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Inhibitory neurotransmitter in the mammalian brain
GABA, also known as gamma-aminobutyric acid or γ-aminobutyric acid, is the chief inhibitory neurotransmitter in the developmentally mature mammalian central
GABA
Index of chemical compounds with the same name
Aminobutyric acid or aminobutanoic acid refers to any of three isomeric chemical compounds that differ in the position of the amino group (-NH₂) relative
Aminobutyric_acid
Chemical compound
α-Aminobutyric acid (AABA), also known as homoalanine in biochemistry, is a non-proteinogenic alpha amino acid with chemical formula C4H9NO2. The straight
Α-Aminobutyric_acid
Chemical compound
β-Aminobutyric acid (BABA) is an isomer of the amino acid aminobutyric acid with the chemical formula C4H9NO2. It has two isomers, α-aminobutyric acid and
Β-Aminobutyric_acid
CNS depressant medication
The medication is structurally related to the neurotransmitter γ-aminobutyric acid (GABA), and hence is a GABA analogue. Phenibut is thought to act as
Phenibut
Naturally occurring sedative and hallucinogen
alkaloid and is closely related structurally to the neurotransmitter γ-aminobutyric acid (GABA). The compound is widely used as a ligand and agonist of the
Muscimol
Anticonvulsant drug
γ-Amino-β-hydroxybutyric acid (GABOB), also known as β-hydroxy-γ-aminobutyric acid (β-hydroxy-GABA), sold under the brand name Gamibetal among others
Γ-Amino-β-hydroxybutyric_acid
Epilepsy medication
complex partial seizures. It works by inhibiting the breakdown of γ-aminobutyric acid (GABA). It is also known as γ-vinyl-GABA, and is a structural analogue
Vigabatrin
Ionotropic receptor and ligand-gated ion channel
receptor (i.e., ligand-gated ion channel). Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous
GABAA_receptor
G-protein coupled receptor
GABAB receptors (GABABR) are G-protein coupled receptors for gamma-aminobutyric acid (GABA). GABAB receptors are found in the central nervous system and
GABAB_receptor
Class of transport proteins
Shimada S, Cutting G, Uhl GR (April 1992). "gamma-Aminobutyric acid A or C receptor? gamma-Aminobutyric acid rho 1 receptor RNA induces bicuculline-, barbiturate-
GABAA-rho_receptor
Endogenous GABA precursor
N-Acetyl-γ-aminobutyric acid (N-acetyl-GABA), also known as N-acetyl-4-aminobutyric acid, is a metabolic intermediate in the biosynthesis of γ-aminobutyric acid
N-Acetyl-γ-aminobutyric_acid
Chemical compound
2005). "Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice". Annals of Emergency Medicine
Γ-Hydroxybutyric_acid
Amino acids not naturally encoded in the genome
Miller–Urey experiment), might be important neurotransmitters, such as γ-aminobutyric acid, and can play a crucial role in cellular bioenergetics, such as creatine
Non-proteinogenic_amino_acids
Pharmaceutical compound
Piperidine-4-sulfonic acid (P4S) is a synthetic GABAA receptor agonist and a cyclized analogue of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The
Piperidine-4-sulfonic_acid
Index of enzymes associated with the same name
4-aminobutyric acid aminotransferase may refer to: 4-aminobutyrate—pyruvate transaminase, an enzyme 4-aminobutyrate transaminase, an enzyme This set index
4-aminobutyric acid aminotransferase
4-aminobutyric_acid_aminotransferase
Class of drugs
derivative of the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic acid). Many GABA analogues are used as drugs,
GABA_analogue
derivative) – GABATooltip γ-aminobutyric acid analogue, mitochondrial modulator, racetam RGPU-260 – GABATooltip γ-aminobutyric acid analogue, cardiac stimulant
List_of_Russian_drugs
Organic compounds containing amine and carboxylic groups
non-proteinogenic amino acids are not found in proteins. Examples include 2-aminoisobutyric acid and the neurotransmitter gamma-aminobutyric acid. Non-proteinogenic
Amino_acid
Carboxylic acid – CH3(CH2)3COOH
increase γ-aminobutyric acid (GABA) levels in feces, blood, and brain in rodents. The mechanism of this effect is unknown. However, valeric acid is structurally
Valeric_acid
Index of enzymes associated with the same name
Gamma-aminobutyric acid aminotransferase may refer to: 4-aminobutyrate—pyruvate transaminase, an enzyme, or 4-aminobutyrate transaminase, an enzyme This
Gamma-aminobutyric acid aminotransferase
Gamma-aminobutyric_acid_aminotransferase
Tea
PY (January 1971). "Blood–brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals". Neuropharmacology. 10 (1): 103–108
GABA_tea
Chemical compound
toxic reactive oxygen species; and synthesize the neurotransmitter γ-aminobutyric acid (GABA). A large body of preclinical (i.e., conducted in animal models
Α-Ketoglutaric_acid
Chemical compound
3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) and is
Tolibut
Receptors that respond to gamma-aminobutyric acid
