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Drug for erectile dysfunction and hypertension
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is
Sildenafil
Mammalian protein found in humans
side-effects attributed to nonselective inhibitors such as theophylline. Sildenafil, vardenafil, tadalafil, and avanafil are PDE5 inhibitors that are significantly
CGMP-specific phosphodiesterase type 5
CGMP-specific_phosphodiesterase_type_5
Pharmaceutical compound
Clomipramine/sildenafil (developmental code name CDFR-0812) is a combination of the tricyclic antidepressant (TCA) and serotonin–norepinephrine reuptake
Clomipramine/sildenafil
Form of sexual dysfunction in males
medication-based therapies are used, specifically PDE5 inhibitors such as sildenafil. These drugs function by dilating blood vessels, facilitating increased
Erectile_dysfunction
Inability to achieve orgasm despite adequate stimulation
dysfunction upon taking sildenafil one hour prior to sexual activity. In this study, eight out of the nine women required 50 mg of sildenafil while the 9th woman
Anorgasmia
Vasodilating drug
stimulation, and are used in the treatment of erectile dysfunction (ED). Sildenafil was the first effective oral treatment available for ED. Because PDE5
PDE5_inhibitor
Medication used to treat erectile dysfunction
arterial hypertension. Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil. Some sildenafil users see a bluish tinge
Tadalafil
Human male external reproductive organ
notably including the phosphodiesterase type 5 inhibitor drugs (such as sildenafil citrate, marketed as Viagra), which work by vasodilation. Priapism, a
Human_penis
Chemical compound
related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen
Vardenafil
Colorless gas with the formula NO
beyond biology, with applications in medicine, such as the development of sildenafil (Viagra), and in industry, including semiconductor manufacturing. Nitric
Nitric_oxide
Medical term for seeing everything tinted in blue
commonly associated with cataract surgery and certain medications, such as sildenafil (more commonly known as Viagra), cyanopsia is typically a temporary side
Cyanopsia
Genus of flowering plants belonging to the barberry family
effects are unknown. While there is little clinical evidence to date, as sildenafil, vardenafil, and tadalafil–sold under the brand names Viagra, Levitra
Epimedium
Investigational sexual dysfunction drugs
phosphodiesterase PDE5 inhibitor – erectile dysfunction [4] Clomipramine/sildenafil (CDFR-0812) – combination of clomipramine (tricyclic antidepressant (TCA)
List of investigational sexual dysfunction drugs
List_of_investigational_sexual_dysfunction_drugs
Class of herbal products said to treat erectile dysfunction
not contain sildenafil. Herbal viagras, contrary to what the name suggests, do not normally contain sildenafil citrate. However, sildenafil and chemicals
Herbal_viagra
Chemical compound
blood pressure especially if also exposed to PDE5 inhibitors such as sildenafil. Use is not recommended in pregnancy. It is believed to work by relaxing
Isosorbide_mononitrate
Chemical compound
synthetic drug that is a structural analog of sildenafil (Viagra). It was first reported in 2003. Like sildenafil, aildenafil is a phosphodiesterase type 5
Aildenafil
Medical condition
connected to the nasal congestion commonly reported as a side effect of sildenafil and other phosphodiesterase type 5 inhibitors. These medications increase
Honeymoon_rhinitis
Chemical compound
useful pharmacological properties, with prominent examples including sildenafil, ciprofloxacin, and ziprasidone. Piperazines were originally named because
Piperazine
Drug discovery
major PDE5 inhibitors (a subset of the phosphodiesterase inhibitors) are sildenafil, tadalafil, vardenafil, and avanafil, and although all share the same
Discovery and development of phosphodiesterase 5 inhibitors
Discovery_and_development_of_phosphodiesterase_5_inhibitors
Patient-reported outcome for scoring erection hardness
successful sexual intercourse (SSI) using data from a multinational trial of sildenafil citrate involving 307 men with erectile dysfunction. Results showed that
Erection_Hardness_Score
Chemical compound
structural analog of sildenafil (Viagra). It was first reported in 2005, and it is not approved by any health regulation agency. Like sildenafil, sulfoaildenafil
