammalian protein found in humans
membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal
Vinculin
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INTEGRIN ALPHA-M
INTEGRIN ALPHA-M
Girl/Female
American, British, English, Greek
Healer; With Healing Power
Boy/Male
Afghan, Arabic, Bengali, Indian, Malayalam, Muslim, Pashtun, Punjabi, Sikh, Telugu
Conscience; Integrity
Boy/Male
Korean
Integrity lasts.
Male
African
(ox); the first letter of the Greek alphabet.
Girl/Female
Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Oriya, Sanskrit, Tamil, Telugu
Little; Collection of Many Small Things
Girl/Female
Indian
Loving
Girl/Female
Arabic
Respectable
Boy/Male
Arabic, Muslim
Soundness; Integrity
Boy/Male
Muslim/Islamic
Soundness integrity
Boy/Male
Korean
Eastern integrity.
Girl/Female
English American
Healer.
Girl/Female
Indian
Little
Boy/Male
Hindu
First letter of the greek alphabet
Boy/Male
Muslim
Soundness. Integrity.
Girl/Female
Greek American
Firstbom.' The first letter of the Greek alphabet.
Boy/Male
African, Australian, Chinese, French, Latin, Swedish
First Letter of the Greek Alphabet; Leader
Boy/Male
Arabic, Muslim
Soundness; Integrity; Safety
Boy/Male
Korean
Integrity returns.
Boy/Male
Muslim/Islamic
Integrity of conduct maturity
Boy/Male
Arabic
Soundness; Integrity
INTEGRIN ALPHA-M
INTEGRIN ALPHA-M
INTEGRIN ALPHA-M
INTEGRIN ALPHA-M
INTEGRIN ALPHA-M
INTEGRIN ALPHA-M
INTEGRIN ALPHA-M
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