are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central
GABA_receptor
Drug Class
Redl (April 2002). "Tranexamic Acid, a Widely Used Antifibrinolytic Agent, Causes Convulsions by a γ-Aminobutyric AcidA Receptor Antagonistic Effect"
GABA_receptor_antagonist
Category of drug
evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists". J Med Chem. 56 (3): 993–1006. doi:10.1021/jm301473k
GABA_receptor_agonist
Pharmaceutical compound
Isonipecotic acid, also known as piperidine-4-carboxylic acid (P4C), is a conformationally constrained derivative of γ-aminobutyric acid (GABA) and a
Isonipecotic_acid
Hallucinogenic drug
the major signaling receptor of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The mechanism of action of GABAA receptor agonists is unlike
GABAA_receptor_agonist
Spectrum of mood disorders
suggests that disturbances in neurotransmitters like dopamine and gamma-aminobutyric acid (GABA) may contribute to the development of catatonic symptoms. Furthermore
Catatonic_depression
One of four stable isomers of butanediol
HOCH2CH2CH2CH2OH. It is a colorless viscous liquid first synthesized in 1890 via acidic hydrolysis of N,N'-dinitro-1,4-butanediamine by Dutch chemist Pieter Johannes
1,4-Butanediol
Chemical compound
pikamilon) is a drug formed by a synthetic combination of niacin and γ-aminobutyric acid (GABA). It was developed in the Soviet Union in 1969 and further studied
Picamilon
Chemical compound
D-pantoate and β-alanine, hopantenic acid is the amide of D-pantoate and γ-aminobutyric acid (GABA). This change leads to an additional CH2 in the molecule. Methyl
Hopantenic_acid
Experiment testing the origin of life
α-alanine and β-alanine were positively identified, while aspartic acid and α-aminobutyric acid (AABA) were less certain, due to the spots being faint. Materials
Miller–Urey_experiment
Sleep medication
2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits
Zolpidem
Chemical compound
N-methyl-2-pyrrolidone. In humans, GBL acts as a prodrug for gamma-hydroxybutyric acid (GHB) and is often used as a recreational drug. GHB acts as a central nervous
Γ-Butyrolactone
Amino acid and neurotransmitter
precursor for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABAergic neurons. Glutamic acid exists in two optically isomeric forms; the dextrorotary
Glutamic_acid
Protein-coding gene in humans
Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene. GABA is the major inhibitory neurotransmitter
GABRA1
Chemical compound
signaling receptor of the inhibitory endogenous neurotransmitter γ-aminobutyric acid (GABA). However, it acts as a preferential supra-maximal agonist at
Gaboxadol
Loop diuretic medication
"Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor". Molecular Pharmacology. 47 (2): 283–289. doi:10
Furosemide
Fluoroquinolone antibiotic
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Its empirical formula is C17H18FN3O3 and its molecular weight is 331.4 g/mol
Ciprofloxacin
Blood pressure medication
carcinogens N-nitrosodiethylamine, N-methylnitrosobutyric acid, or N-nitroso-N-methyl-4-aminobutyric acid in the active pharmaceutical ingredient (API). Losartan
Losartan
Medication used for epilepsy, bipolar disorder and migraine
neurotransmitter γ-aminobutyric acid (GABA). Other analogues of valproic acid include valproate pivoxil, valpromide, and valnoctamide. Valproic acid was first
Valproate
Explosive chemical compound
cheap nitration agent, called "mixed acid", cannot be used for RDX synthesis because concentrated sulfuric acid used to stimulate the nitronium ion formation
RDX
Protein-coding gene in the species Homo sapiens
GABA type A receptor associated protein like 1 is a protein that in humans is encoded by the GABARAPL1 gene. GRCh38: Ensembl release 89: ENSG00000139112
GABA type A receptor associated protein like 1
GABA_type_A_receptor_associated_protein_like_1
Pharmaceutical compound
the amide of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Along with GABA and progabide acid (SL-75.102), gabamide is an active metabolite
Gabamide
Enzyme
decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide
Glutamate_decarboxylase
Pharmaceutical compound
receptor agonist and derivative of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). It is said to be a lipophilic prodrug of GABA that in contrast
N-Benzoyl-GABA
Group of antibiotics derived from fungi
phenoxyacetic acid are added to the culture medium, the mould produces penicillin V as the main penicillin instead. 6-Aminopenicillanic acid (6-APA) is a
Penicillin
Pharmaceutical compound
structurally distinct from other GABAA receptor agonists. Unlike γ-aminobutyric acid (GABA), IAA is orally active and is readily able to cross the blood–brain
Imidazoleacetic_acid
Antibiotic
quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites". Antimicrob Agents Chemother. 33 (10): 1704–1708.
