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Search references for HIF1A. Phrases containing HIF1A
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Search references for HIF1A. Phrases containing HIF1A
See searches and references containing HIF1A!HIF1A
Protein-coding gene in the species Homo sapiens
that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF. HIF1A is a basic helix-loop-helix
HIF1A
Aggressive type of brain cancer
within the tumor and can lead to increased hypoxia. This will activate the HIF1A (hypoxia-inducible factor 1-alpha) which is a master regulator of tumor
Glioblastoma
Medical condition
the angiotensin converting enzyme (ACE) and hypoxia-inducible factor 1A (HIF1a) genes. Evidence for the heredity of cellulite is supported by studies showing
Cellulite
One of three major types of muscle
of the Six protein family. Moreover, the hypoxia-inducible factor 1-α (HIF1A) has been identified as a master regulator for the expression of genes involved
Skeletal_muscle
Mammalian protein found in humans
conditions, HIF1A is activated with little activation of HIF2A. However, in tumors the balance of HIF1A and HIF2A is tipped towards HIF2A. While HIF1A serves
Von Hippel–Lindau tumor suppressor
Von_Hippel–Lindau_tumor_suppressor
Protein-coding gene in humans
which HIF1A activates its expression during hypoxia. Increased expression of DDX3X by HIF1A in hypoxia is initiated by the direct binding of HIF1A to the
DDX3X
Directed movement of vesicles and substances within a cell
How microtubules play a role in intracellular transport * (HIF1A), * (Dynein), * (Importin), * (Cytoplasm), * (Nucleus), * (Septina)
Intracellular_transport
Protein that responds to low oxygen
process in which HIF1A is involved is skin healing. Researchers at the Stanford University School of Medicine demonstrated that HIF1A activation was able
Hypoxia-inducible_factor
Mammalian protein found in humans
E4F1, EFEMP2, EIF2AK2, ELL, EP300, ERCC6, GNL3, GPS2, GSK3B, HSP90AA1, HIF1A, HIPK1, HIPK2, HMGB1, HSPA9, Huntingtin, ING1, ING4, ING5, IκBα, KPNB1,
P53
American biochemist and cell biologist
J. (2008). UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1a turnover. Cell 134, 804-816 Verma, R., Oania, R., Fang, R., Smith, G.T.
Raymond_J._Deshaies
Mammalian protein found in humans
carcinoma cells with oxygen and nutrients by increasing the translation of HIF1A and supporting angiogenesis. mTOR also aids in another metabolic adaptation
MTOR
Increased blood pressure in lung arteries
pulmonary hypertension. Prolonged hypoxia also induces the transcription factor HIF1A, which directly activates downstream growth factor signaling that causes
Pulmonary_hypertension
Medical condition
metabolic dysfunction, alpha-ketoglutarate gets depleted which hampers HIF1a degradation and upregulates VEGF; this upregulation causes weak blood vessels
Glutaric_aciduria_type_1
ENSG00000169635 C2H2 ZF Known motif – High-throughput in vitro [348] BKGGCAY HIF1A ENSG00000100644 bHLH Known motif – In vivo/Misc source [349] VVNGCACGTMBNS
List of human transcription factors
List_of_human_transcription_factors
Cancer originating in or on the ovary
Dicer are associated with improved survival, whereas high levels of let-7b, HIF1A, EphA1, and poly(ADP-ribose) polymerase are associated with worse survival
Ovarian_cancer
Reactive oxygen species produced by mitochondria
induces stabilization of hypoxia-inducible factor-1α (HIF1A) and consequently promotes glycolysis. HIF1A-induced changes in monocyte metabolism by SARS-CoV-2
Mitochondrial_ROS
Enzyme that converts hypoxanthine to inosine monophosphate
on the mRNA and protein level is induced by hypoxia inducible factor 1 (HIF1A). HIF-1 is a transcription factor that directs an array of cellular responses
