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MEF2

  • Mef2

    • Protein family

    organisms, Mef2 proteins mediate the stress response in some tissues. Mef2 proteins contain both MADS-box and Mef2 DNA-binding domains. Mef2 was originally

    Mef2

    Mef2

    Mef2

  • MEF2B

    • Protein-coding gene in humans

    factor part of the MEF2 gene family including MEF2A, MEF2C, and MEF2D. However, MEF2B is distant from the other three branches of MEF2 genes as it lacks

    MEF2B

    MEF2B

    MEF2B

  • MEF2C

    • Protein-coding gene in the species Homo sapiens

    humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family. The gene is located at 5q14.3 on the minus (Crick) strand and is

    MEF2C

    MEF2C

    MEF2C

  • Myocyte-specific enhancer factor 2A

    • Protein-coding gene in the species Homo sapiens

    humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in

    Myocyte-specific enhancer factor 2A

    Myocyte-specific enhancer factor 2A

    Myocyte-specific_enhancer_factor_2A

  • Sphingolipid

    • Family of chemical compounds

    Fxn in the nervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mechanism is evolutionarily conserved. Furthermore

    Sphingolipid

    Sphingolipid

    Sphingolipid

  • MEF2D

    • Protein-coding gene in humans

    Myocyte-specific enhancer factor 2A, NFATC2 Sp1 transcription factor, and YWHAQ. Mef2 GRCh38: Ensembl release 89: ENSG00000116604 – Ensembl, May 2017 GRCm38: Ensembl

    MEF2D

    MEF2D

    MEF2D

  • AMP-activated protein kinase

    • Class of enzymes

    enhancer factor 2 (MEF2), host cell factor (HCF), and others. It also has a positive feedback loop, enhancing its own expression. Both MEF2 and cAMP response

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • Histone acetylation and deacetylation

    • Biological processes used in gene regulation

    (CtBP), myocyte enhancer factor 2 (MEF2) and 14-3-3. All three HDACs work to repress the myogenic transcription factor MEF2 which an essential role in muscle

    Histone acetylation and deacetylation

    Histone acetylation and deacetylation

    Histone_acetylation_and_deacetylation

  • DIPK2A

    • Protein-coding gene in the species Homo sapiens

    model suggested that this gene may be regulated directly or indirectly by MEF2 site binding proteins. Heritability of autism GRCh38: Ensembl release 89:

    DIPK2A

    DIPK2A

    DIPK2A

  • P38 mitogen-activated protein kinases

    • Protein family

    MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac, MEF2, and p53. p38 also has been shown to phosphorylate post-transcriptional regulating

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • Skeletal muscle

    • One of three major types of muscle

    slow-type muscle proteins in cooperation with myocyte enhancer factor 2 (MEF2) proteins and other regulatory proteins. Ca2+/calmodulin-dependent protein

    Skeletal muscle

    Skeletal muscle

    Skeletal_muscle

  • Transcription factor

    • Protein that regulates the rate of DNA transcription

    abundant resident nuclear transcription factors. Examples include: CREB, AP-1, Mef2 II.B.3.b Latent cytoplasmic factors – residing in the cytoplasm when inactive

    Transcription factor

    Transcription factor

    Transcription_factor

  • Corticosteroid receptor

    • family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Corticosteroid receptor

    Corticosteroid receptor

    Corticosteroid_receptor

  • HDAC9

    • Protein-coding gene in the species Homo sapiens

    MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that

    HDAC9

    HDAC9

    HDAC9

  • Activity-regulated cytoskeleton-associated protein

    • Protein-coding gene in the species Homo sapiens

    AMP response element-binding protein (CREB), myocyte enhancer factor 2 (MEF2), and SRF. The 3' UTR of the mRNA contains a cis-acting element required

