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Lyase enzyme that synthesizes cGMP from GTP
Guanylate cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming))
Guanylate_cyclase
Member of a group of proteins that upregulate guanylate cyclase
guanylate cyclase activator (or "GUCA") is a member of a group of proteins that upregulate guanylate cyclase. GUCA is also known as guanylate cyclase-activating
Guanylate_cyclase_activator
Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin
Guanylate_cyclase_2C
Enzyme is involved in vasodilation
many adenylyl cyclases. In 2008, the first structures of a bacterial guanylate cyclase domain (pdb code 2W01) and a sGC guanylate cyclase catalytic domain
Soluble_guanylyl_cyclase
Protein family
Guanylate cyclase-coupled receptors, receptor guanylate cyclases or membrane-bound guanylyl cyclases are single-pass transmembrane proteins. Guanylate
Guanylate cyclase-coupled receptor
Guanylate_cyclase-coupled_receptor
Class of pharmaceutical drugs
Soluble guanylate cyclase (sGC) stimulators are a class of drugs developed to treat heart failure, pulmonary hypertension, and other diseases. The first-in-class
Soluble guanylate cyclase stimulator
Soluble_guanylate_cyclase_stimulator
Protein found in humans
Guanylate cyclase activator 2B is a protein that in humans is encoded by the GUCA2B gene. This gene encodes a preproprotein that is proteolytically processed
Guanylate cyclase activator 2B
Guanylate_cyclase_activator_2B
Protein-coding gene in the species Homo sapiens
Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene. Alternative names: Guanylate cyclase activator 1B Retinal
GUCA1B
Increased blood pressure in lung arteries
platelets), where it increases the activity of the enzyme soluble guanylate cyclase, leading to increased formation of cyclic guanosine monophosphate
Pulmonary_hypertension
Index of enzymes associated with the same name
cyclase, which forms cyclic GMP from guanosine triphosphate (EC 4.6.1.2) GUCY1A2 GUCY1A3 GUCY1B3 Guanylate cyclase 2C Guanylate cyclase 2D Guanylate cyclase
Cyclase
Functions of nitric oxide in organisms
muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic-guanosine
Biological functions of nitric oxide
Biological_functions_of_nitric_oxide
Protein-coding gene in the species Homo sapiens
Retinal guanylyl cyclase 1 also known as guanylate cyclase 2D, retinal is an enzyme that in humans is encoded by the GUCY2D (guanylate cyclase 2D) gene. This
GUCY2D
Protein-coding gene in the species Homo sapiens
Guanylate cyclase soluble subunit alpha-1 is an enzyme that in humans is encoded by the GUCY1A1 gene (previously GUCY1A3). Soluble guanylate cyclase (sGC)
GUCY1A1
Protein found in humans
Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor
NPR1
Pharmaceutical drug
(OQM Div, MSN Laboratories, India). Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup
Plecanatide
Protein-coding gene in the species Homo sapiens
Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B1 gene (previously GUCY1B3). Soluble guanylate cyclase (sGC)
GUCY1B1
Medicine
effects in others include diarrhea. It is an oligopeptide agonist of guanylate cyclase 2C and remains in the GI tract after it is taken by mouth. It was
Linaclotide
Chemical compound
by guanylate cyclase enzymes, which synthesize cGMP, and by PDEs, which degrade cGMP. Enhancing cGMP levels, either by stimulating guanylate cyclase or
Cyclic guanosine monophosphate
Cyclic_guanosine_monophosphate
Protein-coding gene in the species Homo sapiens
Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene. GRCh38: Ensembl release 89: ENSG00000152402 – Ensembl
GUCY1A2
Chemical compound
Runcaciguat is a soluble guanylate cyclase activator developed by Bayer for non-proliferative diabetic retinopathy and chronic kidney disease. Bénardeau
Runcaciguat
Class of enzymes
dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain". Genes & Development. 18 (6): 715–27. doi:10.1101/gad
Diguanylate_cyclase
Pharmaceutical compound
developmental code names CY-6463 and IW-6463) is a brain-penetrant soluble guanylate cyclase (sGC) stimulator which is under development for the treatment of Alzheimer's
Zagociguat
Experimental drug
Frespaciguat (development code MK-5475) is an experimental inhaled soluble guanylate cyclase stimulator developed by Merck for pulmonary arterial hypertension
Frespaciguat
Chemical compound
vascular smooth muscle cells to induce vasodilation. NO binds to soluble guanylate cyclase (sGC) and mediates the synthesis of the secondary messenger cyclic
Riociguat
Protein-coding gene in humans
Retinal guanylyl cyclase 2 also known as guanylate cyclase F (GUCY2F) is a protein that in humans is encoded by the GUCY2F gene. The protein encoded by
GUCY2F
Chemical compound
Avenciguat (development name BI 685509) is a soluble guanylate cyclase activator developed by Boehringer Ingelheim for kidney disease, and cirrhosis.