Sulfoaildenafil
Beminafil Dasantafil Gisadenafil Gisadenafil besylate Mirodenafil Sildenafil Sildenafil citrate Tadalafil Udenafil Vardenafil Vardenafil dihydrochloride
List of phosphodiesterase inhibitors
List_of_phosphodiesterase_inhibitors
Fluid accumulation in the tissue and air spaces of the lungs
pulmonary edema. Sildenafil is used as a preventive treatment for altitude-induced pulmonary edema and pulmonary hypertension. Sildenafil's mechanism of action
Pulmonary_edema
Chemical compound
of sildenafil (20 mg thrice daily) in a non-randomized uncontrolled trial. The study showed potentially unfavorable safety signals with sildenafil plus
Riociguat
Medical condition
fluoxetine may help symptoms, but the data is weak. PDE5 inhibitors, such as sildenafil and tadalafil, are used off-label to treat severe ischemia and ulcers
Raynaud_syndrome
Drug that causes vasodilation by releasing nitric oxide
contraindicated in patients that have recently taken PDE5 inhibitors such as sildenafil (Viagra). Most side effects are direct consequences of the vasodilation
Nitrovasodilator
Controversial honey-based sexual enhancement product
potential health risks. Through its Automated analysis, the FDA found sildenafil, whose usage is only approved under strict medical guidance. Following
Honey_packet
Medication
used together with medications within the PDE5 inhibitor family such as sildenafil due to the risk of low blood pressure. Nitroglycerin is in the nitrate
Nitroglycerin_(medication)
Medication used to treat premature ejaculation
between dapoxetine and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration of 24 subjects
Dapoxetine
British clinical researcher
British clinical researcher for Pfizer, Inc. who led the development of sildenafil citrate (Viagra), as well as a number of Pfizer medications for cardiovascular
Ian_Osterloh
Increased blood pressure in lung arteries
epoprostenol, treprostinil, iloprost, bosentan, ambrisentan, macitentan, and sildenafil, tadalafil, selexipag, riociguat. Lung transplantation may be an option
Pulmonary_hypertension
Chemical compound
drug which acts as a phosphodiesterase inhibitor. It is an analog of sildenafil (Viagra) which has been detected in numerous different brands of "herbal
Acetildenafil
Chemical compound
tissues, primarily in the corpus cavernosum penis. Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very
Avanafil
Chemical compound
(also known as methyl-sildenafil) is a synthetic drug which acts as a phosphodiesterase inhibitor. It is an analog of sildenafil and vardenafil. Homosildenafil
Homosildenafil
Drug interactions with grapefruit juice
Endep, Vanatrip) and nimodipine (Nimotop) Erectile dysfunction drugs sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) Acetaminophen (also
Grapefruit–drug_interactions
Circumstance of death
people under 50 who suffered SCD, 0.2% did so within an hour of sex. Sildenafil, although generally considered to be a safe drug, has been linked to SCD
Death_during_consensual_sex
Species of bear
such as showing them videos of giant pandas mating and giving the males sildenafil (commonly known as Viagra). In the 2000s, researchers started having success
Giant_panda
Physiological phenomenon involving the engorgement of the clitoris
PMID 9138056. Shen, W. U.; Urosevich, Z.; Clayton, D. O. (June 1999). "Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin
Clitoral_erection
Harmful effect resulting from a medication or other medical intervention
combined oral contraceptive pill Priapism associated with the use of sildenafil Rhabdomyolysis associated with statins (anticholesterol drugs) Seizures
Adverse_effect
Pharmaceutical drug classification
Imidafenacin G04BD15 Vibegron G04BE01 Alprostadil G04BE02 Papaverine G04BE03 Sildenafil G04BE04 Yohimbin G04BE05 Phentolamine G04BE06 Moxisylyte G04BE07 Apomorphine
ATC_code_G04
Condition that arises during human sexual arousal when seminal fluid is not ejaculated
PMC 5002007. PMID 27652230. Perelman, Michael A. (2001). "Integrating Sildenafil and Sex Therapy: Unconsummated Marriage Secondary to Erectile Dysfunction
Epididymal_hypertension
Traditional Chinese medicine ingredient
the Chinese people are rapidly modernizing, more and more men are using sildenafil (Viagra) instead of folk remedies to treat erectile dysfunction. The researchers
Tiger_penis
Class of antidepressant medication
