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Protein family
4 G (eIF4G) is a protein involved in eukaryotic translation initiation and is a component of the eIF4F cap-binding complex. Orthologs of eIF4G have been
EIF4G
Multiprotein complex used in gene expression
eIF4A, the cap-binding protein eIF4E, and the large "scaffold" protein eIF4G. The mammalian eIF4F complex was first described in 1983, and has been a
Eukaryotic initiation factor 4F
Eukaryotic_initiation_factor_4F
RNA binding protein
protein which triggers the binding of eukaryotic initiation factor 4 complex (eIF4G) directly to the poly(A) tail of mRNA which is 200-250 nucleotides long
Poly(A)-binding_protein
end of rotavirus mRNAs and is coimmunoprecipitated with eIF4G. The binding of NSP3A to eIF4G and its specific interaction with the 3' end of viral mRNA
Rotavirus_translation
Cellular process of protein synthesis
which consists of three other initiation factors: eIF4A, eIF4E, and eIF4G. eIF4G is a scaffolding protein that directly associates with both eIF3 and
Translation_(biology)
RNA family
stem-loops that radiate from a central hub. BTE has been found to bind to eIF4G and weakly to eIF4E (proteins involved in translation initiation). BTE allows
Luteovirus cap-independent translation element
Luteovirus_cap-independent_translation_element
Chemical compound
to eukaryotic initiation factor eIF4E, preventing its association with eIF4G, another initiation factor. These two proteins, under unregulated conditions
4EGI-1
Protein-coding gene in the species Homo sapiens
viral mRNAs and interacts with the eukaryotic translation initiation factor eIF4G I. RoXaN (rotavirus X protein associated with NSP3) is 110-kDa cellular
Roxan
Protein-coding gene in the species Homo sapiens
humans is encoded by the NOM1 gene. Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation
NOM1
Specially altered nucleotide on the 5' end of pre-mRNA
of translation, the CBC is replaced by the translation factors eIF4E and eIF4G of the eIF4F complex. This complex is then recognized by other translation
Five-prime_cap
Protein family
isothermal titration calorimetry documented that NSP3 and PABP use analogous eIF4G recognition strategies, despite marked differences in tertiary structure
NSP3_(rotavirus)
RNA element
such as poliovirus, this is accomplished by viral proteolytic cleavage of eIF4G so that it cannot interact with the 5'cap binding protein eIF4E. Interaction
Internal_ribosome_entry_site
Acute infectious disease of the liver
picornaviruses, this virus requires an intact eukaryotic initiation factor 4G (eIF4G) for the initiation of translation. The requirement for this factor results
Hepatitis_A
RNA that is read by the ribosome to produce a protein
interaction between the eIF4E and poly(A)-binding protein, which both bind to eIF4G, forming an mRNA-protein-mRNA bridge. Circularization is thought to promote
Messenger_RNA
Formation on 5' ends of mRNAs
replaced by the translation initiation factor eIF4E. The eIF4F complex (eIF4E, eIF4G and eIF4A) then regulates translation in response to the state of the cell
Cap_binding_complex
Protein which binds to a ribosome during translation
initiation process and is composed of the initiation factors eIF4A, eIF4E, and eIF4G. The cap end of the mRNA, being the 5’ end, is brought to the complex where
Initiation_factor
Protein family
40S ribosomal subunit via eIF3. The mRNA cap is bound by eIF4E (25 kDa), eIF4G (185 kDa) acts as a scaffold for the complex whilst the ATP-dependent RNA
EIF4A
Protein-coding gene in the species Homo sapiens
binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by the eIF4G2 gene shares similarity with the C-terminal
EIF4G2
Protein-coding gene in humans
nonsense-mediated mRNA decay (NMD). PABPC1 binds to the poly(A) tail and interact with eIF4G, which stabilizes the circularization of mRNAs. This structure is required
PABPC1
Protein-coding gene in humans
(Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation"
EIF4G3
Protein involved in gene expression
eIF4A, eIF4E, and eIF4G. Each subunit has multiple human isoforms and there exist additional eIF4 proteins: eIF4B and eIF4H. eIF4G is a 175.5-kDa scaffolding
Eukaryotic_initiation_factor
RNA-binding protein in Drosophila
protein called Cup (an eIF4E-binding protein that blocks the binding of eIF4G to eIF4E). There after it recruits deadenylation complex CCR4-Not on to
Smaug_(protein)
Protein coding gene in Humans
initiation complex, along with eIF4E, the 5'-terminal cap binding protein, and eIF4G, the scaffold protein that holds eIF4A and eIF4E together. The eIF4F complex
EIF4A1
Protein-coding gene in the species Homo sapiens
GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo". J. Biol. Chem. 276 (31): 29111–5
EIF4A2
Mammalian protein found in humans
et al. (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". The EMBO Journal. 25 (8): 1659–68. doi:10.1038/sj
MTOR
Protein-coding gene in the species Homo sapiens
Lawrence JC (Apr 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047
EIF3F
RNA-binding protein
mRNAs use many of the same translation initiation factors; such as PABPC1, eIF4G, eIF3, eIF4B, eIF4A and eIF2. Translation is started when the 40S ribosomal
Nuclear cap-binding protein complex
Nuclear_cap-binding_protein_complex
Protein-coding gene in the species Homo sapiens
S2CID 23042477. Lejeune F, Ranganathan AC, Maquat LE (October 2004). "eIF4G is required for the pioneer round of translation in mammalian cells". Nature
UPF2
Protein-coding gene in the species Homo sapiens
therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration
MKNK2
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP". The Journal of Cell Biology. 181 (4): 639–653. doi:10.1083/jcb
Stress_granule
RNA family
translation, as are components of the eIF4F complex (eIF4A, eIF4E, and eIF4G) and eIF4B, which are generally required for mRNA binding and unwinding
Hepatitis C virus internal ribosome entry site
Hepatitis_C_virus_internal_ribosome_entry_site
Protein-coding gene in the species Homo sapiens
recruiting eIF4G, eIF4A, and other factors necessary for translation initiation. However, certain viruses bypass this mechanism by cleaving eIF4G to remove
EIF4E
Protein complex
eIF4E is now free to join the eukaryotic translation initiation factor 4G (eIF4G) and the eukaryotic translation initiation factor 4A (eIF4A). This complex
MTORC1
German-American physicist
(VDAC) of the mitochondrial outer membrane. His 2003 study of the eIF4E–eIF4G interaction provided a structural basis for how the ribosome is recruited
Gerhard_Wagner_(physicist)
Multiprotein complex that functions during the initiation phase of eukaryotic translation
example, mammalian eIF3 directly interacts with the eIF4F complex (via eIF4G), while budding yeast lacks this connection. However, both mammalian and
Eukaryotic initiation factor 3
Eukaryotic_initiation_factor_3
Protein-coding gene in humans
Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1). ENGLAND: 270–9.