Avenciguat
Process by which light activates retinal cells
from its bound calcium ions, and interacts with Guanylate Cyclase, activating it. Guanylate Cyclase then proceeds to transform GTP to cGMP, replenishing
Visual_phototransduction
Chemical compound
Mosliciguat (BAY 1237592) is an inhaled soluble guanylate cyclase activator developed by Bayer for pulmonary arterial hypertension. El-Kersh, Karim; Jalil
Mosliciguat
Medication
decompensation event. It is taken by mouth. Vericiguat is a soluble guanylate cyclase (sGC) stimulator. Common side effects include low blood pressure and
Vericiguat
Vasodilating drug
hours (or 48 hours with tadalafil) of taking alpha-blockers, soluble guanylate cyclase stimulators, or nitrate medications such as isosorbide mononitrate
PDE5_inhibitor
Protein-coding gene in the species Homo sapiens
guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2
ADCY2
Topics referred to by the same term
Grupo Capoeira Angola Pelourinho, Capoeira group by Mestre Moraes Guanylate cyclase-activating protein Vancouver's greenest city action plan, an urban
GCAP
Enzyme with key regulatory roles in most cells
Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase
Adenylyl_cyclase
Protein-coding gene in the species Homo sapiens
GE, Warren MJ, Bird AC, Bhattacharya SS (Mar 1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree
GUCA1A
Chemical compound
increases cyclic GMP levels in the brain and liver by activation of guanylate cyclase. Sodium azide solutions react with metallic ions to precipitate metal
Sodium_azide
Chemical compound
Olinciguat (IW-1701) is a soluble guanylate cyclase stimulator that was in development for sickle cell anemia. After receiving orphan drug status in 2018
Olinciguat
Class of bacterial toxins
pathways. For example, STa enterotoxins bind and activate membrane-bound guanylate cyclase, which leads to the intracellular accumulation of cyclic GMP and downstream
Heat-stable_enterotoxin
Blue dye also used as a medication
the glutamatergic system (via inhibition of NO synthase and soluble guanylate cyclase), modulates mitochondrial function (by acting as an electron acceptor)
Methylene_blue
Protein molecule receiving signals for a cell
serine/threonine-specific protein kinase, as in bone morphogenetic protein and guanylate cyclase, as in atrial natriuretic factor receptor. Of the RTKs, 20 classes
Receptor_(biochemistry)
Chemical compound
(GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer in RNA. It is an ester of
Guanosine_monophosphate
American scientist
natriuretic factor intracellular signaling through guanylate cyclase (GC), and the relation of Guanylyl cyclase C (GC-C) to the pathogenesis of colorectal cancer
Scott_Waldman
Chemical compound
(NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis
Isosorbide_dinitrate
Drug for erectile dysfunction and hypertension
Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth
Sildenafil
Pharmaceutical drug
consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylate cyclase 2C which is present in some cancers, linked to an average of three
Indusatumab_vedotin
Chemical compound
small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in
Uroguanylin
German physician and biomedical scientist
Smolenski, A; Zahedi, RP; Jurk, K (2018). "Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets". Nitric Oxide. 76:
Ulrich Walter (clinical biochemist)
Ulrich_Walter_(clinical_biochemist)
American pharmacologist
Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J
Louis_Ignarro
Amino acid metabolic disorder
"Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted
Phenylketonuria
Human protein-coding gene
also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic peptide receptor which in humans is encoded
NPR2
System of communication
protein serine/threonine kinase, as in bone morphogenetic protein Guanylate cyclase, as in atrial natriuretic factor receptor Intracellular receptors
Cell_signaling
dehalogenase Halohydrin dehalogenase Category:EC 4.6.1 Adenylate cyclase (EC 4.6.1.1) Guanylate cyclase (EC 4.6.1.2) Category:EC 5.1.1 Amino-acid racemase: Phenylalanine
List_of_enzymes
Response of the eye to light and dark
Gray-Keller, M.P. (1994). "Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods". Proceedings of the National
Adaptation_(eye)
Protein-coding gene in humans
Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor
NPR3
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(D12.776)
Receptor for atrial natriuretic peptide
receptor for atrial natriuretic peptide. NPRA and NPRB are linked to guanylyl cyclases, while NPRC is G-protein-linked and is a "clearance receptor" that acts
Atrial natriuretic peptide receptor
