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Protein family
nuclear localization sequences (NLS). Importin has two subunits, importin α and importin β. Members of the importin-β family can bind and transport cargo
Importin
Type of amino acid sequence
signals are recognized by importin α. Importin α contains a bipartite NLS itself, which is specifically recognized by importin β. The latter can be considered
Nuclear_localization_sequence
Proteins involved in nucleocytoplasmic transport
complexes. Importin beta is a variety of karyopherin that facilitates the transport of cargo proteins into the nucleus. First, it is binding importin alpha
Karyopherin
Protein-coding gene in the species Homo sapiens
Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene. The protein encoded by this gene is a member of the importin beta family
KPNB1
Class of adaptor proteins
Importin alpha, or karyopherin alpha refers to a class of adaptor proteins that are involved in the import of proteins into the cell nucleus. They are
Importin_α
Protein-coding gene in the species Homo sapiens
Importin-13 is a protein encoded by the IPO13 gene in humans. Importin-13 is a member of the importin-β family of nuclear transport receptors (NTRs) and
IPO13
Openings in nuclear envelope of eukaryotic cells
material with an NLS will be taken up by importins to the nucleus.[citation needed] Importation begins with Importin-α binding to the NLS sequence of cargo
Nuclear_pore_complex
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-3, also known as karyopherin subunit alpha-4, is a protein that in humans is encoded by the KPNA4 gene. The nuclear import of karyophilic
Importin_subunit_alpha-3
Protein-coding gene in the species Homo sapiens
Importin-7 is a protein that in humans is encoded by the IPO7 gene. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins
IPO7
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene. Nucleocytoplasmic transport, a signal- and energy-dependent process
Importin_subunit_alpha-7
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-6 is a protein that in humans is encoded by the KPNA5 gene. The transport of molecules between the nucleus and the cytoplasm in
Importin_subunit_alpha-6
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene. The transport of molecules
Importin_subunit_alpha-4
GTPase functioning in nuclear transport
localization signal (NLS) are bound by importins and transported into the nucleus. Inside the nucleus, RanGTP binds to importin and releases the import cargo.
Ran_(protein)
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA2 gene. The import of proteins into the nucleus is a process that involves at
Importin_subunit_alpha-1
Biological signaling pathway h
called importins. Once the STAT dimer (bound to importins) enters the nucleus, a protein called Ran (associated with GTP) binds to the importins, releasing
JAK-STAT_signaling_pathway
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-5 is a protein that in humans is encoded by the KPNA1 gene. Importin subunit alpha-5 has been shown to interact with KPNB1 and
Importin_subunit_alpha-5
Protein-coding gene in the species Homo sapiens
Transportin-1 (or Importin-β 2) is a protein that in humans is encoded by the TNPO1 gene. This protein is a karyopherin which interacts with nuclear localization
Transportin_1
Protein tandem repeat
nuclear transport protein importin beta contains 19 HEAT repeats. Representative examples of HEAT repeat proteins include importin β (also known as karyopherin
HEAT_repeat
Chemical compound
RanGTPase would bind to the beta importin which removes it from the complex, followed by the removal of the alpha importin which is also bound to the RanGTPase
Guanosine_diphosphate
Mechanism of molecules moving across the nuclear membrane
factors known as nuclear transport receptors, like karyopherins called importins to enter the nucleus and exportins to exit. Proteins that must be imported
Nuclear_transport
Species of virus
(RNP). At the early stage of infection, the RNP binds to the host cell's importin-α which transports it into the host cell nucleus, where the viral RNA is
Influenza_A_virus
Protein family
the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that
CAS/CSE_protein_family
Protein domain
