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FLIPPASE

  • Flippase
  • Category of enzyme

    Flippases are transmembrane lipid transporter proteins located in the cell membrane. They are responsible for aiding the movement of phospholipid molecules

    Flippase

    Flippase

    Flippase

  • FLP-FRT recombination
  • Site-directed recombination technology

    recombination of sequences between short flippase recognition target (FRT) sites by the recombinase flippase (Flp) derived from the 2 μ plasmid of baker's

    FLP-FRT recombination

    FLP-FRT recombination

    FLP-FRT_recombination

  • MOP flippase
  • Protein families

    (MOP) flippase superfamily (TC# 2.A.66) is a group of integral membrane protein families. The MOP flippase superfamily includes twelve

    MOP flippase

    MOP_flippase

  • Ouf
  • Topics referred to by the same term

    the U.S. invasion of Grenada O-Unit Flippase (OUF), an enzymic protein related to the protein family MOP flippase Search for "ouf" on Wikipedia. Osaka

    Ouf

    Ouf

  • MOP
  • Topics referred to by the same term

    receptor, a class of opioid receptors MOP flippase (Multidrug/Oligosaccharidyl-lipid/Polysaccharide Flippase), a superfamily of transport proteins Muriate

    MOP

    MOP

  • Flip-flop
  • Topics referred to by the same term

    encounter The translocation of a phospholipid in cell membranes carried out by flippase proteins Flippity and Flop, a pair of cartoon characters that appeared

    Flip-flop

    Flip-flop

  • Phospholipid
  • Class of lipids

    transferases, phosphatase and choline phosphotransferase) and allocation (flippase and floppase). Eventually a vesicle will bud off from the ER containing

    Phospholipid

    Phospholipid

    Phospholipid

  • Phospholipid scramblase
  • Protein

    transmembrane lipid transporters known as flippases. Scramblases are distinct from flippases and floppases. Scramblases, flippases, and floppases are three different

    Phospholipid scramblase

    Phospholipid scramblase

    Phospholipid_scramblase

  • P-type ATPase
  • Protein family

    superfamily drive cation uptake or efflux, though one subfamily, the flippases, is involved in flipping phospholipids to maintain the asymmetric nature

    P-type ATPase

    P-type ATPase

    P-type_ATPase

  • Cell membrane
  • Biological membrane that separates the interior of a cell from its outside environment

    via transmembrane protein complexes such as pores, channels and gates. Flippases and scramblases concentrate phosphatidyl serine, which carries a negative

    Cell membrane

    Cell membrane

    Cell_membrane

  • ABC transporter
  • Gene family

    Family (DUF990 Family; InterPro: IPR010390) 3.A.1.142 The Glycolipid Flippase (G.L.Flippase) Family 3.A.1.143 The Exoprotein Secretion System (EcsAB(C)) 3.A

    ABC transporter

    ABC transporter

    ABC_transporter

  • Peptidoglycan
  • Polymer in bacterial cell walls

    EC 2.4.1.227 by MurG. Lipid II is transported across the membrane by flippase (MurJ), a discovery made in 2014 after decades of searching. Once it is

    Peptidoglycan

    Peptidoglycan

  • List of unusual biological names
  • associated with dividing the head and body into regions Fizzy-related Flippase and floppase Protein that "flips" and "flops" phosphatidylserines on the

    List of unusual biological names

    List_of_unusual_biological_names

  • Lipid
  • Substance of biological origin that is soluble in nonpolar solvents

    the extracellular face of the cell membrane after the inactivation of flippases which place them exclusively on the cytosolic side and the activation

    Lipid

    Lipid

    Lipid

  • Fluid mosaic model
  • Model of cell membranes

    process known as flip-flop). However, flip-flop movement is enhanced by flippase enzymes. The processes described above influence the disordered nature

    Fluid mosaic model

    Fluid mosaic model

    Fluid_mosaic_model

  • N-linked glycosylation
  • Attachment of an oligosaccharide to a nitrogen atom

    understood, but it is suggested to be performed by an enzyme known as flippase. Phase II The growing glycan is exposed on the luminal side of the ER membrane

    N-linked glycosylation

    N-linked glycosylation

    N-linked_glycosylation

  • P-glycoprotein
  • Protein found in humans

    binding ABC-type xenobiotic transporter activity phosphatidylethanolamine flippase activity phosphatidylcholine floppase activity ceramide floppase activity

