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Type of molecules within cells
Damage-associated molecular patterns (DAMPs) are molecules within cells that are a component of the innate immune response released from damaged or dying
Damage-associated molecular pattern
Damage-associated_molecular_pattern
Pattern of the immune system
Pathogen-associated molecular patterns (PAMPs) are small molecular motifs conserved within a class of microbes, but not present in the host. They are
Pathogen-associated molecular pattern
Pathogen-associated_molecular_pattern
Proposed model of immune system
signalling proteins to stimulate an immune response, the damage-associated molecular pattern (DAMP) model theorizes that the immune system responds to
Danger_model
South Korean biologist (born c. 1965)
innate immune system response and his development of the damage-associated molecular pattern (DAMP) model of immune response initiation in collaboration
Seung-Yong_Seong
Topics referred to by the same term
Management Program, a software for managing disk storage array Damage-associated molecular pattern, a part of the immune system Damp (structural), the presence
Damp
Family of proteins
be sensed by the immune system as damage-associated molecular patterns (DAMPs). They are able to interact with pattern recognition receptors like TLR2 or
Heat_shock_protein
French-born American immunologist
hydrophobic regions on biological compounds as among the damage-associated molecular patterns (DAMPs) of the danger model. Facing stressors, cells misfold
Polly_Matzinger
Family of cell surface receptors
molecules: pathogen-associated molecular patterns (PAMPs), which are associated with microbial pathogens, and damage-associated molecular patterns (DAMPs), which
Pattern_recognition_receptor
Type of programmed cell death
membrane rupture and release of cytokines, as well as various damage-associated molecular pattern (DAMP) molecules such as HMGB-1, ATP and DNA, out of the
Pyroptosis
Chemical compound
forms by binding to pattern recognition receptors (PRRs) and damage associated molecular patterns damage-associated molecular patterns (DAMPS) that activate
Dapansutrile
wounding events with damage-associated Molecular Patterns (DAMPs). Additionally, plants rely on microbe-associated molecular patterns (MAMPs) to defend themselves
Wound_response_in_plants
Human protein and coding gene
as a pattern recognition receptor (PRR) – a cytosolic sensor that responds to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular
NLRP3
Molecular markers associated with apoptosis
Pathogen-associated molecular patterns (PAMPs) are markers of invading pathogens and Damage-associated molecular patterns (DAMPs) are markers of damaged tissue)
ACAMPs
Theory of ageing
Cellular NAD+ levels have been shown to decrease with age. Damage-associated molecular patterns (DAMPs) are molecules that are released during cell stress
Mitochondrial theory of ageing
Mitochondrial_theory_of_ageing
Organelle in eukaryotic cells responsible for respiration
they are a source of various damage-associated molecular patterns (DAMPs). These DAMPs are often recognised by the same pattern-recognition receptors (PRRs)
Mitochondria
Inflammatory cell death pathway
infections, as well as pathogen-associated molecular patterns, damage-associated molecular patterns, and cytokines that are released during infections,
PANoptosis
Family of vertebrate proteins involved in cell division and inflammation
example, S100A1, S100A2, S100A3. They are also considered as damage-associated molecular pattern molecules (DAMPs), and knockdown of aryl hydrocarbon receptor
S100_protein
Class of proteins
of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that
NOD-like_receptor
Protein family
infection by recognizing Pathogen Associated Molecular Patterns (PAMP) and endogenous Damage Associated Molecular Patterns (DAMP). PEPR 1 considered as the
Leucine-rich repeat receptor like protein kinase
Leucine-rich_repeat_receptor_like_protein_kinase
Ability of the immune system to quickly and specifically recognize an antigen
pathogen, respectively with pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs). Innate immune memory (also
Immunological_memory
Necrotic cell death regulated by intracellular signaling, exerted by activated MLKL
