AI & ChatGPT searches , social queries for GERMLINE
Search references for GERMLINE. Phrases containing GERMLINE
See searches and references containing GERMLINE!
Search references for GERMLINE. Phrases containing GERMLINE
See searches and references containing GERMLINE!GERMLINE
Cells of a multicellular organism that pass on genetic material to progeny
In biology and genetics, the germline is the population of a multicellular organism's cells that develop into germ cells. In other words, they are the
Germline
Situation in which some gamete-producing cells are affected by a mutation
Germline mosaicism, also called gonadal mosaicism, is a type of genetic mosaicism where more than one set of genetic information is found specifically
Germline_mosaicism
Genetically modified human embryo
widespread criticism and legal debates. This highlights the implications of germline engineering, which involves introducing the desired genetic material into
Designer_baby
Manipulation of an organism's genome
onto 80 percent of the boy's body, which was affected by the illness. Germline gene therapy would result in any change being inheritable, which has raised
Genetic_engineering
Inherited genetic variation
A germline mutation, or germinal mutation, is any detectable variation within germ cells (cells that, when fully developed, become sperm and ova). Mutations
Germline_mutation
Process of editing the human genome so that the changes are inherited
Human germline engineering (HGE) is the process by which the genome of an individual is modified in such a way that the change is heritable. This is achieved
Human_germline_engineering
Medical technology
but do not prohibit germline engineering. A 2020 issue of the journal Bioethics was devoted to moral issues surrounding germline genetic engineering in
Gene_therapy
Organism composed of cells of different genotypes
are passed to them because their mother retained them).[citation needed] Germline chimerism occurs when the germ cells (for example, sperm and egg cells)
Chimera_(genetics)
How an animal develops its sexual-reproduction cells
primordial germ cells, migrate to the location of the gonad, and form the germline of the animal. Cleavage in most animals segregates cells containing germ
Germline_development
Biological term for all non-reproductive bodily cells
used to refer to the cells of the body, in contrast to the reproductive (germline) cells, which usually give rise to the egg or sperm (or other gametes in
Somatic_(biology)
Distinction between germ cell lineages producing gametes and somatic cells
copied only from germline cells to somatic cells. This means that new information from somatic mutation is not passed on to the germline. This barrier concept
Weismann_barrier
Alteration in the nucleotide sequence of a genome
mutation in a parent. A germline mutation can be passed down through subsequent generations of organisms. The distinction between germline and somatic mutations
Mutation
Type of genetic engineering
1016/B978-0-443-19045-2.00003-9. ISBN 978-0-443-19045-2. "Special Issue on Human Germline Editing". Bioethics. 34. 2020. "Customized Human Genes: New Promises and
Genome_editing
Type of mutation on somatic cell
occurs in a cell other than a gamete, germ cell, or gametocyte. Unlike germline mutations, which can be passed on to the descendants of an organism, somatic
Somatic_mutation
Methods to achieve pregnancy by artificial or partially artificial means
that in somatic cells from the same individual. This low frequency in the germline leads to embryos that have a low frequency of point mutations in the next
Assisted reproductive technology
Assisted_reproductive_technology
Genetic mutation not inherited from a parent
mutation in an individual organism. These may occur in gametogenesis due to a germline mutation in a parent, or as a postzygotic mutation. Single-nucleotide polymorphisms
De_novo_mutation
Transcription factor and coding gene in humans
and interferon-stimulated gamma factor 3 (ISGF3). A natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not
STAT1
Gamete-producing cell
and they only divide by mitosis. The lineage of germ cells is called the germline. Germ cell specification begins during cleavage in many animals or in the
Germ_cell
Epigenetic transmission without DNA primary structure alteration
must occur in the gametes in animals, but since plants lack a definitive germline and can propagate, epigenetic marks in any tissue can be heritable. The
