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INOSITOL TRISPHOSPHATE

  • Inositol trisphosphate
  • Chemical compound

    Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis

    Inositol trisphosphate

    Inositol_trisphosphate

  • Inositol trisphosphate receptor
  • Class of transport proteins

    Inositol trisphosphate receptor (InsP3R, IP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3,

    Inositol trisphosphate receptor

    Inositol trisphosphate receptor

    Inositol_trisphosphate_receptor

  • Inositol phosphate
  • Class of chemical compounds

    inositol ring. inositol monophosphate (IP or IP1) inositol bisphosphate (IP2) inositol trisphosphate (IP3) inositol tetrakisphosphate (IP4) inositol pentakisphosphate

    Inositol phosphate

    Inositol phosphate

    Inositol_phosphate

  • Inositol
  • Carbocyclic sugar

    biochemistry, medicine, and related sciences, inositol generally refers to myo-inositol (formerly meso-inositol), the most important stereoisomer of the chemical

    Inositol

    Inositol

    Inositol

  • Inositol-trisphosphate 3-kinase
  • Class of enzymes

    Inositol (1,4,5) trisphosphate 3-kinase (EC 2.7.1.127), abbreviated here as ITP3K, is an enzyme that facilitates a phospho-group transfer from adenosine

    Inositol-trisphosphate 3-kinase

    Inositol-trisphosphate 3-kinase

    Inositol-trisphosphate_3-kinase

  • Inositol-polyphosphate 5-phosphatase
  • Class of enzymes

    The enzyme inositol-polyphosphate 5-phosphatase (EC 3.1.3.56), systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses two related

    Inositol-polyphosphate 5-phosphatase

    Inositol-polyphosphate 5-phosphatase

    Inositol-polyphosphate_5-phosphatase

  • Inositol-1,3,4-trisphosphate 5/6-kinase
  • inositol-1,3,4-trisphosphate 5/6-kinase (EC 2.7.1.159, Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol

    Inositol-1,3,4-trisphosphate 5/6-kinase

    Inositol-1,3,4-trisphosphate_5/6-kinase

  • ITPKB
  • Protein-coding gene in humans

    Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene. The protein encoded by the ITPKB gene is one of 3 isoforms

    ITPKB

    ITPKB

    ITPKB

  • Ryanodine receptor
  • Class of intracellular transport proteins

    but they are shorter than the mammalian ones and may be closer to inositol trisphosphate (IP3) receptors. Ryanodine receptors mediate the release of calcium

    Ryanodine receptor

    Ryanodine receptor

    Ryanodine_receptor

  • Phosphatidylinositol
  • Signaling molecule

    Phosphatidylinositol or inositol phospholipid is a biomolecule. It was initially called "inosite" when it was discovered by Léon Maquenne and Johann Joseph

    Phosphatidylinositol

    Phosphatidylinositol

    Phosphatidylinositol

  • Phosphatidylinositol (3,4,5)-trisphosphate
  • Chemical compound

    Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide 3-kinases' (PI 3-kinases)

    Phosphatidylinositol (3,4,5)-trisphosphate

    Phosphatidylinositol (3,4,5)-trisphosphate

    Phosphatidylinositol_(3,4,5)-trisphosphate

  • Inositol-polyphosphate multikinase
  • Class of enzymes

    ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase. This enzyme catalyses the following chemical reaction 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate ⇌ {\displaystyle

    Inositol-polyphosphate multikinase

    Inositol-polyphosphate multikinase

    Inositol-polyphosphate_multikinase

  • ITPR2
  • Protein-coding gene in humans

    Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this

    ITPR2

    ITPR2

    ITPR2

  • Inositol polyphosphate kinase
  • Enzyme family

    various inositol phosphates. Members of the family include inositol-polyphosphate multikinases, inositol-hexakisphosphate kinases, inositol-trisphosphate 3-kinases

    Inositol polyphosphate kinase

    Inositol polyphosphate kinase

    Inositol_polyphosphate_kinase

  • ITPKA
  • Protein-coding gene in the species Homo sapiens

    Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene. ITPKA is one of three inositol-trisphosphate 3-kinase (ITP3K)

