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Mammalian protein found in humans
Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues
CGMP-specific phosphodiesterase type 5
CGMP-specific_phosphodiesterase_type_5
Vasodilating drug
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase
PDE5_inhibitor
Topics referred to by the same term
Type 5 may refer to: Type 5 diabetes, an inherited form of diabetes CGMP-specific phosphodiesterase type 5 Hyper-IgM syndrome type 5 PDE5 inhibitor, a
Type_5
Class of enzymes
by cAMP or cGMP by inhibition of their degradation by PDE. Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, which enhances
Phosphodiesterase
Drug for erectile dysfunction and hypertension
blood pressure. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis
Sildenafil
Systematic naming of drugs
naming of drugs, especially pharmaceutical drugs. In general, drugs have 3 types of names: chemical names, for which IUPAC nomenclature is the most accepted
Drug_nomenclature
Circumstance of death
dysfunction. One treatment for erectile dysfunction is cGMP-specific phosphodiesterase type 5 inhibitors, which enable patients to resume having sex despite
Death_during_consensual_sex
Enzyme
isoforms exhibit different affinities for cAMP and cGMP. The existence of the Ca2+-stimulated Phosphodiesterase 1 was first demonstrated by Cheung (1970), Kakiuchi
PDE1
Colorless gas with the formula NO
protecting cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, allowing for
Nitric_oxide
Drug
(84% in humans), is another cGMP-specific phosphodiesterase inhibitor which inhibits PDE9, a cGMP preferring phosphodiesterase. PDE9 is expressed as high
Phosphodiesterase_inhibitor
Drug discovery
monophosphate (cGMP) which leads to several biological processes like effect on intracellular calcium level by the Ca2+ pathway. Phosphodiesterase 5 (PDE5) is
Discovery and development of phosphodiesterase 5 inhibitors
Discovery_and_development_of_phosphodiesterase_5_inhibitors
Increased blood pressure in lung arteries
The US FDA approved sildenafil, a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), for the treatment of PAH in 2005. It is marketed
Pulmonary_hypertension
Heterotrimeric G protein involved in vertebrate phototransduction
α-subunit activates cGMP phosphodiesterase. cGMP phosphodiesterase breaks down cGMP, an intracellular second messenger which opens cGMP-gated cation channels
Transducin
Class of enzymes which split esters into an acid and alcohol via hydrolysis
many types of molecules, including nucleotides, proteins, and alkaloids. Phosphodiesterase (PDE), inactivates the second messenger cAMP cGMP specific phosphodiesterase
Esterase
1.3.11) Category:EC 3.1.4 Phospholipase C (EC 3.1.4.3) CGMP specific phosphodiesterase type 5 (EC 3.1.4.17) Phospholipase D (EC 3.1.4.50) (3-methyl-2-oxobutanoate
List_of_enzymes
Arteries of the penis
signal is terminated when cGMP is broken down by the enzyme cGMP specific phosphodiesterase type 5 (PDE5), the enzyme that is targeted by sildenafil and other
Helicine_arteries_of_penis
Medication used to treat erectile dysfunction
citation needed] The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP.[medical citation needed] Tadalafil
Tadalafil
Protein domain
domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain
GAF_domain
Protein-coding gene in the species Homo sapiens
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an enzyme that in humans is encoded by the PDE9A gene. The protein encoded by this gene
PDE9A
Chemical compound
for impotence, which inhibits cGMP specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP, which is produced by guanylate
7-Nitroindazole
Class of enzymes
(March 1997). "Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)". The Journal of Biological Chemistry. 272 (11): 6823–6
Phosphodiesterase_3
The enzyme PDE-5, found in the corpus cavernosum smooth muscle, is responsible for degrading cyclic guanosine monophosphate (cGMP) to 5-GMP. Inhibitors
Ototoxic_medication
Molecule that blocks enzyme activity
sildenafil (Viagra). This compound is a potent inhibitor of cGMP specific phosphodiesterase type 5, the enzyme that degrades the signalling molecule cyclic
Enzyme_inhibitor
Chemical compound
Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP-specific while PDE1, -2, -3,
Cyclic guanosine monophosphate
Cyclic_guanosine_monophosphate
Protein-coding gene in the species Homo sapiens
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta is the beta subunit of the protein complex PDE6 that is encoded by the PDE6B gene. PDE6 is
PDE6B
Chemical compound