Transgenerational epigenetic inheritance
Transgenerational_epigenetic_inheritance
Condition in multi-cellular organisms
activity led to what he called a genetic chimera.[non-primary source needed] Germline or gonadal mosaicism is a particular form of mosaicism wherein some gametes—i
Mosaic_(genetics)
Small nucleus in the cells of some organisms
next cycle of fission. In other words, they act as separate storage for germline DNA. Micronuclei in newly formed red blood cells in humans are known as
Micronucleus
Suite of free genome analysis software by Nvidia
Parabricks offers workflows for DNA and RNA analyses and the detection of germline and somatic mutations, using open-source tools. It is designed to improve
Nvidia_Parabricks
Any biological cell forming the body of an organism
In contrast, gametes derive from meiosis within the germ cells of the germline and they fuse during sexual reproduction. Stem cells also can divide through
Somatic_cell
Family of genetic conditions caused by mutations affecting Ras genes
The RASopathies are a group of developmental syndromes caused by germline mutations in genes belonging to the Ras/MAPK pathway. Common features include
RASopathy
cells (OSCs), also known as egg precursor cells or female germline cells, are diploid germline cells with stem cell characteristics: the ability to renew
Oogonial_stem_cells
variations and phenotypes, with supporting evidence. The database includes germline and somatic variants of any size, type or genomic location. Interpretations
ClinVar
1986 nuclear accident in the Soviet Union
without an increase in developmental anomalies or a significant rise in germline mutations. A 2021 study based on whole-genome sequencing of children of
Chernobyl_disaster
Species of hominid in the genus Homo
Arnadottir GA, Eiriksson O, et al. (January 2021). "Differences between germline genomes of monozygotic twins". Nature Genetics. 53 (1): 27–34. doi:10
Human
Concept of eternal life
according to Kirkwood. Individual organisms ordinarily age and die, while the germlines which connect successive generations are potentially immortal. The basis
Immortality
inherited cancer predisposition associated with pathogenic CDH1 (gene) germline mutations, and without apparent correlation with the hereditary diffuse
Hereditary lobular breast cancer
Hereditary_lobular_breast_cancer
Gene editing method
arising from somatic mutations, such as cancer. However, its use in human germline genetic modification is highly controversial. The development of this technique
CRISPR_gene_editing
Rate at which mutations occur during some unit of time
Recently reported estimates of the human genome-wide mutation rate. The human germline mutation rate is approximately 0.5 × 10−9 per basepair per year.
Mutation_rate
Proposed explanation for immunoglobulin diversity
immunoglobulin diversity that proposed that each antibody was encoded in a separate germline gene. This does not occur in most species (including humans), but may occur
Germ_line_theory
Type of gene
Drosophila. Apart from its expression in the gut, esg is also expressed in germline stem cells and cyst stem cells of the testis and, during development, in
Escargot (transcription factor)
Escargot_(transcription_factor)
there are two genomes that need to be considered - the germline and the tumour. The germline genome considers inter-individual inherited genetic variations
Cancer_pharmacogenomics
Process by which organisms develop cells
Germ-Soma Differentiation is the process by which organisms develop distinct germline and somatic cells. The development of cell differentiation has been one
Germ-Soma_Differentiation
Autosomal dominant cancer syndrome
and Adrenal Gland cancers that it is known to cause. LFS is caused by germline mutations (also called genetic variants) in the TP53 tumor suppressor gene
Li–Fraumeni_syndrome
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
Myeloid neoplasms with germline predisposition Acute myeloid leukaemia with germline CEBPA mutation Myeloid neoplasms with germline DDX41 mutation Myeloid
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
1932 dystopian novel by Aldous Huxley
does represent a form of cloning, but this is not ethically equivalent to germline genome editing, and references to Brave New World may lead some readers
Brave_New_World
Chemical compound (cancer therapy drug)
Agency (EMA) approved olaparib as monotherapy. The FDA approval is in germline BRCA mutated (gBRCAm) advanced ovarian cancer that has received three or
