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Reabsorption of a neurotransmitter by a neurotransmitter transporter
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic
Reuptake
Class of antidepressant medication
Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant medications used to treat major depressive disorder (MDD), anxiety disorders
Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine_reuptake_inhibitor
Drug that inhibits the reuptake of norepinephrine and dopamine
A norepinephrine–dopamine reuptake inhibitor (NDRI) is a type of drug that inhibits the reuptake of the monoamine neurotransmitters norepinephrine and
Norepinephrine–dopamine reuptake inhibitor
Norepinephrine–dopamine_reuptake_inhibitor
Class of antidepressant medication
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Type of drug
Reuptake inhibitors (RIs) are a type of reuptake modulators. It is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter
Reuptake_inhibitor
Class of drugs
reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI or TUI), is a type of drug that acts as a combined reuptake inhibitor
Serotonin–norepinephrine–dopamine reuptake inhibitor
Serotonin–norepinephrine–dopamine_reuptake_inhibitor
Class of drug
A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action
Dopamine_reuptake_inhibitor
Medications that increase norepinephrine
A norepinephrine reuptake inhibitor (NRI), also known as a noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor, is a type of drug that acts
Norepinephrine reuptake inhibitor
Norepinephrine_reuptake_inhibitor
Serotonin–dopamine reuptake inhibitors include: None currently marketed Medifoxamine (Clédial, Gerdaxy) Serotonin–norepinephrine–dopamine reuptake inhibitors
List_of_antidepressants
Drug class
A monoamine reuptake inhibitor (MRI) is a drug that acts as a reuptake inhibitor of one or more of the three major monoamine neurotransmitters serotonin
Monoamine_reuptake_inhibitor
Drug that makes neurotransmitter transporters more active
A reuptake enhancer (RE), also sometimes referred to as a reuptake activator, is a type of reuptake modulator which enhances the plasmalemmal transporter-mediated
Reuptake_enhancer
Type of pharmaceutical drug
A reuptake modulator, or transporter modulator, is a type of drug which modulates the reuptake of one or more neurotransmitters via their respective neurotransmitter
Reuptake_modulator
Class of drug
A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT)
Serotonin_reuptake_inhibitor
A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine
Glycine_reuptake_inhibitor
Drug class
Selective norepinephrine reuptake inhibitors (sNRIs) are a class of drugs that have been marketed as antidepressants and are used for various mental disorders
Selective norepinephrine reuptake inhibitor
Selective_norepinephrine_reuptake_inhibitor
Class of drugs
Endocannabinoid reuptake inhibitors (eCBRIs), also called cannabinoid reuptake inhibitors (CBRIs), are drugs which limit the reabsorption of endocannabinoid
Endocannabinoid reuptake inhibitor
Endocannabinoid_reuptake_inhibitor
Class of medications
selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs) and norepinephrine reuptake inhibitors (NRIs). The
Tricyclic_antidepressant
Antidepressant medication
disorders. Onset of action appears faster than some selective serotonin reuptake inhibitors and similar to tricyclic antidepressants. In 2010, the National
Mirtazapine
Class of medications used to alleviate anxiety
Antidepressants include selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants
Anxiolytic
Medical condition
selective serotonin reuptake inhibitors (SSRIs) (e.g., citalopram, escitalopram, fluoxetine, sertraline), serotonin–norepinephrine reuptake inhibitors (SNRIs)
Spontaneous_orgasm
Symptoms that occur after discontinuing antidepressant medication
antidepressants including selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors
Antidepressant discontinuation syndrome
Antidepressant_discontinuation_syndrome
release] (CTX-1301) – norepinephrine–dopamine reuptake inhibitor Edivoxetine (LY-2216684) – norepinephrine reuptake inhibitor Molindone [extended-release] (AFX-2201
List of investigational attention deficit hyperactivity disorder drugs
List_of_investigational_attention_deficit_hyperactivity_disorder_drugs
Class of medication used to treat depression and other conditions
irritable would be treated with selective serotonin reuptake inhibitors (SSRIs) or norepinephrine reuptake inhibitors, while a person suffering from loss of
Antidepressant
Protein-coding gene in the species Homo sapiens
reuptake of extracellular norepinephrine (NE), which is also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of
Norepinephrine_transporter
Class of drug
Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act
Serotonin antagonist and reuptake inhibitor
Serotonin_antagonist_and_reuptake_inhibitor
Medication mainly used for depression and smoking cessation
disorder and to support smoking cessation. It is a norepinephrine–dopamine reuptake inhibitor (NDRI). Some evidence-based guidelines support first-line use
Bupropion
