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Mammalian protein found in humans
ASPM gene. ASPM is located on chromosome 1, band q31 (1q31). The ASPM gene contains 28 exons and codes for a 3477 amino-acid-long protein. The ASPM protein
ASPM_(gene)
Melanesian inhabitants of New Guinea
Microcephaly (ASPM) gene variants, Nitzan Mekel-Bobrov et al. found that the Papuan people have among the highest rate of the newly evolved ASPM Haplogroup D
Indigenous people of New Guinea
Indigenous_people_of_New_Guinea
Topics referred to by the same term
ASPM may refer to: ASPM (gene), a human gene Active State Power Management, a computer power management protocol Aviation System Performance Metrics, an
ASPM
Protein-coding gene in the species Homo sapiens
demonstrated in either this or another similarly studied microcephaly gene, ASPM. However, an association has been established between normal variation
Microcephalin
Condition in which the head is small due to an underdeveloped brain
many genes can cause microcephaly in mice, similar to human microcephaly. Mutations of the abnormal spindle-like microcephaly-associated (ASPM) gene are
Microcephaly
Topic of study
Jerzy; Larionov, Vladimir (23 March 2004). "Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion". PLOS Biology
Brain_size
Chromosomal crossover resulting in gene duplication or deletion
PMC 1460548. PMID 10101175. Zhang, J. (2003). "Evolution of the human ASPM gene, a major determinant of brain size". Genetics. 165 (4): 2063–2070. doi:10
Unequal_crossing_over
Book by Gregory Cochran and Henry Harpending
(April 2007). "No evidence that polymorphisms of brain regulator genes Microcephalin and ASPM are associated with general mental ability, head circumference
The_10,000_Year_Explosion
study of ASPM gene variants, found that the Israeli Druze people of the Carmel region have among the highest rate of the newly evolved ASPM haplogroup
Genetic history of the Middle East
Genetic_history_of_the_Middle_East
Human chromosome
protein 4B ARV1 encoding protein ARV1 homolog (S. cerevisiae) ARNT (1q21) ASPM (1q31): a brain size determinant ATF3 (1q32) ATP2B4 (1q32) BCL9 (1q21) CATSPERE:
Chromosome_1
known for research on the adaptive evolution of the human brain-size gene ASPM, published in Science in 2005. Since 2021, he has served as Chief AI Officer
Nitzan_Mekel-Bobrov
Region of Indonesia
New Guinea's ASPM gene variants, Mekel-Bobrov et al. found that the Papuan people have among the highest rate of the newly evolved ASPM haplogroup D,
Western_New_Guinea
Overview of animal and human brain evolution
the human brain as it develops. These genes are Microcephalin (MCPH1) and Abnormal Spindle-like Microcephaly (ASPM). The researchers at the University of
Evolution_of_the_brain
American geneticist
as among humanity's great assets. Later studies did not find the ASPM and MCPH1 gene variants identified by Lahn to be associated with mental ability
Bruce_Lahn
Enzyme found in humans
N-terminal and C-terminal regions of ASPM within mitotic cells to either spindle poles or to midbodies, respectively. Since, ASPM co-localizes with Citron-K at
Citron_kinase
insertion/deletion entirely inside one gene D – Deletion of a gene or genes Dup - Duplication of a gene or genes C – Whole chromosome extra, missing, or
List_of_genetic_disorders
Biological evolution of Homo sapiens from 50,000 years ago until present
(April 2007). "No evidence that polymorphisms of brain regulator genes Microcephalin and ASPM are associated with general mental ability, head circumference
Recent_human_evolution
Subfamily of mammals
evolution of the brain size within the sub family Homininae that tested the genes ASPM (abnormal spindle-like microcephaly associated) and MCHP1 (microcephalin-1)
Homininae
"Statistics & download files". www.genenames.org. HUGO Gene Nomenclature Committee. 3 November 2025. Retrieved 3 November 2025.
List of human protein-coding genes 1
List_of_human_protein-coding_genes_1
(2006). "Analysis of Oncogenic Signaling Networks in Glioblastoma Identifies ASPM as a Novel Molecular Target". PNAS. 103 (46): 17402–17407. Bibcode:2006PNAS
Weighted correlation network analysis
Weighted_correlation_network_analysis
German–American aging researcher, geneticist and biostatistician
(2006). "Analysis of Oncogenic Signaling Networks in Glioblastoma Identifies ASPM as a Novel Molecular Target". PNAS. 103 (46): 17402–17407. Bibcode:2006PNAS
Steve_Horvath
R.R., Tishkoff, S.A., Lahn, B.T. (2009), Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens, Science, Vol. 209 pp. 1720–1722
Adaptive evolution in the human genome
Adaptive_evolution_in_the_human_genome
Outer layer of the cerebrum of the mammalian brain
microcephalin, and disorders in this and in ASPM are associated with microcephaly. Mutations in the gene NBS1 that codes for nibrin can cause Nijmegen
Cerebral_cortex
Part of the study of the genome
positive selection is generally the next step. For example, ASPM, CDK5RAP2 and NIN are genes that are positively selected for on the human lineage and have
Neurogenomics
Neuroscience theory of human intelligence
genomic studies reviewed, the authors suggest a mediating role of ASPM and microcephalin genes in the relationship between volumes of gray and white matter
Parieto-frontal integration theory
Parieto-frontal_integration_theory
Evolution-related timelines
"Comment on 'Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens' and 'Microcephalin, a Gene Regulating Brain Size Continues to Evolve
Evolution of human intelligence
Evolution_of_human_intelligence
Han Chinese ethnic subgroup
Kay H. Y.; So, Hon-Cheong; Choy, Kwong Wai; Geng, Xiujuan (May 2020). "ASPM-lexical tone association in speakers of a tone language: Direct evidence
Cantonese_people
Medical condition
the population frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin". Proceedings of the National Academy of Sciences.
Amusia
Municipal airport in Dallas, Texas, United States
com. Retrieved March 16, 2026. "Air Traffic Activity System (ATADS)". www.aspm.faa.gov. Retrieved October 17, 2025. "DAL airport data at skyvector.com"
Dallas_Love_Field
Ethnoreligious group of the Levant
genetic isolate in the predominantly Islamic world. In a 2005 study of ASPM gene variants, Mekel-Bobrov et al. found that the Israeli Druze people of the
Druze
Protein domain
crystallography. Human genes encoding calponin homology domain-containing proteins include: ACTN1, ACTN2, ACTN3, ACTN4, ARHGEF6, ARHGEF7, ASPM, CLMN, CNN1, CNN2
Calponin_homology_domain
2006 book by Nicholas Wade
Europeans and East Asians, but rare in sub-Saharan Africans; and an allele of ASPM that appeared about 6,000 years ago and is common in Europeans, Middle Easterners
Before_the_Dawn_(Wade_book)
travel, tourism, insurance
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