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Protein produced and used by the thyroid
Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is
Thyroglobulin
Endocrine gland in the neck
directly the main carriers of the thyroid hormones, thyroglobulin and throxine-binding globulin. Thyroglobulin will also be measurable in a healthy thyroid,
Thyroid
Enzyme expressed mainly in the thyroid gland
iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid
Thyroid_peroxidase
Species of salamander
tyrosyl residues of thyroglobulin. Two iodinated tyrosyl residues are conjugated together. When they are cleaved from the thyroglobulin chain, thyroid hormone
Axolotl
Hormones produced by the thyroid gland
follicular cells of the thyroid gland. It is produced from the precursor thyroglobulin (this is not the same as thyroxine-binding globulin [TBG]), which is
Thyroid_hormones
Protein family
Thyroglobulin type-1 repeat is an evolutionary conserved protein domain. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic
Thyroglobulin_domain
Medical condition
interpreting thyroglobulin results without thyroglobulin antibodies, since thyroglobulin antibodies commonly interfere in thyroglobulin immunoassays causing
Thyrotoxicosis_factitia
Autoimmune disease
autoimmunity have been proposed: Via thyroglobulin iodination: Iodine exposure leads to higher iodination of thyroglobulin, increasing its immunogenicity by
Hashimoto's_thyroiditis
Antibodies targeted against the thyroid
(anti-TPO antibodies, TPOAb), thyrotropin receptor antibodies (TRAb) and thyroglobulin antibodies (TgAb). TRAb's are subdivided into activating, blocking and
Antithyroid_autoantibodies
Insufficient production of thyroid hormones
autoantibodies against specific thyroid antigens such as thyroid peroxidase, thyroglobulin and the TSH receptor. Hashimoto's thyroiditis is associated with other
Hypothyroidism
place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation
Organification
Family of glycoprotein hormones in vertebrata
triiodothyronine (T3) that remain attached to the thyroglobulin protein. (4) Increased endocytosis of the iodinated thyroglobulin protein across the apical membrane
Thyroid-stimulating_hormone
Chemical compound
The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. The clinical effects of the drug to treat the
Methylthiouracil
Chemical compound
thyroperoxidase iodinates the tyrosyl residues of the thyroglobulin within the colloid. The thyroglobulin was synthesised in the ER of the follicular cell
Triiodothyronine
Medication used for hyperthyroidism
peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine)
Carbimazole
Medical condition
endocrinologist and a surgeon (head and neck surgeon or endocrine surgeon). Thyroglobulin can be used as a tumor marker for well-differentiated papillary thyroid
Papillary_thyroid_cancer
Collective term for blood tests used to check the function of the thyroid
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. TFTs may be requested if a patient is thought
Thyroid_function_tests
Tumor of the thyroid gland
and very focal expression of thyroglobulin i Lipid-rich follicular thyroid carcinoma (a) immunoreactive for thyroglobulin (b); the ultrastructural study
Thyroid_neoplasm
Effect of iodine on the thyroid
injection of iodine in rats almost completely inhibited organification (thyroglobulin iodination) in the thyroid gland. However, recent[when?] research into
Wolff–Chaikoff_effect
Thyroid hormone
oxidase DUOX2. The oxidized iodine then iodinates tyrosyl residues of thyroglobulin (Tg), a glycoprotein synthesized by thyroid cells and stored in the
Thyroxine
Enzyme found in humans
separating out the thyroid hormone, thyroxine (T4), from its precursor, thyroglobulin. This gene encodes a metallopeptidase that belongs to the peptidase
Carboxypeptidase_Q
Malignant tumor made of hormone-producing cells in the thyroid gland
thyroid cancer and occurs more commonly in women over 50 years of age. Thyroglobulin (Tg) can be used as a tumor marker for well-differentiated follicular
Follicular_thyroid_cancer
Medical condition
against different normal components of the thyroid gland, most commonly thyroglobulin, thyroid peroxidase, and the TSH receptor. These antibodies cause the
