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Numerical score aimed at predicting a trait based on variation in multiple genetic loci
called the polygenic index (PGI) or genome-wide score; in the context of disease risk, it is called a polygenic risk score (PRS or PR score) or genetic
Polygenic_score
Far-right organization
white nationalism. In April 2025, the organization was legally renamed Polygenic Scores LLC. The Human Diversity Foundation was founded by Emil Kirkegaard
Human_Diversity_Foundation
Percent of variation in IQ scores in a given population associated with genetic variation
found that the polygenic score could explain 9.9% of the variance between families, while some later analyses estimated that polygenic scores can predict
Heritability_of_IQ
American psychologist and geneticist
into psychology, using genome-wide association studies to study how polygenic scores relate to behavioral and cognitive differences. His 2018 book Blueprint:
Robert_Plomin
Stereotype of Jews
to demonstrate a genetic basis for Ashkenazi achievement based on polygenic scores derived from genome-wide association studies, but the methodologies
Ashkenazi_Jewish_intelligence
Proportion of variance that two traits share due to genetic causes
architecture. Genetic correlations can be used in GWASes by using polygenic scores or genome-wide hits for one (often more easily measured) trait to increase
Genetic_correlation
Medical model that tailors medical practices to the individual patient
Hoffmeister M, et al. (September 2020). "Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk". Am J Hum Genet. 107 (3): 432–444. doi:10
Personalized_medicine
Polygenic adaptation describes a process in which a population adapts through small changes in allele frequencies at hundreds or thousands of loci. Many
Polygenic_adaptation
Reduction of blood flow to the heart
years old), the Framingham Risk Score remains below 10–12% for all deciles of baseline-predicted risk. Polygenic score is another way of risk assessment
Coronary_artery_disease
Dependence of environmental conditions on individual genotype
found evidence for gene–environment interaction. A polygenic score (PGS; also called a polygenic risk score), which is a number assigned to individuals based
Gene–environment_correlation
Stratification of a genetic population based on allele frequencies
study population is correlated with environmental variation, then the polygenic score is no longer measuring the genetic component alone. Several methods
Population structure (genetics)
Population_structure_(genetics)
Effect of alcohol consumption on the human body
Zhu J, Wang J (August 2021). "Relationship between rice farming and polygenic scores potentially linked to agriculture in China". Royal Society Open Science
Alcohol_flush_reaction
Topics referred to by the same term
Kotar (Croatian: Primorsko goranski savez), a Croatian political party Polygenic score, estimated effect of genetic variants Presentation Graphic Stream,
PGS
Ability to perceive and process information about one's surroundings
genome-wide approaches. As an example for the latter, Keers et al. created a polygenic score for environmental sensitivity based on about 25,000 gene variants across
Environmental_sensitivity
Score from a test designed to assess intelligence
Retrieved 20 November 2019. LeMieux, Julianna (1 April 2019). "Polygenic Risk Scores and Genomic Prediction: Q&A with Stephen Hsu". Genetic Engineering
Intelligence_quotient
the HFE gene. Beethoven’s polygenic score for cirrhosis was in agreement with these findings, placing him in the 96th polygenic risk percentile, and conferring
Death_of_Ludwig_van_Beethoven
American startup company
autism, Type 2 diabetes, and cancer. The company adds its embryo polygenic scoring to the conventional PGT analyses done by other labs. The company acquired
Nucleus_Genomics
Discussions and claims of differences in intelligence along racial lines
differences in intelligence between races as definitively false. Analysis of polygenic scores sampled from the 1000 Genomes Project has likewise found no evidence
Race_and_intelligence
Response to the same environmental variation differently by different genotypes
could interact with multiple genes, a polygenic approach can be taken to analyze GxE interactions. A polygenic score is generated using the alleles associated
Gene–environment_interaction
blood from the sofa where Hitler died underwent DNA analysis. Hitler's polygenic score was in the top 1% for autism, bipolar, and schizophrenia – though such
Mental_health_of_Adolf_Hitler
Evolution of societies