proteins that contain armadillo repeats include β-catenin, Sarm1 (SARM1), α-importin, plakoglobin, adenomatous polyposis coli (APC), and many others. The term
Armadillo_repeat
Protein-coding gene in the species Homo sapiens
Importin-11 is a protein that in humans is encoded by the IPO11 gene. GRCh38: Ensembl release 89: ENSG00000086200 – Ensembl, May 2017 GRCm38: Ensembl release
IPO11
Proteine
Importin 8 is a protein that in humans is encoded by the IPO8 gene. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins
IPO8
Uses of drug ivermectin during the COVID-19 pandemic
specifically the inhibition of nuclear transport by importin α/β1. Several other drugs which inhibit importin α/β1 at therapeutic doses have failed clinical
Ivermectin during the COVID-19 pandemic
Ivermectin_during_the_COVID-19_pandemic
Bacterium, genetic engineering tool
on the VirE2 and VirD2, are recognised by the importin alpha protein, which then associates with importin beta and the nuclear pore complex to transfer
Agrobacterium_tumefaciens
Protein-coding gene in the species Homo sapiens
Importin-5 is a protein that in humans is encoded by the IPO5 gene. The protein encoded by this gene is a member of the importin beta family. Structurally
IPO5
Specialized subunit within a cell
(2009). Nuclear import of histone fold motif containing heterodimers by importin 13. Niedersächsische Staats-und Universitätsbibliothek Göttingen. Nott
Organelle
Class of chemical compounds
binding to the AHR (1.) leads to its translocation into the nucleus by importin-β, (2.) heterodimerization with ARNT and binding to the DNA at DREs, (3
Dioxins and dioxin-like compounds
Dioxins_and_dioxin-like_compounds
Organelle in eukaryotic cells
by importins, while those transported from the nucleus to the cytoplasm carry nuclear export signals bound by exportins. The ability of importins and
Cell_nucleus
Protein
of the cell. The importin structure is composed of many alpha helices that integrate the protein into membranes. The role of importin is to move proteins
Phospholipid_scramblase
Protein-coding gene in the species Homo sapiens
Importin-9 is a protein that in humans is encoded by the IPO9 gene. GRCh38: Ensembl release 89: ENSG00000198700 – Ensembl, May 2017 GRCm38: Ensembl release
IPO9
Protein that initiates male sex determination in therian mammals
the nuclear localization signal regions, which allows for the binding of importin β and calmodulin to SRY, facilitating its import into the nucleus. Once
Sex-determining region Y protein
Sex-determining_region_Y_protein
Conversion of a gene's sequence into a mature gene product or products
is via the nuclear pore and transport is controlled by a wide range of importin and exportin proteins. Expression of a gene coding for a protein is only
Gene_expression
Macrophage found in the lungs
translocates into the nucleus via the nuclear pore with the assistance of importins alpha/beta. Once in the nucleus, these complexes accumulate and eventually
Alveolar_macrophage
Protein-coding gene in the species Homo sapiens
localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing
Nuclear_pore_glycoprotein_p62
Protein-coding gene in the species Homo sapiens
FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are
Nucleoporin_50
Protein found in humans
NMD3, Nucleoporin 62, RANBP1, RANBP3, Ran, SMARCB1, and p53. Karyopherin Importin Nuclear transport Nuclear export signal GRCh38: Ensembl release 89: ENSG00000082898
XPO1
Protein-coding gene in the species Homo sapiens
Importin-4 is a protein that in humans is encoded by the IPO4 gene. GRCm38: Ensembl release 89: ENSMUSG00000002319 – Ensembl, May 2017 "Human PubMed Reference:"
IPO4
HIV-1 regulating protein
and importin-β (a nuclear transport factor). The Rev NLS is a highly similar sequence to that of the importin-β-binding site present within importin-α,
Rev_(HIV)
Protein-coding gene in the species Homo sapiens
direct interactions with Importin 8 where Importin 8 associates with the m7G cap-binding site of eIF4E. Indeed, reduction in Importin 8 levels reduce the oncogenic
EIF4E
Family of intracellular transcription factors
phosphorylated dimer is then actively transported to the nucleus via an importin α/β ternary complex. Originally, STAT proteins were described as latent
STAT_protein
solenoid proteins formed from HEAT repeats; importin beta is a member of this family, and its adaptor protein importin alpha is an alpha solenoid formed from