SSRI antidepressant
among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used for the treatment of major depressive disorder
Fluoxetine
Antidepressant medication
insomnia. It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. The medication is taken orally. Common side effects
Trazodone
List of pharmaceutical drugs under clinical development for treatment of depression
atypical serotonin reuptake inhibitor (SRI) (kanna-derived) SVN-015 – serotonin–dopamine reuptake inhibitor SYT-510 – endocannabinoid reuptake inhibitor TF-0066
List of investigational antidepressants
List_of_investigational_antidepressants
Class of drug
A serotonin–dopamine reuptake inhibitor (SDRI) is a type of drug which acts as a reuptake inhibitor of the monoamine neurotransmitters serotonin and dopamine
Serotonin–dopamine reuptake inhibitor
Serotonin–dopamine_reuptake_inhibitor
Drug class
A GABA reuptake inhibitor (GRI), also known as a GABA transporter blocker, is a type of drug which acts as a reuptake inhibitor of the major inhibitory
GABA_reuptake_inhibitor
SSRI antidepressant
among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used to treat major depressive disorder, generalized
Sertraline
Central nervous system stimulant
therapeutic doses. Methylphenidate is believed to work by blocking the reuptake of dopamine and norepinephrine by neurons. It is a CNS stimulant of the
Methylphenidate
SSRI antidepressant
name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is primarily used to treat major depressive
Fluvoxamine
Type of medication
antidepressant treatments, including selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), mirtazapine, bupropion,
Monoamine_oxidase_inhibitor
SNRI medication
chronic pain. It is taken by mouth. Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). The precise mechanism for its antidepressant and anxiolytic
Duloxetine
When antidepressants become ineffective
administration of a drug. It occurs more often with selective serotonin reuptake inhibitors (SSRIs), which are the most commonly prescribed antidepressants
Antidepressant treatment tachyphylaxis
Antidepressant_treatment_tachyphylaxis
Chemical compound
inhibitor of dopamine and noradrenaline reuptake in vitro, with weaker but still significant inhibition of serotonin reuptake. 3F-PVP 4F-PVP 4Cl-PVP 3,4-DCMP
O-2390
Serotonin-norepinephrine-dopamine reuptake inhibitor
norepinephrine reuptake over dopamine reuptake, 13.8-fold preference for inhibition of norepinephrine reuptake over serotonin reuptake, and 2.2-fold preference
Centanafadine
Proteins that function as integral plasma-membrane transporters
(DATs), and norepinephrine transporters (NETs) and are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, and norepinephrine)
Monoamine_transporter
SNRI antidepressant
depressive disorder. It is an antidepressant of the serotonin–norepinephrine reuptake inhibitor (SNRI) class and is taken by mouth. It is recommended that the
Desvenlafaxine
Antidepressant
TCA because, unlike other TCAs, it seems to be a fairly weak monoamine reuptake inhibitor. Similarly to other TCAs, however, trimipramine does have antihistamine
Trimipramine
Drug class
An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine
Adenosine_reuptake_inhibitor
Selective serotonin reuptake inhibitors (SSRIs) (e.g., escitalopram, fluoxetine, paroxetine, sertraline) Serotonin–norepinephrine reuptake inhibitors (SNRIs)
List of psychiatric drugs by type
List_of_psychiatric_drugs_by_type
SNRI antidepressant
others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. It is used to treat major depressive disorder,
Venlafaxine
Investigational generalized anxiety disorder drugs
serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) [4] Vilazodone (EMD-68843; SB-659746A; Viibryd) – serotonin reuptake inhibitor (SRI) and serotonin
List of investigational generalized anxiety disorder drugs
List_of_investigational_generalized_anxiety_disorder_drugs
Behavioral measure in animals
methamphetamine. These drugs likewise induce stereotypies. The dopamine reuptake inhibitors (DRIs) amineptine, bupropion, and nomifensine increase spontaneous
Locomotor_activity
Investigational narcolepsy and hypersomnia drugs
likely to become outdated with time. Reboxetine (AXS-12) – norepinephrine reuptake inhibitor (NRI) – narcolepsy [1] Sodium oxybate (Xyrem) controlled release
List of investigational narcolepsy and hypersomnia drugs
List_of_investigational_narcolepsy_and_hypersomnia_drugs
Investigational obsessive–compulsive disorder drugs
selective serotonin reuptake inhibitor (SSRI) [29] Fluoxetine (LY-110140; Prozac; Prozac Weekly; Reneuron; Sarafem) – selective serotonin reuptake inhibitor (SSRI)
List of investigational obsessive–compulsive disorder drugs
List_of_investigational_obsessive–compulsive_disorder_drugs
Medication used to treat ADHD
Atomoxetine, sold under the brand name Strattera, is a selective norepinephrine reuptake inhibitor (SNRI) medication used to treat attention deficit hyperactivity
Atomoxetine
Therapies, medications, and devices
