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Human protein
Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) that limits the activity of protein C (an anticoagulant). An N-terminal fragment
Protein_C_inhibitor
Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). It has been measured in coagulation
Activated protein C–protein C inhibitor
Activated_protein_C–protein_C_inhibitor
Family of enzymes
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the
Protein_kinase_C
Enzymes that block actions of protein kinases
A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that
Protein_kinase_inhibitor
Mammalian protein found in Homo sapiens
people with severe congenital protein C deficiency. Activated protein C–protein C inhibitor ^ α: GLA-domainless protein C is produced by selective proteolysis
Protein_C
Inhibitors of translation
A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to
Protein_synthesis_inhibitor
Drug typically used in cancer treatment
inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins
Tyrosine_kinase_inhibitor
Set of three serine threonine-specific protein kinases
pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular
Protein_kinase_B
Topics referred to by the same term
management option for certain types of aggressive cancers Protein C inhibitor, a serine protease inhibitor Paralympic Committee of India, which selects athletes
PCI
Protein family
protease inhibitors Classes of inhibitor mechanisms of action are: Suicide inhibitor Transition state inhibitor Protein protease inhibitor (see serpins)
Protease_inhibitor_(biology)
Protein which inhibits cyclin-dependent kinase
A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and
Cyclin-dependent kinase inhibitor protein
Cyclin-dependent_kinase_inhibitor_protein
Class of pharmaceutical drugs
inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein
MTOR_inhibitors
Mammalian protein found in Homo sapiens
M; Ecke, S (1994). "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa". Am. J. Physiol. 267 (2 Pt 1):
Acrosin
Type of protein
are inhibited by plasminogen activator inhibitor-1, plasminogen activator inhibitor-2, and protein C inhibitor. Produced mainly in the liver, plasminogen
Plasminogen_activator
The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. RKIP is a member of the
Raf_kinase_inhibitor_protein
Mammalian protein found in humans
tail) is not essential for C1-inhibitor to inhibit proteases. This domain has no similarity to other proteins. C1-inhibitor is highly glycosylated, bearing
C1-inhibitor
Part of enzyme inhibition
Polygalacturonase inhibitor proteins (PGIPs), also known as polygalacturonase-inhibiting proteins, are plant proteins capable of inhibiting the action of
Polygalacturonase_inhibitor
Mammalian protein found in humans
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentration rises in response to inflammation
C-reactive_protein
Human protein
important inhibitors of urokinase are the serpins plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2), which inhibit the
Urokinase
Serine proteinase inhibitors which inhibit trypsin
A trypsin inhibitor (TI) is a protein and a type of serine protease inhibitor (serpin) that reduces the biological activity of trypsin by controlling
Trypsin_inhibitor
Mammalian protein found in humans
interact with protein C inhibitor. Prostate-specific antigen interacts with and activates the vascular endothelial growth factors VEGF-C and VEGF-D, which
Prostate-specific_antigen
Class of compounds
of c-Met by small molecules inhibitors is one strategy for inhibition of the tyrosine kinase. Early in the 1980s MET was described as the protein product
C-Met_inhibitor
Proteins that control apoptosis
Inhibitors of apoptosis are a group of proteins that mainly act on the intrinsic pathway that block programmed cell death, which can frequently lead to
Inhibitor_of_apoptosis
Class of medication
SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional
SGLT2_inhibitor
Superfamily of proteins with similar structures and diverse functions
