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Modification of use and function of cofactors in an organism's metabolic pathways
Cofactor engineering, a subset of metabolic engineering, is defined as the manipulation of the use of cofactors in an organism's metabolic pathways. In
Cofactor_engineering
Non-protein chemical compound or metallic ion
A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst. Cofactors can be considered "helper
Cofactor_(biochemistry)
Biological manufacturing process
"Enhancing Vitamin B12 Production in Engineered Escherichia coli through Cofactor Engineering and Fermentation Media Optimization". doi.org. doi:10.1021/acs.jafc
Precision_fermentation
Chemical element with atomic number 42 (Mo)
congenital cofactor deficiency. A congenital molybdenum cofactor deficiency disease, seen in infants, is an inability to synthesize molybdenum cofactor, the
Molybdenum
Large biological molecule that acts as a catalyst
carboxylase). An example of an enzyme that contains a cofactor is carbonic anhydrase, which uses a zinc cofactor bound as part of its active site. These tightly
Enzyme
Bioengineering process
Protein engineering is the process of developing useful or valuable proteins through the design and production of unnatural polypeptides, often by altering
Protein_engineering
Nicotinamide cofactor analogues (mNADs), also called nicotinamide coenzyme biomimetics (NCBs), are artificial compounds that mimic the natural nicotinamide
Nicotinamide cofactor analogues
Nicotinamide_cofactor_analogues
switching the iron-protoporphyrin cofactor in thermostable P450 enzyme CYP119A1 with an iridium-methyl-protoporphyrin cofactor (Ir(Me)-PIX), followed by directed
Cytochrome_P450_engineering
Theorem in Boolean algebra
{\displaystyle F_{x'}} are sometimes called the positive and negative Shannon cofactors, respectively, of F {\displaystyle F} with respect to x {\displaystyle
Boole's_expansion_theorem
avidin can significantly increase the catalytic capacity of Rhodium(I) cofactor in aqueous phosphate buffer. Another pioneering work was conducted by Kaiser
Artificial_metalloenzyme
Class of enzymes
proteins, the formation of nitriles is favored instead. Ascorbate is a known cofactor of myrosinase, serving as a base catalyst in glucosinolate hydrolysis.
Myrosinase
Set of chemical reactions in organisms
being most abundant of those. Metal cofactors are bound tightly to specific sites in proteins; although enzyme cofactors can be modified during catalysis
Metabolism
Metabolic redox process producing energy in the absence of oxygen
catabolized and their electrons are transferred to other organic molecules (cofactors, coenzymes, etc.). Anaerobic glycolysis is a related term used to describe
Fermentation
Essential nutrient found in citrus fruits and other foods
enzymes for which vitamin C is a cofactor, with function potentially compromised in a deficiency state, and any enzyme cofactor or other physiological function
Vitamin_C
Chemical element with atomic number 16 (S)
(biotin and thiamine) are organosulfur compounds crucial for life. Many cofactors also contain sulfur, including glutathione, and iron–sulfur proteins.
Sulfur
Ubiquitous antioxidant compound in living organisms
the function of citrulline as part of the nitric oxide cycle. It is a cofactor and acts on glutathione peroxidase. Glutathione is used to produce S-sulfanylglutathione
Glutathione
Redox-active coenzyme
proteins, however, generate and maintain a super oxidized form of the flavin cofactor, the flavin-N(5)-oxide. Flavoproteins were first discovered in 1879 by
Flavin_adenine_dinucleotide
American chemist and academic (born 1956)
bacteria, but the production pathway requires the cofactor NADPH, whereas E. coli makes the cofactor NADH. To circumvent this problem, she evolved the
Frances_Arnold
Class of enzymes
P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases. However,
Cytochrome_P450
Chemical compound
dehydrogenase, which uses nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor. Gallic acid is also formed from 3-dehydroshikimate by the action of the
3-Dehydroshikimic_acid
Class of membrane-less organelles within biological cells
shaping the partitioning behavior of small molecules and biochemical cofactors. Further direct evidence comes from experiments using synthetic tools
Biomolecular_condensate
Dietary supplement and medication
tons of nicotinamide were sold in 2014. Nicotinamide, as a part of the cofactor nicotinamide adenine dinucleotide (NADH / NAD+), is crucial to life. In
Nicotinamide
Chemical element with atomic number 28 (Ni)
reduction of protons to form hydrogen gas. A nickel-tetrapyrrole coenzyme, cofactor F430, is present in methyl coenzyme M reductase, which can catalyze the