other cells. Labelled as damage-associated molecular patterns (DAMPs), these molecules serve as sentinels of tissue damage, incurring corresponding responses
Necroptosis
Bulge in the plasma membrane of a cell
produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs". Cell Death and
Bleb_(cell_biology)
Life-threatening response to infection
cells not only recognise pathogen-associated molecular patterns but also damage-associated molecular patterns from damaged tissues. An uncontrolled immune
Sepsis
Interactions in the immune system
neuroimmune system is involved in reflexes associated with parasitic invasions of hosts. Nociceptors are also associated with the body's reflexes to pathogens
Neuroimmune_system
Nasal inflammation due to allergens in the air
epithelial barrier may also release alarmins (a type of damage associated molecular pattern (DAMP) molecule) such as thymic stromal lymphopoietin, IL-25
Allergic_rhinitis
Cell surface receptor found in humans
TLR4 can also be activated by endogenous compounds called damage-associated molecular patterns (DAMPs), including high mobility group box protein 1 (HMGB1)
Toll-like_receptor_4
Protein-coding gene in the species Homo sapiens
intracellular proteins, such as lactate dehydrogenase and various Damage Associated Molecular Patterns (DAMPs) into the extracellular environment, triggering inflammation
NINJ1
Absence of disease-causing microorganisms
in aging-related pathologies". Ageing Research Reviews. Damage-associated molecular patterns and their pathological relevance in ageing. 24 (Pt A): 29–39
Asepsis
Protein
immune modulator and endogenous opponent of proinflammatory damage associated molecular pattern molecules. It is speculated this interaction may be through
CXCR4
Central nervous system stimulant
A, Polo SE (June 2016). "Epigenome Maintenance in Response to DNA Damage". Molecular Cell. 62 (5): 712–727. doi:10.1016/j.molcel.2016.04.006. PMC 5476208
Methamphetamine
Disease caused by accumulation of crystals
These distressed cells then excrete alarmins, proteases, and damage-associated molecular patterns including HMGB1, histones, mitochondrial DNA, demethylated
Crystallopathy
Raised body temperature caused by disease
pyrogens, they can also be induced by internal factors like damage associated molecular patterns such as cases like rheumatoid arthritis or lupus. Major endogenous
Fever
Purinergic receptor
inflammatory responses in green plants, with ATP acting as a damage-associated molecular pattern molecule. In response to cell lysis, ATP is discharged and
DORN1
Cytosolic multiprotein complex that mediates the activation of Caspase 1
cytosolic pattern recognition receptors (PRRs), which are molecular sensors of microbe-derived pathogen-associated molecular patterns (PAMPs), damage-associated
Inflammasome
Genes in plant genomes
may detect a Pathogen-Associated Molecular Pattern or PAMP (alternatively called MAMP for microbe-associated molecular pattern). The R protein encodes
R_gene
Carbohydrate-binding protein
Lectin receptor kinases (LecRKs) are believed to recognize damage associated molecular patterns (DAMPs), which are created or released from herbivore attack
Lectin
Sensory receptor that detects chemicals
binding receptor domains capture pathogen-associated molecular patterns (PAMPS) and damage-associated molecular patterns (DAMPS) which consequently initiates
Chemoreceptor
Part of the innate immune system
Like other PRRs they bind pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) of oligosaccharide origin. Binding
Collectin
Biological system protecting an organism against disease
molecules: pathogen-associated molecular patterns (PAMPs), which are associated with microbial pathogens, and damage-associated molecular patterns (DAMPs), which
Immune_system
Species of fungus
allow the pathogen to evade defense responses triggered by damage-associated molecular patterns from cell wall degradation. Several regions within the genome
Synchytrium_endobioticum
Type of white blood cell
mediators: interferon-γ (IFN-γ), tumor necrosis factor (TNF), and damage associated molecular patterns (DAMPs). These mediator molecules create a pro-inflammatory
Macrophage
Family of heat shock proteins
HSPA13, HSPA14 whereas HSPA9 in mitochondria. HSP70 acts as a damage-associated molecular pattern (DAMP) and activates innate immune response, which is involved
Hsp70
Physical effects resulting from activation of the immune system
molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). PAMPs are compounds that are associated with various pathogens, but which
Inflammation
Medical condition
organ systems. The ischemia-reperfusion injury promotes damage-associated molecular patterns (DAMPs) which encourage pro-inflammatory cytokine circulation
Post-cardiac_arrest_syndrome
Vesicle formed around a particle engulfed by a phagocyte via phagocytosis
Inflammation is only triggered by certain pathogen- or damage-associated molecular patterns (PAMPs or DAMPs), the removal of senescent cells is non-inflammatory
Phagosome
Any type of cell death eliciting an immune response
antitumor therapy. ICD is characterized by secretion of damage-associated molecular patterns (DAMPs).There are three most important DAMPs which are exposed
Immunogenic_cell_death
Dissolution of the chromatin in a dying cell
into the surrounding environment. These contents act as damage-associated molecular patterns (DAMPs) that serve as “danger signals” and stimulate inflammation
Karyolysis
Tissue
molecular patterns) or by signals connected to tissue damage named DAMP (damage associated molecular patterns). Majority of antigen presenting cells (APCs) in
Gut-associated lymphoid tissue
Gut-associated_lymphoid_tissue
Group of cytokine proteins
acts as a damage-associated molecular pattern (DAMP) molecule. DAMPs, also known as alarmins, are recognized by innate immunity cells by pattern recognition
Interleukin-1_family
Therapy using ionizing radiation, usually to treat cancer
(November 2017). "Out of the frying pan and into the fire: damage-associated molecular patterns and cardiovascular toxicity following cancer therapy". Therapeutic
Radiation_therapy
Cell found in connective tissue
physical injury through pattern recognition receptors for damage-associated molecular patterns (DAMPs), microbial pathogens through pattern recognition receptors
Mast_cell
Protein found in humans
inflammatory ligands called pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) in the cytosol by NOD-like receptors
GSDMD
duplicated. This led to the discovery of the first damage associated molecular pattern or DAMP/pattern recognition receptor couple in Arabidopsis, otherwise
PEPR1_and_PEPR2
Molecule which triggers an immune response when attached to a carrier
by complex mechanisms involving inflammatory cytokines, damage-associated molecular patterns (DAMP), or the inflammasome. Once the body has generated
Hapten
Class of chemical compounds
cause damage-associated molecular patterns (DAMPs) involving plant-derived substances and breakdown products. Herbivore-associated molecular patterns (HAMPs)
Green_leaf_volatiles
Class of enzymes
F, Lorenzo GD (13 Mar 2013). "Oligogalacturonides: plant damage-associated molecular patterns and regulators of growth and development". Frontiers in Plant
Polygalacturonase
Type of cytotoxic lymphocyte
cells. They recognize PAMPs (pathogen-associated molecular patterns) and DAMPs (damage-associated molecular patterns) as their ligands. These receptors are
Natural_killer_cell
Mammalian protein found in Homo sapiens
characteristic of Alzheimer disease, are damage-associated molecular patterns (DAMPs) that are recognized by pattern recognition receptors (PRRs) and lead
Interleukin_1_beta
Component of blood aiding in coagulation
Monocytes respond to bacterial pathogen-associated molecular patterns (PAMPs), or damage-associated molecular patterns (DAMPs) by activating the extrinsic
Platelet
Spanish academic
endopolygalacturonase (ThPG1) produced by T. harzianum releases damage-associated molecular pattern (DAMP) signals, which can act as initiators to strengthen
Enrique_Monte
Process of formation of blood clots
Mediators of this process include damage-associated molecular patterns and pathogen-associated molecular patterns, which are recognized by toll-like
Coagulation
Chronic low-grade inflammation that develops with advanced age
inflammasome assembly include pathogen-associated molecular patterns (PAMPS), damage associated molecular patterns (DAMPS), nutrients, and the microbiota
Inflammaging
American neurosurgeon and inventor
on 21 July 2018. Jong, Roh; Dong, Sohn (13 August 2018). "Damage-Associated Molecular Patterns in Inflammatory Diseases". Immune Network. 18 (4): e27. doi:10
Kevin_J._Tracey
