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Mammalian protein found in Homo sapiens
ICAM-1 (intercellular adhesion molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene
ICAM-1
Integrin found on lymphocytes
and monocytes. As of 2007, LFA-1 has 6 known ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A. LFA-1/ICAM-1 interactions have recently been
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Protein domain
events. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1
Intercellular adhesion molecule
Intercellular_adhesion_molecule
Protein found in humans
It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1. Addressin is a lesser-used term to describe the group of adhesion
Addressin
in cellular adhesion, binding to the intercellular adhesion molecule-1 (ICAM-1). CR3 causes phagocytosis and destruction of cells opsonized with iC3b
Macrophage-1_antigen
Inflammatory bowel disease that causes ulcers in the colon
specifically to the human ICAM-1 messenger RNA through Watson-Crick base pair interactions in order to subdue expression of ICAM-1. ICAM-1 propagates an inflammatory
Ulcerative_colitis
Homeopathic cold remedy
The Zicam name is derived from a portmanteau of the words "zinc" and "ICAM-1" (the receptor to which a rhinovirus binds in order to infect cells). It
Zicam
American immunologist
adhesion pairs in all of cell biology, including CD2–LFA-3 and LFA-1–ICAM. The LFA-1–ICAM interaction required Mg2+, and explained the Mg2+-dependence of
Timothy_A._Springer
Movement of white blood cells out of blood vessels and towards the inflamed site
LFA-1 is found on circulating leukocytes, and binds ICAM-1 and ICAM-2 on endothelial cells Mac-1 is found on circulating leukocytes, and binds ICAM-1 on
Leukocyte_extravasation
Medical condition
specifically to the human ICAM-1 messenger RNA through Watson-Crick base pair interactions in order to subdue expression of ICAM-1. ICAM-1 propagates an inflammatory
Inflammatory_bowel_disease
Production of sperm
adhesion molecules ICAM-1 and soluble ICAM-1 have antagonistic effects on the tight junctions forming the blood-testis barrier. ICAM-2 molecules regulate
Spermatogenesis
Physical effects resulting from activation of the immune system
Cytokines also induce the expression of integrin ligands such as ICAM-1 and VCAM-1 on endothelial cells, which mediate the adhesion and further slow
Inflammation
Protein family
with ICAM-1 is achieved through the DBLβ domain adjacent to the head structure. However, many PfEMP1s having DBLβ domain do not bind to ICAM-1, and it
Plasmodium falciparum erythrocyte membrane protein 1
Plasmodium_falciparum_erythrocyte_membrane_protein_1
pharmaceutical substances (INN): recommended INN: list 57". WHO Drug Information. 21 (1). 2007. hdl:10665/74004. "International nonproprietary names for pharmaceutical
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Protein-coding gene in the species Homo sapiens
by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like
ICAM2
Genus of viruses (Enterovirus)
tract (mouth and nose). Rhinovirus A and B use "major" ICAM-1 (Inter-Cellular Adhesion Molecule 1), also known as CD54 (Cluster of Differentiation 54),
Rhinovirus
Chemical compound
cell intercellular adhesion molecule-1 (ICAM-1) proteins through intracellular upregulation of NF-κB. Surface ICAM-1 in turn promotes neutrophil adhesion
Ceruletide
Type of virus
1007/s00262-022-03314-1. ISSN 1432-0851. PMC 10198910. PMID 36445410. Pandha, Hardev S. (31 March 2023). "Data from Phase I Trial of an ICAM-1-Targeted
Oncolytic_virus
Pharmaceutical drug
protein (CRP) levels, interleukin (IL)-6, intercellular adhesion molecules (ICAM)-1, matrix metalloproteinase (MMP)-3, and vascular endothelial growth factor
Golimumab
Mammalian protein found in Homo sapiens
intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory
Integrin_alpha_L
isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular
Soluble cell adhesion molecules