include: for erectile dysfunction the addition of a PDE5 inhibitor such as sildenafil; for decreased libido, possibly adding or switching to bupropion; and
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Excessively strong or long contractions of the esophagus
elixir at the onset of symptoms. Phosphodiesterase inhibitors, such as sildenafil, can be given to reduce symptoms, particularly pain, but small trials
Nutcracker_esophagus
Outcome that is secondary to the one intended
sexual climax in men, and can be used to treat premature ejaculation. Sildenafil was originally intended for pulmonary hypertension; subsequently, it was
Side_effect
Molecule that blocks enzyme activity
in cancer chemotherapy. A common treatment for erectile dysfunction is sildenafil (Viagra). This compound is a potent inhibitor of cGMP specific phosphodiesterase
Enzyme_inhibitor
Class of chemical compounds
4-Fluorophenylpiperazine (pFPP) 3-Trifluoromethylphenylpiperazine (TFMPP) Urologicals Sildenafil Vardenafil Others 6-Nitroquipazine Antrafenine Diethylcarbamazine Diphenazine
Substituted_piperazine
Species of sea squirt
It is said to possess aphrodisiac properties and to have a significant sildenafil-like effect on men for a period of time after consumption. Sánchez Cabezas
Pyura_chilensis
Class of recreational drug
disorientation. Alkyl nitrites interact with other vasodilators, such as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis), to cause a serious
Poppers
Interaction between sex and drugs
hormonal balance. While Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil, tadalafil, vardenafil, and avanafil are primarily known for treating
Sex_and_drugs
Damage to the optic nerve's front part due to lack of blood flow
"Nonarteritic ischemic optic neuropathy developing soon after use of sildenafil (viagra): a report of seven new cases". Journal of Neuro-Ophthalmology
Anterior ischemic optic neuropathy
Anterior_ischemic_optic_neuropathy
Drug
and restored some functionality to hippocampus-based memory functions. Sildenafil, tadalafil, vardenafil, and the newer udenafil and avanafil selectively
Phosphodiesterase_inhibitor
2008 single by 88-Keys featuring Kanye West
Adam, who after a bad string of relationships, decides to take Viagra (Sildenafil Citrate) in an attempt to "stay up" longer. A snippet of the track was
Stay_Up!_(Viagra)
Branch of medicine
March 27, 1998, sildenafil citrate was approved by the Food and Drug Administration (FDA) for the treatment of ED. The approval of Sildenafil transformed
Sexual_medicine
American biotechnology company
is a phosphodiesterase type 5 (PDE5) inhibitor, similar in function to sildenafil. In addition to ED and PAH, tadalafil has undergone clinical trials for
Icos
Drug for angina pectoris sold under many brand names
Indinavir JNJ-7777120 Lodenafil MK-212 Mirodenafil PB-28 Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VCU-1012 VUF-6002 WY-46824 Zipeprol ZINC000443438219
Trimetazidine
2025 film by Sailesh Kolanu
victims for a global pharmaceutical trade to synthesise a highly potent sildenafil for the elite. Returning to the present frame narrative, Arjun reveals
HIT:_The_Third_Case
Supreme Court of Canada case
disclosure requirements for a patent in Canada. While testing the compound sildenafil on patients suffering from angina, Pfizer observed that some patients
Teva Canada Ltd v Pfizer Canada Inc
Teva_Canada_Ltd_v_Pfizer_Canada_Inc
Topics referred to by the same term
viagra in Wiktionary, the free dictionary. Viagra is a brand name for sildenafil, used for treating erectile dysfunction. Viagra may also refer to: VIA
Viagra_(disambiguation)
Class of enzymes
coworkers. This prediction has now come to pass in a variety of fields (e.g. sildenafil as a PDE5 inhibitor and Rolipram as a PDE4 inhibitor). The PDE nomenclature
Phosphodiesterase
Chemical compound
male enhancement product that was already found to contain undeclared sildenafil. Sheppard, S. (1994). "Moroxydine: The story of a mislaid antiviral".
Moroxydine
Brand of male enhancement pills
certain production lot of ExtenZe and ExtenZe Plus was found to contain sildenafil, which is the active ingredient in Viagra. ExtenZe contains dehydroepiandrosterone
ExtenZe
North Korean medical company
Korean (Koryo) medical supplement, whose active ingredient is 50 mg of Sildenafil (Viagra), combined with Korean herbal medicines. Neo-Viagra-Y.R.