Alpha_solenoid
Mammalian protein found in Homo sapiens
Oka S, Matsuo Y, Yamaguchi Y, Nishio K, Ishii Y, Yodoi J (Sep 2004). "Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin
TXNIP
ribonucleoprotein A1 Homeobox A1 Immunoglobulin heavy constant alpha 1 Importin alpha 1 Interferon, alpha 1 Interleukin 13 receptor, alpha 1 Karyopherin
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Mammalian protein
basis for the recognition of a nonclassical nuclear localization signal by importin beta". Molecular Cell. 10 (6): 1345–1353. doi:10.1016/S1097-2765(02)00727-X
Parathyroid hormone-related protein
Parathyroid_hormone-related_protein
Feature of biological cell structure
factors (SAFs) from inhibitory interactions via the transport proteins importin β/α. The unbound SAFs then promote microtubule nucleation and stabilization
Spindle_apparatus
Protein-coding gene in the species Homo sapiens
212518199. PMC 137860. PMID 12384575. "Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)". Fontoura BM, Blobel G, Yaseen NR (October 2000)
TNPO2
Protein-coding gene in the species Homo sapiens
localization of myopodin is sensitive to Importin 13, which directly binds myopodin and facilitates its translocation. Importin binding and nuclear import of myopodin
SYNPO2
Protein-coding gene in humans
nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3". Proceedings of the National Academy of Sciences of the United
STAT3
Mammalian protein found in humans
import of the domain-specific androgen receptor in association with the importin alpha/beta and Ran-guanosine 5'-triphosphate systems". Endocrinology. 149
Androgen_receptor
Protein-coding gene in the species Homo sapiens
PMID 12637565. De Corte V, Van Impe K, Bruyneel E, et al. (2005). "Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes
Macrophage-capping_protein
Protein-coding gene in the species Homo sapiens
microtubule nucleation and is regulated by importin proteins. TPX2 serves as a complement, depleting importin α affinity in order to allow RanGTP-induced
TPX2
Protoplasm that permeates a cell's nucleus
by a nuclear localization sequence (NLS). Cytosolic proteins, known as importins, act as receptors for the NLS, escorting the protein to a nuclear pore
Nucleoplasm
Protein-coding gene in the species Homo sapiens
(bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip". Molecular Biology of the Cell. 10 (7): 2221–33. doi:10
Sterol regulatory element–binding protein 2
Sterol_regulatory_element–binding_protein_2
Biological gene-regulation phenomenon
still under investigation, several pathways have been implicated: Importin-8: Importin-8 has been shown to mediate the nuclear import of mature miRNAs.
RNA_activation
Protein found in humans
doi:10.1038/sj.onc.1200858. PMID 9053844. Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal
60S_ribosomal_protein_L23a
Family of proteins that form microfilaments
(probably in a complex with cofilin) is facilitated by the import protein importin 9. Low levels of actin in the nucleus seems to be important, because actin
Actin
American cell and developmental biologist
identified a biochemical modification of the nuclear transport receptor importin α as a sensor that scales intracellular structures to cell size. Heald
Rebecca_Heald
Mammalian protein found in humans
into the nucleus by directly interacting with the N-terminal domain of importin-β upon immunological stimulation of the mast cells. Growing evidence is
Microphthalmia-associated transcription factor
Microphthalmia-associated_transcription_factor
Antiviral medication
eIF4E through interfering with its interaction with its nuclear importer, Importin 8, thereby impairing its nuclear activities. Clinical relapse in AML patients
Ribavirin
Proto-oncogene derived from polyomavirus SV40
signals (NLSs). It is imported into the nucleus by its interaction with importin α. The NLS sequence is PKKKRKV. SV40 large TAg, other polyomavirus large
SV40_large_T_antigen
Protein-coding gene in the species Homo sapiens
PMID 11085938. Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (July 2001). "Importin 13: a novel mediator of nuclear import and export". EMBO J. 20 (14): 3685–94
UBE2I
Protein-coding gene in the species Homo sapiens
non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate
ZBTB33