Levofloxacin
Chemical compound
receptor, while not affecting the activation of the GABAA receptor by γ-aminobutyric acid (GABA). List of investigational narcolepsy and hypersomnia drugs List
Golexanolone
Chemical compound (CH3CH2CH2COOH)
Butyric acid (/bjuːˈtɪrɪk/; from Ancient Greek: βούτῡρον, meaning "butter"), also known under the systematic name butanoic acid, is a straight-chain alkyl
Butyric_acid
Class of neurotransmitter modulators
agonists, GABAA PAMs do not bind at the same active site as the γ-aminobutyric acid (GABA) neurotransmitter molecule: they affect the receptor by binding
GABAA receptor positive allosteric modulator
GABAA_receptor_positive_allosteric_modulator
Protein found in humans
Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major
GABRA5
Muscle relaxant medication
depressant and derivative of the inhibitory neurotransmitter, gamma-Aminobutyric acid (GABA). Baclofen is a potent GABAB receptor agonist, antispasmodic
Baclofen
Chemical compound
nervous system. It is a potent, noncompetitive antagonist of the gamma-aminobutyric acid (GABA) receptor. In humans, cicutoxin rapidly produces symptoms of
Cicutoxin
GABAB receptor agonist and phenibut analogue
(developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABAB receptor agonist which was
4-Fluorophenibut
Endogenous GABA precursor
of γ-aminobutyric acid (GABA) from putrescine. Other intermediates in this pathway include N-acetylputrescine and N-acetyl-γ-aminobutyric acid (N-acetyl-GABA)
4-Acetamidobutanal
Chemical compound
γ-Hydroxyvaleric acid (GHV), also known as 4-methyl-GHB, is a designer drug related to γ-hydroxybutyric acid (GHB). It is sometimes seen on the grey market
Γ-Hydroxyvaleric_acid
Dicarboxylic acid
production or biosynthesis. Succinate is the re-entry point for the gamma-aminobutyric acid (GABA) shunt into the TCA cycle, a closed cycle which synthesizes
Succinic_acid
Protein in humans
Gamma-aminobutyric acid receptor subunit alpha-2 is a protein in humans that is encoded by the GABRA2 gene. GABRA2 is an alpha subunit that is part of
GABRA2
Protein-coding gene in humans
Gamma-aminobutyric acid receptor subunit alpha-3 is a protein that in humans is encoded by the GABRA3 gene. GABA is the major inhibitory neurotransmitter
GABRA3
Protein-coding gene in the species Homo sapiens
Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene. Gamma-aminobutyric acid (GABA), the major
GABRG2
Anticonvulsant medication
medication, a class of drugs within the chemical derivatives of γ-aminobutyric acid (GABA analogues), an inhibitory neurotransmitter. Although pregabalin
Pregabalin
Protein-coding gene in the species Homo sapiens
solute carrier 6 (SLC6) family of transporters. It mediates gamma-aminobutyric acid's translocation from the extracellular to intracellular spaces within
GABA_transporter_type_1
Naturally occurring glutamate receptor agonist neurotoxin
Ibotenic acid, or ibotenate, also known as premuscimol or as (S)-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid, is a naturally occurring α-amino acid found
Ibotenic_acid
Chemical compound
sugars using acid catalysts. The resulting glucose can then be dehydrated via hydroxymethylfurfural to yield formic acid and levulinic acid, which cyclises
Γ-Valerolactone
Chemical compound
aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. Subsequently, the level of GABA is increased
Aminooxyacetic_acid
Group of four possible stereoisomers found in various plants: a.o., absinthe and mint
Retrieved 2010-04-16. Olsen, Richard W. (2000-04-25). "Absinthe and γ-aminobutyric acid receptors". Proceedings of the National Academy of Sciences of the
Thujone
Protein-coding gene in the species Homo sapiens
Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene. The protein encoded by this gene is a subunit
GABRG1
Protein-coding gene in humans
Gamma-aminobutyric acid receptor-associated protein is a protein that in humans is encoded by the GABARAP gene. Gamma-aminobutyric acid A receptors [GABA(A)
GABARAP
Protein-coding gene in humans
Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene. The product of this gene belongs to the ligand-gated
GABRE
Pharmaceutical compound
Cetyl-GABA, or CEGABA, also known as hexadecyl 4-aminobutanoate or as γ-aminobutyric acid (GABA) cetyl ester, is a GABA receptor agonist which has been used
Cetyl-GABA
Chemical substance that enables neurotransmission
amino acids, monoamines and peptides. Some of the major neurotransmitters are: Amino acids: glutamate, aspartate, D-serine, gamma-aminobutyric acid (GABA)
Neurotransmitter
Drug class
as a reuptake inhibitor of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA) by blocking the action of one or more of the GABA transporters
