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Pair of enantiomers
Lenalidomide, sold under the brand name Revlimid among others, is a medication used to treat multiple myeloma, smoldering myeloma, various indolent lymphomas
Lenalidomide
Cancer of plasma cells
83% at 30 months, lenalidomide plus low-dose dexamethasone an 82% survival at 2 years, and melphalan, prednisone, and lenalidomide had a 90% survival
Multiple_myeloma
Class of immunomodulatory drugs
imide group. The IMiD class includes thalidomide and its analogues (lenalidomide, pomalidomide, mezigdomide, iberdomide, and golcadomide). These drugs
Cereblon_E3_ligase_modulator
Diverse collection of blood-related cancers
blood cells, and antibiotics. Drug therapy may include the medications lenalidomide, antithymocyte globulin, and azacitidine. Some people can be cured by
Myelodysplastic_syndrome
pembrolizumab lenalidomide apixaban nivolumab Source: adalimumab lenalidomide pembrolizumab trastuzumab bevacizumab Source: adalimumab lenalidomide rituximab
List of largest selling pharmaceutical products
List_of_largest_selling_pharmaceutical_products
Pharmaceutical drug
humanized IgG1 monoclonal antibody medication used in combination with lenalidomide and dexamethasone, for adults that have received 1 to 3 prior therapies
Elotuzumab
American biopharmaceutical company
that makes cancer and immunology drugs. Its major product is Revlimid (lenalidomide), which is used in the treatment of multiple myeloma, and also in certain
Celgene
Chemical compound
months (in the placebo+lenalidomide+dexamethasone study arm including 362 people) to 20.6 months (under ixazomib+lenalidomide+dexamethasone, 360 people)
Ixazomib
Immunomodulatory drug
sponsored numerous clinical trials with analogues to thalidomide, such as lenalidomide, that are substantially more powerful and have fewer side effects – except
Thalidomide
Chemical compound
including treatment with bortezomib and an immunomodulatory therapy (such as lenalidomide) and have demonstrated disease progression on or within 60 days of completion
Carfilzomib
Human disease
There may be accompanying erythroid hypoplasia in the bone marrow. Lenalidomide has activity in 5q- syndrome and is FDA approved for red blood cell (RBC)
Chromosome 5q deletion syndrome
Chromosome_5q_deletion_syndrome
Pharmaceutical drug
combination with lenalidomide for the treatment of adults with diffuse large B-cell lymphoma; or, when used in combination with lenalidomide and rituximab
Tafasitamab
Medical condition
Lenalidomide or lenalidomide plus dexamethasone (Rd) is a common treatment for high risk SMM. Many clinical trials have shown that a lenalidomide based
Smouldering_myeloma
Organic compound, core structure of many drugs
in several pharmacologically active compounds, including thalidomide, lenalidomide, cycloheximide, and glutethimide, which exhibit immunomodulatory, anticancer
Glutarimide
Chemical compound
and some synthetic derivatives are commercially valuable drugs, e.g. lenalidomide and pazinaclone. 1-Substituted isoindolines and isoindolinones are chiral
Isoindoline
American pharmaceutical company
(Opdivo), used to treat certain types of cancer (21% of 2025 revenues); lenalidomide (Revlimid), used to treat multiple myeloma, smoldering myeloma, and myelodysplastic
Bristol_Myers_Squibb
Database designed to store chemical information
The drug lenalidomide contains substructures isoindoline (red) and glutarimide (blue)
Chemical_database
Corticosteroid medication
(Thal-dex), lenalidomide, bortezomib (Velcade, Vel-dex), or a combination of doxorubicin (Adriamycin) and vincristine or bortezomib/lenalidomide/dexamethasone
Dexamethasone
Monoclonal antibody
autologous stem cell transplant-ineligible multiple myeloma patients with lenalidomide plus dexamethasone significantly improved their responses.. Treatment
Daratumumab
Method of finding chemicals in a database
