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depression is often associated or correlated with immune function dysregulation, and the two are thought to share similar physiological pathways and risk
Depression and immune function
Depression_and_immune_function
Area of study within psychosomatic medicine
behaviorally induced alterations of immune function, and immune alterations inducing behavioral changes, are likely to have clinical and therapeutic implications
Psychoneuroimmunology
Mood disorder
disease or immune dysregulation in asthma). Depression may also be iatrogenic (the result of healthcare), such as drug-induced depression. Therapies associated
Major_depressive_disorder
Set of physiological feedback interactions
metabolic processes of the immune system, resulting in further availability of glucose. Glucocorticoids have many important functions, including modulation
Hypothalamic–pituitary–adrenal axis
Hypothalamic–pituitary–adrenal_axis
Physical effects resulting from activation of the immune system
immunity, not adaptive immunity. It involves immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial
Inflammation
Israeli behavioral neuroscientist
role of immune system activation in depression, for discovering that disturbances in brain microglia cells underlie some forms of depression, and for elucidating
Raz_Yirmiya
between symbiotic microbes and their host can alter host immune system responses to other microorganisms, including pathogens, and are required to maintain
Microbial symbiosis and immunity
Microbial_symbiosis_and_immunity
Category of small signaling proteins
broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are produced by a broad range of cells, including immune cells
Cytokine
Cytokine protein
innate immune system, called pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). These are present on the cell surface and intracellular
Interleukin_6
Historical view of extreme depression
abnormal motor functions, and abnormal vegetative signs, and they described several forms, including retarded depression, psychotic depression and postpartum
Melancholia
Class of molecules found in the outer membrane of Gram-negative bacteria
primarily through interactions with the immune system. LPS is a potent activator of the immune system and is a pyrogen (agent that causes fever). In
Lipopolysaccharide
Human protein for regulating body temperature
killer cells and neutrophiles. TRPV1 is said to be potentially very important in immune cell functioning as it senses higher temperature and lower pH, which
TRPV1
American humanitarian organization
including depression of immune function, which can result in organ failure and death. Because whole blood is rarely used for transfusion and not kept in
American_Red_Cross
Immune disorder
inborn immune disorder characterized by recurrent infections and low antibody levels, specifically in immunoglobulin (Ig) types IgG, IgM, and IgA. Symptoms
Common variable immunodeficiency
Common_variable_immunodeficiency
American immunophysiologist, researcher and academic
physiological stress alter immune function, while immune-derived cytokines transmit signals to the brain and influence neuroendocrine activity and behavior. These
Keith_Kelley_(scientist)
Study of the effects of humor
different theories of humor and many different kinds of humor including their functions and effects personally, in relationships, and in society. Humor research
Humor_research
Class of antidepressant medication
uncertain and questionable due to their low affinity for the receptor relative to the SERT. The role of inflammation and the immune system in depression has
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
State of health and well-being
diseases, to improve immune system function, and to meet emergency situations. Fitness is defined as the quality or state of being fit and healthy. Around
Physical_fitness
Immune response against an organism's own healthy cells
immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease
Autoimmunity
Disorder of depression and mood episodes
known as manic depression, is a mental disorder characterized by periods of depression and abnormally elevated mood, lasting days to weeks, and in some cases
Bipolar_disorder
American psychiatrist and academic
clinical psychoneuroimmunology and understanding the reciprocal links between depression, sleep, and the immune system" and the George Solomon Memorial Lecture
Michael_R._Irwin
Branch of biology concerning depressive disorders in humans
Keith W. (3 December 2016). "From inflammation to sickness and depression: when the immune system subjugates the brain". Nature Reviews Neuroscience.