lacking. Some norepinephrine–dopamine reuptake inhibitors can be used as antidepressants. Norepinephrine reuptake inhibitors (NRIs) can be used as antidepressants
Management_of_depression
Cough suppressant and dissociative drug
of action, including actions as a nonselective serotonin–norepinephrine reuptake inhibitor and a sigma-1 receptor agonist. Dextromethorphan and its major
Dextromethorphan
Monoamine neurotransmitter
antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs), which block reabsorption
Serotonin
Class of antidepressants
drugs Serotonin–norepinephrine reuptake inhibitor – Class of antidepressant medication Serotonin antagonist and reuptake inhibitor – Class of drug Noradrenergic
Second-generation antidepressant
Second-generation_antidepressant
Associated with concentration changes in synaptic neurotransmitters in the CNS
supporting this theory is the fact that dopamine reuptake inhibitors as well as norepinephrine dopamine reuptake inhibitors are able to increase exercise performance
Central nervous system fatigue
Central_nervous_system_fatigue
Pharmaceutical compound
N-desalkylquetiapine, is a 5-HT2B serotonin receptor modulator, and norepinephrine reuptake inhibitor. It is the principal metabolite of quetiapine. "CAS Common Chemistry"
Norquetiapine
5-HT1A receptor partial agonist and serotonin reuptake inhibitor SNTX-2643 (SENS-01) – atypical serotonin reuptake inhibitor (SRI) (kanna-derived) Dimethyltryptamine
List of investigational social anxiety disorder drugs
List_of_investigational_social_anxiety_disorder_drugs
Mood disorder characterized by emotional, cognitive, and physical symptoms
impairment. The first-line treatment for PMDD is with selective serotonin reuptake inhibitors (SSRIs), which can be administered continuously throughout the
Premenstrual dysphoric disorder
Premenstrual_dysphoric_disorder
Class of antidepressant medication
simultaneously modulate one or more serotonin receptors and inhibit the reuptake of serotonin. The term was created to describe the mechanism of action
Serotonin modulator and stimulator
Serotonin_modulator_and_stimulator
SNRI antidepressant
similar effects and pharmacology, acting as a serotonin–norepinephrine reuptake inhibitor. Levomilnacipran was approved for medical use in the United States
Levomilnacipran
Class of pharmaceutical compounds
An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake of the excitatory neurotransmitters glutamate and aspartate
Excitatory amino acid reuptake inhibitor
Excitatory_amino_acid_reuptake_inhibitor
Pharmaceutical drug classification
Antidepressants (N06A) Specific reuptake inhibitors or receptor modulators SSRIsTooltip Selective serotonin reuptake inhibitors Citalopram# Escitalopram#
ATC_code_N06
Psychoactive substance found in plants in the family Apocynaceae
acetylcholine receptors; its metabolite noribogaine primarily acts as a serotonin reuptake inhibitor and κ-opioid receptor agonist. The psychoactivity of the root
Ibogaine
Sexual health concept
tends to decrease with age. Some medications such as selective serotonin reuptake inhibitors (SSRIs) affect IELT. IELT is one factor used to diagnose and
Intravaginal ejaculation latency time
Intravaginal_ejaculation_latency_time
Chronic neurological sleep disorder
tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and serotonin–norepinephrine reuptake inhibitors (SNRIs) for the treatment of cataplexy
Narcolepsy
Mammalian protein found in humans
cleft back to the presynaptic neuron, in a process known as serotonin reuptake.[full citation needed] This transport of serotonin by the SERT protein
Serotonin_transporter
Opioid analgesic of benzenoid class
selective full agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). Tapentadol is used medically for the treatment of moderate
Tapentadol
Drug increasing motivation in humans
of these drugs include selective serotonin reuptake inhibitors (SSRIs), selective norepinephrine reuptake inhibitors (NRIs), and antipsychotics (which
Motivation-enhancing_drug
SSRI antidepressant
name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder,
Citalopram
Tricyclic antidepressant
nortriptyline, a stronger norepinephrine reuptake inhibitor, further augmenting amitriptyline's effects on norepinephrine reuptake (see table in this section). Amitriptyline
Amitriptyline
Species of plant
this is likely not achieved through typical stimulant mechanisms (such as reuptake inhibition or release of monoamines), nor is this a universal effect. The
Mitragyna_speciosa
Chemical compound
It is a serotonin-norepinephrine reuptake inhibitor (SNRI) with similar norepinephrine, but more serotonin, reuptake inhibition as its parent compound
8-Hydroxyamoxapine
(nonbenzodiazepines/Z-drugs) (e.g., eszopiclone, zaleplon, zolpidem, zopiclone) GABA reuptake inhibitors (e.g., CI-966) Oneirogens (unknown mech.) Harmala alkaloids/β-carbolines
List_of_hallucinogens
Tropane alkaloid and stimulant drug
Pharmacologically, cocaine acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), producing reinforcing effects such as euphoria, increased
Cocaine
Chemical compound
Parkinson's disease. It inhibits the synaptic reuptake of dopamine, serotonin and noradrenaline, making it a triple reuptake inhibitor. It was effective in animal