Autophagic process in which mitochondria are delivered to the vacuole and degraded
role in the immune system. Mitochondrial damage-associated molecular patterns (DAMPs) such as parts of damaged organelles or mtDNA are secreted by cells
Mitophagy
American oncologist
efficient removal of damaged mitochondria is important for limiting inflammation mediated by damage associated molecular pattern receptors. In another
Roberta_Gottlieb
Disease involving heart or blood vessels
(November 2017). "Out of the frying pan and into the fire: damage-associated molecular patterns and cardiovascular toxicity following cancer therapy". Therapeutic
Cardiovascular_disease
Protein found in humans
Pathogen-associated molecular pattern (PAMPs), or which are produced/released during cellular damage – damage-associated molecular patterns (DAMPs). TLRs are
MYD88
Medical condition
Mitochondrial dysfunction also triggers inflammation by activating damage-associated molecular patterns (DAMPs), inflammatory cells, and intracellular protein complexes
Pathophysiology of Parkinson's disease
Pathophysiology_of_Parkinson's_disease
Class of immune system proteins
pathogen-associated molecular patterns (PAMPs). In addition to the recognition of exogenous PAMPs, TLRs can also bind to endogenous damage-associated molecular
Toll-like_receptor
swarming include PAMPs or Pathogen Associated Molecular Patterns and DAMPs or Damage-Associated Molecular Patterns. One attribute of note in neutrophil
Neutrophil_swarming
Chemical processes that make use of arsenic
been shown to provoke immune activation through release of damage-associated molecular patterns (DAMPs). In combination with all-trans retinoic acid, it
Arsenic_biochemistry
DNA sampled from the environment rather than directly from an individual organism
ecological interactions and to be mechanistically mediated by damage-associated molecular patterns (DAMPs) and to have potential for the development of biocidal
Environmental_DNA
Protein domain
cytosolic pattern recognition receptors (PRRs) that sense damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs)
Pyrin_domain
Protein-coding gene in the species Homo sapiens
and fungal infections, as well as pathogen-associated molecular patterns, damage-associated molecular patterns, cytokines, and homeostatic changes during
ZBP1
renders thymic stromal cells sensitive to damage induced by inflammation and damage-associated molecular patterns (DAMPs), such as reactive oxygen species
Thymus_stromal_cells
Protein family
molecules, certain LILRs bind to viral proteins, self-lipids, or damage-associated molecular patterns (DAMPs), implying a broader role in sensing both self and
Leukocyte immunoglobulin-like receptors
Leukocyte_immunoglobulin-like_receptors
Medical condition affting the eyes
damage in the retina. [citation needed] The innate immune response in AIR is often triggered when immune cells recognize damage-associated molecular patterns
Autoimmune_retinopathy
Group of autoantibodies
autoimmune disorders, but are particularly associated with systemic vasculitis, so called ANCA-associated vasculitides (AAV). Immunofluorescence (IF)
Anti-neutrophil cytoplasmic antibody
Anti-neutrophil_cytoplasmic_antibody
Protein-coding gene in the species Homo sapiens
and fungal infections, as well as pathogen-associated molecular patterns, damage-associated molecular patterns, cytokines, and homeostatic changes during
NLRC5
Protein-coding gene in the species Homo sapiens
and fungal infections, as well as pathogen-associated molecular patterns, damage-associated molecular patterns, cytokines, and homeostatic changes during
AIM2
Tetrachloro-tetraiodo-fluorescein used as stain
photodynamic therapy (RBAc-PDT) induces exposure and release of Damage-Associated Molecular Patterns (DAMPs) in human HeLa cells". PLOS ONE. 9 (8) e105778. Bibcode:2014PLoSO
Rose_bengal
Destruction or degeneration of brain cells
Brain injury, also known as brain damage or neurotrauma, is the destruction or degeneration of brain cells. It may result from external trauma, such as
Brain_injury
Language used to describe the human body
pathogen-associated molecular patterns (PAMPs), which are associated with microbial pathogens, and damage-associated molecular patterns (DAMPs), which are associated with
Medical_terminology
Study of changes in DNA and RNA over time
