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Protein found in humans
Flavin-containing monooxygenase 3 (FMO3), also known as dimethylaniline monooxygenase [N-oxide-forming] 3 and trimethylamine monooxygenase, is a flavoprotein
Flavin-containing monooxygenase 3
Flavin-containing_monooxygenase_3
Class of enzymes
The flavin-containing monooxygenase (FMO) protein family specializes in the oxidation of xeno-substrates in order to facilitate the excretion of these
Flavin-containing monooxygenase
Flavin-containing_monooxygenase
Protein found in humans
flavin containing monooxygenase 1". Hines RN, Cashman JR, Philpot RM, Williams DE, Ziegler DM (1994). "The mammalian flavin-containing monooxygenases:
Flavin containing monooxygenase 1
Flavin_containing_monooxygenase_1
Topics referred to by the same term
oxidases Flavin-containing monooxygenase (FMO), a protein family Flavin containing monooxygenase 1, a human gene Flavin containing monooxygenase 3, a human
Flavin
Medical condition
causes a defect in the normal production of an enzyme named flavin-containing monooxygenase 3 (FMO3). When FMO3 is not working correctly or if not enough
Trimethylaminuria
Chemical compound
Human Flavin-Containing Monooxygenase (Form 3): Role in Bioactivation and Detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
Phenylacetone
Drug mixture used mainly to treat ADHD and narcolepsy
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
Adderall
Chemical compound responsible for rotten fish odor
disorder involving a defect in the function or expression of flavin-containing monooxygenase 3 (FMO3) which results in poor trimethylamine metabolism. Individuals
Trimethylamine
Trace amine
"Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism". Pharmacology & Therapeutics. 106 (3): 357–387
Tyramine
CNS stimulant and isomer of amphetamine
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
Dextroamphetamine
Central nervous system stimulant prodrug
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
Lisdexamfetamine
TMAO Chemical compound
Trimethylaminuria is a rare defect in the production of the enzyme flavin-containing monooxygenase 3 (FMO3). Those suffering from trimethylaminuria are unable
Trimethylamine_N-oxide
Protein family
Flavin-containing amine oxidoreductases are a family of various amine oxidases, including maize polyamine oxidase (PAO), L-amino acid oxidases (LAO) and
Flavin-containing amine oxidoreductase
Flavin-containing_amine_oxidoreductase
Enzyme
Kynurenine 3-monooxygenase (EC 1.14.13.9) is an enzyme that in humans is encoded by the KMO gene. The systematic name of this enzyme class is L-kynurenine
Kynurenine_3-monooxygenase
Organic reaction
water to form oxidized flavin, thereby closing the catalytic cycle. BVMOs are closely related to the flavin-containing monooxygenases (FMOs), enzymes that
Baeyer–Villiger_oxidation
Trace amine
semicarbazide-sensitive amine oxidases (SSAOs) AOC2 and AOC3, flavin-containing monooxygenase 3 (FMO3), and aralkylamine N-acetyltransferase (AANAT). N-Methylphenethylamine
Phenethylamine
Coenzyme
opposed to the standard biopsy. Riboflavin FADH2 FMN FMO, flavin-containing monooxygenase NAD Teufel, Robin; Agarwal, Vinayak; Moore, Bradley S. (2016-04-01)
Flavin_adenine_dinucleotide
Human chromosome
encoding protein Flavin adenine dinucleotide synthetase 1 FLG-AS1: encoding protein FLG antisense RNA 1 FMO3: flavin containing monooxygenase 3 FRA1J encoding
Chromosome_1
Protein-coding gene in humans
the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting
FMO5
Central nervous system stimulant
methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". J. Pharmacol. Exp. Ther. 288 (3): 1251–1260. doi:10
Methamphetamine
Class of enzymes
as a carbon source. While most known flavin monooxygenases use NADH or NADPH as substrates (and use the flavins FAD or FMN as prosthetic groups), this
4-Hydroxyphenylacetate 3-monooxygenase
4-Hydroxyphenylacetate_3-monooxygenase
Mammalian protein found in Homo sapiens
canonical squalene monooxygenase is a flavoprotein monooxygenase. Flavoprotein monooxygenase form flavin hydroperoxides at the enzyme active site, which
Squalene_monooxygenase
Class of enzymes
are gentisic acid, oxidised NAD+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
3-hydroxybenzoate 6-monooxygenase
3-hydroxybenzoate_6-monooxygenase
Vitamin