    Activity-regulated cytoskeleton-associated protein

    Activity-regulated cytoskeleton-associated protein

    Activity-regulated_cytoskeleton-associated_protein

  • P53

    • Mammalian protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    P53

    P53

    P53

  • MADS-box

    • Protein family

    MCM1) domain. MEF2-like MADS-domain proteins in animals and fungi have the MEF2 domain as a second conserved domain. In plants, the MEF2-like MADS-domain

    MADS-box

    MADS-box

  • GSX1

    • family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    GSX1

    GSX1

    GSX1

  • Histone deacetylase 5

    • Enzyme found in humans

    It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated

    Histone deacetylase 5

    Histone deacetylase 5

    Histone_deacetylase_5

  • CABIN1

    • Protein-coding gene in the species Homo sapiens

    factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067. Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent

    CABIN1

    CABIN1

    CABIN1

  • Octamer transcription factor

    • Group of proteins

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Octamer transcription factor

    Octamer_transcription_factor

  • Myostatin

    • Mammalian and avian protein

    This process includes mitogen-activated protein kinases and binding of the MEF2 transcription factor within the promoter region of the myostatin gene. Increases

    Myostatin

    Myostatin

    Myostatin

  • Basic helix–loop–helix

    • Protein structural motif

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Basic helix–loop–helix

    Basic helix–loop–helix

    Basic_helix–loop–helix

  • Peroxisome proliferator-activated receptor gamma

    • Nuclear receptor protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Peroxisome proliferator-activated receptor gamma

    Peroxisome proliferator-activated receptor gamma

    Peroxisome_proliferator-activated_receptor_gamma

  • AP-1 transcription factor

    • Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    AP-1 transcription factor

    AP-1 transcription factor

    AP-1_transcription_factor

  • Myc

    • Family of regulator genes

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Myc

    Myc

  • NF-κB

    • Family of transcription factor protein complexes

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    NF-κB

    NF-κB

    NF-κB

  • NFX1

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    NFX1

    NFX1

    NFX1

  • N2a cell

    • N2a cells, leading to differentiation. It also increases the activity of MEF2, mainly MEF2C, in N2a cells. α-lipoic acid (LA) mainly causes N2a differentiation

    N2a cell

    N2a_cell

  • Β-Hydroxy β-methylbutyric acid

    • Chemical compound

    factors (e.g., myoD and myogenin) and gene transcription factors (e.g., MEF2). HMB-induced human myosatellite cell proliferation in vitro is mediated

    Β-Hydroxy β-methylbutyric acid

    Β-Hydroxy β-methylbutyric acid

    Β-Hydroxy_β-methylbutyric_acid

  • Oct-4

    • Mammalian protein found in Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Oct-4

    Oct-4

    Oct-4

  • MYF6

    • Protein-coding gene in the species Homo sapiens

    2016). "MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity". Nature Communications. 7 12397. Bibcode:2016NatCo...712397M. doi:10

    MYF6

    MYF6

    MYF6

  • DTX2

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    DTX2

    DTX2

    DTX2

  • Vitamin D receptor

    • Transcription factor activated by vitamin D

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Vitamin D receptor

    Vitamin D receptor

    Vitamin_D_receptor

  • MYB (gene)

    • Protein-coding gene in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    MYB (gene)

    MYB (gene)

    MYB_(gene)

  • SOX3

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    SOX3

    SOX3

    SOX3

  • PAX7

    • Paired box transcription factor protein

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    PAX7

    PAX7

    PAX7

  • Progesterone receptor

    • Cytoplasmic receptor protein found inside cells

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Progesterone receptor

    Progesterone receptor

    Progesterone_receptor

  • MEF

    • Topics referred to by the same term

    embryonic fibroblast Museo Paleontológico Egidio Feruglio collection code Mef2 (myocyte enhancer factor-2), a family of gene transcription factors Multiscale

    MEF

    MEF

  • EGR1

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    EGR1

    EGR1

    EGR1

  • SOX9

    • Transcription factor gene of the SOX family

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    SOX9

    SOX9

    SOX9

  • Transcription factor Jun

    • Mammalian protein found in Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Transcription factor Jun

