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Protein-coding gene in the species Homo sapiens
The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein
Nociceptin_receptor
Neuropeptide chemical compound
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin acts as a
Nociceptin
Chemical compound
the nociceptin receptor, also known as the ORL-1 receptor. It is several hundred times selective for the ORL-1 receptor over other opioid receptors, and
J-113,397
Opioid analgesic
R6890 is described as a nociceptin receptor (NOP) agonist, although R6890 retains significant affinity at the mu opioid receptor in an animal model. R6890
R6890
Nociceptin receptor agonist
activating opioid receptors. However, instead of acting at the mu, kappa and delta receptors, it is instead an agonist at the nociceptin receptor. Ro65-6570
Ro65-6570
Group of biological receptors
receptor was later identified and cloned based on homology with the cDNA. This receptor is known as the nociceptin receptor or ORL1 (opiate receptor-like
Opioid_receptor
Opioid used to treat pain and opioid use disorder
(December 2009). "Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists".
Buprenorphine
Chemical compound
selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. This was the fourth opioid receptor to be discovered and is still
JTC-801
have low affinity for the mu opioid receptor and instead act as ligands for the non-psychoactive nociceptin receptor. List of benzimidazole opioids List
Orphine
Opioid analgesic drug
opioid receptor agonist, including as a dual μ-opioid receptor and nociceptin receptor full agonist and to a lesser extent as a κ-opioid receptor partial
Cebranopadol
Investigational substance-related disorder drugs
receptor agonist, δ-opioid receptor agonist, κ-opioid receptor antagonist, nociceptin receptor agonist – opioid-related disorders Buprenorphine/naloxone
List of investigational substance-related disorder drugs
List_of_investigational_substance-related_disorder_drugs
Semi-synthetic opioid
non-selective full agonist of the μ-, δ-, and κ-opioid receptors. It has a weak affinity for the nociceptin receptor. In Hong Kong, etorphine is regulated under
Etorphine
Chemical compound
as an agonist at both the μ-opioid receptor and the nociceptin receptor. The interaction with the nociceptin receptor is expected to block the abuse and
AT-121
Chemical compound
for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor, with over 100x selectivity over the other opioid receptors. It produces
Ro64-6198
Nociceptin receptor agonist
through delta, mu, and kappa opioid receptors; however, SCH-221510 is instead an agonist at the nociceptin receptor. Classical opioid analgesics (such
SCH-221510
Receptor antagonist that acts on one or more of the opioid receptors
Norbinaltorphimine is a selective KOR antagonist J-113,397 is a selective nociceptin receptor (NOP) antagonist Other selective antagonists are also known, but
Opioid_antagonist
Chemical compound
(developmental code names V117957; IMB-115) is a high affinity small molecule nociceptin receptor partial agonist. As of February 2024, it is under clinical investigation
Sunobinop
Chemical compound
SB-612,111 is an opioid receptor ligand which is a potent and selective antagonist for the nociceptin receptor (ORL-1), several times more potent than
SB-612,111
Chemical compound
and δ-opioid receptor (Ki = 19.6 nM) and as a noncompetitive antagonist of the κ-opioid receptor (Ki = 1.14 nM) and nociceptin receptor (NOP, Ki = 1.75
AT-076
Chemical compound
as an extremely potent partial agonist at both the μ-opioid receptor and nociceptin receptor. It is a homologue of buprenorphine extended by just one carbon
BU08028
Drug
which acts as a potent partial agonist at both the μ-opioid receptor and nociceptin receptor. In animal studies it was found to be a potent analgesic, with
SR-16435
Chemical compound
nociceptin receptor, with a pKi of 10.07 and much weaker activity at other opioid receptors. It has only moderate affinity for the mu opioid receptor
MCOPPB
Abnormally increased sensitivity to pain
with one major pathway being through stimulation of the nociceptin receptor. Blocking this receptor may therefore be a means of preventing the development
Hyperalgesia
Opioid analgesic drug
the μ-opioid receptor (MOR), but is also an agonist of the δ-opioid receptor (DOR), κ-opioid receptor (KOR), and the nociceptin receptor (NOP), as well
Levorphanol
Active metabolite of buprenorphine
buprenorphine. It is a μ-opioid, δ-opioid, and nociceptin receptor full agonist, and a κ-opioid receptor partial agonist. In rats, unlike buprenorphine
Norbuprenorphine