Soluble_cell_adhesion_molecules
Protein which in humans is encoded by the SDC1 gene
encode the same protein. Syndecan-1 deficient mice show increased inflammation, which was attributed to an increased ICAM-1 and heparan sulfate-dependent
Syndecan_1
Disease characterized by constriction of brain arteries
studies have confirmed the correlation of moyamoya and adhesion molecule 1 (ICAM-1) being increased as compared to normal vascular function counterparts
Moyamoya_disease
Type of white blood cells
bone marrow by lining vessel walls with adhesion molecules such as VCAM-1 and ICAM-1. When eosinophils are activated, they undergo cytolysis, where the breaking
Eosinophil
Chemical compound
lymphocyte function-associated antigen 1 (LFA-1), from binding to intercellular adhesion molecule 1 (ICAM-1). This mechanism down-regulates inflammation
Lifitegrast
Mammalian protein found in humans
integrin, LFA-1 (Lymphocyte function-associated antigen 1), which takes part in high affinity bonding with ICAM-1(Intercellular Adhesion Molecule 1) receptors
Interleukin_8
Deformation of the eye's cornea into a conelike shape
overexpression of proinflammatory cytokines, such as IL-6, TNF-alpha, ICAM-1, and VCAM-1 in the tear fluid. A genetic predisposition to keratoconus has been
Keratoconus
Transmembrane receptors involved in cellular adhesion and signalling
formed by differential RNA splicing; for example, four variants of the beta-1 subunit exist. Through different combinations of the α and β subunits, 24
Integrin
Inflammation of the sinus' membranes
formulation of 0.73 mg of Tremacamra (a soluble intercellular adhesion molecule 1 [ICAM-1] receptor) reduced the severity of illness. A 2018 review has found that
Sinusitis
Mammalian protein found in Homo sapiens
110–160 kDa protein that belongs to the intercellular adhesion molecule (ICAM) family. Like the other proteins in this family, ICAM3 is a type I transmembrane
ICAM3
Layer of cells that line the inner surface of blood vessels
characterized by the expression of molecules such as E-selectin, VCAM-1 and ICAM-1, which stimulate the adhesion of immune cells. Additionally, transcription
Endothelium
Protein-coding gene in the species Homo sapiens
by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like
ICAM5
Mammalian protein found in Homo sapiens
lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)". The Journal of Biological Chemistry
Integrin_beta_2
Enterovirus
in cellular receptor specificity from intercellular adhesion molecule-1 (ICAM-1) (used by C-cluster Coxsackie A viruses) to CD155, leading to a change
Poliovirus
Common viral infection of the upper respiratory tract
rhinovirus is typically acquired by direct contact; it binds to humans via ICAM-1 receptors and the CDHR3 receptor through unknown mechanisms to trigger the
Common_cold
Protein-coding gene in the species Homo sapiens
Furthmayr H, Sanchez-Madrid F (Jun 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent
VCAM-1
Medical imaging technique
certain receptors, functioning as cell adhesion molecules, like VCAM-1, ICAM-1, E-selectin. If microbubbles are targeted with ligands that bind these
Contrast-enhanced_ultrasound
Macrophages located in the liver
activate and release both IL-1 and TNF-alpha. In turn, this activates leukocytes and sinusoidal endothelial cells to express ICAM-1. This results in tissue
Kupffer_cell
Biotechnology company
28 nm in diameter. The virus is known to utilise the viral entry receptor ICAM-1 as its primary entry receptor, with DAF as a co-receptor to infect host
Viralytics
Illness from ingesting arsenic
factors (NF-κB and AP-1), pro-inflammatory cytokines (IL-1, −6, −8, −12, and TNF-α), cell4 adhesion molecules (ICAM-1 and VCAM-1), inducible nitric oxide
Arsenic_poisoning
Multipotent adult stem cells present in multiple tissues
memory CD8 T cell survival. MSC expresses the adhesion molecules VCAM-1 and ICAM-1, which allow T-lymphocytes to adhere to their surface. Then MSC can affect