    P-glycoprotein

    P-glycoprotein

    P-glycoprotein

  • ABCA4
  • Mammalian protein found in humans

    mice suggest that ABCA4 may function as an inward-directed retinoid flippase. Flippase is a transmembrane protein that "flips" its conformation to transport

    ABCA4

    ABCA4

    ABCA4

  • Lipid II
  • Chemical compound

    of the bilayer. Lipid II is then transported across the membrane by a flippase, to expose the disaccharide-pentapeptide monomer, which is the pentapeptide

    Lipid II

    Lipid II

    Lipid_II

  • MVF
  • Topics referred to by the same term

    virulence factor (MVF), a family of transport proteins belonging to the MOP flippase superfamily mvf, the ISO 639-3 code for the Peripheral Mongolian language

    MVF

    MVF

  • Biological membrane
  • Enclosing or separating membrane in organisms acting as selective semi-permeable barrier

    monolayer. This transfer is catalyzed by enzymes called flippases. In the plasma membrane, flippases transfer specific phospholipids selectively, so that

    Biological membrane

    Biological membrane

    Biological_membrane

  • FRT
  • Topics referred to by the same term

    Reach Test for limits of stability Figure Reasoning Test, in IQ testing Flippase recognition target, in genetic modification Free-radical theory of ageing

    FRT

    FRT

  • Mycobacterium tuberculosis
  • Bacterium that causes tuberculosis

    PMID 27553408. Xu Z, Meshcheryakov VA, Poce G, Chng SS (July 2017). "MmpL3 is the flippase for mycolic acids in mycobacteria". Proceedings of the National Academy

    Mycobacterium tuberculosis

    Mycobacterium tuberculosis

    Mycobacterium_tuberculosis

  • Phagocyte
  • Cells that ingest harmful matter within the body

    required for online access) Nagata S, Sakuragi T, Segawa K (December 2019). "Flippase and scramblase for phosphatidylserine exposure". Current Opinion in Immunology

    Phagocyte

    Phagocyte

    Phagocyte

  • Undecaprenyl phosphate
  • Chemical compound

    (NAG) to form lipid II. Lipid II then is flipped across the membrane by a flippase to the outside leaflet of the cell membrane. The NAG-NAM pentapeptide subunit

    Undecaprenyl phosphate

    Undecaprenyl_phosphate

  • ABCB4
  • Protein-coding gene in humans

    family of membrane proteins with phosphatidylcholine as its substrate (flippase activity). The function of this protein has not yet been determined; however

    ABCB4

    ABCB4

    ABCB4

  • Red blood cell
  • Oxygen-delivering blood cell and the most common type of blood cell

    energy-independent phospholipid transport proteins. Proteins called "Flippases" move phospholipids from the outer to the inner monolayer, while others

    Red blood cell

    Red blood cell

    Red_blood_cell

  • Liquid crystal
  • State of matter with properties of both conventional liquids and crystals

    one side of the membrane to the other, this process being catalyzed by flippases and floppases (depending on the direction of movement). These liquid crystal

    Liquid crystal

    Liquid crystal

    Liquid_crystal

  • Phospholipid-translocating ATPase
  • Class of enzymes

    (phospholipid-flipping). Other names in common use include Mg2+-ATPase, flippase, and aminophospholipid-transporting ATPase. Morris MB, Auland ME, Xu YH

    Phospholipid-translocating ATPase

    Phospholipid-translocating_ATPase

  • Bacterial outer membrane
  • Plasma membrane found in gram-negative bacteria

    O-antigen processing function for Wzx (RfbX): a promising candidate for O-unit flippase". J. Bacteriol. 178 (7): 2102–7. doi:10.1128/jb.178.7.2102-2107.1996. PMC 177911

    Bacterial outer membrane

    Bacterial outer membrane

    Bacterial_outer_membrane

  • Site-specific recombinase technology
  • Genome engineering tools

    that is flanked by two identical, but oppositely oriented FRT sites ("flippase" activity). This inversion changes the relative orientation of replication

    Site-specific recombinase technology

    Site-specific_recombinase_technology

  • Lipid bilayer
  • Biological membrane structure

    class of enzymes called flippases. Other lipids, such as sphingomyelin, appear to be synthesised at the external leaflet. Flippases are members of a larger

