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Type of amino acid sequence
A nuclear localization sequence, or signal (NLS) is an amino acid sequence motif that 'tags' a protein for import into the cell nucleus by nuclear transport
Nuclear_localization_sequence
Family of proteins
the cytoplasm and nucleus, via a conserved nuclear export sequence (NES) and a nuclear localization sequence (NLS), both necessary for proper functioning
Dishevelled
Protein family
icosahedral assembly. The C-terminus also contains a basic nuclear localization sequence, while the N-terminus - which is oriented toward the center
Major_capsid_protein_VP1
Topics referred to by the same term
Look up localization, L10n, or localize in Wiktionary, the free dictionary. Localization or localisation may refer to: Localization of function, locating
Localization
Protein-coding gene in the species Homo sapiens
ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining
BRAP
Proto-oncogene derived from polyomavirus SV40
protein to study nuclear localization signals (NLSs). It is imported into the nucleus by its interaction with importin α. The NLS sequence is PKKKRKV. SV40
SV40_large_T_antigen
Fibrous proteins
the type of lamin. However, all C-terminal domains contain a nuclear localization sequence (NLS). Similar to other IF proteins, lamins self-assemble into
Lamin
Biological mechanism for routing proteins
through the addition of a nuclear localization sequence (NLS) that promotes passage through the nuclear envelope via nuclear pores. While some proteins
Protein_targeting
Viral protein found in some polyomaviruses
acid sequence, a "bipartite" nuclear localization sequence at the N-terminus, and highly basic amino acids at both termini. Comparison of the sequences of
Agnoprotein
Antibody in molecular biology and neuroscience
adds a C-terminal PY type nuclear localization sequence, which presumably explains why NeuN/Fox-3 protein can be both nuclear and, in some cell types,
NeuN
Congenital disorder of nervous system
contains both a nuclear localization sequence and a nuclear export sequence. Cleavage of ATN1 to an N terminal fragment relieves ATN1 of its nuclear export signal
Dentatorubral–pallidoluysian atrophy
Dentatorubral–pallidoluysian_atrophy
Protein-coding gene in the species Homo sapiens
"Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences". Science. 268 (5213): 1049–53. Bibcode:1995Sci...268.1049W
Importin_subunit_alpha-1
Protein family
does so by binding to specific recognition sequences, called nuclear localization sequences (NLS). Importin has two subunits, importin α and importin β
Importin
Short peptide present at N-terminal of newly synthesized proteins
referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a
Signal_peptide
Protein-coding gene in the species Homo sapiens
This protein is a karyopherin which interacts with nuclear localization sequence to target nuclear proteins to the nucleus. The classical karyopherin
Transportin_1
Protein-coding gene in the species Homo sapiens
"Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences". Science. 268 (5213): 1049–53. Bibcode:1995Sci...268.1049W
Importin_subunit_alpha-5
Protein-coding gene in the species Homo sapiens
nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import
KPNB1
Macromolecular complex containing protein and RNA molecules
mRNA in the cytoplasm. However, hnRNPs also have their own nuclear localization sequences (NLS) and are therefore found mainly in the nucleus. Though
Heterogeneous ribonucleoprotein particle
Heterogeneous_ribonucleoprotein_particle
Synthetic DNA transposon for vertebrate genetic modification
dominant role in recognition of the DR sequences in the transposon. The RED subdomain overlaps with the nuclear localization signal, but its function remains
Sleeping Beauty transposon system
Sleeping_Beauty_transposon_system
Protein-coding gene in the species Homo sapiens
predicted nuclear localization sequence, while the blue domain is the remainder of the LOC105377021 exon. According to Ali2D (a multiple sequence alignment
LOC105377021
Protein-coding gene in the species Homo sapiens
Briggs LJ, Jans DA (January 1998). "The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties". The Journal of Biological Chemistry
IPO5
Type of protein
stable throughout the cell cycle and is localized to the nucleus due to the presence of a nuclear localization sequence (NLS). SCF-Fbw7 targets Sic1—when at
SCF_complex
Protein complex on the surface of T cells that recognizes antigens
state, NFAT cannot enter the nucleus as its nuclear localization sequence (NLS) cannot be recognized by nuclear transporters due to phosphorylation by GSK-3
T-cell_receptor
typically appears as a nuclear protein in images as its nuclear import is more rapid than its export. Cyclin E's nuclear localization sequence (NLS) allows the
Cyclin_E/Cdk2
Protein-coding gene in the species Homo sapiens