GABA_reuptake_inhibitor
Organic compound and GABA analogue and precursor
alkanolamine and an analogue and precursor of the neurotransmitter γ-aminobutyric acid (GABA). Its formula is H2NCH2CH2CH2CH2OH. It is a colorless liquid
4-Amino-1-butanol
Protein-coding gene in the species Homo sapiens
involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter
Vesicular inhibitory amino acid transporter
Vesicular_inhibitory_amino_acid_transporter
Pharmaceutical drug
which is used in the treatment of epilepsy. It is an analogue of γ-aminobutyric acid (GABA) and acts both via a metabolite and as a prodrug of GABA, in
Progabide
Chemical compound
Guvacine Isonipecotic acid Gaboxadol Muscimol Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a
Isoguvacine
Chemical compound
blocker for GABAA receptor chloride channels, specifically the gamma-aminobutyric acid-activated chloride ionophore. A 2006 study found that, while not structurally
Picrotoxin
Antibiotic medication
erythromycin, clarithromycin is acid-stable, so can be taken orally without having to be protected from gastric acids. It is readily absorbed, and diffuses
Clarithromycin
Class of medications
mechanisms of action but many block sodium channels or enhance γ-aminobutyric acid (GABA) function. Several antiepileptic drugs have multiple or uncertain
Anticonvulsant
Class of CNS depressant drugs
depressants that enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing)
Benzodiazepine
GABA receptor antagonist drug and benzodiazepine antidote
et al. (February 1996). "Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology
Flumazenil
Medication used for postpartum depression
neuroactive steroid which enhances the activity of the neurotransmitter γ-aminobutyric acid (GABA) and is thought to exert antidepressant effects by enhancing
Zuranolone
Benzodiazepine medication
increasing the effect of the chief inhibitory neurotransmitter γ-aminobutyric acid (GABA). Clonazepam was patented in 1960 and approved in 1975 in the
Clonazepam
Pharmaceutical compound
A (December 1975). "Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake". Nature. 258 (5536): 627–628. Bibcode:1975Natur.258..627J
Guvacine
Chemical compound
insecticide. It acts as a noncompetitive antagonist of invertebrate γ-aminobutyric acid (GABA)-gated chloride channels, producing uncontrolled neuronal excitation
Isocycloseram
Group of atoms giving a molecule characteristic properties
g., the gamma-amine in gamma-aminobutyric acid is on the third carbon of the carbon chain attached to the carboxylic acid group. IUPAC conventions call
Functional_group
Pharmaceutical compound
the Amanita muscaria alkaloid muscimol and the neurotransmitter γ-aminobutyric acid (GABA). The drug acts specifically as a low-affinity and low-efficacy
4-PIOL
Metabolic intermediate
aldehyde, is a metabolite of putrescine and a biological precursor of γ-aminobutyric acid (GABA). It can be converted into GABA by the actions of diamine oxidase
4-Aminobutanal
Benzodiazepine sedative
action works by increasing the effect of the neurotransmitter gamma-aminobutyric acid (GABA). Diazepam was patented in 1959 by Hoffmann-La Roche. It has
Diazepam
Medicinal drug
(GABA-T), which metabolizes the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Inhibition of GABA-T reduces the degradation of GABA, leading
GABA_transaminase_inhibitor
Short-acting anaesthetic and sedative drug
"Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors". Neuropharmacology. 57 (4): 446–455. doi:10.1016/j
Etomidate
Combination drug
v t e GABA receptor modulators Ionotropic GABAATooltip γ-Aminobutyric acid A receptor Agonists: 4-AHP (+)-Catechin Bamaluzole Barbiturates (e.g., phenobarbital)
Xywav
Specialized neuron in the cerebellum
controlling motor activity. Purkinje cells mainly release GABA (gamma-aminobutyric acid), a neurotransmitter which inhibits some neurons to reduce nerve impulse
Purkinje_cell
Topics referred to by the same term
Pal), a Pillow Pal lamb made by Ty, Inc. beta-Aminobutyric acid (BABA), an isomer of Aminobutyric acid Trosky Castle, One of the two towers on the famous
Baba
Chemical compound
least in part, by the blockade of the postsynaptic action of gamma-aminobutyric acid, as indicated by its inhibitory effect on the binding of the convulsant
Calycanthine
Chemical compound
activity (which may, at least in part, be mediated by its inhibition of fatty acid synthase), and antagonist activity at the κ-opioid receptor (Ke = 490 nmol L−1)
Amentoflavone
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AMINOBUTYRIC ACID
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