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Class of chemical compounds
phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic
PDE4_inhibitor
Drug
It inhibits PDE4 to the greatest extent, but also shows significant inhibition of other PDE subtypes, and so acts as a selective PDE4 inhibitor or a
Phosphodiesterase_inhibitor
Class of drug
PDE4 inhibitor (found in Sceletium tortuosum (kanna)) Roxindole (EMD-49,980) (also a 5-HT1A and D2-like receptor agonist) Dopamine reuptake inhibitor
Serotonin_reuptake_inhibitor
Class of immunomodulatory drugs
hydroxyl and methoxy groups seem to make the analog a less potent PDE4 inhibitor. An increase in activity was observed with amino and dimethylamino to
Cereblon_E3_ligase_modulator
dihydrochloride Vardenafil hydrochloride trihydrate Zaprinast Phosphodiesterase inhibitor This list was created from the NCI Thesaurus. "Otsuka's Moizerto Ointment
List of phosphodiesterase inhibitors
List_of_phosphodiesterase_inhibitors
Chemical compound
Piclamilast (RP 73401), is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated
Piclamilast
Lung disease involving long-term poor airflow
reduce exacerbations in moderate-to-severe illness. Roflumilast is a PDE4 inhibitor used orally once daily to reduce inflammation; it has no direct bronchodilatory
Chronic obstructive pulmonary disease
Chronic_obstructive_pulmonary_disease
Medication
fibrosis and progressive pulmonary fibrosis. It is a phosphodiesterase 4 (PDE4) inhibitor. It is taken by mouth. Common side effects include diarrhea, decreased
Nerandomilast
Medication for psoriasis and psoriatic arthritis
psoriatic arthritis. The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). It is taken by mouth. Apremilast is indicated in
Apremilast
Chemical compound
phosphodiesterase 3 inhibitor and phosphodiesterase 4 inhibitor. It is given by inhalation. PDE3 inhibitors act as bronchodilators, while PDE4 inhibitors have an
Ensifentrine
Chemical compound
anti-inflammatory program by Inflazyme Pharmaceuticals. HT-0712 appears to act as a PDE4 inhibitor, thereby increasing cAMP levels. When cAMP levels are increased in neurons
HT-0712
Medication
2017. Retrieved 18 November 2013. Boswell-Smith V, Spina D (2007). "PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast"
Roflumilast
Chemical compound
glial cell activation. Ibudilast acts as a phosphodiesterase inhibitor, inhibiting the PDE4 subtype to the greatest extent, but also showing significant
Ibudilast
Mass formed in response to injury to the nervous system
In 2004, Nikulina et al. showed that administration of rolipram, a PDE4 inhibitor, can increase cAMP levels in neurons after spinal cord injury. This
Glial_scar
Index of chemical compounds with the same name
phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'-cyclic-AMP phosphodiesterase Phosphodiesterase (PDE) PDE4 inhibitor This set index article
Phosphodiesterase_4
Chemical compound
serotonin reuptake inhibitor (Ki = 1.4 nM), and has also been found to behave as a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4) (Ki = 7,800 nM)
Mesembrine
Chemical compound
inhibitor of the serotonin transporter (SERT) (that is, a serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki
Mesembrenone
Medication
dermatitis. Difamilast is a non-steroidal topical phosphodiesterase 4 (PDE4) inhibitor. Difamilast was discovered and developed by Otsuka Pharmaceutical.