Biology_of_depression
Medical condition
Immune-mediated diseases include a variety of diseases not only affecting the neuromuscular junction. Immune-mediated disorders range from simple and
Neuromuscular junction disease
Neuromuscular_junction_disease
Chronic medical condition
change in brain structure and metabolism. Observed changes in the immune system include decreased natural killer cell function and, in some cases, autoimmunity
Myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic_encephalomyelitis/chronic_fatigue_syndrome
Protein-coding gene in the species Homo sapiens
modulate several cellular functions in various biological systems including the immune, cardiovascular, respiratory, renal, and nervous systems. GPR65's
GPR65
Study of relationships between nervous and immune systems
the nervous and immune systems including the physiological functioning of the two systems in health and disease, malfunction of either and or both systems
Neuroimmunology
Breakdown of immune system processes
pathogenesis of autoimmune diseases and some cancers. Immune system dysfunction, as seen in IPEX syndrome leads to immune dysfunction, polyendocrinopathy
Immune_dysregulation
Biochemical signaling between the gastrointestinal tract and the central nervous system
endocrine signaling through stress hormones, and immune signaling mediated by cytokines. Gut barrier function and immune activity is influenced by metabolites
Gut–brain_axis
Organ system in vertebrates complementary to the circulatory system
remainder. The other main function is that of immune defense. Lymph is very similar to blood plasma, in that it contains waste products and cellular debris, together
Lymphatic_system
Psychosis beginning suddenly in the first two weeks after childbirth
, postpartum depression) suggests hormonal and immune changes as potential factors contributing to their onset, as well as genetics and circadian rhythm
Postpartum_psychosis
Chronic inflammation and degradation of the stomach lining
legs syndrome, brittle nails, hair loss, impaired immune function, and impaired wound healing. And other symptoms, such as delayed gastric emptying (80%)
Atrophic_gastritis
Neuroscientist (1943–2014)
neuroimmunology, Infectious Behavior: Brain-Immune Connections in Autism, Schizophrenia and Depression, and continued to blog on topics related to these
Paul Patterson (neuroscientist)
Paul_Patterson_(neuroscientist)
Physical activity that improves health
blood levels of fibrinogen and C-reactive protein, an important cardiovascular risk marker. The depression in the immune system following acute bouts
Exercise
Chemical compound
humans and other animals, specifically stimulation of extravascular smooth muscle, vasodilation, hypertensive action, immune system activation, and pain
Neurokinin_A
Inflammation of the thyroid gland
often permanent, with symptoms including fatigue, weight gain, depression, dry skin, and constipation. Thyroid hormone replacement is the treatment of
Thyroiditis
Medical condition
of: Motility disturbance Visceral hypersensitivity Altered mucosal and immune function Altered gut microbiota Altered central nervous system (CNS) processing
Functional gastrointestinal disorder
Functional_gastrointestinal_disorder
Human disease
intoxicating effects of alcohol and the subsequent depression of the normally protective gag and cough reflexes, leads to more frequent and severe pneumonia from
Alcoholic_lung_disease
Autoimmune diseases of the skin
risk factor for depression; however, other immune system factors may also be related to the observed increased incidence of depression in people with psoriasis
Psoriasis
temperature. Therefore, depression allows one to conserve and allocate energy to the immune system more efficiently. Depression further prevents infection
Evolutionary approaches to depression
Evolutionary_approaches_to_depression
Biological processes that may contribute to autism
bacteria and abnormal immune responses on brain development: Some studies on rodents have shown gut bacteria influencing emotional functions and neurotransmitter
Mechanism_of_autism
Spectrum of conditions caused by HIV infection
well as other opportunistic infections, and tumors which are rare in people who have normal immune function. The late stage is often also associated
HIV/AIDS
Food intended for consumption by dogs usually made from meat
fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations
Dog_food
Neuropsychopharmacology Research and Developments
and serotonin on aging processes Biomarkers linking immune activation to mental illness Oxenkrug has also investigated interferon-induced depression,
Gregory_Oxenkrug