Süel KE, Louis TH, Zhang Z, Chook YM (August 2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2". Cell. 126 (3): 543–58. doi:10
TNPO2
Protein found in humans
is predicted to be localized in the nucleus. A stretch of five positively charged lysines, indicating a nuclear localization sequence, can be found at positions
Chromosome 5 open reading frame 47
Chromosome_5_open_reading_frame_47
British biochemist and cell biologist
bipartite nuclear localization sequence which is the major signal for protein entry into the nucleus. Dingwall C, Laskey RA. Nuclear targeting sequences—a consensus
Colin_Dingwall
Domain of organisms
known life forms List of Archaea genera List of sequenced archaeal genomes Nuclear localization sequence Stirrup protein domain The Surprising Archaea (book)
Archaea
Protein-coding gene in the species Homo sapiens
MEX67. Members of the NXF family have a modular structure. A nuclear localization sequence and a noncanonical RNA recognition motif (RRM) (see PROSITEDOC)
NXF1
Protein-coding gene in the species Homo sapiens
Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha
Importin_subunit_alpha-6
Protein-coding gene in the species Homo sapiens
(2003). "A Nonconventional Nuclear Localization Signal within the UL84 Protein of Human Cytomegalovirus Mediates Nuclear Import via the Importin α/β
IPO4
Protein-coding gene in the species Homo sapiens
the KPNA4 gene. The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins
Importin_subunit_alpha-3
ATFS-1 has a nuclear localization sequence that allows it to be imported into the nucleus as well as an N-terminal mitochondrial targeting sequence (MTS) that
Mitochondrial unfolded protein response
Mitochondrial_unfolded_protein_response
Openings in nuclear envelope of eukaryotic cells
of which nuclear localization signal (NLS) are best characterized. Several NLS sequences are known, generally containing a conserved sequence with basic
Nuclear_pore_complex
Protein-coding gene in the species Homo sapiens
Talcott B, Moore MS (April 2000). "The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip". The
RCC1
Third subphase of interphase
accomplished via removal of nuclear localization sequence (NLS)-obscuring phosphates and phosphorylation of the nuclear export signal. It is thought
G2_phase
Protein-coding gene in the species Homo sapiens
FGF1 can also function intracellularly. The protein has a nuclear localization sequence (NLS) but the route that FGF1 takes to get to the nucleus is
Fibroblast_growth_factor_1
Class of roundworms
responsible for binding to the DR sequences in the mirrored IR/DR sequences of the transposon, a nuclear localization sequence (NLS), and a DDE domain that
Tc1/mariner
Protein-coding gene in the species Homo sapiens
shows localization in the cytosol. Immunohistochemistry imaging of human prostate tissue also suggests cytosolic localization. A bipartite nuclear localization
MIPOL1
Protein-coding gene in the species Homo sapiens
the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an
IκBα
Fibrillar network
extended rod domain (42 amino acid longer), that they all carry a nuclear localization signal (NLS) at their C-terminus and that they display typical tertiary
Nuclear_lamina
Protoplasm that permeates a cell's nucleus
a third of these have been found to localize to the nucleoplasm via targeting by a nuclear localization sequence (NLS). Cytosolic proteins, known as importins
Nucleoplasm
Protein-coding gene in the species Homo sapiens
contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type
ZFX
Vertebrate receptor protein and transcription factor
interacts with carboxyl-terminal of Hsp90 and binds to the AhR nuclear localization sequence (NLS) preventing the inappropriate trafficking of the receptor
Aryl_hydrocarbon_receptor
Gene
the protein is localized to the endoplasmic reticulum (ER) and to intracellular vesicles. It does not have a nuclear localization sequence but can enter
ORF9b
Mechanism of molecules moving across the nuclear membrane
nucleus from the cytoplasm carry nuclear localization signals (NLSs) that are bound by importins. An NLS is a sequence of amino acids that acts as a tag
Nuclear_transport
Cytokine protein
enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase"
Interleukin_6
Chemical compound
referred to as the Nuclear Import process, cytosolic proteins like alpha and beta importins would bind the nuclear localization sequence that is located
Guanosine_diphosphate
Protein-coding gene in the species Homo sapiens
disorder with unique facial features. Amplifications of the nuclear localization sequence-encoding part of this gene have been linked to glioblastoma
TLK2
Protein found in humans
presence of two domains. Nuclear localization sequence with a Score of 4 in the amino acids 265–279. The amino acid sequence for this region is: KKQQEIRAQEKKRLR
Coiled-coil domain-containing protein 135
Coiled-coil_domain-containing_protein_135
Protein-coding gene in the species Homo sapiens
