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Breast cancer cell line
MCF-7 is a breast cancer cell line. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was
MCF-7
Cancer cell line panel
point in time from cell line OVCAR-8. Originally the cell line was named MCF-7/ADR-RES; it was renamed together with the change in classification. Two
NCI-60
Protein found in humans
receptor positive (ER+) MCF-7 cell line. IRS-1 siRNA is able to reduce IRS-1 transcript level, thereby reducing protein expression in MCF-7 ER+ cells. Reduction
Insulin_receptor_substrate_1
Chemical compound
did not change the expression of estrogen receptor-α, -β, or p-ERK1/2 in MCF-7 cells. In an ovariectomized animal model, the 4HR group showed similar levels
4-Hexylresorcinol
Negative regulation (or limiting) of body weight and cell proliferation
that MCF-7, a breast adenomacarcinoma cell line, did not express the H19 gene; however a subline of MCF-7 with a multidrug resistance phenotype, MCF-7/AdrVp
H19_(gene)
Genus of flowering plants
of F. indica was much more effective than an aqueous extract at causing MCF-7 breast cancer cell death and inhibiting further cell multiplication. As
Fagonia
RNA family
cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells". The Journal of Biological Chemistry. 280 (20): 20086–20093
Let-7_microRNA_family
Species of legume
intestinal worms and possibly diabetes. It is also thought to help fight against MCF-7 Cancer cells. "Senna petersiana (Bolle) Lock". African Plant Database. Conservatoire
Senna_petersiana
Folding of DNA to create two- and three-dimensional shapes at the nanoscale
DNA-Doxorubicin complex was taken up by human breast adenocarcinoma cancer cells (MCF-7) via cellular internalization with much higher efficiency than doxorubicin
DNA_origami
Investigational selective androgen receptor modulator
agonistic effects in AR-expressing human breast cancer cell lines like MCF-7 and MDA-MB-231, and partially agonistic or antagonistic effects in the prostate
Enobosarm
Medication used to treat cancer
that cisplatin and carboplatin cause different morphological changes in MCF-7 cell lines while exerting their cytotoxic behaviour. The diminished reactivity
Carboplatin
assay based on the enhanced proliferation of human breast cancer cells (MCF-7) in the presence of estrogen active substances. The E-SCREEN test is a tool
E-SCREEN
Species of ant
differentiate cancer cell lines (MCF-7) from healthy ones (MCF-10A). They can also distinguish one cell line (MCF-7) from another cancerous one (MDA-MD-231)
Formica_fusca
MCF-7 cancer cells reduced the malignant phenotype (serum-dependent proliferation and anchorage independent growth). 100% of mice injected with MCF-7
IQGAP1
Chemical compound
This compound shows anticancer effects on human breast adenocarcinoma MCF-7 cells. Moreover. a potent anti-inflammatory effect of tricetin has also
Tricetin
British pop/rock band
Archived from the original on 5 July 2008. Retrieved 7 June 2008. "Mcfly official website, The Band". Mcfly.com. Retrieved 29 November 2021.[permanent dead
McFly
Chemotherapy medication
nanoporous optical antenna resulted in significant anti-cancer effect in MCF-7 breast cancer cells. In 2006, animal research coupling a murine monoclonal
Doxorubicin
Peptide fragment of human growth hormone
Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells". Drug Design, Development and Therapy. 16: 1963–1974
HGH_Fragment_176–191
Form of metabolism in tumors
"Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells". Life Sciences. 223: 38–46. doi:10.1016/j.lfs.2019
Warburg_effect_(oncology)
ginger oleoresin loaded mixed micelles enhances in vitro cytotoxicity on MCF-7 cells and in vivo anticancer activity against dal cells". International
List_of_capsaicinoids
Infertility treatment for women
show 89–251% and 41–246% of the affinity of estradiol for the ER in human MCF-7 breast cancer cells, respectively. The ER affinities of the isomers of 4-hydroxyclomifene
Clomifene
Genus of carnivorous flowering plants
anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio". Cell Death Discovery
Drosera
Mammalian protein found in humans
zone in the neural tube and therefore colored red. Protein Ki-67 in human MCF-7 cells Ki-67 protein (red), tubulin (green) and DNA (blue) in HeLa cells
Proliferation marker protein Ki-67
Proliferation_marker_protein_Ki-67
Cancer that originates in mammary glands