Protein-coding gene in the species Homo sapiens
SH3D21 has been found to interact with Adenylate Kinase 2, Artemin, and Importin 13. The human protein has two isoforms and no paralogs. The second isoform
SH3D21
Biological mechanism for routing proteins
nuclear localization signals: definition, function, and interaction with importin alpha". The Journal of Biological Chemistry. 282 (8): 5101–5. doi:10.1074/jbc
Protein_targeting
Enzyme
methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-α". Genes Dev. 14 (23): 2944–9. doi:10.1101/gad.848200. PMC 317093. PMID 11114884
MRNA (guanine-N7-)-methyltransferase
MRNA_(guanine-N7-)-methyltransferase
Family of proteins that form the nuclear pore complex
gradient and through the nuclear pore complex. Karyopherins can serve as an importin (transporting proteins into the nucleus) or an exportin (transporting proteins
Nucleoporin
Species of plant pathogen
Jonathan D. G.; Banfield, Mark J. (2015). "Probing formation of cargo/importin-α transport complexes in plant cells using a pathogen effector". The Plant
Hyaloperonospora_parasitica
Protein-coding gene in the species Homo sapiens
PMID 9303539. Neville M, Stutz F, Lee L, Davis LI, Rosbash M (1998). "The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear
AGFG1
Final stage of mitosis and meiosis
surface of the chromosomes: it releases envelope components sequestered by importin β during early mitosis. Ran-GTP localizes near chromosomes throughout mitosis
Telophase
Protein-coding gene in humans
Emelyanov A, Singh M, Ashouian N, Birshtein BK (Jun 2000). "BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence"
PAX5
Protein-coding gene in the species Homo sapiens
"A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions". The Journal of Cell Biology. 178 (3): 387–98. doi:10
CRB3
Protein family
Nkds mediates nuclear import via binding to the nuclear import factor importin-alpha3. There are two Nkd proteins (Nkd1 and Nkd2) in most vertebrates
Naked_cuticle
Protein-coding gene in the species Homo sapiens
PMID 10366588. Lai MC, Lin RI, Huang SY, Tsai CW, Tarn WY (Apr 2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated
Transportin-3
Protein-coding gene in the species Homo sapiens
nuclear localization signals specific to different binding grooves of importin alpha". The Journal of Biological Chemistry. 284 (1): 478–485. doi:10.1074/jbc
BNIP5
family of nuclear transport factors – broadly termed karyopherins (aka importins and exportins). Together with his colleagues, he introduced the "virtual
John_D._Aitchison
Protein-coding gene in the species Homo sapiens
MG, Guttridge KL, Munguia J, Waterman ML (August 1998). "Differential importin-alpha recognition and nuclear transport by nuclear localization signals
Lymphoid enhancer-binding factor 1
Lymphoid_enhancer-binding_factor_1
Protein found in humans
the nucleus is mediated by an interaction between its second AT-hook and importin-α2. HMGA Lethal dwarfism in rabbits, due to a loss of function (LOF) mutation
HMGA2
Protein-coding gene in the species Homo sapiens
reference expression data Gene ontology Molecular function microtubule binding importin-alpha family protein binding protein binding syntaxin binding protein kinase
Golgin_subfamily_A_member_2
Biochemical test for age
cellular senescence, an established hallmark of ageing KPNA4: member of the importin family, nuclear transport receptors. Dysfunction of nuclear transport has
Epigenetic_clock
Protein in animal cells
atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Human Molecular Genetics. 11 (15): 1785–95. doi:10.1093/hmg/11.15
Survival_of_motor_neuron
American biochemist and academic
nuclear localization signals: definition, function, and interaction with importin alpha". Journal of Biological Chemistry. 282 (8): 5101–5105. doi:10.1074/JBC
Anita_Corbett
Protein-coding gene in the species Saccharomyces cerevisiae S288c
nucleus. Pho4 has a Nuclear Exchange factor that an importin protein is able to bind to. The importin protein will bind to its "signal" or nuclear exchange
Pho4
Vertebrate receptor protein and transcription factor
Hollingshead B, Perdew GH (January 2003). "The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah
Aryl_hydrocarbon_receptor
Protein-coding gene in the species Homo sapiens
Ben-Efraim, I; Gerace L (January 2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import". J. Cell Biol