    Lipid bilayer

    Lipid bilayer

    Lipid_bilayer

  • Membrane transport protein
  • Membrane protein involved in transportation

    carrier family (classification) TC number (classification) Translocase Flippases Vesicular transport protein Endocytosis Perland, Emelie; Bagchi, Sonchita;

    Membrane transport protein

    Membrane_transport_protein

  • Phospholipid-transporting ATPase IC
  • Protein-coding gene in the species Homo sapiens

    hydrolase activity ATP binding magnesium ion binding aminophospholipid flippase activity Cellular component integral component of membrane Golgi apparatus

    Phospholipid-transporting ATPase IC

    Phospholipid-transporting ATPase IC

    Phospholipid-transporting_ATPase_IC

  • Butyrolactol A
  • Chemical compound

    Wenliang (December 2025). "Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi". Cell. doi:10.1016/j.cell.2025.11.036

    Butyrolactol A

    Butyrolactol_A

  • N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase
  • Class of enzymes

    pyrophosphate on the cytosolic face of the plasma membrane, followed by flippase transfer to the periplasmic space and en bloc transfer to an asparagine

    N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase

    N,N'-diacetylbacillosaminyl-diphospho-undecaprenol_alpha-1,3-N-acetylgalactosaminyltransferase

  • UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  • Class of enzymes

    Z, Raetz CR (December 2007). "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". The Journal of

    UDP-4-amino-4-deoxy-L-arabinose formyltransferase

    UDP-4-amino-4-deoxy-L-arabinose_formyltransferase

  • Surfactin
  • Chemical compound

    Attachment of a cation causes the complex to cross the bilipidic layer using flippase enzymes. The headgroup aligns itself with the phospholipids of the inner

    Surfactin

    Surfactin

    Surfactin

  • Congenital disorder of glycosylation
  • Medical condition

    M5GlcNAc2-structure is then flipped to the ER lumen, via the action of a "flippase" This is deficient in RFT1-CDG (CDG-In). Finally, three mannosyltransferases

    Congenital disorder of glycosylation

    Congenital_disorder_of_glycosylation

  • Roger D. Kornberg
  • American biochemist and professor of structural biology

    called flip-flops. The term gave rise to the naming of proteins called flippases and floppases. Kornberg has served on the Scientific Advisory Boards of

    Roger D. Kornberg

    Roger D. Kornberg

    Roger_D._Kornberg

  • 1-Lysophosphatidylcholine
  • Class of phospholipids

    Fujimura-Kamada, K.; Yamamoto, T. (Feb 2011). "Functions of phospholipid flippases". J Biochem. 149 (2): 131–43. doi:10.1093/jb/mvq140. PMID 21134888. Harvat

    1-Lysophosphatidylcholine

    1-Lysophosphatidylcholine

    1-Lysophosphatidylcholine

  • Recombinase-mediated cassette exchange
  • The persistence of these entities is granted by a recombinase called "flippase" or "Flp". Four monomers of this enzyme associate with two identical short

    Recombinase-mediated cassette exchange

    Recombinase-mediated_cassette_exchange

  • Eat-me signals
  • translocate to the outer membrane, signaling for engulfment. ATP-dependent flippases maintain lipid asymmetry within the plasma membrane via the translocation

    Eat-me signals

    Eat-me signals

    Eat-me_signals

  • Membrane curvature
  • leaflets is actively formed and controlled within cells by proteins such as flippases, or removed to discourage curvature by proteins such as scramblases. When

    Membrane curvature

    Membrane_curvature

  • RFT1
  • Protein-coding gene in the species Homo sapiens

    Defects are associated with congenital disorder of glycosylation type 1N. Flippase GRCh38: Ensembl release 89: ENSG00000163933 – Ensembl, May 2017 GRCm38:

    RFT1

    RFT1

    RFT1

  • Lactosylceramide
  • Class of chemical compounds

    it initially cross from the cytosolic side of the membrane by means of flippase activity. Biosynthesis of lactosylceramide then includes expansion of the

    Lactosylceramide

    Lactosylceramide

    Lactosylceramide

  • UDP-glucuronic acid dehydrogenase
  • Class of enzymes

    Z, Raetz CR (December 2007). "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". The Journal of