Nickel
Class of enzymes
aldehydes, ketones and esters. The catalytic cycle is dependent from the cofactor nicotinamide adenine dinucleotide phosphate (NADPH). Unlike traditional
Ene-reductase
Earth's most severe extinction event
by releasing large amounts of nickel, a scarce metal that serves as a cofactor for enzymes involved in methane production. Chemostratigraphic analysis
Permian–Triassic extinction event
Permian–Triassic_extinction_event
Most abundant structural protein in animals
hydroxylase enzymes performing these reactions require vitamin C as a cofactor, a long-term deficiency in this vitamin results in impaired collagen synthesis
Collagen
Vitamin used in animal cell metabolism
involved in metabolism. One of eight B vitamins, it serves as a vital cofactor in DNA synthesis and both fatty acid and amino acid metabolism. It plays
Vitamin_B12
Matrix equal to its conjugate-transpose
Adjugate Alternating sign Augmented Bézout Jabotinsky Cartan Circulant Cofactor Commutation Confusion Coxeter Distance Duplication and elimination Euclidean
Hermitian_matrix
Emission of light by a living organism
they emit visible light. In some species, the luciferase requires other cofactors, such as calcium or magnesium ions, and sometimes also the energy-carrying
Bioluminescence
Organic reaction
dinucleotide (FAD) cofactor. In the catalytic cycle (see figure on the right), the cellular redox equivalent NADPH first reduces the cofactor, which allows
Baeyer–Villiger_oxidation
Chemical compound
volatile compounds when mixed with glucose and amino acids at 90 °C. It is a cofactor in tyrosine oxidation, though because a crude extract of animal liver is
Chemistry_of_ascorbic_acid
Series of interconnected biochemical reactions
being targeted for potential treatments of tuberculosis. The prospect of engineering various metabolic pathways into mammals which do not possess them is
Glyoxylate_cycle
Chemical element with atomic number 74 (W)
"Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from hyperthermophilic Archaea". Journal of Biological
Tungsten
Chemical element with atomic number 33 (As)
level of the citric acid cycle, arsenic inhibits lipoic acid, which is a cofactor for pyruvate dehydrogenase. By competing with phosphate, arsenate uncouples
Arsenic
Array of numbers
{\begin{bmatrix}1&3&4\\5&7&8\end{bmatrix}}.} The minors and cofactors of a matrix are found by computing the determinant of certain submatrices
Matrix_(mathematics)
Organelle in eukaryotic cells responsible for respiration
as the precursor for lipoic acid biosynthesis. Since lipoic acid is a cofactor for key mitochondrial enzyme complexes, including the pyruvate dehydrogenase
Mitochondria
Class of enzymes
to the FeMo cofactors. Each FeMo cofactor then acts as a site for nitrogen fixation, with N2 binding in the central cavity of the cofactor. The MoFe protein
Nitrogenase
German polymath (1646–1716)
His works show calculating the determinants using cofactors. Calculating the determinant using cofactors is named the Leibniz formula. Finding the determinant
Gottfried_Wilhelm_Leibniz
Chemical compound
Hoffman, Brian M. (May 2005). "Trapping H- Bound to the Nitrogenase FeMo-Cofactor Active Site during H2 Evolution: Characterization by ENDOR Spectroscopy"
Ammonia
Biomolecule consisting of chains of amino acid residues
chemical compound or ion for biological activity, these are known as cofactors. Proteins can work together to achieve a particular function, and they
Protein
Biological process to convert light into chemical energy
Whitmarsh & Govindjee 1999, p. 13. Anaerobic Photosynthesis, Chemical & Engineering News, 86, 33, August 18, 2008, p. 36 Kulp TR, Hoeft SE, Asao M, Madigan
Photosynthesis
Chemical compound
metabolism. Fritz Lipmann won the Nobel Prize in 1953 for his discovery of the cofactor coenzyme A. Acetyl-CoA is a metabolic intermediate that is involved in
Acetyl-CoA
Bluesmart Boosted BufferBox Casetext Canopy Labs Chaldal.com Circle Codecademy Cofactor Genomics Coinbase Container Linux (CoreOS Linux) CrowdMed Creative Market
List_of_Y_Combinator_startups
Chemical compound
Although this reaction requires nicotinamide adenine dinucleotide (NAD) as a cofactor, the enzymic mechanism regenerates it, resulting in the net use of no NAD
Shikimic_acid
Chemical element with atomic number 82 (Pb)
on many enzymes, or mimicking and displacing other metals that act as cofactors in many enzymatic reactions. The essential metals that lead interacts
Lead
Chemical compound
a precursor to pantothenic acid, a prosthetic group found in several cofactors. In the biological context, is usually encountered as its conjugate base
Α-Ketoisovaleric_acid