Nucleoporin_153
Protein found in humans
S2CID 14132033. Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones
60S_ribosomal_protein_L4
Protein-coding gene in the species Homo sapiens
8A". Mingot, J M; Kostka S; Kraft R; Hartmann E; Görlich D (July 2001). "Importin 13: a novel mediator of nuclear import and export". EMBO J. 20 (14). England:
RNA-binding_protein_8A
Physical interactions and constructions between multiple proteins
from cytoplasm to nucleus or vice versa in the case of the nuclear pore importins).[citation needed] In many biosynthetic processes enzymes interact with
Protein–protein_interaction
Protein-coding gene in the species Homo sapiens
"Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily". J. Biol. Chem. 275 (51): 40163–8. doi:10.1074/jbc.M006242200
XPOT
Protein-coding gene in humans
binding to the 3′ UTR of the ARID3A transcript. In the absence of let-7, importin-9 facilitates the nuclear import of ARID3A, which then forms a complex
ARID3A
Protein complexes that mix with other proteins to form spliceosome
snRNP-snurportin 1 complex is transported into the nucleus via the protein importin β. Inside the nucleus, the core snRNPs appear in the Cajal bodies, where
SnRNP
Protein-coding gene in the species Homo sapiens
mechanism that is incompletely understood, but involves its binding to importin-β. Within the nucleus, it can modulate nuclear hormone receptor activity
IGFBP3
Protein found in humans
"Ribosomal Protein L12 Uses a Distinct Nuclear Import Pathway Mediated by Importin 11". Mol. Cell. Biol. 22 (4): 1266–75. doi:10.1128/MCB.22.4.1266-1275.2002
60S_ribosomal_protein_L12
Protein-coding gene in the species Homo sapiens
RNA-recognition motifs (RRMs). The first two, RRM1 and RRM2, bind both α-importin and the poly(A) tail of processed mRNA. This feature prevents mRNA from
PABPC1
Type of DNA in bacterial genomes
into the nucleus via interactions with the host cell proteins such as importin a, bacterial VirE3, and dynein-like proteins. Several other bacterial virulence
Transfer_DNA
Protein-coding gene in the species Homo sapiens
translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly
EIF4ENIF1
Mammalian protein found in humans
identical protein binding enzyme binding ubiquitin protein ligase binding importin-alpha family protein binding disordered domain specific binding cis-regulatory
Retinoblastoma_protein
German cell biologist
(2010-03-01). "Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP" (PDF). Journal of Cell Science. 123 (Pt 5): 736–746. doi:10
Inke_Nathke
IMPORTIN
IMPORTIN
IMPORTIN
IMPORTIN
Girl/Female
Australian, Czech, Czechoslovakian, French, German, Hebrew, Indian, Slovenia, Swedish, Telugu
Female Version of John; The Lord is Gracious; God is Merciful
Female
Greek
Variant spelling of Greek Eileithyia, ILITHYIA means "relieve." In mythology, this is the name of a goddess of childbirth. Her Latin name is Lucina.
Female
Native American
Native American Choctaw unisex name SHIKOBA means "feather."
Girl/Female
Tamil
Beautiful & pleasant
Girl/Female
Muslim/Islamic
Light sunshine
Boy/Male
Hindu, Indian
A Gift of Badrinarayan
Boy/Male
American, Australian, Chinese, French, Hebrew, Polish, Spanish
God will Judge; God will Establish; Raised by God; Abbreviation of the Hebrew Name Jehoichin; Jehovah has Established
Boy/Male
Gujarati, Hindu, Indian
Lord Shiva
Girl/Female
Spanish
Spear.
Boy/Male
Hindu
Its part of Mahi milk prod
IMPORTIN
IMPORTIN
IMPORTIN
IMPORTIN
IMPORTIN
a.
Not importing; not bringing from foreign countries.
a.
Importing or implying mysticism; involving some secret meaning; allegorical; emblematical; as, a mystic dance; mystic Babylon.
n.
Want or failure of importation; a not importing of commodities.
n.
A right belonging to the crown of England, of taking two tuns of wine from every ship importing twenty tuns or more, -- one before and one behind the mast. By charter of Edward I. butlerage was substituted for this.
a.
Surpassing; extraordinary; distinguished (in a bad sense); -- formerly used with words importing a good quality, but now joined with words having a bad sense; as, an egregious rascal; an egregious ass; an egregious mistake.
v. t.
The act or practice of importing, or bringing into a country or state; -- opposed to exportation.
a.
Full of meaning.
p. pr. & vb. n.
of Import