short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of
Importin_subunit_alpha-4
Group of cytokine proteins
N-terminal propiece cleavage product (ppIL-1α), which contains a nuclear localization sequence (NLS), and translocates to the nucleus, functioning as a transcription
Interleukin-1_family
Protein-coding gene in the species Homo sapiens
Hubberstey AV (2001). "Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis"
Large proline-rich protein BAG6
Large_proline-rich_protein_BAG6
HIV-1 Rev protein which is imported into the nucleus via its nuclear localization sequence. This phase of the virus life cycle is both Rev and RRE independent
HIV_Rev_response_element
peptide, no transmembrane domains, no mitochondrial targeting, no nuclear localization sequence, and no tracking motifs. PhosPhoSite Plus and DTU Health Tech
KLHL36
progression. This unstructured linker region also contains a nuclear localization sequence, which triggers the host cell to transport the protein from
Large_tumor_antigen
Protein-coding gene in the species Homo sapiens
McMorrow I, Bastos R, Horton H, Burke B (1994). "Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153". Biochim. Biophys
Nucleoporin_153
Protein-coding gene in the species Homo sapiens
takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires
Importin_subunit_alpha-7
A nuclear weapon is an explosive device that derives its destructive force from nuclear reactions, either nuclear fission (fission or atomic bomb) or
Nuclear_weapon
DNA replication in eukaryotic organisms
Tye BK (October 1997). "Nuclear accumulation of Saccharomyces cerevisiae Mcm3 is dependent on its nuclear localization sequence". Genes to Cells. 2 (10):
Eukaryotic_DNA_replication
Mammalian protein found in humans
residues, essential for sequence-specific DNA interaction and co-repressor binding such as LMO3. A nuclear localization sequence (NLS; residues 316–325)
P53
Protein-coding gene in the species Homo sapiens
This protein is predicted to be a nuclear protein. There appears to be a bipartite nuclear localization sequence beginning at position 80. The C11orf86
C11orf86
Protein domain
family. The dimerization subdomain is immediately followed by a nuclear localization sequence that also comprises the site for inhibitory interactions with
Rel_homology_domain
Protein-coding gene in the species Homo sapiens
translation due to two nuclear localization sequences predicted at residues 1,233 and 1,281. No nuclear export sequence is conserved amongst orthologs
C2orf16
Protein-coding gene in the species Homo sapiens
polyproline helix. PRR12 contains a possible nuclear import signal starting at P1794. A typical nuclear localization sequence would have the following residues:
Proline-rich_12
Protein family
heterodimerize, and a classic nuclear localization sequence (NLS) in the C-terminus of Mef2A, -C, and – D ensures nuclear localization of the protein. D-Mef2
Mef2
Laboratory technique
lab). The signal encodes within RNA and the signal presences of the nuclear localization signal (NLS) within GFP-MS2 are two signals that introduce from EGFP-MS2-RNA
MS2_tagging
Medical specialty
Nuclear medicine (nuclear radiology) is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease
Nuclear_medicine
Species of virus
nuclear localization signals within its protein sequences. These amino acid sequences tag the protein for import into the cell's nucleus via nuclear transport
Blueberry mosaic associated virus
Blueberry_mosaic_associated_virus
RNA family
called FUS (ideally, FUS should localize to the nucleus since it possesses an exposed nuclear localization sequence). The authors of this study also
U1_spliceosomal_RNA
Gene editing technique
primer binding site (PBS) sequence due to its enhanced substrate affinity. better PE2 with enhanced nuclear localization sequences[more detail needed] [more
Prime_editing
Protein-coding gene in the species Homo sapiens
probability. This prediction is supported by the presence of a nuclear localization sequence (NLS) found between residues 142–151. Although the bioinformatics
BNIP5
Protein-coding gene in the species Homo sapiens
an N-terminal replication factory-targeting sequence (RFTS), followed by a nuclear localization sequence (NLS), and three functional domains. The three
DNA_ligase_1
Protein-coding gene in the species Homo sapiens
protein was its nuclear export signals (L rich regions), Nuclear localization signals, and phosphorylation sites. The nuclear localization signals and export
C16orf86
Protein-coding gene in the species Homo sapiens
Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene. Signal-mediated nuclear import and export proceed through
NUP98
Protein-coding gene in the species Homo sapiens
that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC)
NUPL1
Protein-coding gene in the species Homo sapiens
