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Antipsychotic medication
Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company
Sertindole
Group of chemical compounds
naratriptan and LY-334370, and the more structurally complex antipsychotic sertindole. The piperidinylindoles are similar to cyclized tryptamines like the
Piperidinylindole
Muscle relaxant medication
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Cyclobenzaprine
Medication used to treat anxiety disorders
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Buspirone
Measurement made on an electrocardiogram
generation/"typical") haloperidol thioridazine mesoridazine chlorpromazine sertindole DMARDs and antimalarial drugs hydroxychloroquine chloroquine quinine Antibiotics
QT_interval
Atypical antipsychotic and antiemetic medication
clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zotepine and more (although not statistically significantly) weight gain
Amisulpride
Antiemetic medication
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Ondansetron
South American psychoactive decoction
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Ayahuasca
Atypical antipsychotic medication
ziprasidone, but less than chlorpromazine, clozapine, perphenazine, and sertindole. As with some other anti-psychotics, quetiapine may lower the seizure
Quetiapine
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
List_of_antidepressants
Chemical compound
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Meclizine
Dissociative anesthetic and anti-depressant
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Ketamine
Medication mainly used for depression and smoking cessation
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Bupropion
Group of chemical compounds
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Β-Carboline
Monoamine neurotransmitter
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Serotonin
Antidepressant medication
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Trazodone
Paliperidone • Perospirone • Piquindone • Quetiapine • Remoxipride • Risperidone • Sertindole • Tiospirone • Ziprasidone • Zotepine Antiemetics: AS-8112 • Alizapride •
List_of_dopaminergic_drugs
Beta blocker drug
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Propranolol
Mushrooms containing psychoactive indole alkaloids
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Psilocybin_mushroom
SSRI antidepressant
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Fluoxetine
Atypical opioid analgesic
risperidone) Piperidinylindoles (e.g., BRL-54443, LY-334370, naratriptan, sertindole, SN-22) Pirlindole Pyridinylbenzimidazoles (e.g., droperidol) Pyridopyrroloquinoxalines
7-Hydroxymitragynine
Drug that binds to but does not activate muscarinic cholinergic receptors
1400 1000 1100 Human Risperidone 11000 ≥3700 13000 ≥2900 >15000 Human Sertindole ND ND 2692 ND ND Human Tenilapine 260 62 530 430 660 Human Thioridazine
Muscarinic_antagonist
Serotonin modulator antidepressant
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Vortioxetine
Non-opioid analgesic drug
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Suzetrigine
Wakefulness-promoting medication
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Modafinil
Antihistamine medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Diphenhydramine
Muscle relaxant medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Baclofen
Class of medications
prolongation — more prominent in those treated with amisulpride, pimozide, sertindole, thioridazine and ziprasidone. Torsades de pointes Seizures, particularly
Antipsychotic
CNS depressant medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Phenibut
Chemical element with atomic number 54 (Xe)
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Xenon
Psychoactive drug, often called ecstasy
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
MDMA
Tricyclic antidepressant
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Amitriptyline
Class of depressant drugs derived from barbituric acid
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Barbiturate
Medication
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Xanomeline/trospium_chloride
Psychedelic drug
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
2C-B
Psychedelic drug
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
LSD
Common name for flowering plants in the family Convolvulaceae
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Morning_glory
Blood pressure medication
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Carvedilol
Anticonvulsant medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Oxcarbazepine
Colourless non-flammable greenhouse gas
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Nitrous_oxide
Psychoactive substance found in plants in the family Apocynaceae
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Ibogaine
Benzodiazepine medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Lorazepam
Pharmaceutical compound
hERG blocker, with an IC50 of 270 nM. For comparison, haloperidol and sertindole had IC50 values for this action of 170 nM and 64 nM, respectively. Similarly
Lu_35-138
Oral cough medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Benzonatate
Anti-seizure medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Phenytoin
Antifungal chemical compound
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Ketoconazole
Species of psychoactive cactus
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Peyote
Class of indoles
Piperidinylindoles like SN-22, BRL-54443, naratriptan, LY-334370, and sertindole Tetrahydropyridinylindoles like RU-24969 (5-MeO-THPI), EMD-386088, MTHPI
Substituted_tryptamine
Medication to treat high blood pressure and alopecia
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Minoxidil
Antihistamine drug
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Hydroxyzine
Serotonergic psychedelic