Pharmaceutical compound
taken orally. The drug acts as a dual agonist of the μ-opioid receptor and nociceptin receptor. It is thought that the combination of these activities may
Lexanopadol
Nociceptin receptor agonist
to act through delta, kappa and mu opioid receptors, but instead is an agonist of the nociceptin receptor. A study has shown that MT-7716 was able to
MT-7716
Chemical compound
selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor-like 1) receptor. The function of this receptor is not well understood
NNC_63-0532
Protein-coding gene in the species Homo sapiens, named for ketazocine
indication but were ultimately never marketed. δ-opioid receptor μ-opioid receptor Nociceptin receptor GPR139 GRCh38: Ensembl release 89: ENSG00000082556 –
Κ-opioid_receptor
Combination drug formulation
antagonist of the δ-opioid receptor (DOR) and weak partial agonist of the nociceptin receptor (NOP); and (2) samidorphan, a preferential antagonist of the MOR
Buprenorphine/samidorphan
Topics referred to by the same term
3-Nitrooxypropanol, an enzyme inhibitor Nociceptin receptor, a neurotransmitter receptor in the opioid receptor family Croatian Partisans (Narodnooslobodilački
NOP
Pharmaceutical compound
an agonist at the nociceptin receptor with only slightly lower potency. It has substantially weaker activity at the mu opioid receptor, at which it is a
SR-14136
Investigational insomnia drugs
JNJ-7922; MIN-202) – orexin OX2 receptor antagonist Sunobinop (IMB-115; IT-1315; RSC117957; S-117957; V-117957) – nociceptin receptor agonist Trazodone extended-release
List of investigational insomnia drugs
List_of_investigational_insomnia_drugs
Nociceptin receptor antagonist
BTRX-246040, also known as LY-2940094, is a potent and selective nociceptin receptor antagonist which is under development by BlackThorn Therapeutics
BTRX-246040
Family of proteins
Opioid receptor InterPro: IPR001418 delta Opioid receptor (OPRD1, OPRD) kappa Opioid receptor (OPRK1, OPRK) mu Opioid receptor (OPRM1, OPRM) Nociceptin receptor
Rhodopsin-like_receptors
Dissociative hallucinogenic drug, mostly used recreationally
member of the arylcyclohexylamine class. PCP works primarily as an NMDA receptor antagonist. PCP is most commonly used in the US. While usage peaked in
Phencyclidine
Chemical compound
and as an antagonist of the δ-opioid receptor. It also possesses relatively low affinity for the nociceptin receptor (Ki = 36.5 nM), where it acts as an
Thienorphine
Sensory neuron that detects pain
portal Capsaicin and its mechanism of action in nociceptors Nociceptin and nociceptin receptor Piperine from black pepper TRPC ion channel "NOI - Neuro Orthopaedic
Nociceptor
– non-selective μ-opioid receptor, nociceptin receptor, and δ-opioid receptor full agonist and κ-opioid receptor partial agonist Desmetramadol (O-desmethyltramadol;
List of investigational analgesics
List_of_investigational_analgesics
Medication used to treat ADHD
88 nM for the KOR, 1,490 nM for the δ-opioid receptor (DOR), and >5,000 nM for the nociceptin receptor (ORL-1). Atomoxetine itself showed dramatically
Atomoxetine
Sensation and perception of temperature
is usually irrelevant to the functioning of a thermoceptor. Transient receptor potential channels (TRP channels) are believed to play a role in many species
Thermoception
Class of peptides that bind to opioid receptors
1983. The PNOC gene encoding prepronociceptin, which is cleaved into nociceptin and potentially two additional neuropeptides. Adrenorphin, amidorphin
Opioid_peptide
Opioid analgesic
potent agonist of all three of the opioid receptors, μ, κ (κ1 and κ3 but notably not κ2), and δ, as an NMDA receptor antagonist, and as a serotonin-norepinephrine
Levomethorphan
Opioid receptor antagonist
μ-opioid receptor (MOR), then the δ-opioid receptor (DOR), and lowest for the κ-opioid receptor (KOR); naloxone has negligible affinity for the nociceptin receptor
Naloxone
Drugs that lower neurotransmission levels, reducing brain activity
related nociceptin receptor 1 Calo', Girolamo; Guerrini, Remo; Rizzi, Anna; Salvadori, Severo; Regoli, Domenico (April 2000). "Pharmacology of nociceptin and
Depressant
Chemical compound
"High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor". Journal of Medicinal Chemistry. 43 (7): 1329–1338. doi:10.1021/jm991129q
Spirodecanone
Pentapeptide
κ-opioid receptor), endorphins (MOR), endomorphins, and nociceptin-orphanin FQ. The opioid receptors are ~40% identical to somatostatin receptors (SSTRs)
Enkephalin
Class of G protein-coupled receptors
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline)
Adrenergic_receptor
Class of opioid receptors found in humans