The drug lenalidomide contains substructures isoindoline (red) and glutarimide (blue)
Substructure_search
German biopharmaceutical company
License Application (BLA) to the FDA for tafasitamab in combination with lenalidomide for the treatment of relapsed/refractory diffuse large B-cell lymphoma
MorphoSys
Chemical compound
reported in 2013 from an early stage clinical trial in combination with Lenalidomide and Dexamethasone. Follow up data reported "encouraging efficacy" in
Indatuximab_ravtansine
Monoclonal antibody
multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor; in combination with carfilzomib and dexamethasone
Isatuximab
Medication
systemic therapy. In November 2025, the FDA approved epcoritamab with lenalidomide and rituximab for relapsed or refractory follicular lymphoma. The FDA
Epcoritamab
Cancer originating in lymph nodes
inotuzumab ozogamicin, or epratuzumab and immunomodulators such as lenalidomide and interferon. The latter medications have been used in combination
Follicular_lymphoma
Chemical compound
treatment of multiple myelomas in adults. It was seen that bortezomib plus lenalidomide plus dexamethasone as well as bortezomib plus melphalan and prednisone
Bortezomib
Chemical compound
developed by Bristol Myers Squibb and has a higher binding affinity than lenalidomide or pomalidomide. It has undergone clinical trials for various cancers
Iberdomide
Paraneoplastic syndrome
being studied. Immunomodulatory imide drugs such as thalidomide and lenalidomide have been used in combination with dexamethasone to treat POEMS syndrome
POEMS_syndrome
Class of chemical compounds
enhance activity by locking proteins into specific states. One example is lenalidomide (an immunomodulatory drug), which binds cereblon (CRBN) and reprograms
Molecular_glue
Type of blood cancer
unclear. A phase I clinical research trial found that the addition of lenalidomide to the R-CHOP regimen produce an ~80% complete response rate in GBC as
Diffuse_large_B-cell_lymphoma
Award
Benjamin L. Ebert American “for his discovery of the mode of action of lenalidomide in the treatment of haematological disorders” 2022 Arul Chinnaiyan American
Sjöberg_Prize
Device for birth control and STI prevention
number 04208575). "Phase III FIRST (MM-020/IFM 07-01) trial of REVLIMID (lenalidomide) plus dexamethasone in newly diagnosed multiple myeloma patients who
Condom
Brazil's federal drug control statute
Zuclopenthixol Acitretin Adapalene Bexarotene Isotretinoin Tretinoin Thalidomide Lenalidomide Pomalidomide List revoked in September 2016. Abacavir Amprenavir Atazanavir
Brazilian Controlled Drugs and Substances Act
Brazilian_Controlled_Drugs_and_Substances_Act
Monoclonal antibody
trial (AMaRC 01-16) assessing KappaMab alone and in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory kappa light chain-restricted
MDX-1097
Treatment of cancer using drugs that inhibit cell division or kill cells
treatment for AL amyloidosis. Other drugs used to treat myeloma such as lenalidomide have shown promise in treating AL amyloidosis. Chemotherapy drugs are
Chemotherapy
Immune system messenger protein which induces inflammation
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Tumor_necrosis_factor
Drug
(Ninlaro) was approved by the FDA in 2015 for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma after at least
Proteasome_inhibitor
American oncologist
Society for Clinical Investigation. In 2014, Ebert's lab found that lenalidomide, a cancer drug, targeted two proteins, IKZF1 and IKZF3, for degradation
Benjamin_L._Ebert
Japanese pharmaceutical company
Administration approved Ixazomib developed by Takeda for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma after at least
Takeda_Pharmaceutical_Company
Non-departmental public body in England
increased above £30,000. The first drug to go through the new process was lenalidomide, whose ICER was £43,800. The following example from NICE explains the