Difamilast
Abnormal formation of clumps of inflammatory cells (granulomata)
phosphodiesterase 4 (PDE4) inhibitors like apremilast (a thalidomide derivative), roflumilast, and the less subtype-selective PDE4 inhibitor, pentoxifylline
Sarcoidosis
Chemical compound
ISSN 1528-7483. Nazarian R, Weinberg JM (November 2009). "AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis"
Crisaborole
Chemical compound
candidate developed by Wyeth-Ayerst. It is a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule
Filaminast
Chemical compound
bladder. It is structurally related to papaverine, is a phosphodiesterase inhibitor and has no anticholinergic effects. It is available in Asia,[specify]
Drotaverine
Chemical compound
JI, Eyerich K, Sommer MO, et al. (December 2023). "Next Generation PDE4 Inhibitors that Selectively Target PDE4B/D Subtypes: A Narrative Review". Dermatology
Zatolmilast
Class of enzymes
pass in a variety of fields (e.g. sildenafil as a PDE5 inhibitor and Rolipram as a PDE4 inhibitor). The PDE nomenclature signifies the PDE family with an
Phosphodiesterase
Vasodilating drug
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase
PDE5_inhibitor
Long-term form of skin inflammation
kinase inhibitor, has uncertain efficacy and safety. Difamilast, a PDE4 inhibitor, was approved for medical use in Japan in September 2021, and in the
Atopic_dermatitis
Chemical compound
competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces
Pentoxifylline
Chemical compound
used in research as a well-characterized PDE4 inhibitor. It has been used in studies to understand whether PDE4 inhibition could be useful in autoimmune
Rolipram
Investigational cognition and memory disorder drugs
Research programme: phosphodiesterase IV inhibitors - Dart NeuroScience – phosphodiesterase PDE4 inhibitors [47] Research programme: serotonin 6 receptor
List of investigational cognition and memory disorder drugs
List_of_investigational_cognition_and_memory_disorder_drugs
Investigational antipsychotics
mechanism of action – schizophrenia [83] CVL-047 – phosphodiesterase PDE4 inhibitor – schizophrenia [84] CY-150112 – undefined mechanism of action – schizophrenia
List of investigational antipsychotics
List_of_investigational_antipsychotics
Autoimmune diseases of the skin
Griffiths CE (July 2015). "Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a
Psoriasis
Chemical compound
in the development of newer drugs. Cilomilast is a second-generation PDE4 inhibitor with anti-inflammatory effects that target bronchoconstriction, mucus
Cilomilast
Chemical compound
neuroprotective effects. It is a phosphodiesterase inhibitor, and also acts as an adenosine reuptake inhibitor. Propentofylline was studied as a possible treatment
Propentofylline
List of pharmaceutical drugs under clinical development for treatment of depression
receptor antagonist Rolipram (ME-3167; ZK-62711) – phosphodiesterase 4 (PDE4) inhibitor Sabcomeline (BCI-224; CEB-242; Memric; SB-202026) – muscarinic acetylcholine
List of investigational antidepressants
List_of_investigational_antidepressants
Test of antipsychotic-like activity
pomaglumetad (LY-404039); and phosphodiesterase inhibitors like the PDE4 inhibitor rolipram and the PDE10A inhibitors papaverine, mardepodect (PF-2545920), and
Conditioned avoidance response test
Conditioned_avoidance_response_test
Chemical compound
Hu, Pei; Wang, Hongyun; Jiang, Ji (1 June 2018). "Determination of a PDE4 inhibitor Hemay005 in human plasma and urine by UPLC-MS/MS and its application
Mufemilast
Area of the brain
phosphodiesterase 4 (PDE4) inhibitors, such as Rolipram, cause emesis as one of their side effects. It has been found that these PDE4 isoforms are expressed
Chemoreceptor_trigger_zone
Finnish pharmaceutical company
administered, potent and selective inhibitor of the enzyme dopamine β-hydroxylase (DBH). Ronomilast is a PDE4 inhibitor for chronic inflammatory disorders
Biotie_Therapies
Investigational Parkinson's disease drugs
decarboxylase (AAAD) inhibitor) [2] Altropane (123-I Altropane; [123I]-E-IACFT; NAV-5001; O-587) – dopamine reuptake inhibitor (DRI) and single-photon
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Chemical compound
antagonist of the A1 and A2 subtypes, and as a phosphodiesterase inhibitor selective for the PDE4 isoform. It is currently in clinical trials for the treatment