Olaparib
Hypothetical last common ancestor of all animals
accepted to have been a multicellular heterotroph — with the novelties of a germline and oogamy, an extracellular matrix (ECM) and basement membrane, cell-cell
Urmetazoan
Cell division producing haploid gametes
the informational redundancy needed to repair damage in the DNA of the germline. The repair process used appears to involve homologous recombinational
Meiosis
Transmembrane protein
regulator MTOR signalling. TMEM127 is a tumor suppressor gene, inactivating germline mutations in which causes hereditary pheochromocytoma and paraganglioma
TMEM127
2018 scientific and bioethical controversy
general body) and germline (sex cells and embryos for reproduction). The development of CRISPR gene editing enabled both somatic and germline editing (such
He_Jiankui_affair
Drosophila melanogaster male and female germline development. This structure has roles in maintaining germline cysts, coordinating the number of mitotic
Fusome
American science fiction author
T. C. McCarthy is an American science fiction author. His first novel, Germline, won the 2012 Compton Crook Award. McCarthy earned a bachelor's degree
T._C._McCarthy
Viruses can become part of the DNA of those they infect
process by which viral genetic material becomes stably integrated into the germline of a host organism and inherited by offspring through Mendelian inheritance
Endogenization
Schürenkamp M, Pfeiffer H, Neuhuber F, Brinkmann B (2015). "Elevated germline mutation rate in teenage fathers". Proc R Soc B. 282 (1803): 1–6. doi:10
List_of_oldest_fathers
Group of diseases involving cell growth
cancer (e.g. p53 mutations). Germline DNA repair mutations are noted on the figure's left side. However, such germline mutations (which cause highly
Cancer
English-American philosopher and futurist
the original on 15 October 2013. Retrieved 16 May 2013. Resources for Germline Technology, Washington Post, February 9, 2003. More, Max. "Transhumanism:
Max_More
Protein-coding gene in the species Homo sapiens
biallelic germline mutations of MBD4 have been identified in acute myeloid leukemias, uveal melanomas, and glioblastomas. and monoallelic MBD4 germline mutations
MBD4
Protein-coding gene in the species Homo sapiens
differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1). The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found
Kinase_insert_domain_receptor
One of two offspring produced by the same pregnancy
Steingrimsdottir, Thora; Norddahl, Gudmundur L. (2021-01-07). "Differences between germline genomes of monozygotic twins". Nature Genetics. 53 (1): 27–34. doi:10
Twin
Scientific hypothesis about inheritance
not original to Lamarck. August Weismann's germ plasm theory held that germline cells in the gonads contain information that passes from one generation
Lamarckism
Biological elevation of emotional well-being
well-being in humans and other animals through biological methods, including germline engineering through screening embryos with genes associated with a high
Biohappiness
Conspiracy theory regarding a totalitarian world government
Bioethics's proposed international treaty prohibiting human cloning and germline engineering. Furthermore, he argues that conspiracy theorists underestimate
New World Order conspiracy theory
New_World_Order_conspiracy_theory
Genes and regulatory proteins
miwi (for mouse piwi). PIWI proteins play a crucial role in fertility and germline development across animals and ciliates. Recently identified as a polar
Piwi
Type of cancer
Ewing sarcoma susceptibility. Sometimes Ewing sarcoma is associated with a germline mutation. The underlying mechanism often involves a genetic change known
Ewing_sarcoma
Cultivation of plants and animals to produce foods, fibers, fuels, and raw materials
has expanded the genes available to breeders to use in creating desired germlines for new crops. Increased durability, nutritional content, insect and virus
Agriculture
Medical condition
the colon and an increased risk of colorectal cancer. It is caused by germline mutations in DNA polymerase ε (POLE) and δ (POLD1). Affected individuals
Polymerase proofreading-associated polyposis
Polymerase_proofreading-associated_polyposis
Pair of cloned sheep
animals. Embryonic stem cells provide a means to transfer new DNA into the germline. They also allow precise genetic modifications by gene targeting. Modified
Polly_and_Molly
Surroundings of tumors including nearby cells and blood vessels