    Transcription factor Jun

    Transcription_factor_Jun

  • Cyclin D/Cdk4

    • Multi-protein structure

    can also directly block the association of MEF2 with GRIP-1, a transcription co-activator, which inhibits MEF2’s ability to induce muscle gene expression

    Cyclin D/Cdk4

    Cyclin_D/Cdk4

  • WRKY transcription factor

    • Proteins that bind DNA

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    WRKY transcription factor

    WRKY_transcription_factor

  • CTCF

    • Transcription factor

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    CTCF

    CTCF

    CTCF

  • SMAD2

    • Protein found in humans

    McDermott JC (February 2001). "Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins". Nucleic Acids Res. 29 (3): 732–42.

    SMAD2

    SMAD2

    SMAD2

  • MLLT1

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    MLLT1

    MLLT1

    MLLT1

  • MXD4

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    MXD4

    MXD4

    MXD4

  • OLIG2

    • Protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    OLIG2

    OLIG2

    OLIG2

  • HOXD3

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    HOXD3

    HOXD3

    HOXD3

  • NFYB

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    NFYB

    NFYB

    NFYB

  • Zinc finger protein ZPR1

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Zinc finger protein ZPR1

    Zinc finger protein ZPR1

    Zinc_finger_protein_ZPR1

  • Farnesoid X receptor

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Farnesoid X receptor

    Farnesoid X receptor

    Farnesoid_X_receptor

  • Peroxisome proliferator-activated receptor delta

    • Nuclear receptor protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Peroxisome proliferator-activated receptor delta

    Peroxisome proliferator-activated receptor delta

    Peroxisome_proliferator-activated_receptor_delta

  • Factor in the germline alpha

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Factor in the germline alpha

    Factor in the germline alpha

    Factor_in_the_germline_alpha

  • NFE2L3

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    NFE2L3

    NFE2L3

    NFE2L3

  • Heritability of autism

    • CNTN3, SCN7A, and RNF8. Several of these genes appeared to be targets of MEF2, one of the transcription factors known to be regulated by neuronal activity

    Heritability of autism

    Heritability of autism

    Heritability_of_autism

  • TFAP2C

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    TFAP2C

    TFAP2C

    TFAP2C

  • CCAAT/enhancer binding protein zeta

    • Protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    CCAAT/enhancer binding protein zeta

    CCAAT/enhancer binding protein zeta

    CCAAT/enhancer_binding_protein_zeta

  • PPP3CC

    • Protein-coding gene in the species Homo sapiens

    et al. (2001). "Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in

    PPP3CC

    PPP3CC

    PPP3CC

  • IFI16

    • Protein-coding gene in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    IFI16

    IFI16

    IFI16

  • HOXD10

    • Protein-coding gene in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    HOXD10

    HOXD10

    HOXD10

  • CNBP

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    CNBP

    CNBP

    CNBP

  • PAX1

    • Protein-coding gene in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    PAX1

    PAX1

    PAX1

  • ATOH1

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    ATOH1

    ATOH1

    ATOH1

  • FOXG1

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    FOXG1

    FOXG1

    FOXG1

  • STAT1

    • Transcription factor and coding gene in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    STAT1

    STAT1

    STAT1

  • Pituitary-specific positive transcription factor 1

    • Protein that controls rate of transcription of GH genes

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Pituitary-specific positive transcription factor 1

    Pituitary-specific positive transcription factor 1

    Pituitary-specific_positive_transcription_factor_1

  • NFKB2

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    NFKB2

    NFKB2

    NFKB2

  • Calcineurin

    • Class of enzymes

    of histone deacetylase 4 (HDAC) by calcineurin leads to regulation of the Mef2 transcription factor, which mediates transition of fast muscle fibers to

    Calcineurin

    Calcineurin

    Calcineurin

  • Gia (protein)

    • outflow. Genes important for cardiac development in Drosophila include NK2, MEF2, GATA, Tbx, and Hand. Patel MV, Zhu JY, Jiang Z, Richman A, VanBerkum MF