Etazolate
Protein-coding gene in the species Homo sapiens
acrodysostosis. This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors. Furthermore, changes in expression
PDE4D
American biotechnology company
capsaicin analog, designed to treat interstitial cystitis. IC485, a PDE4 inhibitor, designed to treat emphysema, chronic bronchitis, chronic obstructive
Icos
Investigational substance-related disorder drugs
Eyevinal; Ibinal; KC-404; Ketas; MN-166; Pinatos) – phosphodiesterase PDE4 inhibitor, toll-like receptor 4 (TLR4) antagonist – alcoholism, opioid-related
List of investigational substance-related disorder drugs
List_of_investigational_substance-related_disorder_drugs
Chemical compound
Atizoram (CP-80633) is a phosphodiesterase 4 inhibitor. Wright, K. F.; Turner, C. R.; Jayasinghe-Beck, R.; Cohen, V. L.; Cheng, J. B.; Watson, J. W. (August
Atizoram
Chemical compound
A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic
PDE3_inhibitor
Chemical compound
relax. It is a non-competitive selective inhibitor of PDE4 in human bronchial tissue and granulocytes. PDE4 is an isoenzyme that hydrolyzes cyclic AMP
Glaucine
Category of drugs
DMARDs fail, tocilizumab can be used for tumor necrosis factor (TNF) inhibitor treatments in NICE guidance. Combinations of DMARDs are often used, because
Disease-modifying antirheumatic drug
Disease-modifying_antirheumatic_drug
Investigational antimigraine drugs
Eyevinal; Ibinal; KC-404; Ketas; MN-166; Pinatos) – phosphodiesterase PDE4 inhibitor – headache [51] IPX-232 – undefined mechanism of action – migraine [52]
List of investigational headache and migraine drugs
List_of_investigational_headache_and_migraine_drugs
CC-1088 is a thalidomide analogue inhibitor of phosphodiesterase 4 that was being developed up to 2005 by Celgene Corp., for treating of inflammatory
CC-1088
Investigational long COVID drugs
Eyevinal; Ibinal; KC-404; Ketas; MN-166; Pinatos) – phosphodiesterase PDE4 inhibitor and toll-like receptor 4 (TLR4) antagonist [1] Sodium pyruvate (EmphyClear;
List of investigational long COVID drugs
List_of_investigational_long_COVID_drugs
Pharmaceutical compound
Name; developmental code name NOE-105) is a phosphodiesterase PDE10A inhibitor which is under development for the treatment of Tourette's syndrome and
Gemlapodect
Anticoagulant drug
is an antiplatelet drug of the nucleoside transport inhibitor and PDE3 inhibitor class that inhibits blood clot formation when given chronically and causes
Dipyridamole
Species of succulent
as a phosphodiesterase-4 inhibitor (PDE4), acetylcholinesterase inhibitor (AChE), CB1 receptor blocker, and CYP17A1 inhibitor. Mesembrine is a major alkaloid
Mesembryanthemum_tortuosum
Species of flowering plant
Glaucine has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive
Glaucium_flavum
Type of medication applied to the skin
Psoriasis Atopic dermatitis Other inflammatory skin diseases Targeted Immunotherapies PDE4 inhibitors; Jak inhibitors Psoriasis Atopic dermatitis (off label)
Topical_cream_formulation
Protein-coding gene in humans
bipolar disorder. PDE4B is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram. PDE4B is involved in dopamine-associated
PDE4B
Mammalian protein found in humans
Coadministration of a protease inhibitor with a PDE5 inhibitor is expected to substantially increase the PDE5 inhibitor concentration and may result in
CGMP-specific phosphodiesterase type 5
CGMP-specific_phosphodiesterase_type_5
Type of drugs
2017). "Meta-Analysis of the Relative Efficacy and Safety of Oral P2Y12 Inhibitors in Patients With Acute Coronary Syndrome". The American Journal of Cardiology
Commonly_prescribed_drugs
Overview of and topical guide to immunology
stage Membrane attack complex (MAC) C6 C7 C8 C9 Complement pathway inhibitors C1-inhibitor - Classical, Lectin, Alternate Decay-accelerating factor (CD59)
Outline_of_immunology
Protein-coding gene in humans
functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis". Blood. 103 (7): 2661–7. doi:10.1182/blood-2003-06-2154
RAP1GDS1
Chemical compound
derivatives DPCPX also acts as a phosphodiesterase inhibitor, and is almost as potent as rolipram at inhibiting PDE4. It has been used to study the function of
Dipropylcyclopentylxanthine