putative receptor binding site exists between residues 75-124. A nuclear localization sequence (NLS) exists about 150 amino acids into the protein. The additional
PEDF
Protein-coding gene in the species Homo sapiens
N-terminal disordered domain. Conversely, MSH2 does not have a nuclear localization sequence (NLS), so it is believed that MSH2 and MSH6 dimerize in the
MSH2
2008). "AAIndexLoc: predicting subcellular localization of proteins based on a new representation of sequences using amino acid indices". Amino Acids. 35
List of protein subcellular localization prediction tools
List_of_protein_subcellular_localization_prediction_tools
Protein found in humans
N-terminal portion of the protein consists of a PWWP domain, a nuclear localization sequence, and two copies of the AT-hook DNA binding motif. The C-terminal
PSIP1
Protein that initiates male sex determination in therian mammals
encompasses the high-mobility group (HMG) domain, which contains nuclear localization sequences and acts as the DNA-binding domain. The C-terminal domain has
Sex-determining region Y protein
Sex-determining_region_Y_protein
Protein-coding gene in the species Homo sapiens
Transportin-3 is a protein that in humans is encoded by the TNPO3 gene. TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich
Transportin-3
Protein-coding gene in the species Homo sapiens
NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate
RBPJ
Amino acid sequence causing a protein to be exported from the nucleus to the cytoplasm
the cytoplasm through the nuclear pore complex using nuclear transport. It has the opposite effect of a nuclear localization signal, which targets a protein
Nuclear_export_signal
Developmental protein
annotated with 10 intrinsically disordered domains, a nuclear localization sequence, a nuclear export sequence, a PDZ binding domain, and a coiled-coiled domain
Dishevelled binding antagonist of beta catenin 1
Dishevelled_binding_antagonist_of_beta_catenin_1
Protein
binds to single strand breaks. The first linker contains a nuclear localization sequence and also has a region that interacts with DNA repair protein
XRCC1
Cell cycle protein
also differs from the expected sequence: it contains a phenylalanine rather than a leucine. The nuclear localization sequence (NLS) of chicken cyclin B3 appears
Cyclin_B3
Medical imaging technique
the nuclear spin energy transition, and magnetic field gradients localize the polarization in space. By varying the parameters of the pulse sequence, different
Magnetic_resonance_imaging
Protein found in humans
higher-order oligomers. The protein sequence also has a nuclear localization signal (NLS, residues 82–98), a former nuclear export signal (NES residues 239–250)
TAR_DNA-binding_protein_43
Transcriptional repressor protein
helices. Additionally, the N-terminus of the protein contains a nuclear localization sequence (NLS). The CIART protein is an important negative regulator
CIART
of the HIV-1 Matrix Protein Does Not Contain a Conventional Nuclear Localization Sequence But Is Required for DNA Binding and Protein Self-Association
Sabine_Piller
Gene on human chromosome 10
has a nuclear localization sequence (NLS) of PKKTKEK, meaning it can localize within the nucleus of the cell. It is also predicted to localize within
BTBD16
1986 nuclear accident in the Soviet Union
only two nuclear accidents rated at the maximum severity on the International Nuclear Event Scale, the other being the 2011 Fukushima nuclear accident
Chernobyl_disaster
Protein and coding gene in humans
enter the nucleus by inducing a conformational change in its nuclear localization sequence. On the other hand, the protein complex FBXL3 mediates the degradation
Casein kinase 1 isoform epsilon
Casein_kinase_1_isoform_epsilon
Protein-coding gene in the species Homo sapiens
closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs)
KLF4
Class of adaptor proteins
karyopherin proteins. Importin α is known to bind to the nuclear localization signal (NLS) sequence of nucleus targeted proteins. After this recognition,
Importin_α
Protein-coding gene in humans
"BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence". The Journal of Biological Chemistry. 275 (22): 16752–7. doi:10
PAX5
Protein-coding gene in the species Homo sapiens
motif is commonly known to be a lysosome targeting motif. A nuclear localization sequence of 5 positive amino acids is found near the 5' end indicating
TMCO6
Human gene and protein
endoplasmic reticulum. There is a conserved pattern 7 nuclear localization sequence, with an amino acid sequence of PASRARR, at position 275. There is a signal
TMEM271
Human protein and coding gene
results in increased DNA damage in neurons. Mutations in the FUS nuclear localization sequence impairs the poly (ADP-ribose) polymerase (PARP)-dependent DNA
RNA-binding_protein_FUS
NUCLEAR LOCALIZATION-SEQUENCE
NUCLEAR LOCALIZATION-SEQUENCE
Boy/Male
Tamil
Vyushtt | வà¯à®¯à¯à®·à¯à®¤à¯à®¤
Clear
Vyushtt | வà¯à®¯à¯à®·à¯à®¤à¯à®¤
Boy/Male
English
Clear.