BCC lines were established in the late 1970s. A very few of them, namely MCF-7, T-47D, MDA-MB-231, and SK-BR-3, account for more than two-thirds of all
Breast_cancer
Protein-coding gene in the species Homo sapiens
complex and conclusions of published studies often conflict. Exposure of MCF-7 breast cancer cells to high physiological levels (up to 100 nM) of estrogen
Annexin_A1
Enzyme involved in estrogen production
of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice". The Journal of Nutritional Biochemistry. 23 (10): 1230–7. doi:10.1016/j.jnutbio.2011
Aromatase
Proteins activated by the hormone estrogen
estrogen receptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responses". Breast Cancer Research. 7 (1) R101. doi:10.1186/bcr958
Estrogen_receptor
Protein found in humans
"Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells". Proceedings of the National Academy of Sciences
Nuclear receptor coactivator 3
Nuclear_receptor_coactivator_3
Mammalian protein found in humans
caspase-3, creating an increase in apoptosis and tumor growth suppression in MCF-7 cells. GRCh38: Ensembl release 89: ENSG00000085063 – Ensembl, May 2017 GRCm38:
CD59
Chemical compound
the molecular formula C25H25NO6. Epanorin inhibits the proliferation of MCF-7 cancer cells. "Epanorin,18463-10-0 - LookChemical.com". www.lookchemical
Epanorin
Mammalian protein found in Homo sapiens
advanced tumors does not impair tumor progression. Overexpression of c-jun in MCF-7 cells can result in overall increased aggressiveness, as shown by increased
Transcription_factor_Jun
Protein-coding gene in the species Homo sapiens
"Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product". Biochem. Biophys
Trefoil_factor_1
Chemical compound
1200 ppm, genistin caused significant increase of growth of breast tumors (MCF-7), cellular proliferation and estrogen-responsive pS2 gene expression in
Genistin
Protein-coding gene in the species Homo sapiens
TUG-891 reduced the proliferation of MCF-7 and MDA-MB-231 cells. 4) GW9508 increased the motility of FFAR4 knockdown MCF-7 and SK-BR-3 breast cancer cells
Free_fatty_acid_receptor_1
Mammalian protein found in humans
and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells". Biochemistry and Cell Biology. 82 (3): 401–405. doi:10.1139/o04-041
RIG-I
Class of antibiotics
and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells". BMC Cancer. 16 (1) 762. doi:10.1186/s12885-016-2790-3. PMC 5043608
Anthracycline
Back to the Future protagonist
2025-01-02. Retrieved 2025-01-08. "All battle pass skins in Fortnite Chapter 7 Season 1". Polygon. Archived from the original on 25 January 2026. Retrieved
Marty_McFly
Organometallic compound: Fe(II) sandwiched between two cyclopentadienyl rings
line A549, colorectal cancer cell line HCT116, and breast cancer cell line MCF-7. An experimental drug was reported which is a ferrocenyl version of tamoxifen
Ferrocene
Process by which cells are grown under controlled conditions
(adrenocortical cancer) HeLa (cervical cancer) KBM-7 (chronic myelogenous leukemia) LNCaP (prostate cancer) MCF-7 (breast cancer) MDA-MB-468 (breast cancer) PC3
Cell_culture
Species of flowering plant
lines—MDA-MB-231 (a triple-negative type that lacks hormone receptors), MCF-7 (estrogen receptor-positive [ER+], progesterone receptor-positive [PR+]
Taraxacum_mongolicum
Protein-coding gene in the species Homo sapiens
upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells". Mol. Cancer. 3: 15. doi:10.1186/1476-4598-3-15. PMC 420486. PMID 15140260
PLCD4
cell line from an Iraqi patient". Breast Cancer: Targets and Therapy. 2015 (7): 223–230. doi:10.2147/BCTT.S74509. PMC 4536763. PMID 26300657. Lasfargues
List of breast cancer cell lines
List_of_breast_cancer_cell_lines
Hormonal medication used for birth control
that are less androgenic. Levonorgestrel stimulates the proliferation of MCF-7 breast cancer cells in vitro, an action that is independent of the classical
Levonorgestrel
Protein-coding gene in the species Homo sapiens
(June 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–1310. doi:10
Estrogen_receptor_alpha
Nano-scale semiconductor particles
as water-based nanofluids to consider in vitro cytotoxic effects against MCF-7 breast cancer cells". Artificial Cells, Nanomedicine, and Biotechnology
Quantum_dot
Chemotherapy medication
Gewirtz DA (April 1994). "Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells". Molecular Pharmacology. 45 (4): 649–656. doi:10
Daunorubicin
Chemical compound
Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway". Evidence-Based
Pentagalloylglucose
Probe which tests for biological molecules
specificity and selectivity between a QCM and MDA-MB 231 breast cells, MCF 7 cells, and starved MDA-MB 231 cells in vitro. With other researchers she
Biosensor
Elements with atomic numbers 57-70
Abdollahpour, F. (1 January 2010). "Effect of cerium lanthanide on Hela and MCF-7 cancer cell growth in the presence of transferring". Research in Pharmaceutical
Lanthanide
Long chain molecule
2006). "Estrogen-like properties of fluorotelomer alcohols as revealed by mcf-7 breast cancer cell proliferation". Environ. Health Perspect. 114 (1): 100–5
Fluorotelomer_alcohol
Chemical compound
for drug interactions. Dienogest weakly stimulates the proliferation of MCF-7 breast cancer cells in vitro, an action that is independent of the classical
Dienogest
Species of tree
particularly Her2 negative cells (MCF-7 and MDA-MB-231), compared to Her2 positive (SKBR-3) and non-cancerous cells (MCF-10A). This supports its traditional
Flueggea_leucopyrus
Species of flowering plant
of the plant. The methanol extract showed notable activity against the MCF-7 breast cancer cell line (IC50: 19.25 µg/mL after 24 hours), while the water
Silene_latifolia
Chemical compound
IC50Tooltip half-maximal inhibitory concentration of 65 pM for STS inhibition in MCF-7 cells, with an almost complete inhibition of the hydrolysis of physiological
Estrone_sulfamate
Pharmaceutical drug
receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth". Breast Cancer Research and Treatment. 98
Pegvisomant
Species of flowering plant in the pea family
it did not have anti-oxidative activity itself. Human breast carcinoma MCF-7 cells were pretreated with the extract of A. americana for 24 hours. Subsequent
Apios_americana
released by MCF-7 cells to attract the THP-1 monocytes. Other cells and different methods of apoptosis may be able to release LPC, but MCF-7 cells have
Find-me_signals
Family of regulator genes
cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells". The Journal of Biological Chemistry. 280 (20): 20086–20093
Myc
Protein-coding gene in the species Homo sapiens
human breast cancer cells MCF-7. In the latter, high concentrations of calycosin significantly suppressed the proliferation of MCF-7 cells, thereby promoting
RASD1
Chemical compound
Numbers differ per experiment. In colon cancer a LD50 of 50 nM is shown. In MCF-7 derived breast cancer cells an IC50 dose of 10 nM over a long time (exposure
Convallatoxin
"Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells". Life Sciences. 223: 38–46. doi:10.1016/j.lfs.2019
Warburg_effect_inversion
Species of fungus
A549 (human lung adenocarcinoma), A375 (human malignant melanoma), and MCF-7 (human breast cancer). Tolypocladium inflatum has long been of interest
Tolypocladium_inflatum
Family of heat shock proteins
(October 2001). "Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia"
Hsp70
Type of gene used for anticancer
peripheral blood mononuclear cells (PBMC). Jurkat, MCF-7, and L929 overexpressing cells as well as MCF-7 cells overexpressing a dominant-negative mutant
Anticancer_gene
Sotiriou C. (2004). "Gene regulation by phorbol 12-myristate 13-acetate in MCF-7 and MDA-MB-231, two breast cancer cell lines exhibiting highly different
Marc_Lacroix_(biochemist)
Chemical compound
August 2019). "The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and Its Mechanism: An Investigation Using Network Pharmacology-Based
Cordycepin
Chemical compound
several other cytochrome P450 enzymes, in malignant breast tissue; the MCF-7 human breast cancer cell line express messenger RNA for this cytochrome
20-Hydroxyeicosatetraenoic acid
20-Hydroxyeicosatetraenoic_acid
mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor
H1299
Class of ribonucleic acid that is not translated into proteins
as in endocrine diseases such as diabetes mellitus. Specifically in the MCF-7 cell line, addition of 17β-estradiol increased global transcription of the
Non-coding_RNA
Maximum security prison in Minnesota, United States
Minnesota Correctional Facility – Oak Park Heights (MCF-OPH) is Minnesota's only Level Five maximum security prison. The facility is located near the
Oak_Park_Heights_Prison
Design and manufacture of artificial nucleic acid structures
Doxorubicin (DOX) was conjugated with the tetrahedron and was loaded into MCF-7 breast cancer cells that contained the P-glycoprotein drug efflux pump.