evolution of development, and patterns and processes underlying genomic changes during evolution. The history of molecular evolution starts in the early
Molecular_evolution
Gene known for its role in breast cancer
Friedenson B (2012). "Evidence that BRCA1- or BRCA2-associated cancers are not inevitable". Molecular Medicine. 18 (9): 1327–37. doi:10.2119/molmed.2012
BRCA2
viruses. Upon recognition of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), an immune cell will initially
Alzheimer's disease and COVID-19
Alzheimer's_disease_and_COVID-19
Gene known for its role in breast cancer
suppressors, DNA damage sensors and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance
BRCA1
Cellular mechanism
spontaneous DNA damage involving tens of thousands of individual molecular lesions per cell per day. DNA modifications can also be programmed. Molecular lesions
DNA_repair
Sendai virus, virus of rodents
highly immunogenic because dying necroptotic cells release damage-associated molecular pattern (DAMPs) molecules, which initiate adaptive immunity. The
Murine_respirovirus
Indian immunologist
and fungal infections, as well as pathogen-associated molecular patterns, damage-associated molecular patterns, cytokines, and homeostatic changes during
Thirumala-Devi_Kanneganti
Medical condition
ovarian syndrome. The cause of female pattern hair loss remains unclear; androgenetic alopecia for women is associated with an increased risk of polyendocrine
Pattern_hair_loss
Damage to concrete affecting its mechanical strength and its durability
damaged by the corrosion of reinforcement bars, the carbonatation of hardened cement paste or chloride attack under wet conditions. Chemical damage is
Concrete_degradation
Enzyme found in humans
and fungal infections, as well as pathogen-associated molecular patterns, damage-associated molecular patterns, cytokines, and homeostatic changes during
RIPK1
Medical condition
identify the associated form of the disease. Complications with the diagnosis have occurred through clinical presentations and molecular findings. Genetic
Hemochromatosis_type_4
Biological process that causes an organism to develop its shape
developmental biology, along with the control of tissue growth and the patterning of cellular differentiation. The process controls the organized spatial
Morphogenesis
Group of neurological disorders affecting motor neurons
slowly, and worsen over the course of more than three months. Various patterns of muscle weakness are seen, and muscle cramps and spasms may occur. One
Motor_neuron_diseases
Hypothesis that aging is caused by accumulated DNA damage
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damage. Damage in this context
DNA_damage_theory_of_aging
Molecules involved in pattern triggered plant immunity
on plant cell membranes. These receptors are able to recognize the molecular pattern of elicitors and trigger intracellular defence signalling via the
Elicitor
Protein
primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle
P21
Irish molecular biologist
the idea that IL-1 family members represent the canonical ‘damage-associated molecular patterns’ that promote inflammation upon release from necrotic cells
Seamus_Martin_(biochemist)
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
Boy/Male
Greek
Tame.
Female
Greek
(Λαλαγη) Classical Greek name derived from the word lalagein, LALAGE means "to babble."Â
Girl/Female
African, Bengali, Gujarati, Hindu, Indian, Kannada, Kenyan, Malayalam, Marathi, Sanskrit, Sindhi, Tamil, Telugu
Small; Atom; Black; Molecule; Seed
Surname or Lastname
English
English : presumably an occupational name for someone who sold damask, a richly woven material of a kind originally made in Damascus. The English word also came to denote a rich pink color, and it is possible that the surname arose as a nickname with reference to someone’s complexion.
Boy/Male
Arabic, Muslim, Sindhi
Associate
Girl/Female
Latin
Untamed.
Boy/Male
Muslim/Islamic
Associate
Surname or Lastname
English (of Norman origin)
English (of Norman origin) : habitational name from any of various places in France called Gamaches (see Gamache).
Boy/Male
Muslim
Associate
Surname or Lastname
English
English : variant of Dredge.German : from a Germanic personal name Trago, or a habitational name from a place named Drage, near Hamburg or in Schleswig-Holstein.Norwegian : variant of Drag, from the dative case.