demonstrated that human germline genetic variants can significantly influence the composition of the tumor microenvironment. These germline variants affect the
Tumor_microenvironment
Small particle, often in plants
translational control. The germline granules appear to be ancestral and universally conserved in the germlines of all metazoan phyla. Many germline granule components
Granule_(cell_biology)
American developmental biologist
research at the Whitehead Institute and MIT focuses on how germline immortality is maintained by germline stem cell behavior [2]. She received a Tsuneko & Reiji
Yukiko_Yamashita
Biologist and academic administrator
on understanding the function of the intercellular bridges that connect germline cells (which develop into eggs/oocytes or sperm) and on the regulated production
Lynn_Cooley
cancer. The silencing of transposons is therefore extremely critical in the germline in order to stop transposon mutations from developing and being passed
Transposon_silencing
Internal organ in the male reproductive system
from heat-induced DNA damage that could otherwise lead to infertility and germline mutation. The relative size of the testes is often influenced by mating
Testicle
Kenyan-British developmental biologist
Gurdon Institute at the University of Cambridge since 1992, and Director of Germline and Epigenomics Research since 2013. Surani was educated at Plymouth University
Azim_Surani
British geneticist and cancer researcher
Kote-Jarai; Fredrick R Schumacher; Rosalind Eeles (27 November 2019). "Germline genetic variation in prostate susceptibility does not predict outcomes
Rosalind_Eeles
Gene known for its role in breast cancer
landmark Association for Molecular Pathology v. Myriad Genetics lawsuit. All germline BRCA2 mutations identified to date have been inherited, suggesting the
BRCA2
Protein-coding gene in the species Drosophila melanogaster
silencing in the germline. The Maelstrom protein forms a complex with piRISC to silence transposons and therefore stabilize the germline cell genome. A
Maelstrom_gene
Chinese-American physician (1940–2015)
colleague Joseph Fraumeni, of Li–Fraumeni syndrome, which is caused by germline mutations of the p53 tumor suppressor gene and genetically predisposes
Frederick_Pei_Li
Chemical compound
inhibitor marketed by Pfizer for the treatment of advanced breast cancer with germline BRCA mutations. Talazoparib is similar to the first in class PARP inhibitor
Talazoparib
Species of salamander
clearing and lineage tracing from dye labeling. The newer technologies of germline modification and transgenesis are better suited for live imaging the regenerative
Axolotl
Virus-derived DNA in another organism
element (EVE) is a DNA sequence derived from a virus, and present within the germline of a non-viral organism. EVEs may be entire viral genomes (proviruses)
Endogenous_viral_element
Medical condition
thorough clinical evaluation. SKS can be confirmed with the detection of a germline or mosaic mutation in the MTOR gene. Frequency of this disease is unknown
Smith–Kingsmore_syndrome
Unspecialized biological cell that can become specialized
1998). "decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary". Cell. 94 (2): 251–260. doi:10
Stem_cell
Protein found in humans
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation
Colony stimulating factor 1 receptor
Colony_stimulating_factor_1_receptor
PARP inhibitor anti-cancer drug compound
PARP inhibitor drug class. In China, it is approved for the treatment of germline BRCA mutation-associated recurrent advanced ovarian, fallopian tube, and
Pamiparib
Specialized subunit within a cell
Rybarska A, Hoege C, Gharakhani J, Jülicher F, Hyman AA (June 2009). "Germline P granules are liquid droplets that localize by controlled dissolution/condensation"
Organelle
Distribution of male and female functions across a species
reproduction involves meiosis, an adaptive process for repairing damage in the germline DNA transmitted to progeny. The distinctions between different sexual systems
Sexual_system
Rhetorical tactic and potential fallacy
Eugenics Intelligence amplification Moral enhancement Prostheses (De facto) germline interventions Selective Cloning Counseling Genetic Genomic Pre-conception
Appeal_to_nature
Type of protein
elegans has identified RNA-binding proteins as essential factors during germline and early embryonic development. Their specific function involves the development