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Deupsilocin
Atypical antipsychotic medicine
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Cariprazine
Medication
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Metoclopramide
Dopaminergic medication
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Levodopa
Atypical antipsychotic medication
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Paliperidone
Atypical antipsychotic medication
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Olanzapine
Medication mainly used to treat gout
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Colchicine
Species of plant
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Kava
Atypical antipsychotic medication
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Aripiprazole
Compound that activates dopamine receptors
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Dopamine_agonist
Anticonvulsant medication
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Pregabalin
Typical antipsychotic medication
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Chlorpromazine
Medication
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Tavapadon
Weight loss medication
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Phentermine
Pharmaceutical compound
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Landipirdine
Loop diuretic medication
Antipsychotics: increased risk of ventricular arrhythmias with amisulpride, sertindole, or pimozide (avoid with pimozide) if hypokalemia occurs; enhanced hypotensive
Furosemide
Species of cactus
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Echinopsis_lageniformis
Medication for nausea, psychosis, and anxiety
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Prochlorperazine
Chemical compound
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
5-MAPB
Type of medication
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Monoamine_oxidase_inhibitor
Local anaesthetic drug
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Tetracaine
Supplement and medication used to treat sleep disorders
risperidone) Piperidinylindoles (e.g., BRL-54443, LY-334370, naratriptan, sertindole, SN-22) Pirlindole Pyridinylbenzimidazoles (e.g., droperidol) Pyridopyrroloquinoxalines
Melatonin as a medication and supplement
Melatonin_as_a_medication_and_supplement
Antipsychotic medication
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Risperidone
Species of amphibian
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Colorado_River_toad
Hallucinogenic class of psychoactive drug
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Psychedelic_drug
1997 book by Alexander Shulgin and Ann Shulgin
risperidone) Piperidinylindoles (e.g., BRL-54443, LY-334370, naratriptan, sertindole, SN-22) Pirlindole Pyridinylbenzimidazoles (e.g., droperidol) Pyridopyrroloquinoxalines
TiHKAL
Dissociative hallucinogenic drug, mostly used recreationally
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Phencyclidine
Type of α-amino acid
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Phenylalanine
Psychedelic drug
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Dimethyltryptamine
Pharmaceutical compound
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
3,4,5-Trimethoxyamphetamine
Medication used for high blood pressure and ADHD
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Guanfacine
Gamma-aminobutyric acid analogs
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Gabapentinoid
Naturally occurring psychedelic compound
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Mescaline
DMT-infused smoking blend
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Changa_(drug)
alkaloid C02AA02 Risperidone Risperdal, Zepidone pyridopyrimidine N05AX08 Sertindole Serdolect phenylindole N05AE03 Sulpiride Sulpirid, Eglonyl benzenesulfonamide
List_of_antipsychotics
Solvent, now banned for ozone depletion
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
1,1,1-Trichloroethane
Chemical compound
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
5-Fluoro-MPMI
Species of plant
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Ipomoea_corymbosa
Parkinson's disease medication
Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone
Carbidopa/levodopa
Serotonin antagonist/antiemetic
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
Tropisetron
Atypical antipsychotic
Olanzapine (+samidorphan) Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole Others Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine
Sulpiride
Pharmaceutical compound
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
4-PrO-DiPT
Serotonin receptor agonist
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
4-Hydroxytryptamine
Trace amine
certain triptans like avitriptan and naratriptan; the antipsychotics sertindole and tepirindole; and the MAOI antidepressants pirlindole and tetrindole
Tryptamine
Amine hormone
risperidone) Piperidinylindoles (e.g., BRL-54443, LY-334370, naratriptan, sertindole, SN-22) Pirlindole Pyridinylbenzimidazoles (e.g., droperidol) Pyridopyrroloquinoxalines
Melatonin
Atypical antipsychotic
Pae CU (2013). "Asenapine, blonanserin, iloperidone, lurasidone, and sertindole: distinctive clinical characteristics of 5 novel atypical antipsychotics"
Blonanserin
Medication against high blood pressure
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Amlodipine
Class of pharmaceutical drugs
Perospirone + ? ? ? ? Quetiapine ++ ++ +++ ++ ++ Risperidone +++ +++ ++ - + Sertindole ++ ? ? ? ? Ziprasidone ++/+ ++/+ ? - ? Zotepine ++ ? ? ? ? Legend: - Inefficacious
Atypical_antipsychotic
Drug used to treat angina
Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine
Ranolazine
Pharmaceutical compound
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole) AV965 AZD-3676 Beta blockers (e.g., alprenolol, carteolol, cyanopindolol
4-AcO-EPT
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