National Institute for Health and Care Excellence
National_Institute_for_Health_and_Care_Excellence
Chemical compound
myeloma who have received at least one prior treatment regimen including lenalidomide; and in combination with dexamethasone for the treatment of adults with
Pomalidomide
Rare type of blood cancer
alpha-interferon and hydroxyurea (also known as hydroxycarbamide) may play a role. Lenalidomide and thalidomide may be used in its treatment, though peripheral neuropathy
Primary_myelofibrosis
Activation or suppression of the immune system to treat disease
Immunomodulatory imide drugs (IMiDs) thalidomide and its analogues (lenalidomide, pomalidomide, and apremilast), BCG vaccine, & COVID vaccines [dubious
Immunotherapy
Medication used as chemotherapy and to suppress the immune system
azathioprine. Cyclophosphamide, used in combination with thalidomide or lenalidomide and dexamethasone has documented efficacy as an off-label treatment of
Cyclophosphamide
Pharmaceutical drug
dexamethasone in people who have received at least one prior therapy including lenalidomide. In the US, belantamab mafodotin is indicated for use in combination
Belantamab_mafodotin
Experiment TNFα inhibitor
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Pegipanermin
Cleaved form of B-cell maturation antigen
outcomes among patients with relapsed or refractory MM treated with lenalidomide, ruxolitinib and methylprednisolone, baseline sBCMA levels were found
Serum B-cell maturation antigen
Serum_B-cell_maturation_antigen
Gene therapy medication used to treat multiple myeloma
proteasome inhibitor and an immunomodulatory agent, and are refractory to lenalidomide. In April 2024, the FDA label boxed warning was expanded to include T
Ciltacabtagene_autoleucel
Anemia which requires regular blood transfusion
While for transfusion-dependent myelodysplastic syndrome patients, lenalidomide is approved for treating lower-risk patients and hypomethylating agents
Transfusion-dependent_anemia
Protein superfamily of cytokine receptors
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
TNF_receptor_superfamily
Company based in Riga, Latvia
Clobetasol Ketoconazole Oxytocin Terbinafine Apixaban Dapagliflozin Lenalidomide Pomalidomide Ursodeoxycholic acid (UDCA) Apremilast Dexpanthenol Lidocaine
Grindeks
Medical condition
"Primary effusion lymphoma in an elderly patient effectively treated by lenalidomide: case report and review of literature". Blood Cancer Journal. 4 (3).
AIDS-related_lymphoma
Protein in humans
protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide". Leukemia. 26 (11): 2326–2335. doi:10.1038/leu.2012
Cereblon
Artificial stimulation of the immune system to treat cancer
humanized IgG1 monoclonal antibody medication used in combination with lenalidomide and dexamethasone, for adults that have received 1 to 3 prior therapies
Cancer_immunotherapy
Swiss medicine regulations
of the drug is possible since 2018. tramadol, amoxicillin, ritonavir, lenalidomide B Drugs which can cause health damage even under correct use. Drugs for
Dispensing category (Switzerland)
Dispensing_category_(Switzerland)
Medical condition
phase to study the efficacy of DA-EPOCH (which includes rituximab) plus lenalidomide in treating PEL. Current studies are also examining the effects of drug-based
Primary_effusion_lymphoma
Combination drug
are ineligible for autologous stem cell transplant in combination with lenalidomide and dexamethasone (D-Rd) in newly diagnosed adults who are ineligible
Daratumumab/hyaluronidase
Medication for psoriasis and psoriatic arthritis
The inhibition potency of apremilast in TNF-α production is similar to lenalidomide. Celgene reported seven kinds of crystal forms — A, B, C, D, E, F, and
Apremilast
Membrane receptor protein found in humans
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Tumor necrosis factor receptor 1
Tumor_necrosis_factor_receptor_1
Protein found in humans