scholarship examining the interaction between biomarkers (genes, hormones, polygenic scores, etc.) and social and material environments. This distinction roughly
Sociocultural_evolution
DNA locus associated with variation in a quantitative trait
phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment
Quantitative_trait_locus
Dutch epidemiologist (1968–2022)
in Atlanta, Georgia, United States. Much of her research focused on polygenic score-based genetic risk prediction for complex diseases like diabetes and
Cecile_Janssens
Study of genetic variants in different individuals
interaction Genomics Linkage disequilibrium Molecular epidemiology Polygenic score Population genetics Genetic epidemiology Common disease-common variant
Genome-wide_association_study
Statistical genetics technique
linkage disequilibrium score regression (LDSR or LDSC) is a technique that aims to quantify the separate contributions of polygenic effects and various confounding
Linkage disequilibrium score regression
Linkage_disequilibrium_score_regression
1995 scientific report on human intelligence
the hereditarian hypothesis of the Black–White achievement gap using polygenic scores and tests for divergent selection". American Journal of Physical Anthropology
Intelligence: Knowns and Unknowns
Intelligence:_Knowns_and_Unknowns
Set of methods in genetics
Genetic linkage Genomics Linkage disequilibrium Molecular epidemiology Polygenic score Population genetics Quantitative trait locus Transcriptome-wide association
Fine-mapping
Amount of bone mineral in bone tissue
considered as a risk factor for osteoporosis. Bone mineral density is polygenic and many of the genetic mechanisms remain poorly understood. There are
Bone_density
Statistical method for genetic variance component estimation
Genome-wide Association Studies (GWAS) as well as the design and accuracy of polygenic scores. GCTA estimates from common variants are typically substantially lower
Genome-wide complex trait analysis
Genome-wide_complex_trait_analysis
Genetic characteristic
disease or trait. Polygenic Risk Scores (PRS): approach that combines the influence of multiple genetic variants and provides a measurable score for an individual's
Genetic_predisposition
Australian statistical geneticist and researcher
Psychiatric Genetics at Oxford University. Naomi pioneered the use of polygenic scores in human genetics, and has made significant contributions to both the
Naomi_Wray
British genomic research study
Retrieved 14 November 2022. "Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals"
East_London_Genes_&_Health
Mechanisms of sexual orientation development in humans
sensory and visual information. The researchers also found that a polygenic score for same-sex sexual behaviour correlated with brain structure, suggesting
Neuroscience and sexual orientation
Neuroscience_and_sexual_orientation
British-American author, editor, and blogger (born 1963)
the hereditarian hypothesis of the Black–White achievement gap using polygenic scores and tests for divergent selection". American Journal of Physical Anthropology
Andrew_Sullivan
Developmental psychology theory
associated with genetic sensitivity. For example, Keers et al. created a polygenic score for environmental sensitivity based on thousands of gene variants and
Vantage_sensitivity
tests (including tests from 23andMe and Ancestry.com) to calculate polygenic risk scores (PRS) for complex diseases and cognitive and personality traits
Impute.me
View that behavior develops from both
expressed in its actuality. Research has demonstrated the synchrony of polygenic scores of major depressive disorders (MDD) with stressful life events and
Interactionism (nature versus nurture)
Interactionism_(nature_versus_nurture)
Effort to improve purported human genetic quality
tests to select people for education and employment. He suggests that polygenic scores might supplement testing in a manner that is essentially free of biases
Eugenics
Genetic profiling of embryos prior to implantation
for social reasons. Bioethics Designer baby Family-based QTL mapping Polygenic score Sperm sorting "PGD / PGS – A boon for couples with genetic issues –
Preimplantation genetic diagnosis
Preimplantation_genetic_diagnosis
Genetically modified human embryo
In the 2020s, companies such as Orchid Bioscience began offering polygenic risk scores (PRS) analysis for embryos during IVF. PRS estimates the likelihood
Designer_baby
Hyman, S., Laibson, D., & Visscher, P. M. (2021). Problems with using polygenic scores to select embryos. New England Journal of Medicine, 385(1), 78–86.