Thyroid_disease
Hormone-producing cell in the thyroid gland
acids from the blood circulation on the basolateral side, synthesize thyroglobulin and thyroperoxidase from amino acids and secrete these into the thyroid
Thyroid_follicular_cell
Chemical compound
facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin, a necessary step in the synthesis of triiodothyronine (T3) and thyroxine
Thiamazole
Medical imaging technique
fluid density on a CT scan, whereas a cyst with haemorrhage or high thyroglobulin content is iso-dense to muscle. Thyroid nodules that are detected by
Computed tomography of the thyroid
Computed_tomography_of_the_thyroid
Proxy markers for certain cancers
tumor thymidine kinase lymphoma, leukemia, lung cancer, prostate cancer thyroglobulin (Tg) post-operative marker of thyroid cancer (but not in medullary thyroid
Tumor_marker
Medical intervention
eradicated, and there may be a drop in the cancer blood marker test, thyroglobulin, TG, as the node become non-functional. Another interventional use for
Medical_ultrasound
Topics referred to by the same term
Garden (fetish club), London, England Thapsigargin, a tumor promoter Thyroglobulin, a protein Transgenic, the transfer of genes between organisms Triglyceride
TG
Scientist at McGill University
important discoveries in glycobiology. She discovered in 1969 that thyroglobulin undergoes carbohydrate modifications, part of a class of proteins known
Annette_Herscovics
Autoimmune endocrine disease
linked to multiple genes Genes believed to be involved include those for thyroglobulin, thyrotropin receptor, protein tyrosine phosphatase nonreceptor type
Graves'_disease
Topics referred to by the same term
Anti-transglutaminase antibodies Anti-topoisomerase antibodies Anti-thyroglobulin antibodies This disambiguation page lists articles associated with the
ATA_antibodies
Protein-coding gene in the species Homo sapiens
overall health, in good status. Within the thyroid follicular cell, thyroglobulin is hydrolyzed to form thyroid hormones and mono- and diiodotyrosine
Iodotyrosine_deiodinase
Type of allergic reaction
neuropathies Schwann cell antigen Neuritis, paralysis Hashimoto's thyroiditis Thyroglobulin antigen Hypothyroidism, hard goiter, follicular thymitis Inflammatory
Type_IV_hypersensitivity
Glands of the endocrine system that secrete hormones to blood
consists of follicles with a stored protein called colloid, containing thyroglobulin, a precursor to other thyroid hormones, which are manufactured within
Endocrine_gland
Medication used to treat hyperthyroidism
facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin. This is one of the essential steps in the formation of thyroxine (T4)
Propylthiouracil
Class of compounds
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Proteoglycan
Thyroid hormone medication
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Levothyroxine
British scientist
Deborah Doniach and Peter Campbell, he made the classic discovery of thyroglobulin autoantibodies in Hashimoto's thyroiditis which helped to open the whole
Ivan_Roitt
Protein-coding gene in the species Homo sapiens
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Osteoglycin
thyroid gland, the antigen was thyroglobulin. He was a mentor to Noel Rose in this research endeavor to prepare thyroglobulin from rabbits. In 1967 the State
Ernst_Witebsky
Protein family
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Glycophorin
Chemical element with atomic number 34 (Se)
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Selenium
Medical condition
(ng/dL divided by μg/dL). Nearly all patients have increased serum thyroglobulin, which is consistent with follicular destruction. Microscopic evaluation
De_Quervain's_thyroiditis
Medical condition
immunohistological features of susceptible women are indicated by: antibodies to thyroglobulin (TgAb) antibodies to thyroid peroxidase (TPOAb) increase in TPOAb subclasses
Postpartum_thyroiditis
Topics referred to by the same term
World War II Hugo Treffner Gymnasium, a school in Tartu, Estonia Human Thyroglobulin, a protein produced by the thyroid gland Hunting plc, a British energy
HTG_(disambiguation)