the two proteins, centred on a methionine in alpha1-antitrypsin as an inhibitor of tissue elastase and on arginine in antithrombin as an inhibitor of thrombin
Serpin
Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates transcription in mammals. PIAS proteins
Protein inhibitor of activated STAT
Protein_inhibitor_of_activated_STAT
Protein structural motif
An inhibitor cystine knot (also known as ICK or Knottin) is a protein structural motif containing three disulfide bridges. Knottins are one of three folds
Inhibitor_cystine_knot
Protein-coding gene in the species Homo sapiens
repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene. It belongs to the IAP family of proteins and therefore
Baculoviral IAP repeat-containing protein 2
Baculoviral_IAP_repeat-containing_protein_2
Drug class
BET inhibitors in combination with γ-secretase inhibitors for T-cell acute lymphoblastic leukemia and BRAF-inhibitor (vemurafenib) for BRAF-inhibitor resistant
BET_inhibitor
Human protein
Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein that in humans is encoded
Plasminogen activator inhibitor-1
Plasminogen_activator_inhibitor-1
Antiviral drug
inhibitor." Enfuvirtide binds to gp41 and interferes with its ability to approximate the two membranes. It is also referred to as a "fusion inhibitor
Entry_inhibitor
Class of proteins involved in inflammation
Acute-phase proteins (APPs) are a class of proteins whose concentrations in blood plasma either increase (positive acute-phase proteins) or decrease (negative
Acute-phase_protein
Molecule that blocks enzyme activity
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity. Enzymes are proteins that speed up chemical reactions necessary for
Enzyme_inhibitor
Drug
Proteasome inhibitors (INN stem –zomib) are drugs that block the action of proteasomes. Proteasomes are large proteins complexes that are used to break
Proteasome_inhibitor
Protein family
Ribonuclease inhibitor (RI) is a large (~450 residues, ~49 kDa), acidic (pI ~4.7), leucine-rich repeat protein that forms extremely tight complexes with
Ribonuclease_inhibitor
Protein found in humans
Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the
Bcl-2
Enzyme
that inhibitors of the radically functioning protein tyrosine kinase enzymes have on related ailments.[citation needed] (See Tyrosine-kinase inhibitor )
Tyrosine_kinase
Enzyme
procollagen C-terminal proteinase enhancer (PCPE), reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and tissue factor pathway inhibitor (TFPI-2))
Metalloprotease_inhibitor
Chemical compound
AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl
AM-679_(FLAP_inhibitor)
Drug class
A CETP inhibitor is a member of a class of drugs that inhibit cholesterylester transfer protein (CETP). They are intended to reduce the risk of atherosclerosis
CETP_inhibitor
Type of inhibitor
covalent inhibitors (TCIs) or Targeted covalent drugs are rationally designed inhibitors that bind and then bond to their target proteins. These inhibitors possess
Targeted_covalent_inhibitors
Mammalian protein found in Homo sapiens
is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased
Factor_X
Protein used as a biomarker of kidney function
Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic polypeptide), is a protein encoded by the CST3 gene. In humans
Cystatin_C
Mammalian protein found in humans
A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene. A protease inhibitor, it is also known as
Alpha-1_antitrypsin
Protein-coding gene in the species Homo sapiens
known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene. cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis
Baculoviral IAP repeat-containing protein 3
Baculoviral_IAP_repeat-containing_protein_3
Class of antiviral drugs used to treat HIV/AIDS and hepatitis C
inhibitors of human proteases may be used to treat cancer. See the articles matrix metalloproteinase inhibitor (–mastat) and proteasome inhibitor (–zomib)
Protease inhibitor (pharmacology)
Protease_inhibitor_(pharmacology)