Atrial_natriuretic_peptide_receptor
muscle of trachea, stomach and gall bladder 63 Guanylin GN Peptide gut guanylate cyclase 2C (heat stable enterotoxin receptor) regulates electrolyte and water transport
List_of_human_hormones
Medication for lowering blood pressure
to release cyanide, methaemoglobin and nitric oxide. NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of
Sodium_nitroprusside
Topics referred to by the same term
dental composite filling Glucocorticoids, a class of steroid hormones Guanylate cyclase, an enzyme catalysing the synthesis of cyclic-GMP from GTP Neisseria
GC
Drug that causes vasodilation by releasing nitric oxide
stimulates the soluble form of the enzyme guanylate cyclase in the smooth muscle cells of blood vessels. Guanylate cyclase produces cyclic guanosine monophosphate
Nitrovasodilator
Class of enzymes
eNOS is the primary controller of smooth muscle tone. NO activates guanylate cyclase, which induces smooth muscle relaxation by: Increased intracellular
Nitric_oxide_synthase
System of signaling molecules within a cell
systems can be synthesized and activated by enzymes, for example, the cyclases that synthesize cyclic nucleotides, or by opening of ion channels to allow
Second_messenger_system
Protein-coding gene in the species Homo sapiens
Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene. Adenylyl cyclase is a membrane bound enzyme that catalyses the formation
ADCY9
Investigational sexual dysfunction drugs
gel; MED-2001; MED-2003; MED-2004; MED-2005; MED-3000; MED2002) – guanylate cyclase stimulant, nitric oxide donor, nitric oxide stimulant – erectile dysfunction
List of investigational sexual dysfunction drugs
List_of_investigational_sexual_dysfunction_drugs
American biochemist (1938–2024)
Stryer, L. (1988). "Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ion". Nature. 334 (6177): 64–66. Bibcode:1988Natur.334
Lubert_Stryer
Protein and coding gene in humans
vascular smooth muscle cell membranes and activates the enzyme soluble guanylate cyclase (sGC), which catalyzes the conversion of guanosine triphosphate into
Endothelial_NOS
Involuntary non-striated muscle
soluble guanylate cyclase and membrane bound adenylate cyclase, respectively. The cyclic nucleotides (cGMP and cAMP) produced by these cyclases activate
Smooth_muscle
Protein-coding gene in the species Homo sapiens
Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene. This gene encodes a form of adenylyl cyclase expressed in the brain
ADCY1
Protein family
domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylate cyclase domain, or the response regulatory domain. In its most common setting
HAMP_domain
Protein-coding gene in the species Homo sapiens
(February 1991). "Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase". Science. 251 (4996): 915–918. Bibcode:1991Sci...251..915D. doi:10
Recoverin
Toxin from bacteria that destroys or disrupts cells
pathways. For example, STa enterotoxins bind and activate membrane-bound guanylate cyclase, which leads to the intracellular accumulation of cyclic GMP and downstream
Exotoxin
Chemical compound
derived relaxing factor (EDRF) causes a decrease in the stimulation of guanylate cyclase, and cyclic GMP (cGMP) levels fall in vascular smooth muscle. This
Amrinone
Chemical compound
acute decompensated heart failure. Cinaciguat activates the soluble guanylate cyclase (sGC) which is a receptor for nitric oxide. This increases biosynthesis
Cinaciguat
650.200 – adenylate cyclase MeSH D08.811.520.650.200.040 – adenylate cyclase toxin MeSH D08.811.520.650.600 – guanylate cyclase MeSH D08.811.520.650
List_of_MeSH_codes_(D08)
Reduction of blood flow to the heart
bloodstream, it forms free radical nitric oxide, or NO, which activates guanylate cyclase and in turn stimulates the release of cyclic GMP. This molecular signaling
Coronary_artery_disease
Human chromosome
GNL2: G protein nucleolar 2 GSTM1 (1p13) GUCA2B: encoding protein Guanylate cyclase activator 2B HDAC1 (1p35) HES2: Hes family bHLH transcription factor
Chromosome_1
Protein-coding gene in humans
expression data Gene ontology Molecular function protein binding guanylate cyclase activator activity GTPase regulator activity peptide hormone receptor
RUNDC3A
Protein found in humans
adenylate cyclase activity response to organic cyclic compound cellular response to monosodium glutamate negative regulation of guanylate cyclase activity
Hippocalcin
Sense that detects smells
the mouse main olfactory epithelium of type B express the soluble guanylate cyclase Gucy1b2". Molecular and Cellular Neuroscience. 65: 114–124. doi:10
Sense_of_smell
Protein-coding gene in the species Homo sapiens
Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene. This gene encodes a membrane-bound adenylyl cyclase that catalyses the
ADCY7
Cells covering neuron soma in PNS ganglia
excitatory neurotransmitter signal by removal (uptake) of glutamate Guanylate cyclase Rat DRG, TG IHC for cGMP Second messenger that internalizes the message
Satellite_glial_cell
Medical model that tailors medical practices to the individual patient
February 2018). "A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection"
Personalized_medicine
Protein-coding gene in the species Homo sapiens
Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene. The human ADCY5 gene is located on the long arm of chromosome 3 and
ADCY5
Chemical compound
increased ATP-sensitive K+ channel (KATP) opening. Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). cGMP activates protein
Nicorandil
Amino acid
into the vascular smooth muscle layer. There, it activates soluble guanylate cyclase, leading to relaxation of the smooth muscle and a reduction in vascular
Arginine
Class of enzymes
Serine/threonine-specific protein kinase, as in bone morphogenetic protein Guanylate cyclase, as in atrial natriuretic factor receptor The following is a list
Enzyme-linked_receptor
Branch of medicine dealing with the heart
vasodilation through nitric oxide, which manipulates cGMP levels through guanylate cyclase. COX inhibitors (namely aspirin), warfarin, direct Xa inhibitors,
Outline_of_cardiology
factor MeSH D12.776.543.750.100.665.500 – receptors, pituitary adenylate cyclase-activating polypeptide, type i MeSH D12.776.543.750.100.665.750 – receptors
List of MeSH codes (D12.776.543)
List_of_MeSH_codes_(D12.776.543)
Effect of chronic drug abuse
significant stimulatory effect on guanylate cyclase, an enzyme found in cone cells. Upon activation, guanylate cyclase converts more guanosine triphosphate
Drug_abuse_retinopathy
S-carboxymethylcysteine synthase EC 4.6.1.1: adenylate cyclase EC 4.6.1.2: guanylate cyclase EC 4.6.1.3: Now EC 4.2.3.4, 3-dehydroquinate synthase EC
List_of_EC_numbers_(EC_4)
Degeneration of cone cells in the eye
autosomal dominant cone-rod dystrophy is caused by mutations in the guanylate cyclase 2D (not geometrical) gene (GUCY2D) on chromosome 17.[citation needed]
Cone_dystrophy
Protein-coding gene in the species Homo sapiens
multicellular organismal response to stress positive regulation of guanylate cyclase activity regulation of sodium ion transport positive regulation of
NOS1
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
1992). "Comparison of a cloned ANF-sensitive guanylate cyclase (GC-A) with particulate guanylate cyclase from adrenal cortex". Naunyn-Schmiedeberg's Archives
AP-1_transcription_factor
Mammalian protein found in humans
Zhang M, Hsu S, Takimoto E, Kass DA (August 2008). "Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute
CGMP-specific phosphodiesterase type 5
CGMP-specific_phosphodiesterase_type_5
Family of transport proteins
a short peptide, was studied. Speract activates a receptor-type guanylate cyclase (GC) and stimulates a rise in intracellular cGMP concentrations. Speract
Cyclic nucleotide–gated ion channel
Cyclic_nucleotide–gated_ion_channel
Class of neurotransmitters
mechanism follows: NO acts through the stimulation of the soluble guanylate cyclase, which is a heterodimeric enzyme with subsequent formation of cyclic-GMP
Gasotransmitter
Topics referred to by the same term
refer to: Satellite ground station Server-Gated Cryptography Soluble guanylate cyclase (sGC) Standard Geographical Classification code (Canada) Structural
SGC
Medical condition
approved for PAH. Currently, only riociguat (a stimulator of soluble guanylate cyclase) is approved for treatment of adults with inoperable CTEPH or persistent
Chronic thromboembolic pulmonary hypertension
Chronic_thromboembolic_pulmonary_hypertension
Arteries of the penis
mediated by a release of nitric oxide (NO). NO binds to the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate
Helicine_arteries_of_penis
Protein-coding gene in the species Homo sapiens
Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". American Journal
Heat shock protein 90kDa alpha (cytosolic), member A1
Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1
Species of annelid worm
hyperpolarizing photoreceptors: possible involvement of a Go-regulated guanylate cyclase". The Journal of Neuroscience. 20 (14): 5254–63. doi:10.1523/JNEUROSCI
Platynereis_dumerilii
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GUANYLATE CYCLASE
GUANYLATE CYCLASE
GUANYLATE CYCLASE
GUANYLATE CYCLASE
GUANYLATE CYCLASE
GUANYLATE CYCLASE
GUANYLATE CYCLASE
GUANYLATE CYCLASE
GUANYLATE CYCLASE
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