can cause severe health concerns and prevent proper immune system functioning. Immune responses to pharmaceutical exposure can be very common in accidental
Pharmacotoxicology
Neural, cognitive, and behavioral effects of physical exercise
exercise involve possible interrelated effects on brain structure, brain function, and cognition. Research in humans has demonstrated that consistent aerobic
Neurobiological effects of physical exercise
Neurobiological_effects_of_physical_exercise
American neuroscientist
reproduction and growth to bolster immune function. The net result of these photoperiod-mediated adjustments is enhanced immune function and increased survival
Randy_J._Nelson
Clinical application of psychiatry to treat nutritional issues
essential for overall health, as it supports digestion, strengthens immune function, and helps produce important nutrients. The presence of different species
Nutritional_psychiatry
Cell surface receptor found in humans
(cluster of differentiation 284), is a key activator of the innate immune response and plays a central role in the fight against bacterial infections. TLR4
Toll-like_receptor_4
Inflammation of nervous tissue
central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in response to these
Neuroinflammation
Autoimmune disease
1155/2013/182472. PMC 3652173. PMID 23691429. Weetman AP (June 2010). "Immunity, thyroid function and pregnancy: molecular mechanisms". Nature Reviews. Endocrinology
Hashimoto's_thyroiditis
Class of immune system proteins
role in the innate immune system. They are single-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that
Toll-like_receptor
Period in American history, 1929–1939
the Great Depression is commonly (though not universally) dated to the Wall Street crash of October 1929. The nadir came in 1931–1933, and recovery came
Great Depression in the United States
Great_Depression_in_the_United_States
Insufficient body levels of zinc
combination with other nutritional deficiencies (e.g., vitamin A). Impaired immune function in people with zinc deficiency can lead to the development of respiratory
Zinc_deficiency
Type of cancer of lymph nodes
Risk factors include poor immune function, autoimmune diseases, Helicobacter pylori infection, hepatitis C, obesity, and Epstein–Barr virus infection
Non-Hodgkin_lymphoma
Chronic low-grade inflammation that develops with advanced age
aging and inflammation and how they change with chronological age. Fine control and modulation of the immune system response becomes fragile and less precise
Inflammaging
Intense stress or pain one feels at experiencing longing
who have divorced have compromised immune systems because of inflammatory cytokines followed by a state of depression. The sentiment is expressed in a collection
Broken_heart
no immunity, competitive replacement, extinction by interbreeding with early modern human populations, natural catastrophes, climate change, and inbreeding
Neanderthal_extinction
Biological concept
response and adaptation to chronic stress but also in the regulation of the immune system and the development of chronic diseases such as hypertension and diabetes
Allostasis
Health problem in cats
deficiencies in immune system function. In cats, the most common cause of immune deficiency is infection with retroviruses, FIV or FeLV, and cats with these
Cat_skin_disorders
Organic chemical that functions both as a hormone and a neurotransmitter
limited area and performs an exocrine or paracrine function. The peripheral systems in which dopamine plays an important role include the immune system, the
Dopamine
Microorganism consumed in food
consequences. Rarely, consumption of probiotics by children with lowered immune system function or who are already critically ill may result in bacteremia or fungemia
Probiotic
memory function, include the immune system and hormonal processes. The ENS mediates HPA-axis function via gastrointestinal hormones, cytokines and neuropeptides
Gut–memory_connection
Clear liquid secreted from glands in eyes of mammals
lubricating the eyes (basal tears), removing irritants (reflex tears), and also aiding the immune system. Tears also occur as a part of the body's natural pain
Tears
Autoimmune disease
weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are
Guillain–Barré_syndrome
Inflammatory disease featuring pain and stiffness
if not treated quickly. The pain and stiffness can result in a lowered quality of life, and can lead to depression. The exact cause of PMR, including
Polymyalgia_rheumatica
Type of inflammatory bowel disease
environmental, immune, and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system
Crohn's_disease
Condition of not having enough sleep