Protein-coding gene in the species Homo sapiens
has been fleshed out. NgR is a membrane protein that, when bound to neurite outgrowth inhibitor (Nogo), inhibits cell growth through the activation of rho
Reticulon_4_receptor
Mammalian protein found in Homo sapiens
repeats bind extracellular matrix proteins, growth factors, proteases, protease inhibitor complexes, and other proteins involved in lipoprotein metabolism
LRP1
Biological protein kinase C inhibitor
BIM-3, and BIM-8 are bisindolylmaleimide-based protein kinase C (PKC) inhibitors. These inhibitors also inhibit PDK1 explaining the higher inhibitory potential
BIM-1
Protein family
2017). "Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive
P38 mitogen-activated protein kinases
P38_mitogen-activated_protein_kinases
Family of enzymes
cell biology, protein kinase A (PKA) is a family of serine-threonine kinases whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is
Protein_kinase_A
Protein-coding gene in the species Homo sapiens
cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C
PKIA
Chemical compound
specifically as an inhibitor of PKA, being 30 times more potent than H-8 at inhibiting PKA and 10 times less potent at inhibiting protein kinase G. It achieves
H-89
Protein-coding gene in the species Homo sapiens
Peptidase inhibitor 16 is a protein that in humans is encoded by the PI16 gene. GRCh38: Ensembl release 89: ENSG00000164530 – Ensembl, May 2017 GRCm38:
Peptidase_inhibitor_16
Protein-coding gene in the species Homo sapiens
X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4)
XIAP
Aerobic respiration enzyme
enzyme cytochrome c oxidase or Complex IV (was EC 1.9.3.1, now reclassified as a translocase EC 7.1.1.9) is a large transmembrane protein complex found in
Cytochrome_c_oxidase
Protein-coding gene in the species Homo sapiens
Inhibitor of CDK, cyclin A1 interacting protein 1 is a protein that in humans is encoded by the INCA1 gene. GRCh38: Ensembl release 89: ENSG00000196388
Inhibitor of CDK, cyclin A1 interacting protein 1
Inhibitor_of_CDK,_cyclin_A1_interacting_protein_1
Class of pharmacological agent
Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK
Rho_kinase_inhibitor
Protein-coding gene found in humans
trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in
SPINK1
GTP-binding proteins functioning on cell-cycle regulation
the protein surface. Other proteins exist that may change the activity of Ras family proteins. One example is GDI (GDP Disassociation Inhibitor). These
Ras_GTPase
RNA family
G/C rich RNA element which is involved in controlling cell cycle regulated translation of the p27Kip1 protein in human cells. The p27kip1 protein is
P27_cis-regulatory_element
Antiretroviral medication
(HAART). Ritonavir is a protease inhibitor, though it now mainly serves to boost the potency of other protease inhibitors. It may also be used in combination
Ritonavir
Protein-coding gene in the species Homo sapiens
cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene. The protein encoded by this gene is a member of
PKIB
Protein domain
in seed storage proteins (including 2S albumin, gliadin, and glutelin) and bifunctional trypsin/alpha-amylase inhibitors. These proteins share the same
Plant_lipid_transfer_proteins
InterPro Domain
domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family
Kunitz_domain
Mammalian protein found in humans
while PCSK9 inhibitor treatment provides additional benefits beyond maximally tolerated statin therapy in high-risk individuals, PCSK9 inhibitor use probably
PCSK9
Transmembrane protein
kinase inhibitor. Many therapeutic approaches are aimed at the EGFR. Cetuximab and panitumumab are examples of monoclonal antibody inhibitors. However
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Protein domain
The inhibitor of apoptosis domain, also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR, is a structural motif found in
Inhibitor_of_apoptosis_domain
Biomarkers of blood signals
monomers (FMs), plasmin-α2-antiplasmin complex (PAP), activated protein C–protein C inhibitor (APC-PCI), and D-dimer (DD). These compounds are markers of