Site-specific recombinase technology
allowing the reaction to be reversed without the involvement of a high-energy cofactor. Cleavage on the other strand also causes a phospho-tyrosine bond between
Cre-Lox_recombination
Matrix operation which flips a matrix over its diagonal
matrix if the bases are orthonormal. Adjugate matrix, the transpose of the cofactor matrix Conjugate transpose Converse relation Moore–Penrose pseudoinverse
Transpose
Molecule produced by a living organism
cyclic adenosine monophosphate), and are incorporated into important cofactors of enzymatic reactions (coenzyme A, flavin adenine dinucleotide, flavin
Biomolecule
American media company
the spin-off of Cars.com on June 1, 2017. Cofactor Digital (ShopLocal) – On December 15, 2016, it sold Cofactor to Liquidus, a digital marketing solutions
Tegna_Inc.
Digital signature scheme
{\displaystyle \ell } is a large prime and 2 c {\displaystyle 2^{c}} is called the cofactor; of base point B ∈ E ( F q ) {\displaystyle B\in E(\mathbb {F} _{q})} with
EdDSA
Chemical compound
War I and World War II for use as military propellants and in military engineering work. During World War I, HM Factory, Gretna, the largest propellant
Nitroglycerin
Biotechnique to clean sulfur from crude oil
target for enhancement through protein engineering. The NADH-FMN oxidoreductase (DszD) regenerates the FMNH2 cofactor needed for the reactions catalyzed by
Biodesulfurization
Dicarboxylic acid
competitive inhibition. 2-oxoglutarate-dependent dioxygenases require an iron cofactor to catalyze hydroxylations, desaturations and ring closures. Simultaneous
Succinic_acid
contains a pigmented prosthetic group (or cofactor). A common example is haemoglobin, which contains a heme cofactor, which is the iron-containing molecule
Chromoprotein
Mathematical operation on vectors in 3D space
This determinant can be computed using Sarrus's rule or cofactor expansion. Using Sarrus's rule, it expands to a × b = ( a 2 b 3 i + a 3
Cross_product
Type of chemical bonding with metal ions
metalloenzymes feature metals that are chelated, usually to peptides or cofactors and prosthetic groups. Such chelating agents include the porphyrin rings
Chelation
Unscientific claims presented as scientific
gain, or when powerful individuals of the public conflate causation and cofactors by clever wordplay. These ideas reduce the authority, value, integrity
Pseudoscience
Class of enzymes that divide DNA
groups (Types I, II, III, IV, and V) based on their composition and enzyme cofactor requirements, the nature of their target sequence, and the position of
Restriction_enzyme
Chemical element with atomic number 6 (C)
stabilization of an otherwise labile species. In nature, the iron-molybdenum cofactor (FeMoco) responsible for microbial nitrogen fixation likewise has an octahedral
Carbon
Polymer harvested from certain trees
weight proteins with unknown function. The proteins possibly serve as cofactors, as the synthetic rate decreases with complete removal. More than 29 million
Natural_rubber
Biological molecules constituting nucleic acids
and 3'-phosphates. NADP, a dinucleotide enzymatic cofactor. FAD, a dinucleotide enzymatic cofactor in which one of the ribose sugars adopts a linear configuration
Nucleotide
Branch of chemistry
motif to construct synthetic systems. The binding of enzymes with their cofactors has been used as a route to produce modified enzymes, electrically contacted
Supramolecular_chemistry
Linked series of chemical reactions occurring within a cell
control analysis Metabolic network Metabolic network modelling Metabolic engineering Biochemical systems equation Linear biochemical pathway Nelson DL, Cox
Metabolic_pathway
Chemical element with atomic number 30 (Zn)
the second most abundant trace metal in humans after iron, an important cofactor for many enzymes, and the only metal which appears in all enzyme classes
Zinc
Chemical element with atomic number 26 (Fe)
oxygen transport, myelin synthesis, mitochondrial respiration, and as a cofactor for neurotransmitter synthesis and metabolism. Animal models of nutritional
Iron
Metalloprotein that binds with oxygen
(2000). "Invivonear-Infraredspectroscopy". Annual Review of Biomedical Engineering. 2: 715–54. doi:10.1146/annurev.bioeng.2.1.715. PMID 11701529. Siebenmann
Hemoglobin
Protein containing a heme prosthetic group
molecule: as an electron transporter, an oxygen carrier, and as an enzyme cofactor, heme binding proteins have consistently attracted the attention of protein
Hemoprotein
Chemical element with atomic number 8 (O)
with the lumenal side of thylakoid membranes. Manganese is an important cofactor, and calcium and chloride are also required for the reaction to occur.