    ITPKA

    ITPKA

    ITPKA

  • Inositol-phosphate phosphatase
  • Class of enzymes

    phosphatase, myo-inositol 1-phosphatase, inositol phosphatase, inositol monophosphate phosphatase, inositol-1(or 4)-monophosphatase, myo-inositol-1(or 4)-phosphate

    Inositol-phosphate phosphatase

    Inositol-phosphate phosphatase

    Inositol-phosphate_phosphatase

  • ITPR1
  • Protein-coding gene in the species Homo sapiens

    Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene. ITPR1 has been shown to interact with: AHCYL1, CA8

    ITPR1

    ITPR1

    ITPR1

  • Inositol-tetrakisphosphate 1-kinase
  • Enzyme

    inositol-trisphosphate 6-kinase, 1D-myo-inositol-trisphosphate 6-kinase, ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase, inositol-trisphosphate 5-kinase

    Inositol-tetrakisphosphate 1-kinase

    Inositol-tetrakisphosphate_1-kinase

  • ITPKC
  • Protein-coding gene in the species Homo sapiens

    Inositol-trisphosphate 3-kinase C is a protein that in humans is encoded by the ITPKC gene. It is one of 3 human genes that encode for an Inositol-trisphosphate

    ITPKC

    ITPKC

    ITPKC

  • Muscarinic acetylcholine receptor
  • Acetylcholine receptors named for their selective binding of muscarine

    class Gq, which use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signaling pathway. A receptor so

    Muscarinic acetylcholine receptor

    Muscarinic acetylcholine receptor

    Muscarinic_acetylcholine_receptor

  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
  • Phosphatase enzyme

    4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase

    Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

    Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase

  • Phosphoinositide phospholipase C
  • Protein family

    messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). The chemical reaction may be expressed as: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

    Phosphoinositide phospholipase C

    Phosphoinositide phospholipase C

    Phosphoinositide_phospholipase_C

  • Barbara E. Ehrlich
  • American biologist and academic (born 1952)

    Recent research investigates the function of polycystin-2, the inositol trisphosphate receptor, and the ryanodine receptor. Ehrlich was born in New London

    Barbara E. Ehrlich

    Barbara E. Ehrlich

    Barbara_E._Ehrlich

  • Mast cell
  • Immune cell found in connective tissue

    to catalyze phosphatidylinositol bisphosphate breakdown to yield inositol trisphosphate (IP3) and diacyglycerol (DAG). IP3 elevates calcium levels, and

    Mast cell

    Mast cell

    Mast_cell

  • Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
  • Class of enzymes

    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) catalyzes the chemical reaction 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O =

    Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

    Phosphatidylinositol-3,4,5-trisphosphate_3-phosphatase

  • Gq alpha subunit
  • Family of heterotrimeric G protein alpha subunits

    phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium

    Gq alpha subunit

    Gq_alpha_subunit

  • Myo-Inositol trispyrophosphate
  • Chemical compound

    cardiovascular disease and dementia Phytic acid Inositol Inositol phosphate Inositol trisphosphate myo-Inositol Biolo, A; Greferath, R; Siwik, DA; Qin, F;

    Myo-Inositol trispyrophosphate

    Myo-Inositol trispyrophosphate

    Myo-Inositol_trispyrophosphate

  • Michael Berridge
  • British physiologist and biochemist

    for his work on cell signaling, in particular the discovery that inositol trisphosphate acts as a second messenger, linking events at the plasma membrane

    Michael Berridge

    Michael_Berridge

  • Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels
  • Group of membrane channel proteins

    The ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) family includes Ryanodine receptors and Inositol trisphosphate receptors. Members

    Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels

    Ryanodine-Inositol_1,4,5-triphosphate_receptor_calcium_channels

  • Adenophostin
  • Chemical compound

    Adenophostin A is a potent inositol trisphosphate (IP3) receptor agonist, but is much more potent than IP3. IP3R is a ligand-gated intracellular Ca2+ release

    Adenophostin

    Adenophostin

    Adenophostin

  • Calreticulin
  • Soluble protein

    affinity, but high capacity, and can be released on a signal (see inositol trisphosphate). Calreticulin is located in storage compartments associated with