synthesis of the niacin-containing coenzymes, NAD and NADP, from tryptophan involves the FAD-dependent enzyme, kynurenine 3-monooxygenase. Dietary deficiency
Riboflavin
Class of enzymes
phosphate can be used as an alternative cofactor. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
4-hydroxybenzoate 3-monooxygenase (NAD(P)H)
4-hydroxybenzoate_3-monooxygenase_(NAD(P)H)
Class of enzymes
products are catechol, oxidised NADP+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
Phenol_2-monooxygenase
Class of enzymes
6-trihydroxypyridine, oxidised NAD+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
2,6-dihydroxypyridine 3-monooxygenase
2,6-dihydroxypyridine_3-monooxygenase
Class of enzymes
protocatechuic acid, oxidised NADP+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
3-hydroxybenzoate 4-monooxygenase
3-hydroxybenzoate_4-monooxygenase
Class of enzymes
3-dihydroxyphenylpropionic acid, oxidised NAD+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
Melilotate_3-monooxygenase
Class of enzymes
oxidised NAD+, water, and carbon dioxide. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
Salicylate_1-monooxygenase
P450-containing monooxygenase systems, although self-sufficient, non-monooxygenase P450s have been also described. All known P450-containing monooxygenase systems
P450-containing_systems
Chemical compound
of the benzo ring followed by conversion to 6-bromoindole. Flavin-containing monooxygenase then couples two of these indole units to give the dye. The
6,6'-Dibromoindigo
Class of enzymes
phosphate can be used as an alternative cofactor. This enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
3-hydroxyphenylacetate 6-hydroxylase
3-hydroxyphenylacetate_6-hydroxylase
Class of enzymes
CHMO is a member of the Baeyer-Villiger monooxygenase (BVMO) family and flavin-containing monooxygenases (FMO) superfamily. Cyclohexanone undergoes
Cyclohexanone_monooxygenase
Protein found in humans
Flavin-containing monooxygenase 2 (FMO2), also known as dimethylaniline monooxygenase [N-oxide-forming] 2, is a mammalian enzyme that in humans is encoded
FMO2
Protein-coding gene in humans
the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting
FMO4
Class of enzymes
and O2, whereas its 3 products are 5-hydroxy-4-imidazoleacetate, NAD+, and H2O. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen
Imidazoleacetate 4-monooxygenase
Imidazoleacetate_4-monooxygenase
Family of proteins which produce bioluminescence
Renilla reniformis. In this organism, the luciferase (Renilla-luciferin 2-monooxygenase) is closely associated with a luciferin-binding protein as well as a
Luciferase
Chemical compound
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
4-Hydroxyphenylacetone
Class of enzymes
N(6)-hydroxy-L-lysine, oxidised NADP+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
L-lysine 6-monooxygenase (NADPH)
L-lysine_6-monooxygenase_(NADPH)
Baeyer–Villiger monooxygenases with a flavin reductase from E. coli". Appl. Microbiol. Biotechnol. 98 (9): 3975–86. doi:10.1007/s00253-013-5338-3. PMID 24190498
Flavin_reductase
Mammalian protein found in Homo sapiens
Dopamine β-hydroxylase (DBH), also known as dopamine β-monooxygenase, is an enzyme (EC 1.14.17.1) that in humans is encoded by the DBH gene. Dopamine
Dopamine_beta-hydroxylase
Chemical compound
375 (3): 211–8. PMID 8011178. Becker D, Schräder T, Andreesen JR (November 1997). "Two-component flavin-dependent pyrrole-2-carboxylate monooxygenase from
Pyrrole-2-carboxylic_acid
Class of enzymes
5-trihydroxytoluene, oxidised NAD+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
Orcinol_2-monooxygenase
Class of enzymes
8-dihydroxyquinoline, oxidised NAD+, and water. The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one
2-hydroxyquinoline 8-monooxygenase
2-hydroxyquinoline_8-monooxygenase
Chemical compound
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
P-Hydroxynorephedrine
Chemical compound
albendazole monooxygenase (sulfoxide-forming) (a cytochrome P450 oxidase) or albendazole monooxygenase (a flavin-containing monooxygenase. albendazole
Ricobendazole
Class of chemical compounds
Kedzierski, B.; Ziegler, D. M.; Buhler, D. R. (1989). "The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine"
Pyrrolizidine_alkaloid
Sympathomimetic agent
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
Phenylpropanolamine
Group of stereoisomers
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