thalidomide. Thalidomide and other derivatives such as pomalidomide and lenalidomide are known as immunomodulatory drugs (or IMiDs) and have been investigated
Cullin-4B
Celgene Corporation's immunomodulatory drugs (IMiDs), pomalidomide or lenalidomide, as a rescue treatment in relapsing myeloma patients. The first patient
Pelareorep
Clumping of abnormal cold-sensitive proteins in blood
anti-CD38 drugs such as daratumumab and isatuximab or immunosuppression with lenalidomide or thalidomide may be used in IgA or IgG disease, but treatment strategies
Cryoglobulinemia
Group of disorders
Pralatrexate, Romidepsin, Brentuximab vedotin, Belinostat, Bendamustine, lenalidomide, and alisertib have shown activity against CTCL, NOS and are being further
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
Class of pharmaceutical drug
approved by the FDA in the US. Czarnik has invented drugs such as (R)-d1-lenalidomide and (R)-d1-pioglitazone for clinical studies. Numerous publications have
Deuterated_drug
Medical condition
treatment options include immunomodulatory drugs such as thalidomide or lenalidomide. The monoclonal antibody against the plasma cell surface protein CD38
Monoclonal gammopathy of renal significance
Monoclonal_gammopathy_of_renal_significance
Protein found in humans
thalidomide. Thalidomide and other derivatives such as pomalidomide and lenalidomide are known as immunomodulatory drugs (or IMiDs) and have been investigated
Cullin-4A
Class of immunosuppressive drug
(e.g. pentoxifylline) and bupropion. Thalidomide and its derivatives lenalidomide and pomalidomide are also active against TNF. Several 5-HT2A agonist
TNF_inhibitor
Regimen commonly used in chemotherapy
vincristine (Oncovin), methotrexate, leucovorin non-Hodgkin lymphoma RdC lenalidomide (Revlimid), dexamethasone, cyclophosphamide AL amyloidosis R-Benda rituximab
Chemotherapy_regimen
Topics referred to by the same term
Party, a former political party in Trinidad and Tobago Thalidomide, lenalidomide and pomalidomide, in the development of analogs of thalidomide drugs
TLP
Index of chemical compounds with the same molecular formula
mass: 259.27 g/mol, exact mass: 259.0957 u) may refer to: Ciclobendazole Lenalidomide This set index page lists chemical structure articles associated with
C13H13N3O3
Medical condition
often include induction with a three drug regimen such as borezomib-lenalidomide-dexamethasone followed by autologous stem-cell transplantion and
Plasma_cell_leukemia
Class of enzymes
myeloma who have received at least one prior line of therapy including lenalidomide and a proteasome inhibitor. Efgartigimod alfa/hyaluronidase (Vyvgart
Hyaluronidase
Medical condition
inhibitors: captopril, enalapril. Other drugs: digoxin, ranitidine, lenalidomide, methyldopa, interleukin 2, dobutamine, acetazolamide. Contaminants:
Eosinophilic_myocarditis
ulceration (rare). Topical: Erythema. 2.4 Immunomodulatory Agents (IMiDs) Lenalidomide PO Numerous actions; anti-angiogenesis (via inhibition of VEGF release)
List_of_antineoplastic_agents
Medical condition
combined with chemotherapy; obinutuzumab; combination immunotherapy with lenalidomide and rituximab; and radiolabeled monoclonal antibody therapy. Phosphatidylinositol
Indolent_lymphoma
Protein which in humans is encoded by the SDC1 gene
621–627. PMID 16739330. Indatuximab Ravtansine (BT062) In Combination With Lenalidomide and Low-Dose Dexamethasone In Patients With Relapsed and/Or Refractory
Syndecan_1
Genetic disorder affecting blood vessel development
(brand name Avastin), pazopanib, and thalidomide or its derivatives (lenalidomide, pomalidomide) interfere with the production of new blood vessels that
Hereditary hemorrhagic telangiectasia
Hereditary_hemorrhagic_telangiectasia
American biochemist and inventor (born 1957)
deuterium-substitution in drug discovery.. He has also invented drugs such as (R)-d1-lenalidomide and (R)-d1-pioglitazone, for clinical studies. Czarnik; A.W. Alcoholic
