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Type of cellular stress response
The heat shock response (HSR) is a cell stress response that increases the number of molecular chaperones to combat the negative effects on proteins caused
Heat_shock_response
Family of proteins
Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to a stressor. They were first described in relation to
Heat_shock_protein
called stress response systems. These systems are very similar within prokaryotes and some of the systems, specifically the heat shock response, are conserved
Bacterial_stress_response
Family of heat shock proteins
The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure
Hsp70
Italian geneticist (1936–2014)
2014) was an Italian geneticist best known for his discovery of the heat shock response in the model organism Drosophila (fruit flies). Ritossa was born
Ferruccio_Ritossa
Process of regulating a functional proteome
translational reduction. The cytosolic heat shock response (HSR) is mainly mediated by the transcription factor family HSF (heat shock family). HSF is constitutively
Proteostasis
Illness from ingesting arsenic
arsenic effects to the heat shock response. Short-term arsenic exposure has effects on signal transduction inducing heat shock proteins with masses of
Arsenic_poisoning
Protein domain
than optimum growth temperature, by contrast with heat shock proteins induced in the heat shock response, which help the cell to survive in temperatures
Cold-shock_domain
into it, it will trigger a stress response. The heat shock response involves a class of stress proteins called heat shock proteins. These can help defend
Cellular_stress_response
Protein-coding gene in the species Homo sapiens
Heat shock factor protein 1 (HSF 1) is a protein that in humans is encoded by the HSF1 gene. HSF1 is highly conserved in eukaryotes and is the primary
Heat_shock_factor_protein_1
Transcription factor
heat shock factors (HSF), are the transcription factors that regulate the expression of the heat shock proteins. A typical example is the heat shock factor
Heat_shock_factor
Medication
of diseases.[medical citation needed] Arimoclomol activates the heat shock response. It is believed to act at Hsp70. Arimoclomol was discovered by Hungarian
Arimoclomol
American professor of biology
looks at the manipulation of stress response pathways, such as the heat shock response and the unfolded protein response of the mitochondria and the endoplasmic
Andrew_Dillin
RNA thermometer in Drosophila
translational efficiency during the heat shock response. The hsp90 gene product is involved in the Drosophila heat shock response. Translation of the hsp90 mRNA
Hsp90_cis-regulatory_element
Topics referred to by the same term
Honkai: Star Rail, a 2023 gacha video game Health services research Heat shock response, via HSPA1A gene Homogeneously staining region Hidden surface removal
HSR
Physiological response to sudden exposure to cold
Cold shock response is a series of neurogenic cardio-respiratory responses caused by sudden immersion in cold water. In cold water immersions, such as
Cold_shock_response
InterPro Family
for regulation of protein folding machinery, as well as the heat shock response. It is a heat-inducible protein and during stress it prevents unfolded proteins
GrpE
American molecular biologist
R.I. (1991). "Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated
Richard_I._Morimoto
Protein-coding gene in the species Homo sapiens
and humans. Heat shock proteins are primarily responsible for maintaining the integrity of cellular proteins particularly in response to environmental
GroEL
Family of enzymes
after thermal stress, suggesting that PIM1 may play a role in the heat shock response. Lon proteases have two specific subfamilies: LonA and LonB, differentiated
Lon_protease_family
Load caused by rapid temperature change
and poor heat transfer models, larger temperature differentials can be tolerated for hot shock than for cold shock. In addition to thermal shock resistance
Thermal_shock
Mechanical component
converting the kinetic energy of the shock into another form of energy (typically heat) which is then dissipated. Most shock absorbers are a form of dashpot
Shock_absorber
Dangerously low blood pressure due to damage from an organ infection
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is defined as an abnormal immune response to infection that leads
Septic_shock
an overlap between oxidative stress response and other regulatory networks like heat shock response, SOS response. The defenses against deleterious effects
Oxidation_response
RNA family
protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation
BiP internal ribosome entry site
BiP_internal_ribosome_entry_site
regulons in bacteria are those involved in response to stress such as heat shock. The heat shock response in E. coli is regulated by the sigma factor
Regulon
Chemical compound