4-Hydroxyamphetamine
Enzyme
EC 1.13 or EC 1.14. Most oxygenases contain either a metal, usually iron, or an organic cofactor, usually flavin. These cofactors interact with O2, leading
Oxygenase
Insufficient level of copper in the body, leading to anaemia and nervous symptoms
cell precursors and the presence of ring sideroblasts (erythroblasts containing multiple iron granules around the nucleus). Unlike most cases of myelodysplastic
Copper_deficiency
Chemical compound
when an oxygen atom added to 4-methylthiobutylglucosinolate by a flavin monooxygenase. Sulforaphane and other isothiocyanates have been studied for their
Glucoraphanin
Chemical compound
P450. They instead postulate the pulmonary endothelial enzyme flavin-containing monooxygenase 2 is primarily responsible for the toxicity of ANTU, via its
Α-Naphthylthiourea
Enzyme in the human body
cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis
CYP1A2
1.14.13.8: flavin-containing monooxygenase EC 1.14.13.9: kynurenine 3-monooxygenase EC 1.14.13.10: 2,6-dihydroxypyridine 3-monooxygenase EC 1.14.13.11:
List_of_EC_numbers_(EC_1)
Dutch scientist (born 1968)
exploration of novel oxidative enzymes, with special emphasis on flavin-containing enzymes. Besides exploring the biocatalytic potential of these biocatalysts
Marco_Fraaije
Protein found in humans
connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21". Genomics. 39 (3): 409–11. doi:10.1006/geno.1996
GJA5
Chemical compound
by the flavin-containing monooxygenase". Drug Metabolism and Drug Interactions. 6 (3–4): 337–348. doi:10.1515/dmdi.1988.6.3-4.337. PMID 3271645
7α-Thiomethylspironolactone sulfoxide
7α-Thiomethylspironolactone_sulfoxide
Chemical compound
encephalomyelitis/chronic fatigue syndrome Downregulation of kynurenine-3-monooxygenase (KMO) can be caused by genetic polymorphisms, cytokines, or both. KMO
Kynurenine
Protein-coding gene in humans
Wolf CR (Dec 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica; the Fate of Foreign Compounds in Biological
CYP1A1
Chemical compound
concentrations, presumably because it is also metabolised by flavin containing monooxygenase 1 (FMO1) and 3. Vandetanib is an inhibitor of vascular endothelial
Vandetanib
Mammalian protein found in humans
"Restoration of mutant cytochrome P450 reductase activity by external flavin". Molecular and Cellular Endocrinology. 321 (2): 245–52. doi:10.1016/j.mce
Cytochrome_P450_reductase
Class of enzymes
Burley SK, Swaminathan S (Jun 2006). "Mechanism of action of a flavin-containing monooxygenase". Proceedings of the National Academy of Sciences of the United
Glycerol-3-phosphate dehydrogenase
Glycerol-3-phosphate_dehydrogenase
(internal monooxygenases or internal mixed function oxidases)) Renilla-luciferin 2-monooxygenase EC 1.13.12.5 Cypridina-luciferin 2-monooxygenase EC 1.13
List_of_enzymes
Central nervous system stimulant
human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260
Amphetamine
Chemical compound
enzymes (four cytochrome P450 monooxygenases and two flavin adenine dinucleotide (FAD)-dependent monooxygenases), two acetyltransferases, one oxidoreductase
Penitrem_A
Enzyme protein
CR (December 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–1165. doi:10.1080/004982598238868
CYP2C9
Species of bacterium
integral-membrane alkane monooxygenases, three cytochrome P450 enzymes, and four genes encoding flavin-binding family monooxygenases. These monooxygenases are especially
Alcanivorax_pacificus
Protein-coding gene in the species Homo sapiens
sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. doi:10.1093/oxfordjournals
CYP3A7
Chemical reaction which adds an –OH group to an organic compound
and biological approaches. Nature has evolved enzymes called methane monooxygenases, which are efficient but impractical for commercial applications. Instead
Hydroxylation
Iron–sulfur proteins
succinate dehydrogenase iron–sulphur protein (N-terminal), and methane monooxygenase reductase (N-terminal).[citation needed] One group of ferredoxins, originally
Ferredoxin
Chemical compound
distinct P450 monooxygenases forming flavokermesic acid and kermesic acid, respectively. Whether these monooxygenases are oxygen or flavin dependent is
Carminic_acid
Protein found in humans
steroids and other lipids. The CYP2J2 contains the following domains: • Hydrophobic binding domains • F-G loop (containing non-conservative mutations) primary