Anthony_Czarnik
Drug class
Colomer D, Roué G (October 2014). "Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle
BET_inhibitor
German structural and chemical biologist
Fischer, Eric S.; Thomä, Nicolas H. (April 2016). "Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase". Nature. 532
Nicolas_H._Thomä
gastroesophageal junction adenocarcinoma (GC/GEJC) Epcoritamab In combination with lenalidomide and rituximab for the treatment of adult patients with relapsed or refractory
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
Anti-cancer drug
conventional chemotherapy, targeted therapy with bortezomib, carfilzomib, lenalidomide, pomalidomide, and a monoclonal antibody (daratumumab or isatuximab);
Selinexor
Medical condition
treatments are ineffective, third-line treatments such as thalidomide or lenalidomide may be considered. Another effective treatment for suppressive, non-curative
Tumid_lupus_erythematosus
Pharmaceutical drug classification
L04AX01 Azathioprine L04AX02 Thalidomide L04AX03 Methotrexate L04AX04 Lenalidomide L04AX05 Pirfenidone L04AX06 Pomalidomide L04AX07 Dimethyl fumarate L04AX08
ATC_code_L04
Membrane receptor protein found in humans
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Tumor necrosis factor receptor 2
Tumor_necrosis_factor_receptor_2
Protein found in humans
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Lymphotoxin_alpha
InterPro Family
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Lymphotoxin
immunomodulatory drugs (IMiDs), Imnovid (pomalidomide) or Revlimid (lenalidomide), as a rescue treatment in relapsing myeloma patients. The first patient
Oncolytics_Biotech
Protein-coding gene in the species Homo sapiens
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Lymphotoxin_beta
Pharmaceutical drug
been completed. Drug interactions with erythropoietin include: Major: lenalidomide—risk of thrombosis Moderate: cyclosporine—risk of high blood pressure
Epoetin_alfa
Monoclonal antibody
Biotechnology News. September 2011. Clinical trial number NCT02077959 for "Lenalidomide and Pidilizumab in Treating Patients With Relapsed or Refractory Multiple
Pidilizumab
Overview of and topical guide to immunology
Ciclosporin Pimecrolimus Tacrolimus Voclosporin Abetimus Gusperimus IMiDs Lenalidomide Pomalidomide Thalidomide PDE4 inhibitor Apremilast JAK inhibitors Baricitinib
Outline_of_immunology
lemalesomab (INN) lemidosul (INN) lemildipine (INN) leminoprazole (INN) lenalidomide (USAN) lenampicillin (INN) lenapenem (INN) lenefilcon A (USAN) lenercept
List_of_drugs:_Le
American physician-scientist
Loughran TP Jr, Maciejewski JP (2010). "Phase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes"
Thomas_P._Loughran_Jr.
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Lymphotoxin_beta_receptor
Protein superfamily
Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide Others TNF superfamily
Tumor necrosis factor superfamily
Tumor_necrosis_factor_superfamily
Protein-coding gene in humans
cell transfusions. The disease is treated with a chemotherapy drug, lenalidomide. Human chromosome translocations between the PDGFRB gene and at least
PDGFRB
Medical condition
trial testing the effectiveness and safety of R-CHOP versus R-CHOP plus lenalidomide (unclear mechanism of action) in 570 previously untreated participants
Diffuse large B-cell lymphoma associated with chronic inflammation
Diffuse_large_B-cell_lymphoma_associated_with_chronic_inflammation
(TTP) (ticlopidine and clopidogrel), thromboembolism (thalidomide and lenalidomide), liver failure (gemtuzumab and nevirapine), hypersensitivity (drug eluting
Research on Adverse Drug Events and Reports
Research_on_Adverse_Drug_Events_and_Reports
Alkylating type cancer drug
plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study". The
Melphalan_flufenamide
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