of proteasome function and activation of HSF1, which triggers the heat shock response. The available evidence indicates that celastrol covalently binds
Celastrol
homeostasis (proteostasis). In the cytosol, the heat shock response (HSR) manages the unfolded proteins through heat shock factor 1 (HSF1). HSF-1 is a transcription
Mitochondrial unfolded protein response
Mitochondrial_unfolded_protein_response
Species of fish
organismal performance at subzero temperatures. These include a modified heat shock response, the production of antifreeze glycoproteins that prevent ice crystallization
Notothenia_coriiceps
Chemical compound
Wondrak GT (May 2010). "The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in
Zinc_pyrithione
American biochemist
(fruit flies), in particular the genetics and biochemistry of the heat shock response. Mitchell was born on November 27, 1913, in Los Nietos, California
Herschel_K._Mitchell
Chemical element with atomic number 30 (Zn)
suggests that the topical antimicrobial zinc pyrithione is a potent heat shock response inducer that may impair genomic integrity with induction of PARP-dependent
Zinc
Form of water
concentrations of heavy water. In addition, the cells activated the heat-shock response pathway and the cell integrity pathway, and mutants in the cell integrity
Heavy_water
Class of adaptor proteins
be mediated by importin αs including gametogenesis, development, heat shock response, protein degradation, and viral pathogen infection. Gametogenesis
Importin_α
Species of crustacean
Pierre-Marie; Jollivet, Didier; Shillito, Bruce (2003-07-15). "Heat-shock response and temperature resistance in the deep-sea vent shrimp Rimicaris
Rimicaris_exoculata
Protein-coding gene in the species Homo sapiens
Heat shock protein 47, also known as SERPINH1, is a serpin which serves as a human chaperone protein for collagen. HSP47 contains 3 beta sheets and 9 alpha
Heat_shock_protein_47
Species of fish
emerald rockcod does not show a typical heat shock response; for example, it does not upregulate the heat shock protein gene hsp70 when in warm temperatures
Emerald_rockcod
Constitutive promoter
interactions with mineralocorticoid receptors in the heart. Its role in heat shock response presents it as a target for treating related diseases like spinal
Eukaryotic translation elongation factor 1 alpha 1
Eukaryotic_translation_elongation_factor_1_alpha_1
Heat shock proteins with a molecular mass around 90kDa
Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in
Hsp90
Process to preserve biological matter
cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing". Cytotherapy. 14 (2): 147–52
Cryopreservation
Protein-coding gene in the species Homo sapiens
2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response". Biochemical and Biophysical Research Communications. 360 (2): 447–52
TCIM
Aggregates of specific proteins in neurons and tissues
A, Goffin L, Georgopoulos C (August 1995). "The Escherichia coli heat shock response and bacteriophage lambda development". FEMS Microbiology Reviews
Inclusion_bodies
American physician-scientist
Biomedical Research studying the role of the master regulator of the heat shock response, HSF1, in the development of cancer. In 2013, he started his research
Sandro_Santagata
(fruit flies), in particular the genetics and biochemistry of the heat shock response. Felix Mitelman (born 1940), Swedish cancer geneticist and cytogeneticist
List_of_geneticists
American geneticist (1949–2016)
of Chicago Lindquist investigated the role of heat shock proteins in regulating the cellular response to environmental stresses. Lindquist pioneered
Susan_Lindquist
Suborder of fishes
enzymatic activity. Many notothenoids have lost the nearly universal heat shock response (HSR) due to evolution at cold and stable temperatures. Many notothenioid
Notothenioidei
Lab technique in molecular biology
possibly alter heat shock response. Cells can be studied further by studying the proteins used, post-translational modifications, and heat shock to determine
Pulse-chase_analysis
Sites in the cell nucleus where DNA transcription occurs
1065–1071. doi:10.1038/ng1423. PMID 15361872. Lindquist S (1986). "The heat-shock response". Annu. Rev. Biochem. 55: 1151–1191. doi:10.1146/annurev.bi.55.070186
Transcription_factory
Species of fungus
Candida species by inducing a permanent stress response, a more generalized form of the heat shock response. However, this different codon usage makes it
Candida_albicans
solfataricus, for example, a vapBC gene cassette is thought to regulate heat shock response. Toxin-antitoxin database Robson, Jennifer; McKenzie, Joanna L.;
VapBC
Lebanese-American scientist
and switched her research focus to gene regulatory systems and the shock responses that bacteria undergo when adapting to temperature changes. After graduating
Hana_El-Samad
Use of stem cells to treat or prevent a disease or condition
cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing". Cytotherapy. 14 (2): 147–152
Stem-cell_therapy
Family of enzymes
the absence of oxidative stress, although ASK1 is also involved in heat shock response, which is likewise prevented during ASK1 sequestration. The fact
Glutathione_S-transferase
Cascade of intracellular and molecular events for transmission/amplification of signals
the heat-shock response. Such response is triggered when high temperatures cause the dissociation of inactive HSF1 from complexes with heat shock proteins
Signal_transduction
Protein-coding gene in the species Homo sapiens
specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions
HSF2
Geneticist
subdivision of chromosomes into self-associating domains, and he used the heat shock response as a paradigm to study the relationship between 3D organization and
Victor_Corces
Protein-coding gene in the species Homo sapiens
Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in humans is encoded by the
HSPA8
acid limitation, iron limitation, heat shock and other stress conditions and growth processes. The stringent response is signaled by the alarmone (p)ppGpp
Stringent_response
Protein-coding gene in the species Homo sapiens
Iida J, Hata Y (2003). "C2PA is a nuclear protein implicated in the heat shock response". J. Cell. Biochem. 87 (1): 65–74. doi:10.1002/jcb.10279. PMID 12210723
RGS3
Species of ant
Saharan silver ants produce heat shock proteins (HSPs), but unlike other animals, they do this not in direct response to heat. Instead, they do this before
Saharan_silver_ant
Protein that regulates the rate of DNA transcription
Shamovsky I, Nudler E (March 2008). "New insights into the mechanism of heat shock response activation". Cellular and Molecular Life Sciences. 65 (6): 855–861
Transcription_factor
Protein-coding gene in the species Homo sapiens
Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene. Heat-shock transcription factors (HSFs) activate heat-shock response
HSF4
Protein-coding gene in the species Homo sapiens
Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene. Hsp27 is a chaperone
Hsp27
Protein-coding gene in the species Homo sapiens
trimerization of HSF1 (Heat Shock Factor 1) and thus the body's response to heat shock. In the absence of tTG, the response to heat shock is impaired since
Tissue_transglutaminase
Class of non-coding RNAs in Salmonella
RNA thermometers such as FourU control regulation of temperature via heat shock proteins in multiple prokaryotes. FourU thermometers are relatively small
FourU_thermometer
Mainstream medical research into cancer treatment
mild heat treatment combined with other stresses can cause cell death by apoptosis. There are many biochemical consequences to the heat shock response within
Experimental_cancer_treatment
Ability of organisms to survive high temperature
"Acquired thermotolerance independent of heat shock factor A1 (HsfA1), the master regulator of the heat stress response". Plant Signaling & Behavior. 7 (5):
Thermotolerance
Protein-coding gene in the species Homo sapiens
Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the HSP90AB1 gene. HSP90AB1 is a molecular chaperone. Chaperones
HSP90AB1
Antagonists of a youth's slang
flagellum assembly, transport of materials, cell growth, and the cell's stress response. Sigma factors are essential proteins that start the transcription by binding
Anti-sigma_factors
Indian scientist
continued to work in trying to understand the mechanisms behind heat shock response systems and the functions of satellite non-coding RNA as a transcriptional
Mitali_Mukerji
Class of molecules found in the outer membrane of Gram-negative bacteria
cases, LPS can trigger a brisk host response and multiple types of acute organ failure which can lead to septic shock. In lower levels and over a longer
Lipopolysaccharide
Mammalian protein found in humans
Polyubiquitin-C doesn't activate the heat-shock response, but it plays a key role in sustaining the response. UBC gene transcription is induced during
Ubiquitin_C
Sudden transient acceleration
lost to heatPages displaying short descriptions of redirect targets Pyroshock Response spectrum – Response of a structure to oscillation Shock mount –
Shock_(mechanics)
Canadian indie rock band
Following an eight-year hiatus, Hot Hot Heat reunited at the end of 2023, with the release of their comeback single, "Shock Me" on December 1, 2023. However
Hot_Hot_Heat
Protein-coding gene in the species Homo sapiens
Heat shock 70 kDa protein 1, also termed Hsp72, is a protein that in humans is encoded by the HSPA1A gene. As a member of the heat shock protein 70 family
HSPA1A
Protein-coding gene in the species Homo sapiens
cellular functions, such as apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. PKCε translocates to cardiac muscle
PRKCE
Protein-coding gene in the species Homo sapiens
Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene. HSPH1 has been shown to interact with Cofilin 1. GRCh38: Ensembl release
