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Protein-coding gene in the species Homo sapiens
factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G. IRF9 has been shown to interact with STAT2 and STAT1. ENSG00000285048
IRF9
Chemical process of introducing a phosphate
of a hominin-specific amino acid mutation related to dephosphorylation in IRF9". BMC Ecology and Evolution. 22 (1) 132. doi:10.1186/s12862-022-02088-5.
Phosphorylation
Biochemical process in which a phosphate group is removed from a molecule
may serve as a dephosphorylation site of IRF9. The dephosphorylation may affect the immune activity of IRF9. Phosphorylation Phosphatase Ardito F, Giuliani
Dephosphorylation
ENSG00000140968 IRF Known motif – High-throughput in vitro [433] CGAAACYGAAACY IRF9 ENSG00000213928 IRF Known motif – High-throughput in vitro [434] AWCGAAACCGAAACY
List of human transcription factors
List_of_human_transcription_factors
Family of intracellular transcription factors
(ISG). In type I interferon signaling, STAT1-STAT2 heterodimer combines with IRF9 (Interferon Response Factor) to form ISGF3 (Interferon Stimulated Gene Factor)
STAT_protein
Transcription factor and coding gene in humans
3389/fonc.2023.1180642. PMC 10298177. PMID 37384298. "IRF9 Gene - GeneCards | IRF9 Protein | IRF9 Antibody". GeneCards Human Gene Database. Retrieved 2017-06-01
STAT1
Signaling proteins released by host cells in response to the presence of pathogens
forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds
Interferon
Protein family
hypertrophy, atherosclerosis, and stroke. IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 Interferon Paun A, Pitha PM (2007). "The IRF family, revisited". Biochimie
Interferon_regulatory_factors
Species of bacterium
Eubacteriales Family: Clostridiaceae Genus: Geosporobacter Species: G. ferrireducens Binomial name Geosporobacter ferrireducens Hong et al. 2015 Type strain IRF9
Geosporobacter_ferrireducens
Biological signaling pathway h
indicate that STAT2 requires a protein called interferon regulatory factor 9 (IRF9) to enter the nucleus. Not as much is known about nuclear entrance of other
JAK-STAT_signaling_pathway
HGNC:6121; O14896 7782 IRF7 HGNC:6122; Q92985 7783 IRF8 HGNC:5358; Q02556 7784 IRF9 HGNC:6131; Q00978 7785 IRGC HGNC:28835; Q6NXR0 7786 IRGM HGNC:29597; A1A4Y4
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Transmembrane proteins
STAT SOCS Notes IFN I R IFN-αβεκω IFNAR2 IFNAR1 JAK1, TYK2 Stat1, Stat2 → IRF9 SOCS1 IFNAR1 has two CHRs. IFN II R IFN-γ IFNGR1 IFNGR2 JAK1, JAK2 Stat1
Type_II_cytokine_receptor
Protein-coding gene in Homo sapiens
forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9) and form ISGF-3 (IFN-stimulated gene factor-3), in which this protein acts
STAT2
Heterodimeric receptor
responses to type I IFNs. Conversely, increased expression of STAT1 and IRF9 maintain ISG expression, even in the absence of on-going cytokine receptor
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Protein-coding gene
phosphorylate, dimerize, and attach to interferon regulatory factor 9 (IRF9) to form the interferon-stimulated gene factor 3 (ISGF3) complex. After moving
IFNK
Type II cytokine receptor
recruited and phosphorylated. These two transcription factors then combine with IRF9 to form a complex known as the interferon stimulated gene factor 3 complex
Interferon-lambda_receptor
Mammalian protein found in Homo sapiens
Activator of Transcription (STAT protein); phosphorylated STAT1 and STAT2 bind IRF9 forming a complex named "IFN-Stimulated Gene Factor 3" (ISGF3). This complex
IFNA2
Protein-coding gene in humans
seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (gamma-activation factor) (STAT1:STAT1) complexes
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