    Calreticulin

    Calreticulin

    Calreticulin

  • ITPR3
  • Protein-coding gene in the species Homo sapiens

    Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this

    ITPR3

    ITPR3

    ITPR3

  • PLCD4
  • Protein-coding gene in the species Homo sapiens

    Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation

    PLCD4

    PLCD4

    PLCD4

  • Nicotinamide adenine dinucleotide
  • Coenzyme

    calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate". J. Biol. Chem. 262 (20): 9561–8. doi:10.1016/S0021-9258(18)47970-7

    Nicotinamide adenine dinucleotide

    Nicotinamide adenine dinucleotide

    Nicotinamide_adenine_dinucleotide

  • Second messenger system
  • System of signaling molecules within a cell

    transduction. The enzyme phospholipase C produces diacylglycerol and inositol trisphosphate, which increases calcium ion permeability into the membrane. Active

    Second messenger system

    Second messenger system

    Second_messenger_system

  • Arachidonic acid
  • 20-Carbon polyunsaturated fatty acid

    from phospholipids after phospholipase C (PLC) cleaves off the inositol trisphosphate group, yielding diacylglycerol (DAG), which subsequently is cleaved

    Arachidonic acid

    Arachidonic acid

    Arachidonic_acid

  • Adrenergic receptor
  • Class of G protein-coupled receptors

    phosphatidylinositol 4,5-bisphosphate (PIP2), which in turn causes an increase in inositol trisphosphate (IP3) and diacylglycerol (DAG). The former interacts with calcium

    Adrenergic receptor

    Adrenergic receptor

    Adrenergic_receptor

  • Calcium channel
  • Ion channel complex through which calcium ions pass

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Calcium channel

    Calcium_channel

  • KCNQ2
  • Protein-coding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    KCNQ2

    KCNQ2

    KCNQ2

  • TRPA (ion channel)
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    TRPA (ion channel)

    TRPA (ion channel)

    TRPA_(ion_channel)

  • ANO1
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    ANO1

    ANO1

    ANO1

  • Skin sloughing
  • Shedding dead surface cells off the skin

    Phospholipase C triggers the release of intracellular calcium through inositol trisphosphate (IP3) and diacylglycerol (DAG). This increase of calcium then induces

    Skin sloughing

    Skin_sloughing

  • Adrenaline
  • Hormone and medication

    Adrenaline also binds to α1 adrenergic receptors, causing an increase in inositol trisphosphate, inducing calcium ions to enter the cytoplasm. Calcium ions bind

    Adrenaline

    Adrenaline

    Adrenaline

  • HCN channel
  • Intermembrane proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    HCN channel

    HCN_channel

  • G protein
  • Type of proteins

    phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces calcium release from

    G protein

    G protein

    G_protein

  • Hydralazine
  • Anti-hypertension medication

    the arterial bed. The molecular mechanism involves inhibition of inositol trisphosphate-induced Ca2+ release from the sarcoplasmic reticulum in arterial

    Hydralazine

    Hydralazine

    Hydralazine

  • L-type calcium channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    L-type calcium channel

    L-type calcium channel

    L-type_calcium_channel

  • Head-twitch response
  • Head movement in rodents upon 5-HT2A receptor activation

    phosphatidylinositol-4,5-bisphosphate, leading to intracellular Ca2+ release by inositol trisphosphate and the activation of protein kinase C by diacylglycerol [18]. Gq-biased

    Head-twitch response

    Head-twitch response

    Head-twitch_response

  • Ankyrin-2
  • Protein-coding gene in the species Homo sapiens

    the inositol trisphosphate receptor, and a reduction of ankyrin-B in neonatal cardiomyocytes reduces the half-life of the inositol trisphosphate receptor

    Ankyrin-2

    Ankyrin-2

    Ankyrin-2

  • P-type calcium channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    P-type calcium channel

    P-type_calcium_channel

  • Sweetness
  • Basic taste

    a G-protein gustducin and this sets off a signal which includes inositol trisphosphate (IP3), calcium release, and the opening of TRPM5 channels. This