MKNK1
Protein-coding gene in the species Homo sapiens
splicing results in five transcript variants encoding four distinct isoforms. eIF4G serves as a scaffold, interacting with mRNA and the other components of
Eukaryotic translation initiation factor 4 gamma 1
Eukaryotic_translation_initiation_factor_4_gamma_1
RNA family
intact eIF4G for IRES initiation is specific to HAV IRES among other picornaviruses. eIF4E-binding protein I (4E-BP1) will also interfere with the eIF4G protein
Hepatitis A virus internal ribosome entry site (IRES)
Hepatitis_A_virus_internal_ribosome_entry_site_(IRES)
Protein-coding gene in the species Homo sapiens
Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". The EMBO Journal. 25 (8): 1659–1668. doi:10.1038/sj
EIF3B
Region of a messenger RNA
which in turn recruits the ribosomal complex to the 5′ UTR. Both eIF4E and eIF4G bind the 5′ UTR, which limits the rate at which translational initiation
Five prime untranslated region
Five_prime_untranslated_region
RNA sequences
AUF1 is also known to interact with the translation initiation factor eIF4G and with poly(A)-binding protein, indicating that AUF1 senses the translational
AU-rich_element
American neuroscientist
Inhibition of the interactions between translation initiation factors eIF4E and eIF4G impairs long-term associative memory consolidation but not reconsolidation
Eric_Klann
Ability of plants to withstand pathogens
Natural alleles of host translation elongation initiation factors eif4e and eif4g are also recessive viral-resistance genes. Some have been deployed to control
Plant_disease_resistance
Protein-coding gene in the species Homo sapiens
of the interaction between the translation initiation factors eIF4E and eIF4G". Cell. 128 (2): 257–67. doi:10.1016/j.cell.2006.11.046. PMID 17254965.
PIM2_(gene)
Protein-coding gene in humans
structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G". Proceedings of the National Academy of Sciences of the United States of
KIAA2013
Control of gene expression at the RNA level, between transcription and translation
binds to a long poly(A) tail and mediates the interaction between EIF4E and EIF4G which encourages the initiation of translation. RNA editing is a process
Post-transcriptional regulation
Post-transcriptional_regulation
Protein domain
Rrn3 Translational regulation Elongation factor eEF3 Initiation factor eIF4G Aminoacyl tRNA synthetase transfer protein Cex1p DNA repair DNA-PK (DNA-dependent
HEAT_repeat
Protein-coding gene in the species Homo sapiens
interact with c-Jun mRNA via a non-canonical mechanism. Instead of the EIF4G protein acting as a cap-binding protein to mediate translation, EIF3D has
EIF3D
Gene expressed during adenovirus replication to produce E1A proteins
eukaryotic translation initiation factor. Adenovirus likely displaces Mnk1 from eIF4G and inhibits eIF4E phosphorylation, both of which are important components
Adenovirus_early_region_1A
Protein-coding gene in the species Homo sapiens
Sonenberg N (Apr 1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation". Nature. 392 (6675): 520–3. Bibcode:1998Natur
PAIP1
Protein-coding gene in the species Homo sapiens
which is named after the middle domain of eukaryotic initiation factor 4G (eIF4G). The MIF4G domain of the MIF4GD protein has a molecular weight of 17.0
MIF4GD
Protein-coding gene in humans
PMID 8139536. Harms U, Andreou AZ, Gubaev A, Klostermeier D (July 2014). "eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating
EIF4B
Protein-coding gene in the species Homo sapiens
arborescens. BZW2 contains an eIF5C domain which is also present in eIF2BE, eIF4G, eIF5, and a GAP protein specific for eIF2. Compared to Cytochrome C, a
Basic leucine zipper and W2 domain-containing protein 2
Basic_leucine_zipper_and_W2_domain-containing_protein_2
Protein-coding gene in the species Homo sapiens
Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047
EIF3A
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EIF4G
EIF4G
EIF4G
EIF4G
EIF4G
EIF4G
EIF4G
EIF4G
EIF4G
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