    Gia (protein)

    Gia_(protein)

  • Homeobox

    • DNA pattern affecting anatomy development

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Homeobox

    Homeobox

    Homeobox

  • HOXC5

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    HOXC5

    HOXC5

    HOXC5

  • RAR-related orphan receptor alpha

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    RAR-related orphan receptor alpha

    RAR-related orphan receptor alpha

    RAR-related_orphan_receptor_alpha

  • FLP-FRT recombination

    • Site-directed recombination technology

    elav-Gal4/UAS-Flp or Cre system to express the recombinase specifically in neurons and a Mef2-Gal4/UAS-Flp or Cre system to express it specifically in muscles. The authors

    FLP-FRT recombination

    FLP-FRT recombination

    FLP-FRT_recombination

  • Steroid hormone receptor

    • Group of protein families

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Steroid hormone receptor

    Steroid_hormone_receptor

  • Sex-determining region Y protein

    • Protein that initiates male sex determination in therian mammals

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Sex-determining region Y protein

    Sex-determining region Y protein

    Sex-determining_region_Y_protein

  • ZNF451

    • Protein-coding gene in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    ZNF451

    ZNF451

    ZNF451

  • ZNF649

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    ZNF649

    ZNF649

    ZNF649

  • FOXP2

    • Transcription factor gene of the forkhead box family

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    FOXP2

    FOXP2

    FOXP2

  • Msh homeobox 2

    • Protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Msh homeobox 2

    Msh homeobox 2

    Msh_homeobox_2

  • SOX12

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    SOX12

    SOX12

    SOX12

  • HEY2

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    HEY2

    HEY2

    HEY2

  • Thyroid hormone receptor beta

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Thyroid hormone receptor beta

    Thyroid hormone receptor beta

    Thyroid_hormone_receptor_beta

  • SIX4

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    SIX4

    SIX4

    SIX4

  • ZBTB20

    • Human protein-coding gene

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    ZBTB20

    ZBTB20

    ZBTB20

  • Retinoblastoma protein

    • Mammalian protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Retinoblastoma protein

    Retinoblastoma protein

    Retinoblastoma_protein

  • Nuclear factor 1 B-type

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Nuclear factor 1 B-type

    Nuclear factor 1 B-type

    Nuclear_factor_1_B-type

  • KLF5

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    KLF5

    KLF5

    KLF5

  • MEIS1

    • Protein-coding gene in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    MEIS1

    MEIS1

    MEIS1

  • E2F3

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    E2F3

    E2F3

    E2F3

  • Androgen receptor

    • Mammalian protein found in humans

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Androgen receptor

    Androgen receptor

    Androgen_receptor

  • Eileen Furlong

    • Irish molecular biologist

    Furlong, EE (June 2006). "A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development". Developmental

    Eileen Furlong

    Eileen_Furlong

  • MyoD

    • Mammalian protein found in Homo sapiens

    localized at muscle-related genes in myoblasts along with both MyoD and Mef2 (a myocyte transcription enhancer factor). Here, it serves as a scaffold

    MyoD

    MyoD

    MyoD

  • MXD3

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    MXD3

    MXD3

    MXD3

  • Retinoid X receptor alpha

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Retinoid X receptor alpha

    Retinoid X receptor alpha

    Retinoid_X_receptor_alpha

  • Myogenesis

    • Formation of muscular tissue, particularly during embryonic development

    later arise from satellite cells. Two genes significant in muscle fusion are Mef2 and the twist transcription factor. Studies have shown knockouts for Mef2C

    Myogenesis

    Myogenesis

    Myogenesis

  • TFAP2A

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    TFAP2A

    TFAP2A

    TFAP2A

  • Y box binding protein 1

    • Protein-coding gene in the species Homo sapiens

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    Y box binding protein 1

    Y box binding protein 1

    Y_box_binding_protein_1

  • NFE2L2

    • Human protein and coding gene

    family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group

    NFE2L2

    NFE2L2

    NFE2L2

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