RNA-binding_protein
Small South American monkeys
require consideration. According to recent research, marmosets exhibit germline chimerism, which is not known to occur in nature in any primates other
Marmoset
Upper portion of the human body
2011). "Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model". European
Human_head
DNA mutation
Gondo Y, Nakabeppu Y (2014). "8-oxoguanine causes spontaneous de novo germline mutations in mice". Sci Rep. 4: 4689. Bibcode:2014NatSR...4E4689O. doi:10
Transversion
Planarian regeneration proliferative cells
dividing planarian cells, and they produce all cell types, including the germline. Neoblasts are abundant in the planarian parenchyma, and comprise up to
Neoblast
Protein found in humans
in 2004 and this clinical entity is known to be due to having biallelic germline mutations in the DOCK8 gene. HIES due to DOCK8-deficiency has a distinct
Dedicator of cytokinesis protein 8
Dedicator_of_cytokinesis_protein_8
Genus of viruses
delivery. They can become endogenous, integrating their genome into the host germline genome, so that the virus is henceforth inherited by the host's descendants
Lentivirus
Genetic brain disorder
epigenetic regulation of methylated DNA), and can arise sporadically or from germline mutations. In less than 10% of RTT cases, mutations in the genes CDKL5
Rett_syndrome
Genetic technique
If the resulting chimeric mouse contained the genetic change in their germline, this could then be passed on offspring. In diploid organisms, which contain
Gene_knockout
Familial syndrome causing hamartomas and cancers
Cowden syndrome is inherited in an autosomal dominant fashion.[page needed] Germline mutations in PTEN (phosphatase and tensin homolog), a tumor suppressor
Cowden_syndrome
US non-profit organization
particularly criticize proposals concerning reproductive human cloning and germline genetic modification—both uses of technology colloquially considered 'socially
Center for Genetics and Society
Center_for_Genetics_and_Society
American biophysicist and author
and Sloan Foundations entitled "Human Germline Engineering: Implications for Science and Society"(www.germline.ucla.edu), and in an ARTE documentary examining
Gregory_Stock
Eugenics Intelligence amplification Moral enhancement Prostheses (De facto) germline interventions Selective Cloning Counseling Genetic Genomic Pre-conception
United Nations Declaration on Human Cloning
United_Nations_Declaration_on_Human_Cloning
Study of ancient viruses
present day. Also, some viral genetic fragments which were endogenized into germline cells of an ancient organism have been passed down to our time as viral
Paleovirology
Nuclear testing venue for the Soviet Union in northeast Kazakhstan
control counterparts. Some health scientists are still not sure what the germline mutations mean for the individuals' health, but there is increasing evidence
Semipalatinsk_Test_Site
Family of ray-finned fish
under-allocate carotenoids to their germline cells. Since carotinoids are beneficial antioxidants, their under-allocation to germline cells can lead to increased
Stickleback
South Korean scientific misconduct scandal
Eugenics Intelligence amplification Moral enhancement Prostheses (De facto) germline interventions Selective Cloning Counseling Genetic Genomic Pre-conception
Hwang_affair
Any disorder of the nervous system
endogenous reactive oxygen species is a substantial challenge for neurons. Germline mutations deficient in the repair of DNA damages cause neuronal dysfunction
Neurological_disorder
GERMLINE
GERMLINE
GERMLINE
GERMLINE
Male
English
English form of Greek Diabolos, DEVIL means "accuser, slanderer." In the bible, this is a title for Satan, the prince of demons and author of evil, who estranges men from God and entices them to sin. Figuratively, the devil is a man who, by opposing the cause of God, may be said to act the part of the devil or to side with him.
Boy/Male
Indian, Tamil
Rain-bearing Cloud
Male
English
Short form of English Timothy, TIMO means "to honor God." Compare with other forms of Timo.
Girl/Female
Muslim
Flame. Blaze.
Boy/Male
American, Australian, British, English, German
The People's Friend
Male
Egyptian
, Aseskaf.
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Mythological, Sanskrit
Name of Arjun's Wife
Boy/Male
Tamil
Strong
Boy/Male
Hindu
Ray of light, Name of a star
Girl/Female
French American
French form of Jacob): Supplanter. He grasps the heel.
GERMLINE
GERMLINE
GERMLINE
GERMLINE
GERMLINE