The μ-opioid receptors (using the Greek letter mu, abbreviated MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin
Mu-opioid_receptor
Investigational fibromyalgia drugs
[23] Sunobinop (IMB-115; IT-1315; RSC-117957; S-117957; V-117957) – nociceptin receptor agonist [24] AD-337 – serotonin–norepinephrine reuptake inhibitor
List of investigational fibromyalgia drugs
List_of_investigational_fibromyalgia_drugs
Chemical compound
μ-opioid receptor (Ki = 4.9 (± 2.7) pM), δ-opioid receptor (Ki = 270 nM), and nociceptin receptor (Ki = 36 μM), but not for the κ-opioid receptor. Whether
Buprenorphine-3-glucuronide
InterPro Family
& HCA3 Opioid δ, κ, μ, & nociceptin receptors Prostaglandin EP1, EP3, FP, & TP receptors Short chain fatty acid receptors: FFAR2 & FFAR3 Somatostatin
Gi_alpha_subunit
Subtype of serotonin receptor
5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR)
5-HT2A_receptor
List of pharmaceutical drugs under clinical development for treatment of depression
(LY-2940094) – nociceptin receptor antagonist Buprenorphine/samidorphan (ALKS-5461) – μ-opioid receptor partial agonist, κ-opioid receptor antagonist, δ-opioid
List of investigational antidepressants
List_of_investigational_antidepressants
Investigational Parkinson's disease drugs
nociceptin receptor (NOP) antagonist [161] Cannabidiol/tetrahydrocannabinol (CBD/THC; CanChew; MedChew; THC/CBD) – cannabinoid CB1 and CB2 receptor agonist
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Comprehensive list of compounds structurally related to fentanyl
piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor". Journal of Medicinal Chemistry. 47 (12): 2973–6. doi:10.1021/jm034249d
List_of_fentanyl_analogues
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G
G_protein-coupled_receptor
Chemical compound
site on the MOR. It is not a PAM of the nociceptin receptor, which is less homologous to the other opioid receptors. The drug was first described by 2015
BMS-986187
Type of nicotinic acetylcholine receptor
Systems. Retrieved 3 December 2017. Zaveri, NT (2011). "The nociceptin/orphanin FQ receptor (NOP) as a target for drug abuse medications". Current Topics
Alpha-3 beta-4 nicotinic receptor
Alpha-3_beta-4_nicotinic_receptor
Chemical substance that enables neurotransmission
Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon terminal Synaptic cleft Dendrite A neurotransmitter
Neurotransmitter
Serotonin receptor protein distributed in the cerebrum and raphe nucleus
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter
5-HT1A_receptor
Integral membrane protein
An acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine,
Acetylcholine_receptor
G protein-coupled receptor
The alpha-1 (α1) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G protein. It consists
Alpha-1_adrenergic_receptor
Dissociative drug
of ketamine. MXE is an arylcyclohexylamine. It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP
Methoxetamine
Molecular biologist
G protein-coupled receptors, neuropeptides, orphan receptors, novel neurotransmitters, dopamine receptors, orphanin FQ/nociceptin, MCH, and traditional
Olivier_Civelli
Acetylcholine receptors named for their selective binding of muscarine
Muscarinic acetylcholine receptors (mAChRs) are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain
Muscarinic acetylcholine receptor
Muscarinic_acetylcholine_receptor
Mammalian protein found in humans
Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. It was discovered by determination
Cannabinoid_receptor_1
Class of transmembrane proteins
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in
5-HT_receptor
Class of G protein-coupled receptors
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate
Dopamine_receptor
Main receptor for most antipsychotic drugs
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested
Dopamine_receptor_D2
Receptors that respond to gamma-aminobutyric acid
of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled
GABA_receptor
Chemoreceptors expressed in cell membranes of olfactory receptor neurons
Olfactory receptors (ORs), also known as odorant receptors, are chemoreceptors expressed in the cell membranes of olfactory receptor neurons and are responsible
Olfactory_receptor
Atypical opioid drug
an atypical opioid receptor modulator with unusual actions and effects. It acts as a biased partial agonist of the μ-opioid receptor (MOR), showing strong
SR-17018
Protein family
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. It consists
Alpha-2_adrenergic_receptor
Protein-coding gene in the species Homo sapiens
receptor (β1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors.