CYP2J2
Ca2+/calmodulin-dependent protein kinase EC 2.7.1.124: Now EC 2.7.11.6, [tyrosine 3-monooxygenase] kinase EC 2.7.1.125: Now EC 2.7.11.14, rhodopsin kinase EC 2.7.1.126:
List_of_EC_numbers_(EC_2)
Enzyme found in humans
pathways that may link it to diabetes and obesity. Thus, it acts as a monooxygenase to metabolize arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE)
CYP2E1
Protein-coding gene in the species Homo sapiens
cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis
CYP2S1
Study of the role of metals in biology
or small molecule oxidation in cytochrome P450 oxidases or methane monooxygenase. Some metalloproteins are designed to protect a biological system from
Bioinorganic_chemistry
Type of enzyme
are similar to flavin-containing monooxygenases. In the first step, FADH2 is oxidized by molecular oxygen, generating a high-energy flavin hydroperoxide
Tryptophan_7-halogenase
only contain short chain Flavodoxins. Cyanobacteria and algae most commonly contain the long chain Flavodoxin. Flavodoxins contain a singular Flavin mononucleotide
Flavodoxin_fold
Enzyme that metabolizes substances by oxidation
cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis
CYP3A4
Medication used to treat premature ejaculation
liver and kidney by multiple enzymes such as CYP2D6, CYP3A4, and flavin monooxygenase 1. The major product at the end of the metabolic pathway is circulating
Dapoxetine
Monoamine neurotransmitter
(5-HIAL). The rate-limiting step is hydride transfer from serotonin to the flavin cofactor. There follows oxidation by aldehyde dehydrogenase (ALDH) to
Serotonin
Steroidal antiandrogen and antimineralocorticoid
carboxylesterases. Following formation of 7α-TS, it is S-oxygenated by flavin-containing monooxygenases to form an electrophilic sulfenic acid metabolite. This metabolite
Spironolactone
Chemical compound
ricobendazole, in the liver by cytochrome P450 oxidases (CYPs) and a flavin-containing monooxygenase (FMO), which was discovered later. In humans, the cytochrome
Albendazole
Protein family
Type 1 desaturases have diiron active sites reminiscent of methane monooxygenase. These enzymes are O2-dependent, consistent with their function as either
Fatty_acid_desaturase
Chemical compound
AscD (flavin-dependent halogenase, flavin binding enzyme) is able to catalyze the chlorination of ilicicolinic acid B (2) to yield ilicicolin A (3). Expodiation
Ascofuranone
Biotechnique to clean sulfur from crude oil
Fernandes, Pedro A. (October 5, 2018). "Mechanistic Studies of a Flavin Monooxygenase: Sulfur Oxidation of Dibenzothiophenes by DszC". ACS Catalysis. 8
Biodesulfurization
Raman spectroscopy technique
Stanley, R.J. (2001). "Advances in flavin and flavoprotein optical spectroscopy". Antioxidants & Redox Signaling. 3 (5): 847–866. doi:10.1089/15230860152665028
Resonance_Raman_spectroscopy
Protein-coding gene in humans
Davin A, Corato M, Cova E, Abel K, et al. (August 2011). "Flavin-containing monooxygenase mRNA levels are up-regulated in als brain areas in SOD1-mutant
SOD1
Chemical compound
873–. ISBN 978-1-4757-2085-3. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 737–. ISBN 978-3-88763-075-1. Morton IK, Hall
Nilutamide
British pharmacologist
"Speculations on the relative roles of cytochrome P450 and flavin containing monooxygenase in the metabolism of S12363" he then earned a PhD in clinical
Sean_Ekins
Class of photoreceptor proteins in plants
light, oxygen, or voltage regulated domains (LOV1, LOV2) that each bind flavin mononucleotide (FMN). The FMN is noncovalently bound to a LOV domain in
Phototropin
Protein-coding gene in humans
protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. doi:10
CAMK1
Chemical compound
intermediate is converted into Calanolide A, B, or C with the help of p450 monooxygenase enzyme. The drug has half-life of 20 hours. The drug is metabolised
Calanolide_A
Mammalian gene
(June 2013). "Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque". Biochemical Pharmacology. 85 (12):
MROH9
650 – riboflavin MeSH D08.211.474.650.249 – flavin-adenine dinucleotide MeSH D08.211.474.650.500 – flavin mononucleotide MeSH D08.211.790.249 – g(m2)
List_of_MeSH_codes_(D08)
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FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
FLAVIN CONTAINING-MONOOXYGENASE-3
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