    Sweetness

    Sweetness

    Sweetness

  • KCNK9
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    KCNK9

    KCNK9

    KCNK9

  • TRPV
  • Subgroup of TRP cation channels named after the vanilloid receptor

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    TRPV

    TRPV

    TRPV

  • PLCE1
  • Protein-coding gene in the species Homo sapiens

    [supplied by OMIM] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. Mutations in this gene

    PLCE1

    PLCE1

    PLCE1

  • Aquaporin-2
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Aquaporin-2

    Aquaporin-2

    Aquaporin-2

  • Pacemaker current
  • Electric current in the heart

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Pacemaker current

    Pacemaker_current

  • CACNB3
  • Protein-coding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    CACNB3

    CACNB3

    CACNB3

  • Inositol-tetrakisphosphate 5-kinase
  • liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate

    Inositol-tetrakisphosphate 5-kinase

    Inositol-tetrakisphosphate_5-kinase

  • TRPV4
  • Protein-coding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    TRPV4

    TRPV4

    TRPV4

  • 2-Aminoethoxydiphenyl borate
  • Chemical compound

    inhibition. Diver, J. M.; Sage, S. O.; Rosado, J. A. (2001-11-01). "The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+

    2-Aminoethoxydiphenyl borate

    2-Aminoethoxydiphenyl borate

    2-Aminoethoxydiphenyl_borate

  • Caffeine patch
  • Transdermal patch that releases caffeine into the body

    Apart from blocking adenosine receptors, caffeine also blocks the inositol trisphosphate receptor 1, the ionotropic glycine receptor, and activates ryanodine

    Caffeine patch

    Caffeine_patch

  • Spheroplast
  • Microbe with cell wall mostly removed

     234. ISBN 978-0-470-08766-4. Calvert, C.M.; Sanders, D. (1995). "Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar

    Spheroplast

    Spheroplast

  • Two-pore channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Two-pore channel

    Two-pore_channel

  • Diglyceride
  • Type of fat derived from glycerol and two fatty acids

    enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate diffuses into the cytosol, diacylglycerol remains

    Diglyceride

    Diglyceride

    Diglyceride

  • Alpha-1 adrenergic receptor
  • G protein-coupled receptor

    (PLC), which causes phosphatidylinositol to be transformed into inositol trisphosphate (IP3) and diacylglycerol (DAG). While DAG stays near the membrane

    Alpha-1 adrenergic receptor

    Alpha-1_adrenergic_receptor

  • Kir2.1
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Kir2.1

    Kir2.1

    Kir2.1

  • SCN8A
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    SCN8A

    SCN8A

    SCN8A

  • Ryanodine receptor 1
  • Protein and coding gene in humans

    site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor". The Biochemical Journal. 354 (Pt 2): 413–22. doi:10

    Ryanodine receptor 1

    Ryanodine receptor 1

    Ryanodine_receptor_1

  • Porin (protein)
  • Group of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Porin (protein)

    Porin (protein)

    Porin_(protein)

  • Muscarinic acetylcholine receptor M1
  • Protein-coding gene in the species Homo sapiens

    class Gq that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so

    Muscarinic acetylcholine receptor M1

    Muscarinic acetylcholine receptor M1

    Muscarinic_acetylcholine_receptor_M1

  • Zymolyase
  • Enzyme mixture

    Schizosaccahromyces, Torulopsis Calvert, C.M.; Sanders, D. (1995). "Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar

    Zymolyase

    Zymolyase

  • Ligand-gated ion channel
  • Type of ion channel transmembrane protein

    channel Voltage-dependent calcium channel Receptor (biochemistry) Inositol trisphosphate receptor Metabotropic receptor Ryanodine receptor "Gene Family:

    Ligand-gated ion channel

    Ligand-gated ion channel

    Ligand-gated_ion_channel

  • G protein-coupled inwardly rectifying potassium channel
  • Family of ion channels

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    G protein-coupled inwardly rectifying potassium channel

    G_protein-coupled_inwardly_rectifying_potassium_channel

  • TRPM2
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    TRPM2

    TRPM2

    TRPM2

  • Polycystin 1
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Polycystin 1

    Polycystin 1

    Polycystin_1

  • Voltage-gated potassium channel
  • Class of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Voltage-gated potassium channel