Oxygen
Informal group of fungi
sodium and a source of protein and vitamins as well as other minerals and cofactors required for growth. Many brands of nutritional yeast and yeast extract
Yeast
American biologist
redox partners that transfer reducing equivalents from the enzyme to cofactors. The discovery of these enzymes and their functional expression in both
Jay_Keasling
DNA sequence
gene. TATA-binding protein (TBP) can be recruited in two ways, by SAGA, a cofactor for RNA polymerase II, or by TFIID. When promoters use the SAGA/TATA box
TATA_box
Study of chemical processes of living organisms
NADH molecules and two reduced (ubi)quinones (via FADH2 as enzyme-bound cofactor), and releasing the remaining carbon atoms as carbon dioxide. The produced
Biochemistry
Chemical in plants
I, a soluble enzyme that uses 2-oxogluturate, Fe2+, and ascorbate as cofactors and FNS II, a membrane bound, NADPH dependent cytochrome p450 monooxygenase
Apigenin
Enzyme
that cleaves the DNA palindromic sequence AAGCTT in the presence of the cofactor Mg2+ via hydrolysis. The cleavage of this sequence between the AA's results
HindIII
Function returning one of only two values
input variable; it is the XOR of the two corresponding cofactors. A derivative and a cofactor are used in a Reed–Muller expansion. The concept can be
Boolean_function
Chemical compound
ISSN 0015-6264. Zucca, P.; Littarru, M.; Rescigno, A.; Sanjust, E. (2009). "Cofactor recycling for selective enzymatic biotransformation of cinnamaldehyde to
Cinnamaldehyde
Chemical compound
nicotinic acid (NA) and nicotinamide (NAM) have been shown to be vital cofactors in cellular oxidation/reduction reactions and ATP synthesis. Classic NAD
Nicotinamide_riboside
Metabolic pathway
a heterologous carbon sink in engineered strains. A lot of metabolic engineering work on the MEP pathway has been done in cyanobacteria, photo-autotrophic
Non-mevalonate_pathway
Analytical technique
Electrophoresis (PNC-PAGE): An Efficient Method for Isolating Cadmium Cofactors in Biological Systems". Analytical Letters. 37 (4): 657–665. doi:10.1081/AL-120029742
Polyacrylamide gel electrophoresis
Polyacrylamide_gel_electrophoresis
Class of enzymes
Roland; Sell, Dieter (eds.). White Biotechnology. Advances in Biochemical Engineering / Biotechnology. Vol. 105. Springer Science & Business Media. pp. 133–173
Nitrile_hydratase
Chemical compound
The enzymes involved, IDS epimerase and C−N lyase, do not require any cofactors. Polyaspartic acid, like IDS, binds to calcium and other heavy metal ions
Ethylenediaminetetraacetic acid
Ethylenediaminetetraacetic_acid
Medical condition
glycoprotein (GP)Ib binding assay, VWF antibody assay, or a ristocetin cofactor activity (RiCof) assay. Factor VIII levels are also performed because factor
Von_Willebrand_disease
State of steady internal conditions maintained by living things
copper-zinc superoxide dismutase, and has a role in iron homeostasis as a cofactor in ceruloplasmin.[citation needed] Changes in the levels of oxygen, carbon
Homeostasis
Drug for erectile dysfunction and hypertension
Retrieved 10 February 2009. Mullin R (20 June 2005). "Viagra". Chemical & Engineering News. 83 (25). Archived from the original on 12 October 2008. Retrieved
Sildenafil
Chemical element with atomic number 34 (Se)
selenomethionine. In humans, selenium is a trace element nutrient that functions as cofactor for reduction of antioxidant enzymes, such as glutathione peroxidases and
Selenium
Science of drugs and medications and their effects
and manufacturing of drugs are studied by pharmaceutical engineering, a branch of engineering. Safety pharmacology specializes in detecting and investigating
Pharmacology
Method in electronic engineering
product of the loop gains of any three pairwise nontouching loops Δk = the cofactor value of Δ for the kth forward path, with the loops touching the kth forward
Mason's_gain_formula
Protein fold
tertiary fold found in proteins that bind nucleotides, such as enzyme cofactors FAD, NAD+, and NADP+. This fold is composed of alternating beta strands
Rossmann_fold
Series of interconnected biochemical reactions