responsible for regulating circadian rhythms as well as metabolism and immune function. To describe the temporal course of the sleep-wake cycle, a two-process
Sleep_deprivation
Biomolecule consisting of chains of amino acid residues
protein components of an adaptive immune system whose main function is to bind antigens, or foreign substances in the body, and target them for destruction
Protein
Inflammation of the heart muscle
Overall, myocarditis can be caused by infections, immune conditions, toxins, drug reactions, and physical injuries to the heart. The most common causes
Myocarditis
Medical condition
host's immune system, and it is present in virtually all cases. Treatment is focused on removing the underlying cancer and suppressing the immune system
Anti-Hu associated encephalitis
Anti-Hu_associated_encephalitis
Difficulty experienced by humans during any stage of normal sexual activity
both men and women. Other causes may be aging, fatigue, pregnancy, medications (such as SSRIs), or psychiatric conditions, such as depression and anxiety
Sexual_dysfunction
American psychiatrist
stress and diets high in saturated fat lead to inflammation. Her work focuses on ways stress and depression influence the immune and endocrine system and includes
Janice_Kiecolt-Glaser
Area between the torso and the thigh
play a role in the immune system. A chain of superficial inguinal lymph nodes drain to the deep nodes. There are two depressions called fossae in an
Groin
Psychological behavior
achieve goals. Learned helplessness theory is the view that clinical depression and related mental illnesses may result from a real or perceived absence
Learned_helplessness
Field of study
and an increased risk of PTSD. Trauma exposure can also disrupt the HPA axis, thus altering peripheral immune function. The effect of PTSD on immune function
Epigenetics of anxiety and stress–related disorders
Epigenetics_of_anxiety_and_stress–related_disorders
Aspect of human sexuality
satisfying sex lives. Physical limitations acquired from SCI affect sexual function and sexuality in broader areas, which in turn has important effects on quality
Sexuality after spinal cord injury
Sexuality_after_spinal_cord_injury
Mammalian protein found in humans
resulting in lower CRH levels and HPA function. Abnormally high levels of CRH have been found in people with major depression, and in the cerebrospinal fluid
Corticotropin-releasing hormone
Corticotropin-releasing_hormone
Medical hypothesis on development of immunity
the immune system, particularly inflammatory diseases. These include type 1 diabetes, multiple sclerosis, and also some types of depression and cancer
Hygiene_hypothesis
Life-threatening response to infection
benefit, others not. A person's age, immune system function, the virulence of the pathogen causing infection, and the amount of microorganisms in the body
Sepsis
Microorganisms in or on human skin and biofluids
proliferation and death, (ii) regulating immune system function, and (iii) influencing metabolism of host-produced factors, foods and pharmaceuticals
Human_microbiome
Condition negatively affecting an organism
abnormal condition that adversely affects the structure or function of all or part of an organism and is not immediately due to any external injury. Diseases
Disease
Language used to describe the human body
viruses, bacteria, and parasites, as well as cancer cells and foreign bodies. Humans have two major immune subsystems: The innate immune system, which provides
Medical_terminology
Anticonvulsant medication
to reduce the risk of future episodes of depression. Lamotrigine is also used off label for unipolar depression (major depressive disorder), treatment-resistant
Lamotrigine
Overabundance of bioavailable antioxidant compounds
function nominally. Antioxidants attenuate the Th-1 immune response, responsible for eliminating bacterial and fungal threats, while the Th-2 immune response
Antioxidative_stress
Medical condition
infection and fueled by immune activation of macrophages and microglia. These cells are actively infected with HIV and secrete neurotoxins of both host and viral
HIV-associated neurocognitive disorder
HIV-associated_neurocognitive_disorder
Organism's response to a stressor such as an environmental condition or a stimulus
hypothalamus, and stria terminalis. Through these mechanisms, stress can alter memory functions, reward, immune function, metabolism, and susceptibility
Stress_(biology)
In neurophysiology, a reduction of neuronal synapse efficacy
or down. LTD and LTP coincide with metaplasticity and synaptic scaling to maintain proper neuronal network function. Long-term depression can be described
Long-term_depression
Essential nutrient