for clinical measurement of thyroglobulin as a marker of thyroid cancer recurrence in patients who exhibit anti-thyroglobulin autoantibodies. A limitation
Stable isotope standards and capture by anti-peptide antibodies
Stable_isotope_standards_and_capture_by_anti-peptide_antibodies
Mammalian protein found in Homo sapiens
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Protein_C
Ion, and compounds containing the ion
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Perchlorate
follistatin-like domain (FS), extracellular calcium-binding domain (EC), and thyroglobulin type-1 domain (TY) fold into a compact FS–EC–TY core that enables activity
Testican
Hormone antagonist acting upon thyroid hormones
thyroperoxidase), decreasing iodide oxidation, iodination of tyrosyl residues in thyroglobulin, and coupling of iodotyrosyl and iodothyronyl residues. It is thought
Antithyroid_agent
Plummer effect, a high iodine concentration inhibits the proteolysis of thyroglobulin and the release of pre-formed thyroid hormones from thyroid follicles
Plummer_effect
Excessive production of thyroid hormone
Thyrostatics are believed to work by inhibiting the iodination of thyroglobulin by thyroperoxidase and, thus, the formation of tetraiodothyronine (T4)
Hyperthyroidism
Medical condition
Neonatal jaundice Umbilical hernia Occasional Abnormality of circulating thyroglobulin concentration Slow heart rate Saddle nose deformity Edema of face Decreased
Thyroid_dyshormonogenesis
Chemical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Resmetirom
Compulsion towards imitating symptoms of illness to gain attention or care
thyroid uptake, which would be elevated in true hyperthyroidism Low thyroglobulin levels, which should be elevated in true hyperthyroidism Hypoglycaemia
Factitious disorder imposed on self
Factitious_disorder_imposed_on_self
Amino acid
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Tyrosine
Chemical compound
1971 showed that CB interferes with the release of iodine derived from thyroglobulin and blocks colloid endocytosis. Moreover, it was found that CB has an
Cytochalasin_B
Polymer in bacterial cell walls
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Peptidoglycan
Topics referred to by the same term
in certain autoimmune diseases Anti-topoisomerase antibodies Anti-thyroglobulin antibodies Allen Telescope Array Atmosphere absolute, a variant of the
Ata
Thyroid hormone deficiency present at birth
thyrotropin (TSH) resistance, iodine trapping defect, organification defect, thyroglobulin, and iodotyrosine deiodinase deficiency. In a small proportion of cases
Congenital_hypothyroidism
Topics referred to by the same term
International Trans Golgi network in biology IEEE 802.11n Task Group N Thyroglobulin, a protein Getty Thesaurus of Geographic Names TGN (AM) radio station
TGN
Isotope of iodine
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Iodine-131
Digestive organ
antigens and associated autoimmune diseases, secretion of glycoproteins (thyroglobulin and mucin) and peptide hormones, the digesting and readsorbing ability
Stomach
Biochemical classification for carbohydrates
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Glycoconjugate
Chemical element with atomic number 53 (I)
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Iodine
Malignancy originating in the thyroid gland
body scans, and routine laboratory blood tests for changes in thyroglobulin, thyroglobulin antibodies, or calcitonin, depending on the subtype of thyroid
Thyroid_cancer
Glycoprotein produced in the stomach which binds to vitamin B12
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Intrinsic_factor
Chemical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
2-Thiouracil
Medical condition
believed that antibodies binding to the follicular cells, colloid, or thyroglobulin antigens activate the process that causes follicular destruction. Breed
Hypothyroidism_in_dogs
Mammalian protein found in humans
of their luminal domains, with p41 and p43 containing an additional thyroglobulin-like region that influences proteolytic processing and MHC class II
CD74
Beta blocker drug
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Propranolol
Species of mammal