Girl/Female
Australian, Greek
The Mythological Mother of Perseus by Zeus; Form of Danae
Surname or Lastname
English
English : variant spelling of Gamage.
Girl/Female
French
Untamed.
Girl/Female
Sikh
Associated, Connected
Surname or Lastname
English
English : variant spelling of Talmadge.Americanized form of one or more like-sounding Jewish surnames, most likely from eastern Ashkenazic Tolmach, either an occupational name from Russian tolmach ‘interpreter’ or a habitational name from a village called Tolmach in Ukraine.
Surname or Lastname
English and Scottish
English and Scottish : nickname for a wild or uncouth person, from Middle English, Old French salvage, sauvage ‘untamed’ (Late Latin salvaticus literally ‘man of the woods’, a derivative of Latin silva ‘wood’, influenced by Latin salvus ‘whole’, i.e. natural).Irish : generally of English origin (it was taken to County Down in the 12th century), this name has also sometimes been adopted as equivalent of Gaelic Ó Sabháin, the name of a small south Munster sept, which was earlier Anglicized as O’Savin (see Savin).Americanized form of Ashkenazic Jewish Savich.A Jacob Savage, born in Exeter, Devon, England, in 1604, is recorded in Essex, NJ, by the early 1630s. Edward Savage, of Huguenot descent, emigrated from Ireland to Massachusetts in 1696. His grandson and namesake, who was born in Princeton, MA, in 1761 gained fame as an artist for his portrait of George Washington (1789–90).
Female
Greek
Abbreviated form of Greek Damalis, DAMALI means "calf."
Girl/Female
Greek
Form of Danae; the mythological mother of Perseus by Zeus.
Girl/Female
Sikh
Virtuous brave
Girl/Female
Greek
Babble. Verbose.
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
Boy/Male
British, English
From the Bear Estate
Boy/Male
Tamil
Unique, Focused
Girl/Female
Tamil
Goddess of fire, Fire
Male
Chinese
square, in the sense of correctness.
Male
English
Anglicized form of Gaelic Suibhne, SWEENEY means "well-going."
Boy/Male
British, Danish, English, Finnish, German, Greek, Latin
Victory of the People; People's Victory
Boy/Male
British, English
From the Village Meadow
Boy/Male
Sikh
The Sun
Girl/Female
Muslim/Islamic
Responsible
Male
Gypsy/Romani
 Possibly a Romani form of Hungarian Peti, PITTI means "rock; stone."
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
DAMAGE ASSOCIATED-MOLECULAR-PATTERN
n.
One who customarily associates with another; a companion; an associate; any object which is associated or combined with a similar object.
n.
See Pavage.
v. t.
To bring loss or damage to; to harm; to injure.
a.
Uncivilized; untaught; unpolished; rude; as, savage life; savage manners.
n.
To ocassion damage to the soudness, goodness, or value of; to hurt; to injure; to impair.
v. i.
To receive damage or harm; to be injured or impaired in soudness or value; as. some colors in /oth damage in sunlight.
a.
Admitted to some, but not to all, rights and privileges; as, an associate member.
a.
Having only one eye; with one eye only; as, monocular vision.
n.
An associate; a confederate or partner in any scheme.
n.
Damage; hurt.
v. i.
To unite in company; to keep company, implying intimacy; as, congenial minds are disposed to associate.
a.
Pertaining to, connected with, produced by, or consisting of, molecules; as, molecular forces; molecular groups of atoms, etc.
imp. & p. p.
of Damage
v. t.
To join or connect; to combine in acting; as, particles of gold associated with other substances.
imp. & p. p.
of Associate
a.
Adapted to be used with only one eye at a time; as, a monocular microscope.
v. t.
See Endamage.
a.
Connected by habit or sympathy; as, associate motions, such as occur sympathetically, in consequence of preceding motions.
v. t.
To make savage.
adv.
With molecules; in the manner of molecules.