participates in innate immune responses; and HLA class II genes, which are important for adaptive immune function. Cytokines such as IL2 and IL12, essential
Vitamin_D
Diagnosis used in the 1930s to describe infants who wasted away while in hospital
Hospitalism (or anaclitic depression in its sublethal form) was a pediatric diagnosis used in the 1930s to describe infants who wasted away while in a
Hospitalism
Biological system of neurotransmitters
regulating physiological and cognitive processes, including fertility, pregnancy, pre- and postnatal development, various activity of immune system, appetite
Endocannabinoid_system
Pseudoscientific alternative medical adhesive foot pads
and unspecified chemicals from the body. Kinoki also claimed that the pads can treat various kinds of disease, including headaches, depression, and even
Detoxification_foot_pads
Any disorder of the nervous system
immune system; lysosomal storage diseases such as Niemann–Pick disease can lead to neurological deterioration. The National Institute for Health and Care
Neurological_disorder
Physiological reaction to a perceived threat or harmful event
Hormones on Immune Function May be Vital for the Adaptive Reconfiguration of the Immune System During Fight-or-Flight Behavior". Integrative and Comparative
Fight-or-flight_response
while stimulation of immune cells with Aβ42 can directly activate it. Aβ plaques and oligomers can function similar to DAMPs, priming and activating the NLRP3
Alzheimer's disease and COVID-19
Alzheimer's_disease_and_COVID-19
Greek-American scientist (born 1951)
axis (HPA axis) and has studied the neuroendocrine alterations associated with mood disorders, sleep, pain perception, and immune function. In particular
George_P._Chrousos
Abnormal growth of scar tissue within the penis
distress and sexual performance anxiety. Peyronie's disease can substantially impair sexual function and quality of life, leading to depression, relationship
Peyronie's_disease
Substance that reduces or suppresses inflammation
inflammation by lessening the redness, swelling, fever, or pain and loss of function which are part of bodies inflammatory response. Anti-inflammatory
Anti-inflammatory
Family of biomolecules
Moreover, blood NGF levels are increased in times of stress, during immune disease, and with asthma or arthritis, amongst other conditions. Whereas neurotrophic
Neurotrophic_factors
Steroid medication
medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also
Prednisone
American psychiatrist and academic (born 1957)
New Mind-Body Science of Depression, W.W. Norton, New York, 2013 [ISBN missing] Raison, C.L., Miller, A.H. Immune System and Central Nervous System Interactions
Charles_Raison
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DEPRESSION AND-IMMUNE-FUNCTION
DEPRESSION AND-IMMUNE-FUNCTION
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Sindhi, Telugu, Traditional
Healing Hand Movement; Expression
Female
Finnish
Estonian and Finnish pet form of Greek Hanna, ANU means "favor; grace."
Surname or Lastname
English and German
English and German : nickname for someone with a deformed hand or who had lost one hand, from Middle English hand, Middle High German hant, found in such appellations as Liebhard mit der Hand (Augsburg 1383).Jewish (Ashkenazic) : nickname from German Hand ‘hand’ (see 1).Irish : Anglicized form of Gaelic Ó Flaithimh (see Guthrie), resulting from an erroneous association of the Gaelic name with the Gaelic word lámh ‘hand’. It is used as an English equivalent for several other names of Gaelic origin too, e.g. Claffey, Glavin, and McClave.Dutch : from a variant of hont ‘dog’, ‘hound’, either a derogatory nickname, or a habitational name for someone living at a house distinguished by the sign of a dog.
Female
Danish
, compassion, grace; and, prayers.
Boy/Male
Indian
Expression
Girl/Female
Tamil
Expression
Surname or Lastname
English, Scottish, Danish, Norwegian, Swedish, German, and Jewish (Ashkenazic)
English, Scottish, Danish, Norwegian, Swedish, German, and Jewish (Ashkenazic) : topographic name for someone who lived on patch of sandy soil, from the vocabulary word sand. As a Swedish or Jewish name it was often purely ornamental.Dutch and Belgian : reduced form of Van den Sand(e), Van den Zande, a habitational name from places such as Zande in West Flanders or various minor places named with zand ‘sand’.English and Scottish : from a short form of Alexander.French : from a Germanic personal name, Sando.
Female
Serbian
(Bulgarian and Serbian Ðна): Bulgarian and Serbian form of Greek Hanna, ANA means "favor; grace."
Male
English
Unisex pet form of English Andrew and Andrea, ANDY means "man; warrior."