Girl/Female
Latin
Clear.
Girl/Female
Italian Spanish American English Latin
Clear.
Surname or Lastname
English
English : probably a habitational name from clere, a component of several place names in north Hampshire (Highclere, Burghclere, Kingsclere). This is of uncertain origin, probably from a Celtic stream name meaning ‘bright’ (cognate with Latin clarus ‘clear’, ‘bright’).English and Irish : variant of Clare.Translation of German Klar 1.
Girl/Female
Ukrainian
Clear.
Girl/Female
Latin
Clear.
Girl/Female
French
Clear.
Girl/Female
Latin
Clear.
Boy/Male
Hindu
Clear
Boy/Male
Muslim
Clear
Girl/Female
Latin
Clear.
Girl/Female
Latin
Sweet.
Girl/Female
Italian
Clear.
Boy/Male
Indian
Clear
Girl/Female
Latin
Clear.
Girl/Female
Latin Swedish
Clear.
Boy/Male
Tamil
Clear
Boy/Male
Muslim
Clear
Girl/Female
Latin
Clear.
NUCLEAR LOCALIZATION-SEQUENCE
NUCLEAR LOCALIZATION-SEQUENCE
Boy/Male
Muslim/Islamic
Ally confederate
Surname or Lastname
English (chiefly southern Yorkshire and East Midlands)
English (chiefly southern Yorkshire and East Midlands) : regional name from the district in southern Yorkshire around Sheffield and Ecclesfield called Hallam, or a habitational name from a place of this name in Derbyshire. The Derbyshire name is from Old English halum, dative plural of halh ‘nook’, ‘recess’ (see Hale 1). The Yorkshire district, sometimes called Hallamshire, is possibly of the same derivation or alternatively from hallum, dative plural of Old English hall ‘stone’, ‘rock’, Old Norse hallr.
Girl/Female
Hindu, Indian, Kannada, Tamil
Cute Eyes
Surname or Lastname
English
English : unexplained.Probably an Americanized form of German Flick. Compare Fleak.
Girl/Female
British, English
Friend of the Sea
Boy/Male
Hindu, Indian, Tamil, Telugu
Leek Garden; Garden of Onnion
Male
Finnish
Finnish form of Greek Esaias, ESA means "God is salvation."
Girl/Female
Spanish American
Beautiful.
Male
Arthurian
, son of Gawain (flourishing).
Girl/Female
Hindu, Indian
Auspicious
NUCLEAR LOCALIZATION-SEQUENCE
NUCLEAR LOCALIZATION-SEQUENCE
NUCLEAR LOCALIZATION-SEQUENCE
NUCLEAR LOCALIZATION-SEQUENCE
NUCLEAR LOCALIZATION-SEQUENCE
n.
Act of localizing, or state of being localized.
v. t.
To gather, as about a nucleus or center.
superl.
Without defect or blemish, such as freckles or knots; as, a clear complexion; clear lumber.
superl.
Able to perceive clearly; keen; acute; penetrating; discriminating; as, a clear intellect; a clear head.
a.
Alt. of Nuclear
n.
The formation and utterance of vocal sounds.
a.
Of or pertaining to a nucleus; as, the nuclear spindle (see Illust. of Karyokinesis) or the nuclear fibrils of a cell; the nuclear part of a comet, etc.
superl.
Without diminution; in full; net; as, clear profit.
superl.
Without mixture; entirely pure; as, clear sand.
n.
The act of making loyal to a king.
adv.
In a clear manner; plainly.
n.
The act of focalizing or bringing to a focus, or the state of being focalized.
n.
The exercise of the vocal organs; vocalization.
pl.
of Nucleus
n.
A substance associated with nuclein in cell nuclei, and by some considered as the fundamental substance of the nucleus.
v. t.
To leap or pass by, or over, without touching or failure; as, to clear a hedge; to clear a reef.
n.
The act of vocalizing, or the state of being vocalized.
a.
Having a nucleus; nucleate; as, nucleated cells.
superl.
Free from impediment or obstruction; unobstructed; as, a clear view; to keep clear of debt.
a.
Having a nucleus; nucleated.