Bibliography_of_eugenics
Evolution-related timelines
accounted for by environmental factors. In 2021, subsequent research using polygenic scores for educational attainment and cognitive performance in African and
Evolution of human intelligence
Evolution_of_human_intelligence
American neuroscientist
collaboration with Rahul Desikan and Chun Fan, Dale has developed a polygenic score for quantifying the 'personalized' risk for quantifying Alzheimer's
Anders_Dale
Influence of a single gene on multiple phenotypic traits
diagnosis, develop new therapies, and better prevent diseases. Polygenic risk scores (PRS), built from these findings, holds promise for predicting individual
Pleiotropy
American geneticist
the implications of population history for association studies and polygenic scores. Rosenberg has contributed to the understanding of mathematical properties
Noah_Rosenberg
British epidemiologist and academic
conditions such as breast cancer. For examples,BioBank has identified a polygenic risk score for coronary heart disease, revealing that 8% of the UK population
Naomi_Allen_(scientist)
Icelandic biopharmaceutical company
risk factors was combined and calculated into what was called a polygenic risk score, placing the individual on a spectrum of risk with regard to that
DeCODE_genetics
Icelandic neurologist (born 1949)
followed the next day by Google-backed 23andMe. deCODEme included polygenic risk scores built principally on its discoveries to gauge individual predisposition
Kári_Stefánsson
Study of mapping wiring diagrams
similar genetic origin, and research found that those with higher polygenic scores for schizophrenia and bipolar disorder have lower amounts of connectivity
Connectomics
Mandloi, Nitin; Wadia, Pettarusp M. (November 2022). "Genome-Wide Polygenic Score Predicts Large Number of High Risk Individuals in Monogenic Undiagnosed
Parkinson's disease in South Asians
Parkinson's_disease_in_South_Asians
Joint abnormality in dogs
eventually cause lameness and arthritis of the joints. It is a genetic (polygenic) trait that is affected by environmental factors. It is common in many
Canine_hip_dysplasia
1956 and 1980 volumes by Günther Anders
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
The Outdatedness of Human Beings
The_Outdatedness_of_Human_Beings
American professor of psychiatry
She is noted for publishing a study that demonstrated that using a polygenic risk score (PRS) based on data from genome-wide association studies improved
Diana_Perkins
into considering and deciding variant pathogenicity and generalizable polygenic scores, modern clinical classifications of genetic variant pathogenicity are
Genetic_history_of_Africa
Professor of psychology in education
imagination for learning; and (3) the relationship between genome-wide polygenic scores and educational attainment. von Stumm, S., Hell, B., & Chamorro-Premuzic
Sophie_von_Stumm
Abnormally elevated levels of lipids or lipoproteins in the blood
addition to LDL cholesterol. This may be sporadic (due to dietary factors), polygenic, or truly familial as a result of a mutation either in the LDL receptor
Hyperlipidemia
Biological elevation of emotional well-being
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Biohappiness
South Korean scientific misconduct scandal
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Hwang_affair
Joint abnormality
crippling lameness and painful arthritis of the joints. It is a genetic (polygenic) trait that is affected by environmental factors. It is common in many
Hip_dysplasia
1932 dystopian novel by Aldous Huxley
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Brave_New_World
genetic variants can be detected for personality traits. These traits are polygenic. Significant genetic variants are present for most of the behavioral traits
Genomics of personality traits
Genomics_of_personality_traits
Type of mathematical model
that there is a continuous normally-distributed trait expressing risk polygenically influenced by many genes, which all individuals above a certain value
Threshold_model
South African engineer
Forest (15 June 2022). "MyOme Develops Cross-Ancestry Breast Cancer Polygenic Risk Score, Plans Product Launch". GenomeWeb. Retrieved 25 January 2023. "Matthew
Matthew_Rabinowitz
Topics referred to by the same term
Pierre Robin syndrome, a congenital condition of facial abnormalities Polygenic risk score, in genetics Present tense, in linguistics Procedural reasoning system
PRS
Company in Salt Lake City, Utah, US
evaluate the magnitude of the curve. Adolescent Idiopathic Scoliosis is a polygenic trait, meaning it is affected by the characteristics of more than a single
Axial_Biotech
Bangladeshi epidemiologist
cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression". Nature Genetics. 53 (9): 1300–1310
Habibul_Ahsan
Methods for diagnosing tuberculosis
in response to TB. The Xpert MTB Host Response test calculated a polygenic risk score based on the expression levels of guanylate-binding protein 5 [GBP5]
Diagnosis_of_tuberculosis
Occurrence in an interbreeding population of two or more discontinuous genotypes
PMID 20858594. "Difference Between Minisatellite and Microsatellite". "Polygenic Risk Scores". www.genome.gov. Retrieved 2024-02-17. Research, Center for Drug
Gene_polymorphism
Long-term inflammatory disease of the airways of the lungs
Iribarren C, McGeachie M, Dahlin A, et al. (November 2021). "A polygenic risk score for asthma in a large racially diverse population". primary. Clinical
Asthma
Psychometric factor also known as "general intelligence"
each group is 100% heritable. Much research points to g being a highly polygenic trait influenced by many common genetic variants, each having only small