Beta-1_adrenergic_receptor
Chemical compound
affinity for the κ-opioid receptor (Ki = 300 nM) and the nociceptin receptor (Ki = 18 μM), but not for the μ- or δ-opioid receptors. Whether N3G acts as an
Norbuprenorphine-3-glucuronide
Norbuprenorphine-3-glucuronide
Chemical compound
(MOR) and δ-opioid receptors (DOR), along with many non-opioid receptors. However, it shows modest affinity for the nociceptin receptor (NOP). In one study
JDTic
Mammalian protein found in humans
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline)
Beta-2_adrenergic_receptor
Class of analgesic drug
other than the three classic opioid receptors, including the nociceptin receptor, sigma receptor and Toll-like receptor 4, and can be counteracted in animal
Opioid
G-protein coupled receptor
GABAB receptors (GABABR) are G-protein coupled receptors for gamma-aminobutyric acid (GABA). GABAB receptors are found in the central nervous system and
GABAB_receptor
G-protein-coupled receptor
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants
Orexin_receptor
Receptor activated by peptide hormone GLP-1
The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It
Glucagon-like peptide-1 receptor
Glucagon-like_peptide-1_receptor
Pharmaceutical compound
nM and an Emax of 93.0 ± 2.0 per cent. It showed no affinity for nociceptin receptors. Vu LY, Luo D, Johnson K, Denehy ED, Songrady JC, Martin J, et al
Atoxifent
Mammalian protein found in humans
in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder". Psychiatric Genetics. 17
Metabotropic glutamate receptor 8
Metabotropic_glutamate_receptor_8
Protein controlling mammalian coloration
melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a
Melanocortin_1_receptor
Chemical compound
"High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor". Journal of Medicinal Chemistry. 43 (7): 1329–1338. doi:10.1021/jm991129q
6-CAT
Protein found in humans
Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene. TAAR1 is a
TAAR1
Class of ligand activated receptors localized in surface of plama cell membrane
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell
Cell_surface_receptor
Type of cellular receptor that facilitates taste
A taste receptor is a type of cellular receptor that facilitates the sensation of taste. When food or other substances enter the mouth, molecules interact
Taste_receptor
Species of plant
mitragynine and to a lesser extent, 7-hydroxymitragynine) that bind to opioid receptors, mostly as partial μ-opioid agonists. Kratom can also be subjectively
Mitragyna_speciosa
Pharmaceutical compound
The drug is a non-competitive partial biased agonist of the μ-opioid receptor (MOR) similarly to SR-17018. It has similar effects in animals as SR-17018
SR-15099
Opioid analgesic
2000). "Study on mechanism of interaction of nociceptin and opioids binding with opioid receptor-like 1 receptor". Acta Pharmacologica Sinica. 21 (6): 536–46
Lofentanil
Type of protein
A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside
Neurotransmitter_receptor
Group of receptors to cannabinoid compounds
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system of vertebrates– a class of cell membrane receptors in the G protein-coupled
Cannabinoid_receptor
Class of four receptor proteins to the molecule adenosine
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand. There are four
Adenosine_receptor
Subtype of Dopamine Receptor
Dopamine receptor D3 (DRD3) is a protein belonging to the dopamine receptor family of G protein-coupled receptors. In humans, it is encoded by the DRD3
Dopamine_receptor_D3
G protein-coupled receptor
G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified into the V1 (V1A), V2, and V3 (V1B) receptor subtypes. These three
Vasopressin_receptor
Protein-coding gene in the species Homo sapiens
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the
Tachykinin_receptor_1
Pharmaceutical compound
compounds combining opioid activity with activity at receptors for neuropeptides such as nociceptin, neurokinin, neurotensin and neuropeptide FF, which
KGOP01
Protein-coding gene in the species Homo sapiens
Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for vasopressin
Vasopressin_receptor_1A
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NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
NOCICEPTIN RECEPTOR
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