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Protein-coding gene in the species Homo sapiens
Microcephalin (MCPH1) is a gene that is expressed during fetal brain development. Certain mutations in MCPH1, when homozygous, cause primary microcephaly—a
Microcephalin
Book by Gregory Cochran and Henry Harpending
Neanderthal relatives - in this case, microcephalin, an adaptive allele associated with brain development. Microcephalin (MCPH1) regulates brain size, and
The_10,000_Year_Explosion
Human hybridization during the Paleolithic
suggested that a group of alleles collectively known as haplogroup D of microcephalin, a critical regulatory gene for brain volume, originated from an archaic
Interbreeding between archaic and modern humans
Interbreeding_between_archaic_and_modern_humans
Subfamily of mammals
genes ASPM (abnormal spindle-like microcephaly associated) and MCHP1 (microcephalin-1) and their association with the human brain. In this study researchers
Homininae
American geneticist
M, et al. (March 2007). "The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence" (PDF). Human Molecular Genetics
Bruce_Lahn
Condition in which the head is small due to an underdeveloped brain
after microcephalin (MCPH1), based on their role in brain size and primary microcephaly syndromes when mutated. In addition to microcephalin, these include
Microcephaly
Biological evolution of Homo sapiens from 50,000 years ago until present
together, linked to immunity and ultraviolet sensitivity. The gene microcephalin (MCPH1), involved in the development of the brain, likely originated
Recent_human_evolution
Human evolution hypothesis
population, suggesting inheritance from Neanderthals. In the case of the Microcephalin D allele, evidence for rapid recent expansion indicated introgression
Multiregional origin of modern humans
Multiregional_origin_of_modern_humans
Transfer of genetic material from one species to another
and animals, including humans, in which it may have introduced the microcephalin D allele. It has been proposed that, historically, introgression with
Introgression
Overview of animal and human brain evolution
control the size of the human brain as it develops. These genes are Microcephalin (MCPH1) and Abnormal Spindle-like Microcephaly (ASPM). The researchers
Evolution_of_the_brain
Neanderthal fossils
(November 2006). "Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage". Proceedings
Neanderthal_1
Outer layer of the cerebrum of the mammalian brain
disorders such as fragile X syndrome and Rett syndrome. MCPH1 codes for microcephalin, and disorders in this and in ASPM are associated with microcephaly
Cerebral_cortex
Evolution-related timelines
Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens' and 'Microcephalin, a Gene Regulating Brain Size Continues to Evolve Adaptively in Humans"
Evolution of human intelligence
Evolution_of_human_intelligence
Mammalian protein found in humans
likewise shows evidence of a selective sweep in African Americans. Microcephalin GRCh38: Ensembl release 89: ENSG00000066279 – Ensembl, May 2017 GRCm38:
ASPM_(gene)
Medical condition
frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin". Proceedings of the National Academy of Sciences. 104 (26): 10944–49
Amusia
doi:10.1038/ng.193. PMC 2684794. PMID 19165922. Introgression and microcephalin FAQ John Hawks [1] Almos PZ, Horváth S, Czibula A, Raskó I, Sipos B
Genetic_history_of_Europe
Neuroscience theory of human intelligence
studies reviewed, the authors suggest a mediating role of ASPM and microcephalin genes in the relationship between volumes of gray and white matter of
Parieto-frontal integration theory
Parieto-frontal_integration_theory
2006 book by Nicholas Wade
of variation in two genes related to brain development: an allele of microcephalin that appeared about 37,000 years ago and is common in Europeans and
Before_the_Dawn_(Wade_book)
Artificial miniature brain like organ
the disease is thought to be caused by a homozygous mutation in the microcephalin gene. The disease is difficult to reproduce in mouse models because
Cerebral_organoid
Protein-coding gene in the species Homo sapiens
ISSN 0968-0004. PMID 10322433. "WDR5 WD repeat domain 5 [Homo sapiens (human)] - Gene - NCBI". "MCPH1 microcephalin 1 [Homo sapiens (human)] - Gene - NCBI".
WDR53
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MICROCEPHALIN
Girl/Female
Hindu, Indian
More Wish
Boy/Male
Tamil
Victorious
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American, British, English
Lives at the Cattle Enclosure
Boy/Male
Muslim
Guardian of religion
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American, Arabic, Australian, Muslim, Punjabi, Swahili
Rush Boldly in to Danger; Heart; Inner
Surname or Lastname
English
English : habitational name from a place in Derbyshire, so named from the genitive of the Old English personal name Pīl + burh (dative byrig) ‘fortified place’.William Pillsbury (or Pilsbury) came to MA from England as early as 1641, settling first in Dorchester and then in Ipswich. His descendant John Sargent Pillsbury (1828–1901), who made the name famous for flour, was a miller and governor of MN.
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Assamese, Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Tamil, Telugu
Symbol; Shadow; Lord Indra; Symbolic; Proud
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Arabic, Muslim
Wise; Intelligent; Understanding
Boy/Male
Hindu, Indian
Lovely; Good
Girl/Female
Indian
Boat
MICROCEPHALIN
MICROCEPHALIN
MICROCEPHALIN
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MICROCEPHALIN