this branch happens the reduction of CO2 to a methyl residue bound to a cofactor. The intermediates are formate for bacteria and formyl-methanofuran for
Biological_carbon_fixation
Explosive chemical compound
contained 300 grams (11 oz) of PETN. Hans Michels, professor of safety engineering at University College London, told a newspaper that 6 grams (0.21 oz)
Pentaerythritol_tetranitrate
Genome engineering tools
Site-specific recombinase technologies are genome engineering tools that depend on recombinase enzymes to replace targeted sections of DNA. In the late
Site-specific recombinase technology
Site-specific_recombinase_technology
Controversy centering on concerns about the biomedical significance of bisphenol A (BPA)
elements within the promoter of target genes on DNA. Subsequently, various cofactors are recruited allowing transcription of genes including those involved
Health_effects_of_Bisphenol_A
Technique for joining nucleic acid fragments
Ligation works in fundamentally the same way for both DNA and RNA. A cofactor is generally involved in the reaction, usually ATP or NAD+. Eukaryotic
Ligation_(molecular_biology)
In mathematics, invariant of square matrices
( − 1 ) i + j M i , j {\displaystyle (-1)^{i+j}M_{i,j}} is known as a cofactor. For every i {\displaystyle i} , one has the equality det ( A ) = ∑ j =
Determinant
Microbial protein found in Streptococcus pyogenes M1 GAS
family. Wild-type Streptococcus pyogenes Cas9 requires magnesium (Mg2+) cofactors for RNA-mediated DNA cleavage, although varying levels of activity has
Cas9
charge per phase as cofactors in neural injury induced by electrical stimulation". IEEE Transactions on Bio-Medical Engineering. 37 (10): 996–1001. doi:10
Shannon_criteria
Anion of sulfur with 3 oxygen atoms
kilogram or per litre) without specifying the amount". People with molybdenum cofactor deficiency cannot perform a number of metabolic functions, including the
Sulfite
Carboxylic acid with chemical formula CH3CH2CO2H
(30 September 2023). "The oxidoreductase activity of Rnf balances redox cofactors during fermentation of glucose to propionate in Prevotella". Research
Propionic_acid
Chemical element with atomic number 23 (V)
the closely related chloroperoxidase (which may use a heme or vanadium cofactor) and iodoperoxidases.[citation needed] The bromoperoxidase produces an
Vanadium
COFACTOR ENGINEERING
COFACTOR ENGINEERING
Surname or Lastname
English, French, Spanish, Portuguese, German, Polish, Czech, Slovak, Hungarian (Dániel), Romanian, and Jewish
English, French, Spanish, Portuguese, German, Polish, Czech, Slovak, Hungarian (Dániel), Romanian, and Jewish : from the Hebrew personal name Daniel ‘God is my judge’, borne by a major prophet in the Bible. The major factor influencing the popularity of the personal name (and hence the frequency of the surname) was undoubtedly the dramatic story in the Book of Daniel, recounting the prophet’s steadfast adherence to his religious faith in spite of pressure and persecution from the Mesopotamian kings in whose court he served: Nebuchadnezzar and Belshazzar (at whose feast Daniel interpreted the mysterious message of doom that appeared on the wall, being thrown to the lions for his pains). The name was also borne by a 2nd-century Christian martyr and by a 9th-century hermit, the legend of whose life was popular among Christians during the Middle Ages; these had a minor additional influence on the adoption of the Christian name. Among Orthodox Christians in Eastern Europe the name was also popular as being that of a 4th-century Persian martyr, who was venerated in the Orthodox Church.Irish : reduced form of McDaniel, which is actually a variant of McDonnell, from the Gaelic form of Irish Donal (equivalent to Scottish Donald), erroneously associated with the Biblical personal name Daniel. See also O’Donnell.Peter Daniel was one of the pioneer settlers in the 17th century in Stafford County, VA, where he was a justice of the peace. His grandson, Peter Vivian Daniel, was a U.S. Supreme Court justice from 1841 to his death in Richmond, VA, in 1860.