G_factor_(psychometrics)
2018 scientific and bioethical controversy
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
He_Jiankui_affair
1987 film
Azhagammal unconscious due to excessive pill consumption. Perumal, a polygenic villager, misinterprets the situation, assuming Dr. Rathinam is having
Aayusu_Nooru
Canadian philosopher (born 1953)
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Nikolas_Kompridis
Country in East Asia
longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population". Science Advances. 11 (23) eadt0539
Taiwan
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
United Nations Declaration on Human Cloning
United_Nations_Declaration_on_Human_Cloning
American neurologist
ALS. As part of this effort, her team is also developing polygenic and environmental risk scores to predict an individual's likelihood of developing ALS
Eva_Feldman
Hypothesis that human males have more variance in certain traits compared to females
Lee, Chanwook; Li, Hui; Li, Ruoxi (August 2018). "Gene discovery and polygenic prediction from a genome-wide association study of educational attainment
Variability_hypothesis
and genetic background effects in a breeding population. Furthermore, polygenic traits (or complex traits) controlled by several small-effects markers
Genomic_selection
Natural, artificial, or technological alteration of the human body
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Human_enhancement
Polyacrylamide Polycistronic Polycistronic mRNA Polydactyly Polygene Polygenic disorder Polymerase Polymerize Polymorphism Polypeptide Polyploid Polyribosome
Index_of_genetics_articles
Variety of ethical positions
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Ethics_of_cloning
Rare neurodegenerative disease
for 10–15% of cases overall and can include monogenic, oligogenic, and polygenic modes of inheritance. There is considerable variation among clinicians
ALS
International treaty
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Convention_for_the_Protection_of_Human_Rights_and_Dignity_of_the_Human_Being_with_regard_to_the_Application_of_Biology_and_Medicine
American physicist (born 1966)
"designer" children". The Economist. 2019-11-07. Retrieved 2020-04-23. "Polygenic Risk Scores and Genomic Prediction: Q&A with Stephen Hsu". genengnews.com. 2019-04-01
Stephen_Hsu
Neurodevelopmental disorder
each slightly increase the likelihood of a person having ADHD; it is polygenic and thus arises through the accumulation of many genetic risks each having
Attention deficit hyperactivity disorder
Attention_deficit_hyperactivity_disorder
Rhetorical strategy and accusation
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Playing_God_(ethics)
Long-term high blood pressure in the arteries
over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits". Nature Genetics. 56 (5): 778–791. doi:10
Hypertension
American political scientist, economist, and author (born 1952)
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
Francis_Fukuyama
Progressive neurodegenerative disease
autosomal dominant mutations, as Alzheimer's disease is substantially polygenic. When autosomal dominant variants cause the disease, it is known as early-onset
Alzheimer's_disease
Diabetes-induced damage to the retina of the eye
HM, Marquez-Luna C, Rocheleau G, et al. (May 2021). "Genome-wide polygenic risk score for retinopathy of type 2 diabetes". Human Molecular Genetics. 30
Diabetic_retinopathy
Medical diagnosis based on behavior
effects are usually very small, so they are combined onto a polygenic risk score. These scores, despite accounting for hundreds of variants, only explain
Diagnosis_of_schizophrenia
Autoimmune disease in which the immune system attacks healthy tissue
PMID 26033081. Crouch DJ, Bodmer WF (August 2020). "Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants". Proceedings
Lupus
Indian-American neuroscientist and neuroradiologist (1978–2019)
and tau pathology in Alzheimer's disease. 3) Development of the polygenic hazard score (PHS) for predicting Alzheimer's disease age of onset, in collaboration
Rahul_Desikan
Professor of Genetic Epidemiology and Statistics
PMID 29132412. Euesden, J; Lewis, CM; O'Reilly, PF (May 2015). "PRSice: Polygenic Risk Score software". Bioinformatics. 31 (9): 1466–1468. doi:10.1093/bioinformatics/btu848
Cathryn_Lewis
Medical condition
University of Pennsylvania Smell Identification Test, ccUPSIT). Polygenic Risk Scores for age of onset for XDP have yet to be established. However, if
X-linked dystonia parkinsonism
X-linked_dystonia_parkinsonism
Canadian-British professor of genetics
cautioning against biological determinism and reading too much into polygenic risk scores. King has appeared in numerous television and radio documentaries
Turi_King
English author and Christian apologist (1874–1936)
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
G._K._Chesterton
1943 book by C. S. Lewis
engineering Epigenome editing PGD Embryo quality Oocyte selection Polygenic (risk) score (technical article) Prenatal testing Selective abortion Sex selection
The_Abolition_of_Man
Wigdor EM, Ripke S, Walters RK, Kosmicki JA, Grove J, et al. (July 2017). "Polygenic transmission disequilibrium confirms that common and rare variation act
Heritability_of_autism
Archaeogenetic name for an ancestral genetic component
PMC 10781624. PMID 38200293. By calculating ancestry-specific polygenic risk scores, we show that height differences between Northern and Southern Europe
Western_Steppe_Herders
travel, tourism, insurance
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