Korean hare, Lepus coreanus (Mammalia, Lagomorpha), revealed by nuclear thyroglobulin gene and mtDNA control region sequences". Biochemical Genetics. 48 (7–8):
Korean_hare
Medical condition
ocular signs and symptoms, but positive tests for antibodies (anti-thyroglobulin, anti-microsomal and anti-thyrotropin receptor) and abnormalities in
Graves'_ophthalmopathy
Human protein
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Mucin_short_variant_S1
Chemical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Liotrix
Medical condition
the Multinodular Goiter-1 Locus and Exclusion of the Candidate Genes Thyroglobulin, Thyroperoxidase, and Na+/I− Symporter*". The Journal of Clinical Endocrinology
Nontoxic_multinodular_goitre
Medical condition
Lymphoma Neprilysin Lymphosarcoma CD3 CD79a Endocrine Thyroid cancer Thyroglobulin Medullary thyroid cancer (Calcitonin Carcinoembryonic antigen) Pheochromocytoma
Germinoma
Cell-surface glycoprotein
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
CD44
antibodies to red blood cells, platelets, lymphocytes, clotting factors, and thyroglobulin. The disease can result in deposition of immune complexes or autoimmune
List_of_dog_diseases
Chemical changes in proteins following their translation from mRNA
an iodine atom to the aromatic ring of a tyrosine residue (e.g. in thyroglobulin) nucleotide addition such as ADP-ribosylation persulfidation, the addition
Post-translational modification
Post-translational_modification
Chemical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
VK2809
Protein family
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Glypican
Chemical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Sobetirome
Protein domain
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
ADAM_(protein)
Symptoms resulting from kidney damage
lungs, causing hypoxia and dyspnoea. Hypothyroidism: deficiency of the thyroglobulin transport protein thyroxin (a glycoprotein that is rich in iodine and
Nephrotic_syndrome
Chemical-analysis technique
molecular weight), and a sample containing a very large molecule such as thyroglobulin to determine the void volume. (Blue dextran is not recommended for Vo
Size-exclusion_chromatography
Neurotoxin
of thyroglobulin type I domain (Thyroglobulin type-1 1 and Thyroglobulin type-1 2) and a signal peptide. Based on the presence of the thyroglobulin domains
U24-ctenitoxin-Pn1a
Antibody directed against an autogenic protein
(microsomal) Hashimoto's thyroiditis, Graves' disease Anti-thyroglobulin antibodies (TgAbs) Thyroglobulin Hashimoto's thyroiditis Anti-thyrotropin receptor antibodies
Autoantibody
Nuclear protein
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Thyroid_hormone_receptor
Mammalian protein found in Homo sapiens
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Thrombopoietin
Chemical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Liothyronine
Protein with oligosaccharide modifications
component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin Thyroglobulin Thyroxine-binding proteins Transcortin Tumor necrosis factor alpha Uteroglobin
Glycoprotein
Common human medical data ranges for blood test results
triiodothyronine 60, 75 175, 181 ng/dL 0.9, 1.1 2.5, 2.7 nmol/L Thyroxine-binding globulin (TBG) 12 30 mg/L Thyroglobulin (Tg) 1.5 30 pmol/L 1 20 μg/L
Reference ranges for blood tests
Reference_ranges_for_blood_tests
Organosulfur compound (S=C(NH2)2)
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Thiourea
Chemical compound or ion
the thyroid gland. The pertechnetate ion is not incorporated into the thyroglobulin. It is also used in the study of blood perfusion, regional accumulation
Pertechnetate
Chemical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Omzotirome
Mammalian protein found in Homo sapiens
all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis, and proteolysis; thyroid peroxidase
Thyrotropin_receptor
Pharmaceutical compound
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Elunetirom
Thyroid gland prepared for medical use
sodium (sodium iopodate) Propranolol Propylthiouracil Others Iodine Iodine-131 Selenium Thyroglobulin Tyrosine See also: Receptor/signaling modulators
Desiccated_thyroid_extract
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