Hypoxanthine-guanine phosphoribosyltransferase
Hypoxanthine-guanine_phosphoribosyltransferase
Protein-coding gene in humans
for metastasis. STAT3 has been shown to interact with: AR EGFR ELP2 EP300 HIF1A JAK1 JUN KHDRBS1 KPNA4 mTOR MYOD1 NCOA1 NDUFA13 NFKB1 NR3C1 PML RAC1 RELA
STAT3
Class of enzymes important in regulating DNA transcription
/ mitochondria heart, skeletal muscle, pancreas, placenta PLAG1, PLAG2 HIF1A, BCL6, endothelin receptor, ACTN1, ACTN4, androgen receptor, Tip60 Maintenance
Histone_deacetylase
Protein structural motif
FIGLA; HAND1; HAND2; HES1; HES2; HES3; HES4; HES5; HES6; HES7; HEY1; HEY2; HIF1A; ID1; ID2; ID3; ID4; KIAA2018; LYL1; MASH1; MATH2; MAX; MESP1; MESP2; MIST1;
Basic_helix–loop–helix
Protein complex
synthesis. Under hypoxic conditions, hypoxia inducible factor one alpha (HIF1A) will stabilize and activate transcription of REDD1, also known as DDIT4
MTORC1
Quiescent stage of the cell cycle in which the cell does not divide
factors respond to the presence of reactive oxygen species (ROS) while HIF1A and LKB1 respond to hypoxic conditions. In hematopoietic stem cells, autophagy
G0_phase
Mammalian protein found in Homo sapiens
process. Nuclear receptor 4A1 has been shown to interact with: AKT1, Bcl-2, HIF1A, Nuclear receptor co-repressor 2, Promyelocytic leukemia protein, Retinoid
Nuclear_receptor_4A1
Boosting the number of red blood cells in the bloodstream
Kanayaa, K.; Kamitania, T. (2003). "pVHL-independent ubiquitination of HIF1a and its stabilization by cobalt ion". Biochemical and Biophysical Research
Blood_doping
Protein-coding gene in the species Homo sapiens
which has been shown to reduce cancer risk and increase DDIT4 expression. HIF1A Tuberous sclerosis protein MTOR 14-3-3 protein DDIT4L/ REDD2 GRCh38: Ensembl
DDIT4
Quintin J, Cramer RA, ... , Stunnenberg HG, Xavier RJ, Netea MG. mTOR/HIF1a-mediated aerobic glycolysis as metabolic basis for trained immunity. Science
Mihai_Netea
American medical doctor and hematologist
transcription factors that influence stem cell fate decisions (HOXB4, HOXA9, c-Myb, HIF1A) and has unraveled the pathobiology of several congenital disorders of thrombopoiesis
Kenneth_Kaushansky
Italian pathologist (born 1977)
the angiotensin converting enzyme (ACE) and hypoxia-inducible factor 1A (HIF1a) genes. Emanuele E, Politi P, Bianchi M, Minoretti P, Bertona M, Geroldi
Enzo_Emanuele
Protein found in humans
nuclear translocator has been shown to interact with: AIP, AHR, EPAS1, HIF1A, NCOA2, SIM1, and SIM2. GRCh38: Ensembl release 89: ENSG00000143437 – Ensembl
Aryl hydrocarbon receptor nuclear translocator
Aryl_hydrocarbon_receptor_nuclear_translocator
Affect on molecular properties due to spatial arrangement of electron orbitals
to the active site of pVHL. pVHL mediates the proteasomal degradation of HIF1A and with that the physiological response to hypoxia. Stereoelectronic effects
Stereoelectronic_effect
Cell type in the immune system
growth factors (GM-CSF, M-CSF, PDGFB, LIF) as well as angiogenic genes (HIF1A, VEGFB). This expression profile was first shown in RORyt+ CD8+T-cells,
Mucosal-associated invariant T cell
Mucosal-associated_invariant_T_cell
Class of neurotransmitters
catalase, nitric oxide synthase, mitogen-activated protein kinase, PPAR gamma, HIF1A, NRF2, ion channels, cystathionine beta synthase, and numerous other functionalities
Gasotransmitter
Protein-coding gene in the species Homo sapiens
been shown to interact with: NOTCH1 NCOR2, PCAF, SND1, SNW1, SOX18, and HIF1a. GRCh38: Ensembl release 89: ENSG00000168214 – Ensembl, May 2017 GRCm38:
RBPJ
Protein-coding gene in the species Homo sapiens
humans is encoded by the HIF1AN gene. FIH has been shown to interact with HIF1A and Von Hippel-Lindau tumor suppressor. Additionally, asparaginyl hydroxylation