BTS_74,398
Chemical compound
acting as both a potent NMDA antagonist and also a triple reuptake inhibitor which inhibits reuptake of all three monoamine neurotransmitters serotonin, dopamine
3-Methyl-PCPy
Investigational panic disorder drugs
antagonist [3] Venlafaxine controlled release – serotonin–norepinephrine reuptake inhibitor (SNRI) [4] ADX-71149 (JNJ-1813; JNJ-40411813; JNJ-mGluR2-PAM)
List of investigational panic disorder drugs
List_of_investigational_panic_disorder_drugs
Nonspecific long-lasting anxiety
behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) are the first-line psychological
Generalized_anxiety_disorder
Chemical compound
been found to be 14 to 70 nM for norepinephrine reuptake inhibition and 13 to 80 nM for dopamine reuptake inhibition in rat brain synaptosomes and human
Α-Pyrrolidinopentiophenone
Combination medication
serotonin–norepinephrine reuptake inhibitor, among other actions, while bupropion acts as a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine
Dextromethorphan/bupropion
Atypical antidepressant
antidepressant, bupropion, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, Monoamine oxidase inhibitor among others)
Tianeptine
Genetically targeted enzyme replacement therapy
effects of an increase in cytosolic Ca2+ during diastole by increasing reuptake into the SR.[citation needed] Jaski BE, Jessup ML, Mancini DM, Cappola
Mydicar
Substance that mimics effects of catecholamines
as directly activating postsynaptic receptors, blocking breakdown and reuptake of certain neurotransmitters, or stimulating production and release of
Sympathomimetic_drug
Pharmaceutical compound
receptors and as an agonist of others, and additionally acts as a dopamine reuptake inhibitor, among other actions. A 1978 study found that nuciferine acts
Nuciferine
Designer drug of the substituted cathinone class
norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release. N-Ethylpentedrone also slightly inhibits reuptake serotonin without its
N-Ethylpentedrone
Allosteric serotonin reuptake inhibitor is a type of selective serotonin reuptake inhibitor (SSRI). Evidence of the allosteric action of escitalopram on
Allosteric serotonin reuptake inhibitor
Allosteric_serotonin_reuptake_inhibitor
Psychoactive species of plant
the lining of the stomach. The action of cathine and cathinone on the reuptake of epinephrine and norepinephrine has been demonstrated in lab animals
Khat
Symptoms caused by an excess of serotonin in the central nervous system
drugs. These may include selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors
Serotonin_syndrome
Chemical compound
were identified in 1989. It acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with stimulant and euphoriant properties. Cocaethylene
Cocaethylene
Abandoned antidepressant
in chemical structure to the modafinil derivative and atypical dopamine reuptake inhibitor JJC8-016, as well as to the antihistamine and anticholinergic
Cinfenine
Class of antidepressants
incidence of many side effects often associated with selective serotonin reuptake inhibitor (SSRI) antidepressants; hence, in part, the "specific serotonergic"
Noradrenergic and specific serotonergic antidepressant
Noradrenergic_and_specific_serotonergic_antidepressant
Pharmaceutical compound
and is a known metabolite of mephedrone. The drug acts as a monoamine reuptake inhibitor and monoamine releasing agent, albeit with relatively low potency
4-Methylephedrine
SNDRI antidepressant drug
countries like the United States. It is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and was developed by Luye Pharma Group. Toludesvenlafaxine
Toludesvenlafaxine
SSRI antidepressant
among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class. It is mainly used to treat major depressive disorder
Escitalopram
Investigational fibromyalgia drugs
Esreboxetine ((S,S)-Reboxetine; AXS-14; PNU-165442G) – norepinephrine reuptake inhibitor (NRI) [1] Pregabalin controlled release (GRO-12; Lyrica CR; Pregabalin
List of investigational fibromyalgia drugs
List_of_investigational_fibromyalgia_drugs
Synthetic opioid pain medication
among others, is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderate to severe pain. When taken by mouth
Tramadol
SSRI drug and metabolite of fluoxetine
Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is the (S) enantiomer of norfluoxetine, the active
Seproxetine
Dissociative anesthetic and anti-depressant
with allosteric sites on the monoamine transporters to produce monoamine reuptake inhibition. However, no functional inhibition (IC50) of the human monoamine
Ketamine
Irreversible non-selective MAO inhibitor and antidepressant drug
toxicity. Examples include selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), clomipramine, imipramine
Phenelzine
Major metabolite of rasagiline
unlike selegiline and its amphetamine metabolites, it lacks monoamine reuptake-inhibiting and -releasing activities and associated amphetamine-like psychostimulant
(R)-1-Aminoindane
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