Korea Oriental Instant Medicinal Centre
Korea_Oriental_Instant_Medicinal_Centre
Chemical compound
manufacture of various pharmaceutical drugs including cyclizine, meclizine, and sildenafil. The lithium salt, lithium N-methylpiperazide, is used as a reagent in
N-Methylpiperazine
Pharmaceutical compound
acts as a phosphodiesterase inhibitor, selective for the PDE5 subtype. Sildenafil Vardenafil Discovery and development of phosphodiesterase 5 inhibitors
Gisadenafil
Systematic naming of drugs
action (a type of antihypertensive and erectile dysfunction drug) Sildenafil Sildenafil Tadalafil -prost- Prostaglandin analogues Prostaglandin Latanoprost
Drug_nomenclature
Explosive chemical compound
, sildenafil) non-selective PDE inhibitors (e.g., caffeine) PDE9 inhibitors (e.g., paraxanthine) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine
Pentaerythritol_tetranitrate
Any disease or malfunction of the autonomic nervous system
To treat genitourinary autonomic neuropathy, medications may include sildenafil (a guanine monophosphate type-5 phosphodiesterase inhibitor). To treat
Dysautonomia
Pharmaceutical compound
Acetildenafil Aildenafil Avanafil Icariin Lodenafil Mirodenafil Nitrosoprodenafil Sildenafil Sulfoaildenafil Tadalafil Udenafil Vardenafil Sex steroids Androgens (e
Volufralin
Chemical compound
of cGMP, thereby enhancing and/or prolonging its effects. For example, Sildenafil (Viagra) and similar drugs enhance the vasodilatory effects of cGMP within
Cyclic guanosine monophosphate
Cyclic_guanosine_monophosphate
Pharmaceutical drugs with patent protections
Viagra (sildenafil) is a famous example of proprietary drug, owned by Pfizer.
Proprietary_drug
Adulteration of drugs
Erectile dysfunction drugs: In the Netherlands two chemical analogs of sildenafil (Viagra) were found in adulterated marijuana. Methamphetamine: psychiatrist
Lacing_(drugs)
Treatment for erectile dysfunction
PMID 15772683. Kim SC, Chang IH, Jeon HJ (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already
Trimix_(drug)
Widening of blood vessels
inhibitors: these agents indirectly increase the effects of nitric oxide sildenafil (Viagra) tadalafil (Cialis) vardenafil (Levitra) tetrahydrocannabinol
Vasodilation
Chemical compound
It is within the PDE5 inhibitor class (which also includes avanafil, sildenafil, tadalafil, and vardenafil). Like other PDE5 inhibitors, it is used to
Udenafil
SSRI antidepressant
(E) Alprostadil (PGE1) PDE5 inhibitors Avanafil Lodenafil Mirodenafil Sildenafil Simmerafil Tadalafil Udenafil Vardenafil Alpha blockers Moxisylyte (thymoxamine)
Sertraline
Chemical compound
that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which successfully reached the market. It is a phosphodiesterase
Zaprinast
Peptide hormone and neuropeptide
antidepressant-like effects of sexual activity. A drug for sexual dysfunction, sildenafil enhances electrically evoked oxytocin release from the pituitary gland
Oxytocin
SSRI antidepressant
(E) Alprostadil (PGE1) PDE5 inhibitors Avanafil Lodenafil Mirodenafil Sildenafil Simmerafil Tadalafil Udenafil Vardenafil Alpha blockers Moxisylyte (thymoxamine)
Escitalopram
Decreased ability to see color or color differences
treatment of tuberculosis. Blue–yellow color blindness can be caused by sildenafil, an active component of Viagra. Hydroxychloroquine can also lead to hydroxychloroquine
Color_blindness
Body fluid leakage in the lungs while swimming
Avoidance of excessive pre-swim hydration is advisable Nifedipine or sildenafil could theoretically be beneficial due to their ability to modify pulmonary
Swimming-induced pulmonary edema
Swimming-induced_pulmonary_edema
Medical condition from optic nerve damage
semaglutide, amiodarone and phosphodiesterase type 5 (PDE5) inhibitors like sildenafil (Viagra, the firstline treatment for erectile dysfunction), have been
Non-arteritic anterior ischemic optic neuropathy
Non-arteritic_anterior_ischemic_optic_neuropathy
Medication for lowering blood pressure
mechanism is similar to that of phosphodiesterase 5 (PDE5) inhibitors such as sildenafil (Viagra) and tadalafil (Cialis), which elevate cGMP concentration by inhibiting
Sodium_nitroprusside
North Korean alleged medical cure
analysis of the product shows that its active ingredient is 50 mg of Sildenafil (the lowest dose of Pfizer's genuine Viagra tablets), though used in a
Neo-Viagra-Y.R.