Mesenchymal_stem_cell
Interface between lymphocyte and target cell
interaction occurs between LFA-1 present in the p-SMAC of a T-cell, and non-specific adhesion molecules (such as ICAM-1 or ICAM-2) on a target cell. When bound
Immunological_synapse
Family of proteins
expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response
Poly_(ADP-ribose)_polymerase
South African immunologist, physician, public health advocate and academic
Provided the first evidence that isoforms of the adhesion/ signaling molecule (ICAM-1) circulate in plasma and the circulating levels of isoform patterns might
Malegapuru_Makgoba
dose-escalation and dose-expansion phase 1 study". The Lancet Oncology. 16 (8): 949–956. doi:10.1016/S1470-2045(15)00132-1. PMID 26179200. "Highlights of prescribing
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Prostate cancer vaccine
costimulatory molecules collectively designated as TRICOM (LFA-3, ICAM-1, and B7.1) to stimulate an immune response. Treatment is initiated by subcutaneous
Prostvac
Protein-coding gene in the species Homo sapiens
exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII
Macrophage_mannose_receptor_1
Medical condition
(November 1991). "CD43, a molecule defective in Wiskott–Aldrich syndrome, binds ICAM-1". Nature. 354 (6350): 233–5. Bibcode:1991Natur.354..233R. doi:10.1038/354233a0
Wiskott–Aldrich_syndrome
White blood cell with immune function
In melanoma and gastric cancer cells, intercellular adhesion molecule 1 (ICAM-1) antibody can significantly inhibit in vitro LAK-induced lysis of cancer
Lymphokine-activated killer cell
Lymphokine-activated_killer_cell
Human chronic inflammatory disease
Upregulation of intercellular adhesion molecule-1 (ICAM-1) and cytokines associated with T-helper 1 immune response, may also play an important role
Lichen_planus
French graduate engineering school
curricula lead to the following French & European degrees : Ingénieur ICAM (ICAM Graduate engineer Masters level program) Master of Science & PhD doctorate
Institut catholique d'arts et métiers
Institut_catholique_d'arts_et_métiers
Chemical compound
therapeutic that targets the messenger RNA for the production of human ICAM-1 receptor and is being developed for the treatment of acute disease flares
Alicaforsen
Russian therapeutic cancer treatment
species Coxsackievirus A and utilizes intercellular adhesion molecule 1 (ICAM-1) and decay-accelerating factor (DAF/CD55) as cellular receptors. These
EnteroMix
Immune cells found in lymph nodes
memory B cells. Adhesion between FDCs and B cells is mediated by ICAM-1 (CD54)–LFA-1 (CD11a) and VCAM–VLA-4 molecules. Activated B-cells with low affinity
Follicular_dendritic_cells
Large protein superfamily of cell surface and soluble proteins
PMID 14690046. B. D. Gomperts; Ijsbrand M. Kramer; Peter E. R. Tatham (1 July 2009). Signal transduction. Academic Press. pp. 378–. ISBN 978-0-12-369441-6
Immunoglobulin_superfamily
Venules in some lymphatic organs
endothelial cells express the adhesion molecules GlyCAM-1 (in mucosal HEV this is MAdCAM-1), ICAM-1 and CD34. They also secrete the chemokine CCL21. Naïve
High_endothelial_venules
American chemical engineer
treat due to the lack biomarkers. In 2014, Auguste and her lab found that ICAM-1 represents a marker for triple negative breast cancer as well as a potential
Debra_Auguste
Albumin found in human blood
(October 2009). "Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes
Human_serum_albumin
Protein-coding gene in the species Homo sapiens
Endothelial cells from mice tumours over-expressing Egfl7 express much less ICAM-1, VCAM-1 and E-selectin than control tumours. Consequently, tumours over-expressing
EGFL7
Species of virus
their CD18-containing cell surface integrins and the endothelial-expressed ICAM-1. Microfusions between the cells then take place in a manner dependent on
Human_cytomegalovirus
Component of blood aiding in coagulation