HSPH1
Physiological reaction or injury caused by electric current
An electrical injury (electric injury) or electrical shock (electric shock) is damage sustained to the skin or internal organs on direct contact with
Electrical_injury
Protein-coding gene in the species Homo sapiens
Heat shock protein family A (Hsp70) member 12B is a protein that in humans is encoded by the HSPA12B gene. The protein encoded by this gene contains an
Heat shock protein family A (Hsp70) member 12B
Heat_shock_protein_family_A_(Hsp70)_member_12B
Protein-coding gene in the species Homo sapiens
protein (BiPS) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the
Binding immunoglobulin protein
Binding_immunoglobulin_protein
down-regulation MeSH G07.621.487.750 – up-regulation MeSH G07.621.500 – heat-shock response MeSH G07.621.888 – water-electrolyte balance MeSH G07.621.888.500
List_of_MeSH_codes_(G07)
Protein found in humans
shown to improve the activity of HSP90 inhibitors by suppressing the heat shock response in castration-resistant prostate cancer, and was evaluated in phase
Clusterin
Introduction of foreign genetic material into host cells
altering the environment of the cell and then stressing it by giving it a heat shock. Typically the cells are incubated in a solution containing divalent cations
Gene_delivery
Protein-coding gene in the species Homo sapiens
Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. The gene, HSP90AA1, encodes the human stress-inducible 90-kDa
Heat shock protein 90kDa alpha (cytosolic), member A1
Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1
Protein-coding gene in the species Homo sapiens
Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by
HSP90B1
Indian scientist (born 1954)
interaction is temperature dependent: Implication for the mechanism of heat-shock response. Chattopadhyay, R., & Roy, S.* (2002) J Biol Chem, 277, 33641-7.
Siddhartha_Roy
Situation where cities are warmer than surrounding areas
The urban heat island (UHI) effect is a meteorological and climatological phenomenon in which urban areas experience significantly warmer temperatures
Urban_heat_island
Yeast protein
HSP12, or Heat Shock Protein 12, is a small stress response protein synthesized by yeast in multiple disfavorable conditions. HSP12 originates from budding
HSP12
Temperature-dependent RNA structure
thermometers often regulate genes required during either a heat shock or cold shock response, but have been implicated in other regulatory roles such as
RNA_thermometer
Biological adjustment to new climates
increasing the number of membrane proteins. In response to certain stressors, some organisms express so-called heat shock proteins that act as molecular chaperones
Acclimatization
United States national security policy
head or use duct tape over his eyes. They may not beat or electrically shock or burn him or inflict other forms of physical pain, any form of physical
Department of Defense Directive 2310
Department_of_Defense_Directive_2310
Sensor which measures heat transfer
allow the measurement of highly transient surface temperatures. Fast-response direct heat-flux sensors are Atomic Layer Thermopiles with a temporal resolution
Heat_flux_sensor
1949 American film noir by Raoul Walsh
White Heat is a 1949 American film noir, directed by Raoul Walsh. Its screenplay, written by Ivan Goff and Ben Roberts, is based on a story by Virginia
White_Heat
RNA-based gene silencing process
function of RdDM in stress response is to help counter this activation. In one example, the retrotransposon ONSEN is upregulated by heat stress, but normally
RNA-directed_DNA_methylation
Abnormally low blood pressure
shock. Shock is classified based on the underlying cause, including hypovolemic shock, cardiogenic shock, distributive shock, and obstructive shock.
Hypotension
Hazmat labeling system
required a specific response. In this case, sodium was able to react with water to release hydrogen gas and large amounts of heat, which has the potential
NFPA_704
Protein-coding gene in the species Homo sapiens
Heat shock transcription factor 5 is a protein that in humans is encoded by the HSF5 gene. GRCh38: Ensembl release 89: ENSG00000176160 – Ensembl, May 2017
HSF5
Protein-coding gene in the species Homo sapiens
DnaJ heat shock protein family (Hsp40) member A4 is a protein that in humans is encoded by the DNAJA4 gene. GRCh38: Ensembl release 89: ENSG00000140403
DNAJA4
Standard for testing electrotechnical products
impact shock IEC 60068-2-78 - Test Cab: Damp heat, steady state IEC 60068-2-80 - Test Fi: Vibration - Mixed mode IEC 60068-2-81 - Test Ei: Shock - Shock response
IEC_60068
ambient, can be considered heat shock or heat stress. Heat tolerance is broadly defined as the ability of the plant tolerate heat – means that grow and produce
Breeding for heat stress tolerance
Breeding_for_heat_stress_tolerance
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