    Voltage-gated potassium channel

    Voltage-gated_potassium_channel

  • Kir6.2
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Kir6.2

    Kir6.2

    Kir6.2

  • CACNG2
  • Protein found in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    CACNG2

    CACNG2

    CACNG2

  • SK channel
  • Protein subfamily of calcium-activated potassium channels

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    SK channel

    SK channel

    SK_channel

  • KiSS1-derived peptide receptor
  • Mammalian protein found in Homo sapiens

    of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell. Kisspeptins are neuropeptides

    KiSS1-derived peptide receptor

    KiSS1-derived peptide receptor

    KiSS1-derived_peptide_receptor

  • Gap junction
  • Cell-cell junction composed of innexins or connexins

    between cells through the transmission of small second messengers, such as inositol triphosphate (IP 3) and calcium (Ca2+ ), although different hemichannel

    Gap junction

    Gap junction

    Gap_junction

  • List of Clarivate Citation laureates in Physiology or Medicine
  • "for research on cell signaling, particularly discovering that inositol trisphosphate acts as a second messenger, linking events at the plasma membrane

    List of Clarivate Citation laureates in Physiology or Medicine

    List_of_Clarivate_Citation_laureates_in_Physiology_or_Medicine

  • GJB1
  • Protein-coding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    GJB1

    GJB1

    GJB1

  • Emodepside
  • Chemical compound

    phospholipases) hydrolyses phosphatidylinositolbisphosphate to yield inositol trisphosphate (IP3) and diacylglycerol (DAG). As IP3 receptors have sparse or

    Emodepside

    Emodepside

    Emodepside

  • Aquaporin-1
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Aquaporin-1

    Aquaporin-1

    Aquaporin-1

  • KCNJ1
  • Protein-coding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    KCNJ1

    KCNJ1

    KCNJ1

  • Intracellular receptor
  • Receptors located inside the cell

    that bind to them are usually intracellular second messengers like inositol trisphosphate (IP3) and extracellular lipophilic hormones like steroid hormones

    Intracellular receptor

    Intracellular_receptor

  • KCNJ4
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    KCNJ4

    KCNJ4

    KCNJ4

  • TRPV1
  • Human protein for regulating body temperature

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    TRPV1

    TRPV1

    TRPV1

  • Ion channel
  • Pore-forming membrane protein

    Qin, An; Zhao, Jie; Zhou, Lu; Yu, Ye (2024-09-26). "Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1". Science. 386 (6723)

    Ion channel

    Ion channel

    Ion_channel

  • CACNA1F
  • Protein encoding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    CACNA1F

    CACNA1F

    CACNA1F

  • KCNH2
  • Mammalian protein found in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    KCNH2

    KCNH2

    KCNH2

  • GJA1
  • Protein-coding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    GJA1

    GJA1

    GJA1

  • Fatty acid metabolism
  • Set of biological processes

    These phospholipids can be cleaved into diacylglycerol (DAG) and inositol trisphosphate (IP3) through hydrolysis of the phospholipid, phosphatidylinositol

    Fatty acid metabolism

    Fatty_acid_metabolism

  • ORAI1
  • Protein-coding gene in the species Homo sapiens

    activation of phospholipase C by various cell surface receptors, inositol trisphosphate is formed that releases calcium from the endoplasmic reticulum.

    ORAI1

    ORAI1

    ORAI1

  • Cation channels of sperm
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Cation channels of sperm

    Cation_channels_of_sperm

  • Babraham Institute
  • Life sciences research institution

    include the discovery of liposomes by Alec Bangham, the role of Inositol trisphosphate in the release of calcium from intracellular stores by Michael Berridge

    Babraham Institute

    Babraham Institute

    Babraham_Institute

  • Voltage-gated sodium channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Voltage-gated sodium channel

    Voltage-gated_sodium_channel

  • TRPC5
  • Protein-coding gene in the species Homo sapiens

    More reference expression data Gene ontology Molecular function inositol 1,4,5 trisphosphate binding ion channel activity store-operated calcium channel activity

    TRPC5

    TRPC5

    TRPC5

  • INPP5A
  • Protein-coding gene in the species Homo sapiens

    Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. The protein encoded by this gene is a membrane-associated

    INPP5A

    INPP5A

    INPP5A

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