DNA_nanotechnology
Protein-coding gene in the species Homo sapiens
methylation states through activation of p38 MAPK and elevation of p53 in MCF-7 breast cancer cells, brazilin leads to the restoration of p21 expression
DNMT1
List of immortalized cell lines overgrown by other, more aggressive cells
(January 2007). "A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian
List of contaminated cell lines
List_of_contaminated_cell_lines
Protein-coding gene in the species Homo sapiens
and four human epithelioid cancer cell lines, A549 lung, PC3 prostate, MCF-7 breast, and HT-29 colon cells, secreted high amounts of succinate into their
SUCNR1
cell lines used to elucidate the role of miR-206 in breast cancer include MCF-7, MDA-MB-231, and MDA-MB-468 cell lines. Single nucleotide polymorphisms
MiR-206
Chemical compound
JC, Habrioux G (1998). "Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids". Cancer Lett. 130 (1–2): 209–16
Tropoflavin
Species of flowering plant
anti-proliferative effect of Chimaphila umbellata in human breast cancer cells (MCF-7). "Pipsissewa" is a Cree name meaning "It-breaks-into-small-pieces". NatureServe
Chimaphila_umbellata
Protein-coding gene in the species Homo sapiens
culture studies showed that the knockdown of FFAR4 levels in cultured human MCF-7, MDA-MB-231, and SKBR3 breast cancer cells slowed their proliferation and
Free_fatty_acid_receptor_4
Class of enzymes
the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells". Biochemical and Biophysical Research Communications
Stearoyl-CoA_9-desaturase
Chemical compound
unrestrained, malignant growth. 13(S)-HODE stimulates the proliferation of human MCF-7 estrogen receptor positive and MBA-MD-231 estrogen receptor negative human
13-Hydroxyoctadecadienoic acid
13-Hydroxyoctadecadienoic_acid
Transcription factor
and 89% of metastatic prostate cancers. In the breast cancer cell line, MCF-7, it was found that FoxA1 was bound to 50% of estrogen receptor binding sites
Pioneer_factor
Genus of algae
Halimeda macroloba have recently been found to exhibit cytotoxicity towards MCF-7 and HT-29 cells, which are derived from human breast cancer cell lines and
Halimeda
Northern Irish_American cancer researcher and academic administrator
Gottesman, M. M.; Dickson, R. B. (October 7, 1992). "Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells". Journal
Robert_Clarke_(academic)
Chemical compound
cultured mouse RAW264.7 macrophages, macrophages differentiated from human monocytes, Huh7 human liver carcinoma cells, human MCF-7 breast cancer cells
Itaconic_acid
Electric current produced in living cells
variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner". BMC Cancer. 16 628. doi:10.1186/s12885-016-2664-8
Developmental_bioelectricity
Chemical compound
affinity for the estrogen receptor (ER) and inhibits the growth of ER-positive MCF-7 breast cancer cells in vitro. However, contradictorily, subsequent research
D-15414
Chemical compound
proliferation of ER-positive cells and ER-negative cells of human breast cancer (MCF-7)". Oncology. 47 (1): 19–24. doi:10.1159/000226779. PMID 2137212. Kubota
Estradiol_dipropionate
Free-floating three-dimensional culture of cells
Claffey KP, White BA (February 2012). "Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs"
3D_cell_culture
Globo-series glycosphingolipid antigen
monoclonal antibody MBr1, Globo H has been isolated from breast cancer cell line MCF-7, and its structure has been determined through several analyses, including
Globo_H
Protein-coding gene in the species Homo sapiens
recombined with other genes. One such gene fusion that has been identified in a MCF-7 breast cancer cell line is a chimera between the RAD51C and ATXN7 genes
RAD51C
Oil bodies of liverworts
liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells". Cancer Letters. 291 (1): 108–119. doi:10.1016/j.canlet
Complex_oil_bodies
Protein-coding gene in the species Homo sapiens
(June 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–1310. doi:10
Major_vault_protein
Protein-coding gene in the species Homo sapiens
normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells". Cancer Research. 61 (19): 7065–7070. PMID 11585737. Yoshida A, Rzhetsky
ALDH1A3
Chen Y, Ziober BL, Tsiftsoglou AS, Kramer RH (2001). "Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin"
Integrin_alpha_7
Chemical compound
pro-death phenotype. In vivo bafilomycin reduced average tumor volume in MCF-7 and MDA-MB-231 xenograft mouse models by 50% and did not show toxic effects
Bafilomycin
State biology research institute, Sarawak, Malaysia
screening of more Aglaia samples which led to compounds that are active against MCF-7 cell line and NCI-60 cell line in 2008. In 2006, the centre started a project
Sarawak_Biodiversity_Centre
Chemical compound
Cell line IC50(nM) NCI-H596 78 MK 56 BT-474 49 SK-BR-3 381 32D/EGFR 300 32D/EGFRvIII 10 MCF-7 2500 MCF-7/EGFRvIII <5000 T24 4526
AEE788
Protein-coding gene in the species Homo sapiens
localization levels in MCF-7 human breast carcinoma cells. For instance, the allele expressing the leucine-198 polymorphism and 7 alanine repeats generates
Glutathione_peroxidase_1
Chemical compound
HL, Fishman J (April 1984). "Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells". J. Biol. Chem. 259 (8): 4840–5. doi:10
Quinalizarin
Chemical compound
therapy (>5 years). Dydrogesterone weakly stimulates the proliferation of MCF-7 breast cancer cells in vitro, an action that is independent of the classical
Dydrogesterone
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