Coagulation_activation_marker
Investigational hair loss drugs
areata – ACVR1 protein inhibitor, Janus kinase 1 inhibitor, Janus kinase 2 inhibitor, Janus kinase 3 inhibitor, TYK2 kinase inhibitor Ivarmacitinib (ARQ-252
List of investigational hair loss drugs
List_of_investigational_hair_loss_drugs
Chemical compound
is a small-molecule inhibitor of protein kinase CK2 (casein kinase II), a constitutively active serine/threonine-specific protein kinase that is overexpressed
Silmitasertib
that lack MinC carry alternative proteins that can position their Z-ring. MinC is known to dimerize and functions as an FtsZ protein inhibitor, antagonizing
MinC
been known since 1950s. Rubratoxins are also known as protein phosphatase 2A (PP2A) specific inhibitor. The PP2A inhibitory activity of rubratoxin A is about
Rubratoxin
Process of formation of blood clots
fibrinogen to fibrin, it also activates Factors VIII and V and their inhibitor protein C (in the presence of thrombomodulin). By activating Factor XIII, covalent
Coagulation
Chemical compound
Selective Protein Kinase C Inhibitor, Ro-31-8220, Inhibits Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression, Induces c-Jun Expression, and
Ro-318220
Mammalian protein found in Homo sapiens
Physiological inhibitors of factor XIa include protein Z-dependent protease inhibitor (ZPI, a member of the serine protease inhibitor/serpin class of proteins), which
Factor_XI
Chemical compound
SMAC mimetic, it functions as an inhibitor of several members of the IAP protein family (including XIAP, c-IAP1, and c-IAP2). "Xevinapant - Merck & Co"
Xevinapant
Protein-coding gene in the species Homo sapiens
E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene. Protein inhibitor of activated STAT2 has been shown to interact
Protein inhibitor of activated STAT2
Protein_inhibitor_of_activated_STAT2
Class of drugs
myostatin inhibitor. Resistance training reduces myostatin activity and increases follistatin activity. Pharmacological myostatin inhibitors can therefore
Myostatin_inhibitor
Protein-coding gene in humans
mutant covalent inhibitor, sotorasib (AMG 510, Amgen) for the treatment of non-small cell lung cancer (NSCLC), the first KRAS inhibitor to reach the market
KRAS
Drug class
An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety of proteins required for
Hsp90_inhibitor
Pharmaceutical compound
pancreatic cancer. It is an inhibitor of the RAS GTPase family. It is an orally administered small molecule pan-RAS inhibitor. It was developed by Revolution
Daraxonrasib
Small molecule (PROTAC)
molecule that can remove specific unwanted proteins. Rather than acting as a conventional enzyme inhibitor, a PROTAC works by inducing selective intracellular
Proteolysis_targeting_chimera
Medical condition
transient hypercoagulable state. The main function of protein C is its anticoagulant property as an inhibitor of coagulation factors V and VIII. A deficiency
Protein_C_deficiency
Index of articles associated with the same name
element-binding protein Polypyrimidine tract-binding protein Fatty acid-binding protein Myosin binding protein C, cardiac CPE binding protein 4EGI-1, a binding
Binding_protein
Mammalian protein found in Homo sapiens
Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene. This gene
Elafin
Mammalian protein found in Homo sapiens
origins, given its autocrine nature. Follistatin acts as an inhibitor for bone morphogenic proteins (BMPs) involved in embryo development. Since BMPs facilitate
Follistatin
Cell cycle regulator
Early Mitotic Inhibitor 1 (EMI1) is an important cell cycle regulator which ensures timely mitotic entry by primarily inhibiting Anaphase-Promoting Complex/Cyclosome
Early_Mitotic_Inhibitor_1
Drug discovery
Nonstructural protein 5A (NS5A) inhibitors are direct acting antiviral agents (DAAs) that target viral proteins, and their development was a culmination
Discovery and development of NS5A inhibitors
Discovery_and_development_of_NS5A_inhibitors
Class of anticancer drugs
PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PD-L1 immune checkpoint
PD-1_and_PD-L1_inhibitors
Mammalian protein
BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading
Survivin
Protein family
death, at the mitochondrion. The Bcl-2 family proteins consists of members that either promote or inhibit apoptosis, and control apoptosis by governing
Bcl-2_family
Pharmacological enzyme inhibitors of poly (ADP-ribose) polymerases
2009-06-28. Retrieved 2019-12-05. Pam Stephan. "PARP Inhibitor and DNA Polymerase Repair - PARP Inhibitor". About.com Health. Archived from the original on
PARP_inhibitor
Protein family
domain-containing protease inhibitors such as trappin-2. This N-terminal domain enables it to become cross-linked to extracellular matrix proteins by transglutaminase
Trappin protein transglutaminase binding domain
Trappin_protein_transglutaminase_binding_domain
Protein found in humans
Apoptosis inhibitor 5 is a protein that in humans is encoded by the gene API5. This protein is an apoptosis inhibitory protein whose expression prevents
Apoptosis_inhibitor_5
Chemical compound
potent, selective, and cell-permeable protein kinase C inhibitor in vitro. And an efficacious antagonist of G-protein-coupled CB1 receptors. This molecule
Chelerythrine
Protein-coding gene in humans
isoforms through alternative splicing. This protein belongs to the CDKN2 cyclin-dependent kinase inhibitor family. p16 comprises four ankyrin repeats,
CDKN2A
Protein family
has been shown to inhibit infection in HIV-1 positive people. Cyclosporine acts as a competitive inhibitor to the capsid protein’s association with CypA
P24_capsid_protein
Protein-coding gene in the species Homo sapiens
TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a two-domain glycoprotein with a molecular weight
TIMP1
Mammalian protein found in humans
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma)
Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene_tyrosine-protein_kinase_Src
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PROTEIN C-INHIBITOR
PROTEIN C-INHIBITOR
Girl/Female
Tamil
Rakshita | ரகà¯à®·à®¿à®¤à®¾, ரகà¯à®·à¯€à®¤à®¾Â
Who protect
Rakshita | ரகà¯à®·à®¿à®¤à®¾, ரகà¯à®·à¯€à®¤à®¾Â
Male
Irish
Old Irish Gaelic name MAEL-MAEDÓC means "devotee of Maedóc."
Male
Irish
Old Irish name MAEDÓC means "my dear Ãedh."
Girl/Female
Tamil
Rakshitha | ரகà¯à®·à®¿à®¤à®¾, ரகà¯à®·à¯€à®¤à®¾Â
Who protect
Rakshitha | ரகà¯à®·à®¿à®¤à®¾, ரகà¯à®·à¯€à®¤à®¾Â
Boy/Male
Hindu
Girl/Female
Hindu, Indian
Protect
Surname or Lastname
English
English : possibly a variant of Porton, a habitational name from Porton in Wiltshire or Poorton in Dorset; both place names are formed with an obscure first element, perhaps the name of a river, + Old English tūn ‘settlement’.Dutch : habitational name for someone from a place named with Dutch poort ‘gate’.
Girl/Female
American, Australian, British, English
Based on the Initials J C; To Protect; An Abbreviation of Jacinda
Girl/Female
Hindu
Who protect
Boy/Male
Greek Shakespearean
A sea god.
Male
Czechoslovakian
, fiery.
Girl/Female
Afghan, Arabic, Australian, Danish, French, Hebrew, Muslim
Protect
Male
Vietnamese
Vietnamese name ̇ȬC means "desire."
Male
Czechoslovakian
, good-worker.
Girl/Female
Arabic, Australian, Muslim
Protect
Boy/Male
Bengali, Indian
Symbol
Boy/Male
Bengali, Indian
Love
Male
Hungarian
Czech and Hungarian form of Latin Ignatius, possibly IGNÃC means "unknowing."
Surname or Lastname
English and French
English and French : regional name from Old French Poitevin, denoting someone from Poitou in western France. The form Potvin has long been established in England and was brought to the U.S. from there. However, French bearers of the surname Poitevin also came to the New World, where their surname underwent a similar transformation on arrival in New England.
Boy/Male
Hindu, Indian
Proven
PROTEIN C-INHIBITOR
PROTEIN C-INHIBITOR
PROTEIN C-INHIBITOR
PROTEIN C-INHIBITOR
PROTEIN C-INHIBITOR
PROTEIN C-INHIBITOR
PROTEIN C-INHIBITOR
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