HIF1AN
Protein-coding gene in the species Homo sapiens
regulating PDK2 activity. Additionally, inhibition of PDK2 subsequently inhibits HIF1A in cancer cells by both a prolyl-hydroxylase (PHD)-dependent mechanism and
PDK2
Protein-coding gene in humans
CCNG1, CTBP1, CTBP2, DAXX, DHFR, EP300, ERICH3, FKBP3, FOXO4, GNL3, HDAC1, HIF1A, HTATIP, IGF1R, MDM4, NUMB, P16, P53, P73, PCAF, PSMD10, PSME3, RPL5, RPL11
Mdm2
HGNC:4909; Q14526 7060 HIC2 HGNC:18595; Q96JB3 7061 HID1 HGNC:15736; Q8IV36 7062 HIF1A HGNC:4910; Q16665 7063 HIF1AN HGNC:17113; Q9NWT6 7064 HIF3A HGNC:15825;
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Metabolism of tumor cells
by activating transcription factors such as hypoxia-inducible factor 1 (HIF1A). The subsequent HIF1-dependent metabolic changes are a major determinant
Tumor_metabolome
Protein-coding gene in the species Homo sapiens
Wang K, Chen Y, Ferguson SD, Leach RE (Dec 2013). "MTA1 and MTA3 Regulate HIF1a Expression in Hypoxia-Treated Human Trophoblast Cell Line HTR8/Svneo". Medical
MTA3
Protein-coding gene in humans
activity through gene expression and regulation. For example, PPARGC1A and [HIF1A] regulated Drp1 activity through gene expression. Inhibition of Drp1 has
DNM1L
Human protein and coding gene
interact with: Aryl hydrocarbon receptor CLOCK CREBBP CRY1 EP300 EPAS1 HIF1A NPAS2 SUMO3 BNIP3 TRIM28 Arntl2 - Arntl2 (Bmal2) is a paralog of Arntl (Bmal1)
Basic helix-loop-helix ARNT-like protein 1
Basic_helix-loop-helix_ARNT-like_protein_1
Protein-coding gene in the species Homo sapiens
IL6 signaling. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation
EP300
Biological term
upregulates HIF1A, which shifts energy production to glycolysis, allowing for the cell to survive in oxygen-poor surroundings. Indeed, deletion of HIF1A increases
Hematopoietic_stem_cell_niche
Autophagic process in which mitochondria are delivered to the vacuole and degraded
tumor microenvironment, hypoxia-inducible transcription factor 1-alpha (HIF1A) increases, which promotes expression of BNIP3, an essential factor for
Mitophagy
Protein-coding gene in the species Homo sapiens
acid residues in various proteins, by stabilizing the transcription factor HIF1A, by stimulating the production of reactive oxygen species, or by altering
SUCNR1
Hypothetical non-therapeutic use of gene therapy by athletes
markers ACE Alu I/D (rs4646994) (called ACE D) ACTN3 Arg577 AMPD1 Gln12 HIF1A 582Ser MTHFR rs1801131 C NOS3 rs2070744 T PPARG 12Ala The six GWAS markers
Gene_doping
its 3' UTR was shown to regulate and be regulated by 3' UTRs of CCND1, HIF1A and NCOA3. MYCN amplification in neuroblastoma has been shown to deplete
Competing_endogenous_RNA
Protein-coding gene in the species Homo sapiens
binds and targets several known factors, including HIF1a and HIF2a for ubiquitination. Mechanism of HIF1a activation by hypoxia and role of pVHL in this pathway
JADE1
Situation where tumor cells have been deprived of oxygen
cell survival, proliferation, angiogenesis and anti-apoptosis. Significant HIF1A expression has been noted in most solid tumors studied, which include cancers
Tumor_hypoxia
Mammalian protein found in humans
been shown to interact with: BIRC2, BSG, CDC2, CFAP298, E2F1, EGFR, HDAC3, HIF1A, IRAK1, KIAA0753. MARK4, MDM2, NDUFA3, NFE2L2, NOTCH1, NUAK1, OPRK1, P53
Ubiquitin_C
Protein found in humans
growth by its inhibitory role on NOD1. PSMA7 has been shown to interact with HIF1A and PLK1. GRCh38: Ensembl release 89: ENSG00000101182 – Ensembl, May 2017
PSMA7
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HIF1A
HIF1A
HIF1A
HIF1A
HIF1A
HIF1A
HIF1A
HIF1A
HIF1A
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