Surname or Lastname
English and German
English and German : topographic name from Old English land, Middle High German lant, ‘land’, ‘territory’. This had more specialized senses in the Middle Ages, being used to denote the countryside as opposed to a town or an estate.English : topographic name for someone who lived in a forest glade, Middle English, Old French la(u)nde, or a habitational name from Launde in Leicestershire or Laund in West Yorkshire, which are named with this word.Norwegian : habitational name from any of three farmsteads so named, from Old Norse land ‘land’, ‘territory’ (see 1 above).
Female
Spanish
Portuguese and Spanish form of Latin Anna, ANA means "favor; grace."Â Compare with another form of Ana.
Female
Bulgarian
(Ðна), compassion, grace; and, prayers.
Boy/Male
Arabic, Muslim
An Effect; Impression
Surname or Lastname
English, German, and Jewish (Ashkenazic)
English, German, and Jewish (Ashkenazic) : metonymic occupational name for a maker of hoops and bands, etc., from Middle English band, bond, Middle High German, Middle Low German bant, German Band denoting something used for tying or binding: ‘hoop’, ‘metal band’, ‘fetter’, ‘shackle’.Old spelling of the Dutch cognates Bant, Bande, from Middle Dutch bant ‘band’.
Girl/Female
Sikh
Expression
Girl/Female
Australian, Dutch
Loving and Musical
Girl/Female
Muslim/Islamic
Full of expression and smile
Boy/Male
German, Spanish
Famous Land
Boy/Male
Muslim
An effect, Impression
Female
Norwegian
Danish and Norwegian form of Greek Hanna, ANE means "favor; grace."
DEPRESSION AND-IMMUNE-FUNCTION
DEPRESSION AND-IMMUNE-FUNCTION
DEPRESSION AND-IMMUNE-FUNCTION
DEPRESSION AND-IMMUNE-FUNCTION
DEPRESSION AND-IMMUNE-FUNCTION
DEPRESSION AND-IMMUNE-FUNCTION
DEPRESSION AND-IMMUNE-FUNCTION
n.
The pressure of the type on the paper, or the result of such pressure, as regards its appearance; as, a heavy impression; a clear, or a poor, impression; also, a single copy as the result of printing, or the whole edition printed at a given time.
a.
Unchaste; lewd; unclean; obscene; as, impure language or ideas.
a.
Not pure; not clean; dirty; foul; filthy; containing something which is unclean or unwholesome; mixed or impregnated extraneous substances; adulterated; as, impure water or air; impure drugs, food, etc.
imp. & p. p.
of Immure
n.
Diminution, as of trade, etc.; inactivity; dullness.
n.
Dejection; despondency; lowness.
n.
The act of expressing; the act of forcing out by pressure; as, the expression of juices or oils; also, of extorting or eliciting; as, a forcible expression of truth.
n.
The act of declaring or signifying; declaration; utterance; as, an expression of the public will.
n.
The operation of reducing to a lower degree; -- said of equations.
n.
A falling in of the surface; a sinking below its true place; a cavity or hollow; as, roughness consists in little protuberances and depressions.
n.
A method of operating for cataract; couching. See Couch, v. t., 8.
a.
Not accurate; not idiomatic; as, impure Latin; an impure style.
a.
Exempt; protected by inoculation.
n.
A sense of heaviness or obstruction in the body or mind; depression; dullness; lassitude; as, an oppression of spirits; an oppression of the lungs.
n.
The act of repressing, or state of being repressed; as, the repression of evil and evil doers.
n.
A form of words in which an idea or sentiment is conveyed; a mode of speech; a phrase; as, a common expression; an odd expression.
n.
Lively or vivid representation of meaning, sentiment, or feeling, etc.; significant and impressive indication, whether by language, appearance, or gesture; that manner or style which gives life and suggestive force to ideas and sentiments; as, he reads with expression; her performance on the piano has expression.
n.
The act of depressing.
n.
A wall; an inclosure.
n.
The angular distance of a celestial object below the horizon.
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