rights within the United States. Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme found in various body tissues, primarily in the corpus
Avanafil
Cellular second messenger
monophosphate (cGMP) 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) Acrasin specific to chemotactic use in Dictyostelium discoideum. phosphodiesterase 4 (PDE
Cyclic adenosine monophosphate
Cyclic_adenosine_monophosphate
Class of enzymes
different substrate specificities. Some are cAMP selective hydrolases (PDE 4, -7 and -8), others are cGMP selective hydrolases (PDE 5, -6 and -9) and the
Phosphodiesterase_2
Fluid accumulation in the tissue and air spaces of the lungs
hypertension. Sildenafil's mechanism of action is via phosphodiesterase inhibition which raises cGMP, resulting in pulmonary arterial vasodilation and inhibition
Pulmonary_edema
System of communication
Offermanns S (October 2005). "Mammalian G proteins and their cell type specific functions". Physiological Reviews. 85 (4): 1159–204. Bibcode:2005PhyRv
Cell_signaling
Chemical compound
than theophylline. Paraxanthine is a selective inhibitor of cGMP-preferring phosphodiesterase (PDE9) activity and is hypothesized to increase glutamate
Paraxanthine
Chemical compound
headache, and gastrointestinal disorders also occurred. Nitrates and phosphodiesterase inhibitors (including PDE5 inhibitors) increase the hypotensive (blood
Riociguat
Genetic eye disease in dogs and cats
years old. This type of PRA has an early onset of severe vision loss. It is caused by a defect in the gene for cGMP-phosphodiesterase, which leads to
Progressive_retinal_atrophy
Cyclic nucleic acid
regulatory needs. Some phosphodiesterases are cNMP-specific, while others can hydrolyze non-specifically. However, the cAMP and cGMP degradation pathways
Cyclic_nucleotide
Process by which light activates retinal cells
bound GTP to GDP, and thus halts the action of phosphodiesterase, stopping the transformation of cGMP to GMP. This deactivation step of the phototransduction
Visual_phototransduction
Protein-coding gene in the species Homo sapiens
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene. PDE6G has
PDE6G
Type of neuroepithelial cell
transducin then activates the enzyme cGMP-specific phosphodiesterase (PDE). PDE then catalyzes the hydrolysis of cGMP to 5' GMP. This is the second amplification
Photoreceptor_cell
Guidance of sperm
hyperpolarization of the membrane. The cGMP signal is terminated by the hydrolysis of cGMP through phosphodiesterase (PDE) activity and inactivation of GC
Sperm_chemotaxis
American Physician-Scientist
The lab discovered that inhibiting phosphodiesterase type 5A(PDE5A), which degraded Cyclic guanosine monophosphate(cGMP) and was inhibited by the drug sildenafil
David_Kass_(physician)
Family of enzymes
number of cAMP hydrolyzing phosphodiesterase (PDE) enzymes, which belong to the substrates activated by PKA. Phosphodiesterase quickly converts cAMP to
Protein_kinase_A
Cell division producing haploid gametes
on cumulus cells. cGMP diffuses into oocytes and halts meiosis by inhibiting phosphodiesterase 3A (PDE3A) and cyclic adenosine 3′,5′-monophosphate (cAMP)
Meiosis
Protein-coding gene in the species Homo sapiens
Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018. "Entrez Gene: PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher
PRKAR1A
Human chromosome
regulator protein PCP4 PDE9A: encoding enzyme high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDXK: encoding enzyme Pyridoxal kinase PFKL: encoding
Chromosome_21
Drug that causes vasodilation by releasing nitric oxide
PDE5 inhibitors block deactivation of cGMP by the enzyme phosphodiesterase-5. In combination with the increased cGMP production caused by nitrovasodilators
Nitrovasodilator
Medication for lowering blood pressure
is similar to that of phosphodiesterase 5 (PDE5) inhibitors such as sildenafil (Viagra) and tadalafil (Cialis), which elevate cGMP concentration by inhibiting
Sodium_nitroprusside
Protein-coding gene in the species Homo sapiens
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene. PDE6A encodes the cyclic-GMP (cGMP)
PDE6A
Light-sensitive receptor protein
cGMP phosphodiesterase. The cGMP phosphodiesterase hydrolyzes (breaks down) cGMP, lowering its local concentration so it can no longer activate cGMP-dependent
Rhodopsin
Chemical compound
of designer analogues of USA FDA-approved inhibitors of type-5 cGMP-specific phosphodiesterase (PDE5), such as sildenafil and vardenafil, have been detected
Sulfoaildenafil
Protein-coding gene in the species Homo sapiens
LK, Scott JD (Apr 2001). "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". The EMBO Journal. 20 (8): 1921–30. doi:10
PRKAR2A
Protein-coding gene in the species Homo sapiens
protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and
GNAT1
Family of transport proteins
activation of the enzyme phosphodiesterase, which hydrolyzes cGMP into 5’-GMP, decreasing the concentration of cGMP. In the absence of cGMP, the CNG channels
Cyclic nucleotide–gated ion channel
Cyclic_nucleotide–gated_ion_channel
Protein and coding gene in humans
statins, angiotensin-converting enzyme inhibitors (ACEi) and phosphodiesterase type 5 (PDE-5) inhibitors (PDE5i). Statin treatment was more effective in
Endothelial_NOS
Part of the eye
causes the Ga-subunit of the protein to activate a phosphodiesterase (PDE6), which degrades cGMP, resulting in the closing of Na+ cyclic nucleotide-gated
Retina
Antihistamine medication
respiratory conditions) and a phosphodiesterase inhibitor (a medication that blocks the enzymes that regulate the levels of cAMP and cGMP, which are molecules
Ketotifen
Lyase enzyme that synthesizes cGMP from GTP
tone, insulin secretion, and peristalsis. Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation
Guanylate_cyclase
Chemical compound
decrease in phosphodiesterase. Phosphodiesterase (PDE) enzymes degrade cyclic di-AMP to the linear molecule 5'-pApA (phosphadenylyl adenosine). 5'-pApA is
Cyclic_di-AMP
Response of the eye to light and dark
increases the activity of phosphodiesterase which hydrolyses cGMP to further reduce its concentration. This reduces opening of the cGMP gated Na+ channels to
Adaptation_(eye)
G protein
capabilities. Transducin removes the inhibition from cGMP Phosphodiesterase, which leads to the breakdown of cGMP. Similarly, α-gustducin binds the inhibitory
Gustducin
Biological process
hyperpolarization of the membrane. The cGMP signal is terminated by the hydrolysis of cGMP through phosphodiesterase (PDE) activity and inactivation of GC
Sperm_guidance
Medication
guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). Among other roles, cGMP serves as a substrate for a cGMP-dependent protein kinase that
Nitroglycerin_(medication)
Protein-coding gene in the species Homo sapiens
Am J Hum Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018. "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta". Wong TH, Chiu
PRKAR1B
Series of chemical reactions resulting in a cell response
– are soluble in water and are localized at the cytosol, including cAMP, cGMP, IP3, Ca2+, cADPR and S1P. Their main targets are protein kinases as PKA
Biochemical_cascade
Functions of nitric oxide in organisms
tissue. Sildenafil (Viagra) works to inhibit the enzyme phosphodiesterase PDE5, which increases the cGMP concentration by inhibiting the conversion to GMP.
Biological functions of nitric oxide
Biological_functions_of_nitric_oxide
Gradual retinal degeneration leading to progressive sight loss
maturation completes. A defect in cGMP-phosphodiesterase has also been documented; this leads to toxic levels of cGMP.[citation needed] Oxidative damage
Retinitis_pigmentosa
Widening of blood vessels
Shawish MI, Ben-Eltriki M, Wright JM (December 2019). "Effect of phosphodiesterase 5 inhibitors on blood pressure". Cochrane Database of Systematic Reviews
Vasodilation
Protein-coding gene in the species Homo sapiens
cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene. cAMP is a signaling molecule
PRKAR2B
Protein-coding gene in the species Homo sapiens
Pyne NJ (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase
GRB2
Enzyme
Pyne NJ (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase
G protein-coupled receptor kinase 2
G_protein-coupled_receptor_kinase_2
Protein-coding gene in the species Homo sapiens
and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP". The Journal of Biological Chemistry. 265 (25): 14971–8
PRKG1
Type of drugs
ISBN 978-1-60913-345-0. Li, Heng; Zuo, Jianping; Tang, Wei (17 October 2018). "Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases". Frontiers
Commonly_prescribed_drugs
retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase". Nature Genetics. 11 (4): 468–471. doi:10.1038/ng1295-468. ISSN 1061-4036
Thaddeus_Dryja
Protein-coding gene in the species Homo sapiens
to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8)" (PDF). FASEB
ADCY8
Protein-coding gene in the species Homo sapiens
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene. The gene codes for the enzyme
PLCB3
Protein-coding gene in the species Homo sapiens
Reports. 15 (5): 518–28. doi:10.1002/embr.201338271. PMC 4210094. PMID 24737872. Du J, Huang C, Zhou B, Ziegler SF (April 2008). "Isoform-specific inhibition
RAR-related orphan receptor alpha
RAR-related_orphan_receptor_alpha
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