Surname or Lastname
English (mainly East Anglia)
English (mainly East Anglia) : metonymic occupational name for someone who dealt in weights and measures, for example a grain factor, from Middle English pekke ‘peck’ (an old measure of dry goods equivalent to eight quarts or a quarter of a bushel).English : variant of Peak 1.Irish : variant of Peak 2.South German : variant of Beck.North German and Dutch : metonymic occupational name for someone who prepared or sold pitch, from Middle Low German pek, Middle Dutch pec, pic.Dutch : from Middle Dutch pec, pick ‘desperate straits’, hence a nickname for a person in difficult circumstances or perhaps for someone with a gloomy disposition.
Surname or Lastname
English
English : from Middle English buyscel, busshell, bysshell ‘bushel’, ‘measure of grain’ (Old French boissel, buissel, of Gaulish origin), hence a metonymic occupational name for a grain merchant or factor, one who measured grain. The name may also have been applied to a maker of vessels designed to hold or measure out a bushel.English : from a diminutive of Biss.Respelling of German Biesel, a habitational name from Bisel in Alsace.
COFACTOR ENGINEERING
COFACTOR ENGINEERING
Boy/Male
Tamil
Nirman | நிரà¯à®®à®¾à®£
The egoless, Humble
Girl/Female
Hindu, Indian, Sanskrit, Tamil, Telugu
Arjuna's Bow
Boy/Male
Arabic, Australian, Farsi, Iranian, Muslim
Name of an Iranian General
Boy/Male
British, English, Swedish
High-born; Brilliant; Noble; Bright; Famous
Girl/Female
Hindu
Nourished, Defended, Loved
Boy/Male
Muslim
Sun of religion
Boy/Male
Norse
An Irishman.
Girl/Female
Sikh
Precious stone
Boy/Male
Tamil
Girl/Female
Hindu
Name of a Raga
COFACTOR ENGINEERING
COFACTOR ENGINEERING
COFACTOR ENGINEERING
COFACTOR ENGINEERING
COFACTOR ENGINEERING
n.
One who deals in grain; a corn factor.
n.
The business of a factor.
n.
One of the elements, circumstances, or influences which contribute to produce a result; a constituent.
n.
An agent or factor; a commission merchant.
n.
A smelling organ; a nose.
n.
The person to whom goods or other things are consigned; a factor; -- correlative to consignor.
n.
One who transacts business for another; an agent; a substitute; especially, a mercantile agent who buys and sells goods and transacts business for others in commission; a commission merchant or consignee. He may be a home factor or a foreign factor. He may buy and sell in his own name, and he is intrusted with the possession and control of the goods; and in these respects he differs from a broker.
n.
The allowance given to a factor, as a compensation for his services; -- called also a commission.
n.
A factor who is a woman.
v.
To consign or intrust to the care of another, as agent or factor; as, the ship was addressed to a merchant in Baltimore.
n.
One of the elements or quantities which, when multiplied together, from a product.
n.
The turning factor of a quaternion.
n.
A steward or bailiff of an estate.
imp. & p. p.
of Factor
n.
A factor or agent resident in a country for traffic.
n.
A negotiator; a factor.
v. t. & i.
An agent or attorney; a factor.
n.
The product obtained by taking a number or quantity three times as a factor; as, 4x4=16, and 16x4=64, the cube of 4.
v. t.
To resolve (a quantity) into its factors.
p. pr. & vb. n.
of Factor