upregulates expression of adhesion molecules (such as E-selectin, ICAM-1, and VCAM-1) in neutrophils. CD40L also activates macrophages and activates cytotoxic
Platelet
Transplantation of cells or tissue across species
as E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1). This response is further perpetuated as normally
Xenotransplantation
Protein found in humans
inflammatory cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally
PSMB8
Protein-coding gene in the species Homo sapiens
1074/jbc.273.49.32535. PMID 9829988. Ramos TN, Bullard DC, Barnum SR (2014). "ICAM-1: isoforms and phenotypes". J. Immunol. 192 (10): 4469–74. doi:10.4049/jimmunol
Oxoeicosanoid_receptor_1
Irish biochemist and lecturer
between 2005 and 2007. She then joined the lab Moonsoo Jin, developing ICAM-1 of rhinovirus therapeutics. Owens won a Marie Curie Reintegration Grant
Róisín_Owens
Type of immune cell
cells shear flow via the LFA-1 integrin ligand ICAM-1 and adhere or migrate down the flow via the VLA-4 integrin ligand VCAM-1. While CXCR5/CXCL13 signaling
Marginal-zone_B_cell
reorientation of the cytoskeleton, which is triggered by engagement of ICAM-1 on the infected cell's surface and expression of several viral proteins
Viral_synapse
Defense mechanism of tumors against immunity
molecules, such as intercellular adhesion molecule-1 (ICAM-1, CD54), vascular cell adhesion molecule-1 (VCAM-1, CD106) and E-selectin (CD62E), as a result from
Endothelial_cell_anergy
Protein found in humans
recently been renamed ICAM-4 due to its similarity to intercellular adhesion molecule, although exactly which integrins bind to ICAM-4 is subject to controversy
ICAM4
Chemical compound
be less effective, cyt A inhibits the expression of ICAM-1. This occurs when the TNF receptor 1 is shredded through the activation of extracellular signal-regulated
Cytotrienin_A
Immunologist
a-actinin for clustered intermediate affinity LFA-1 . The lab showed that the LFA-1 ligand ICAM-1 was a target for pathogen binding, for example the
Nancy_Hogg
Class of enzymes
augments expression of adherence-linked host endothelial receptors ICAm-1 and VCAm-1. Acanthamoeba polyphaga mimivirus is the largest known DNA virus.
Tyrosine–tRNA_ligase
Austrian-born American physician/scientist, editor and essayist
regulates leukocyte adhesion to endothelial cells and expression of ELAM-1 and ICAM-1. Proceedings of the National Academy of Sciences – U.S.A., 89:9991-9995
Gerald_Weissmann
Class of fatty acids
endothelial cells from expressing cell adhesion molecules such as VCAM-1, ICAM-1, and E-selectin thereby limiting circulating leukocytes from adhering
Epoxyeicosatrienoic_acid
Cell adhesion molecules in the immunoglobulin superfamily
Molecules ICAM-1 Intercellular Cell Adhesion Molecule VCAM-1 Vascular Cell Adhesion Molecule PECAM-1 Platelet-endothelial Cell Adhesion Molecule MAdCAM-1 Mucosal
IgSF_CAM
Function modeling methodology for describing manufacturing functions
IDEF0 (ICAM Definition for Function Modeling; where ICAM is Integrated Computer-Aided Manufacturing) is a function modeling methodology for describing
IDEF0
Protein-coding gene in the species Homo sapiens
vascular conditions. ICAM-1 binding is commonly mediated by DBLβ domains, while EPCR binding is primarily mediated by CIDRα1 domains. ICAM-1 serves as a receptor
Endothelial protein C receptor
Endothelial_protein_C_receptor
Type of molecules within cells
in myeloid cells (IL-1, TNF-a, IL-6, IL-8), and it can lead to increased expression of cell adhesion molecules (ICAM-1, VCAM-1) on endothelial cells
Damage-associated molecular pattern
Damage-associated_molecular_pattern
Separation technique to characterize the size of colloidal particles
subpopulations were also used in quartz crystal microbalance studies of antibody and ICAM-1 binding. AF4 can be applied in aqueous and organic solvents, therefore also
Field_flow_fractionation
Medical condition
another possibility is that especially strong intercellular fixation protein ICAM-1 contributes to inflammation with its strong effect of attracting white blood