    UDP-glucuronic acid dehydrogenase

    UDP-glucuronic_acid_dehydrogenase

  • Pseudopeptidoglycan
  • orthologous-to-bacteria CarB, MurC/D (peptide ligase), MurG, MraY, UppP, UppS, and flippase presumably performing an analogous function, and two novel but conserved

    Pseudopeptidoglycan

    Pseudopeptidoglycan

    Pseudopeptidoglycan

  • No-SCAR genome editing
  • Genome manipulation method

    transformation is needed to remove the selective marker. A plasmid expressing flippase (FLP) can be transformed into the recombined cells, which can specifically

    No-SCAR genome editing

    No-SCAR_genome_editing

  • Transporter Classification Database
  • Classification of membrane proteins including ion channels

    Family 2.A.66 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 2.A.67 The Oligopeptide Transporter (OPT) Family 2.A.68 The

    Transporter Classification Database

    Transporter_Classification_Database

  • Microvesicle
  • Type of extracellular vesicle

    the control of three phospholipidic pumps: an inward-directed pump, or flippase; an outward-directed pump, or floppase; and a lipid scramblase, responsible

    Microvesicle

    Microvesicle

    Microvesicle

  • Hyaluronan-mediated motility receptor
  • Protein-coding gene in the species Homo sapiens

    space is still unclear but may involve transport channels or proteins, flippase activity, or exocytosis, similar to other non-conventionally exported cell

    Hyaluronan-mediated motility receptor

    Hyaluronan-mediated motility receptor

    Hyaluronan-mediated_motility_receptor

  • Bacterial murein precursor exporter
  • Family of transport proteins

    translocation (flipping) step of Lipid II requires a specific protein (flippase). Mohammadi et al. (2011) showed that the integral membrane protein FtsW

    Bacterial murein precursor exporter

    Bacterial_murein_precursor_exporter

  • Enterobacterial common antigen
  • occurs on the periplasmic side of the inner membrane. Step 10: WzxE, a flippase, flips Lipid III from the cytoplasmic side of the inner membrane to the

    Enterobacterial common antigen

    Enterobacterial_common_antigen

  • Mark Bretscher
  • British scientist

    hypothetical lipid translocase to the outer monolayer which he named a "flippase". With Munro, he proposed that the Golgi apparatus concentrates cholesterol

    Mark Bretscher

    Mark_Bretscher

  • Cluster of Excellence Frankfurt Macromolecular Complexes
  • Based on real-time 31P-MAS-NMR they found that the homodimeric lipid A flippase MsbA is able to catalyze a reverse adenylate kinase-like reaction in addition

    Cluster of Excellence Frankfurt Macromolecular Complexes

    Cluster_of_Excellence_Frankfurt_Macromolecular_Complexes

  • PLSCR3
  • Protein-coding gene in the species Homo sapiens

    scramblase 3", published 2006-08-03  Pomorski T, Menon AK (Dec 2006). "Lipid flippases and their biological functions". Cellular and Molecular Life Sciences

    PLSCR3

    PLSCR3

    PLSCR3

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Online names & meanings

  • Rayhaan |
  • Boy/Male

    Muslim

    Rayhaan |

    Sweet Basil, Favored by God

  • Jasminjeet
  • Boy/Male

    Indian, Punjabi, Sikh

    Jasminjeet

    Victory of Flower

  • Treowbrycg
  • Boy/Male

    British, English

    Treowbrycg

    From the Tree Bridge

  • Bibi |
  • Girl/Female

    Muslim

    Bibi |

    Lady of rank, And honorific

  • PELAGIA
  • Female

    Greek

    PELAGIA

    (Πελαγία) Feminine form of Greek Pelagios, PELAGIA means "of the sea."

  • Vrishaparvaa
  • Boy/Male

    Hindu

    Vrishaparvaa

    Lord of Dharma

  • Kaaf
  • Boy/Male

    Arabic, Muslim

    Kaaf

    Sufficient; Enough

  • Adams
  • Boy/Male

    Hebrew

    Adams

    Man of the red earth. Adam was the first man created by God.

  • HANNU
  • Male

    Finnish

    HANNU

    Finnish form of German Johann, HANNU means "God is gracious."

  • Tuti
  • Girl/Female

    Arabic, Indonesian

    Tuti

    An Unusual Girl's Name

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