SSRI antidepressant
(E) Alprostadil (PGE1) PDE5 inhibitors Avanafil Lodenafil Mirodenafil Sildenafil Simmerafil Tadalafil Udenafil Vardenafil Alpha blockers Moxisylyte (thymoxamine)
Fluoxetine
Chemical compound
similar efficacy to established drugs for this condition such as bosentan, sildenafil, beraprost and iloprost. It is also being researched for potential anti-cancer
PRX-08066
Pharmaceutical compound
(E) Alprostadil (PGE1) PDE5 inhibitors Avanafil Lodenafil Mirodenafil Sildenafil Simmerafil Tadalafil Udenafil Vardenafil Alpha blockers Moxisylyte (thymoxamine)
Cligosiban
Class of enzymes which split esters into an acid and alcohol via hydrolysis
messenger cAMP cGMP specific phosphodiesterase type 5, is inhibited by Sildenafil (Viagra) Fructose bisphosphatase (3.1.3.11), converts fructose-1,6-bisphosphate
Esterase
Substance that arouses sexual desires
Acetildenafil Aildenafil Avanafil Icariin Lodenafil Mirodenafil Nitrosoprodenafil Sildenafil Sulfoaildenafil Tadalafil Udenafil Vardenafil Sex steroids Androgens (e
Aphrodisiac
Eutectic mixture of local anesthetics
developed by the same group that invented the erectile dysfunction drug sildenafil. The drug was approved in Europe and was released in the UK market in
Lidocaine/prilocaine
Condition present at birth regardless of cause
Chen, P; Luo, K; Zhang, X (16 August 2016). "Effect of L-arginine and sildenafil citrate on intrauterine growth restriction fetuses: a meta-analysis".
Birth_defect
American multinational pharmaceutical and biotechnology corporation
In 1989, Pfizer scientists Peter Dunn and Albert Wood created Viagra (sildenafil) for treating high blood pressure and angina, a chest pain associated
Pfizer
Class of recreational drugs
such as methylmethaqualone and premazepam, and designer analogues of sildenafil (Viagra), which have been reported as active compounds in "herbal" aphrodisiac
Designer_drug
American musician (1933–2006)
mixed with tobacco in Kool cigarettes. He engaged in the off-label use of sildenafil, maintaining that it gave him "extra energy". Once, while traveling in
James_Brown
British chemist
discovering some of the world's best-selling prescription drugs, including sildenafil, amlodipine, and doxazosin. He was visiting lecturer at Universidade de
Simon_Campbell
Medication used to treat anxiety disorders
Acetildenafil Aildenafil Avanafil Icariin Lodenafil Mirodenafil Nitrosoprodenafil Sildenafil Sulfoaildenafil Tadalafil Udenafil Vardenafil Sex steroids Androgens (e
Buspirone
Chemical compound
"herbal" aphrodisiac products, which is a novel nitrosated analogue of sildenafil (Viagra). It has an innovative structure which acts as a prodrug, breaking
Nitrosoprodenafil
Australian men's telehealth company
pharmacist. Their programs may include scheduled drugs such as Viagra (Sildenafil), finasteride, Wegovy or Mounjaro alongside online coaching and diet plans
Pilot_(telehealth_company)
Pharmaceutical compound
Acetildenafil Aildenafil Avanafil Icariin Lodenafil Mirodenafil Nitrosoprodenafil Sildenafil Sulfoaildenafil Tadalafil Udenafil Vardenafil Sex steroids Androgens (e
Orenetide
Chemical compound
Lodenafil Mirodenafil MY-5445 Nitrosoprodenafil Norcarbodenafil SCH-51866 Sildenafil Sulfoaildenafil T-0156 Tadalafil Udenafil Vardenafil PDE7 BRL-50481 PDE9
MK-8189
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SILDENAFIL
SILDENAFIL
SILDENAFIL
SILDENAFIL
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