Chemical compound
is a potent adenosine deaminase inhibitor, which also acts as a phosphodiesterase inhibitor that selectively inhibits phosphodiesterase type 2 (PDE2)
EHNA
Pharmaceutical compound
phosphodiesterase inhibitor, selective for the PDE5 subtype. Sildenafil Vardenafil Discovery and development of phosphodiesterase 5 inhibitors Giuliano FA,
Gisadenafil
Medication used to treat erectile dysfunction
this may result in a serious drop in blood pressure. Tadalafil is a PDE5 inhibitor which increases blood flow to the penis. It also dilates blood vessels
Tadalafil
Type of dendrite found at the apex of cortical pyramidal cell pathways
were treated with Rolipram, a specific phosphodiesterase type IV inhibitor (PDE4 inhibitor), which resultes in the activation of protein kinase A (PKA) and
Apical_dendrite
Chemical compound
juice (which is a CYP3A4 inhibitor) increases the drug's maximum concentration by around 50%. Cilostazol is a selective inhibitor of phosphodiesterase type
Cilostazol
Class of enzymes
PDE4. The 44-amino acid insertion in the catalytic domain of PDE3s is believed to be involved in PDE3's interaction with its substrate and inhibitors
Phosphodiesterase_3
Abandoned PDE10A inhibitor
developmental code name TAK-063) is a selective phosphodiesterase 10A (PDE10A) inhibitor which was under development by Takeda for the treatment of schizophrenia
Balipodect
Chemical compound
Osoresnontrine (BI-409306) is a phosphodiesterase 9 inhibitor in development for schizophrenia, attenuated psychosis syndrome, and Alzheimer's disease
Osoresnontrine
Drug discovery
for inhibitor potency and differences between isotypes of PDE in the Q2 pocket can be exploited for selectivity between isotypes. Drugs that inhibit PDE5
Discovery and development of phosphodiesterase 5 inhibitors
Discovery_and_development_of_phosphodiesterase_5_inhibitors
Chemical compound
Trequinsin is a phosphodiesterase inhibitor. It has been shown to improve sperm motility in vitro. Whitaker, RM; Wills, LP; Stallons, LJ; Schnellmann
Trequinsin
Chemical compound
Arofylline (codenamed LAS 31025) is a phosphodiesterase inhibitor. Ferrer, L; Alberola, J; Queralt, M; Brazís, P; Rabanal, R; Llenas, J; Puigdemont, A
Arofylline
Pharmaceutical compound
KH-001 is an atypical serotonin reuptake inhibitor (SRI) and phosphodiesterase (PDE) inhibitor which is under development for the treatment of premature
KH-001
Chemical compound
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 and by EMA on June 21, 2013. Avanafil is sold under the brand
Avanafil
Protein-coding gene in the species Homo sapiens
gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the secondary messenger, cAMP, which is a
PDE4A
Antihypertensive drug of the ACE inhibitor class
Moexipril was an angiotensin converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. Moexipril
Moexipril
Chemical compound
progression of heart disease. An ACE inhibitor, often enalapril (brand name Enacard) or benazepril (Fortekor). These drugs inhibit the action of angiotensin-converting
Pimobendan
Chemical compound
Irsogladine is a phosphodiesterase inhibitor. 2,4-Dichloro-6-(2,5-dichlorophenyl)-1,3,5-triazine [61479-79-6] (1) (2) Dicyandiamide [461-58-5] (3) 2
Irsogladine
Chemical compound
Cilostamide is a PDE3 inhibitor. De Jonge, HR; Tilly, BC; Hogema, BM; Pfau, DJ; Kelley, CA; Kelley, MH; Melita, AM; Morris, MT; Viola, RM; Forrest, JN
Cilostamide
Chemical compound
Papaverine has also been demonstrated to be a selective phosphodiesterase inhibitor for the PDE10A subtype found mainly in the striatum of the brain. When
Papaverine
Class of enzymes
Phosphodiesterase type 11 (PDE11) is a type of phosphodiesterase enzyme. An inhibitor is BC11-38 & Tadalafil. Kelly, Michy P. (2017). "A Role for Phosphodiesterase
PDE11
Chemical compound
It is a PDE5 inhibitor. It is taken by mouth. Vardenafil's indications and contraindications are the same as with other PDE5 inhibitors; it is closely
Vardenafil
Chemical compound
be a phosphodiesterase inhibitor. It is a potent (IC50 = 36nM) inhibitor of phosphodiesterase-II.[citation needed] It inhibits PDE-3 and phospholipase
Anagrelide
Anxiolytic medication
Tofisopam as a PDE10A inhibitor. WIPO Patent WO/2007/082546 "Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". FDA.