Folliculitis_decalvans
Mammalian protein found in humans
(1992). "CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1". Nature. 354 (6350): 233–5. Bibcode:1991Natur.354..233R. doi:10.1038/354233a0
CD43
Protein of the mucin family
extracellular components. The intercellular interaction between MUC-1 and the receptor ICAM-1 facilitates endothelial and epithelial cell interactions, allowing
Mucin-1
Disease complication
found in serum of women with endometriosis. These molecules include VCAM-1, ICAM-1, metalloproteinases, MMP-2, MMP-3, MMP-7, and MMP-9. Advanced stages of
Endometriosis_and_infertility
Type of chemical bond
intercellular adhesion molecule 1 (ICAM-1), integrin alpha 4 beta 1 with vascular adhesion molecule 1, integrin alpha M beta 2 with ICAM-1, integrin alpha V beta
Catch_bond
Protein-coding gene in the species Homo sapiens
expression of proinflammatory cytokines, adhesion molecules (such as VCAM-1 and ICAM-1), and other mediators of inflammation. Upon binding ligands like EN-RAGE
RAGE_(receptor)
Fat-laden M2 macrophages seen in atherosclerosis
and E-selectin, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). METTL3 is a gene responsible for mediating N6-methyladenosine
Foam_cell
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
inflammatory cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally
Proteasome
Genetic engineering to produce pharmaceuticals
antibodies against Streptococcus mutans, antibodies against doxorubicin, and ICAM 1 receptor in tobacco PlantForm Corporation – biosimilar trastuzumab in tobacco
Pharming_(genetics)
Protein-coding gene in the species Homo sapiens
1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J.
Ezrin
of attached anti-ICAM-1 beads on TNF-α-treated MAECs isolated from SGEF−/− animals. The arrow indicates the location on an attaching anti-ICAM-1 bead.
Nucleotide_exchange_factor
The International Centre for Advanced Materials (ICAM) is a research partnership made up of the energy company BP and four universities: the University
International Centre for Advanced Materials
International_Centre_for_Advanced_Materials
Protein-coding gene in the species Homo sapiens
Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells". Int. Arch
IFNA7
Field of study
"Syndrome differentiation in traditional Chinese medicine and E-cadherin/ICAM-1 gene protein expression in gastric carcinoma". World Journal of Gastroenterology
Public_health_genomics
DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter". Nucleic Acids Research. 42 (3): 1563–74. doi:10.1093/nar/gkt1019
Epigenome_editing
Mammalian protein found in Homo sapiens
expression of the pro-inflammatory intracellular adhesion molecules, ICAM-1 and VCAM-1 by a TP receptor-dependent mechanism. These findings suggest that
Thromboxane_receptor
1, 1999, 163 (1) 212–216; Horley, K., Carpenito, C., Baker, B. and Takei, F., 1989. Molecular cloning of murine intercellular adhesion molecule (ICAM-1)
Fumio_Takei
generally have high density of CD43 and CD44 and adhesion receptors (ICAM-1, ICAM-3, B1 integrins, and ERM adaptor proteins). These receptors mediate cell-matrix
Uropod_(immunology)
Protein-coding gene in the species Homo sapiens
inflammatory cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally
Proteasome (prosome, macropain) subunit, alpha 1
Proteasome_(prosome,_macropain)_subunit,_alpha_1
Country in Central Africa
National Climatic Data Center, 9 August 2004. Retrieved 6 April 2007. Neba 16. "ICAM of Kribi Campo" (PDF). UNIDO. Archived from the original (PDF) on 6 May 2013
Cameroon
endothelial cells by regulating the expression of cell adhesion molecules ICAM-1. This makes it likely that it is involved in the budding of haemogenic endothelial
Aorta-gonad-mesonephros
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ICAM 1
ICAM 1
ICAM 1
ICAM 1
ICAM 1
ICAM 1
ICAM 1
ICAM 1
ICAM 1
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