Tofisopam
Long-term inflammatory arthritis
apremilast, a small molecule phosphodiesterase-4 inhibitor approved for use by the FDA in 2014. By inhibiting PDE4, an enzyme that breaks down cyclic adenosine
Psoriatic_arthritis
Pharmaceutical compound
(TCA) and serotonin–norepinephrine reuptake inhibitor (SNRI) clomipramine and the phosphodiesterase PDE5 inhibitor and erectile dysfunction drug sildenafil
Clomipramine/sildenafil
Chemical compound
competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis, and reduces
Paraxanthine
Chemical compound
MK-8189 is a selective phosphodiesterase 10A inhibitor being developed for schizophrenia. It is developed by Merck in collaboration with Royalty Pharma
MK-8189
Chemical compound
used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary
Milrinone
Chemical compound
T-0156 is a phosphodiesterase 5 inhibitor. Parlak, A; Yildirim, S; Bagcivan, I; Durmus, N (October 2012). "Role of New Agents Affecting NO/cGMP Pathway
T-0156
Chemical compound
based on the direct vasodilatory effect of the drug, a phosphodiesterase inhibitor, and on its influence on the rheological properties of red blood cells
Moxaverine
Chemical compound
Enoximone (INN, trade name Perfan) is an imidazolinone phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective
Enoximone
Chemical compound
Mirodenafil is a PDE5 inhibitor used to treat erectile dysfunction. Developed by SK Chemicals Life Science, mirodenafil is marketed in Korea under the
Mirodenafil
Chemical compound
competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis, and reduces
Aminophylline
Chemical compound
Siguazodan is a phosphodiesterase inhibitor. Sosroseno, W; Sugiatno, E (2008). "Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS
Siguazodan
Chemical compound
is a phosphodiesterase inhibitor. Lusche, DF; Kaneko, H; Malchow, D (18 April 2005). "cGMP-Phosphodiesterase Antagonists Inhibit Ca2+-Influx in Dictyostelium
SCH-51866
Chemical compound
8-Methoxymethyl-3-isobutyl-1-methylxanthine (MMPX) is a phosphodiesterase inhibitor. Baxendale, RW; Fraser, LR (2005). "Mammalian sperm phosphodiesterases
8-Methoxymethyl-3-isobutyl-1-methylxanthine
8-Methoxymethyl-3-isobutyl-1-methylxanthine
Enzyme
Giembycz MA (June 2005). "Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors". Curr Opin Pharmacol. 5 (3): 238–44
PDE1
Chemical compound
Vesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic
Vesnarinone
Chemical compound
is within the PDE5 inhibitor class (which also includes avanafil, sildenafil, tadalafil, and vardenafil). Like other PDE5 inhibitors, it is used to treat
Udenafil
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PDE4 INHIBITOR
PDE4 INHIBITOR
PDE4 INHIBITOR
PDE4 INHIBITOR
PDE4 INHIBITOR
PDE4 INHIBITOR
PDE4 INHIBITOR
PDE4 INHIBITOR
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