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Family of vertebrate proteins involved in cell division and inflammation
The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix
S100_protein
Human protein and coding gene
S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range
S100B
Gene complex
families: the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family. It has been hypothesized that the
Epidermal differentiation complex
Epidermal_differentiation_complex
Type of nasal cancer
sinonasal tract associated with overlying respiratory epithelium and showing S100 protein and actin immunoreactivity The tumor often affects multiple sites within
Biphenotypic sinonasal sarcoma
Biphenotypic_sinonasal_sarcoma
Protein-coding gene in humans
Protein S100-A1, also known as S100 calcium-binding protein A1, is a protein which in humans is encoded by the S100A1 gene. S100A1 is highly expressed
S100A1
Topics referred to by the same term
an International Hydrographic Organization standard S100 protein, low-molecular-weight proteins in vertebrates The road number used in the Netherlands
S100
Protein found in humans
S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein that is encoded by the S100A10 gene in humans and the S100a10 gene in other
S100A10
Protein-coding gene in Homo sapiens
S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as calgranulin A. The proteins S100A8
S100A8
Protein-coding gene in the species Homo sapiens
S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene. The protein encoded by this gene is a member of
S100A11
Protein found in humans
S100 calcium-binding protein A5 (S100A5) is a protein that is encoded by the S100A5 gene in humans. The protein encoded by this gene is a member of the
S100A5
Protein found in humans
S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene. The protein encoded by this gene is a member of the
S100A3
Protein found in humans
Protein S100-A4 (S100A4) is a protein that in humans is encoded by the S100A4 gene. The protein encoded by this gene is a member of the S100 family of
S100A4
Protein-coding gene in the species Homo sapiens
S100 calcium-binding protein G (S100G) is a protein that in humans is encoded by the S100G gene. This gene encodes calbindin D9K, a vitamin D-dependent
S100G
Protein complex found in mammals
Calprotectin is a complex of the mammalian proteins S100A8 and S100A9. Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosis
Calprotectin
Protein found in humans
S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans
S100A9
Protein-coding gene in the species Homo sapiens
S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene. The protein encoded by this gene is a member of
S100A13
Protein found in humans
Protein S100-A7A (S100A7A), also known as koebnerisin, is a protein that in humans is encoded by the S100A7A (alias: S100A15) gene. S100 proteins are
S100A7A
Protein found in humans
S100 calcium-binding protein A7 (S100A7), also known as psoriasin, is a protein that in humans is encoded by the S100A7 gene. S100A7 is a member of the
S100A7
Protein-coding gene in the species Homo sapiens
S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene. The protein encoded by this gene is a member of the S100
S100P
Type of molecules within cells
inflammation associated with sunburn. S100 proteins: S100 is a multigenic family of calcium modulated proteins involved in intracellular and extracellular
Damage-associated molecular pattern
Damage-associated_molecular_pattern
Protein
Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils. The proteins S100A8 and
Calgranulin
Protein-coding gene in the species Homo sapiens
S100 calcium-binding protein A16 (S100A16) is a protein that in humans is encoded by the S100A16 gene. GRCh38: Ensembl release 89: ENSG00000188643 – Ensembl
S100A16
Human protein and coding gene
S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene. The protein encoded by this gene is a member of the
S100A6
Protein-coding gene in the species Homo sapiens
S100 calcium-binding protein A2 (S100A2) is a protein that in humans is encoded by the S100A2 gene and it is located on chromosome 1q21 with other S100
S100A2
Protein-coding gene in the species Homo sapiens
including advanced glycation end products (AGEs), amyloid-β peptides, and S100 proteins. These interactions activate multiple downstream signaling pathways
RAGE_(receptor)
Protein-coding gene in the species Homo sapiens
S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene. This gene encodes a member of the S100 protein
S100A14
Protein-coding gene in the species Homo sapiens
S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. Human S100A12, also known as calgranulin C, was
S100A12
Nootropic drug
Prospekta is a nootropic drug reported to act on the S100 proteins. It was developed by the company Materia Medica and approved in Russia for the treatment
Prospekta
Protein found in humans
precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type
Filaggrin
Whey acid proteins SLPI Elafin HE-4 Lysozyme S100 proteins Calpotectin Psoriasin (S100A7) C-type lectins SP-A SP-D Iron metabolism proteins Lactoferrin
List of antimicrobial peptides in the female reproductive tract
List_of_antimicrobial_peptides_in_the_female_reproductive_tract
Medical condition
system Brain tumor PCNA Astrocytoma Glial fibrillary acidic protein NC/Melanoma S100 protein Melanoma inhibitory activity Cardiovascular/ respiratory Lung
Germinoma
The S100 calcium-binding protein mS100a7a15 is the murine ortholog of human S100A7 (Psoriasin) and human S100A15 (Koebnerisin). mS100a7a15 is also known
MS100a7a15
Mammalian protein found in humans
tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation"
CD68
Proxy markers for certain cancers
like biopsy or imaging. Tumor markers can be proteins, carbohydrates, receptors and gene products. Proteins include hormones and enzymes. To detect enzyme
Tumor_marker
Index of articles associated with the same name
Calcium-binding protein Calcium-binding protein 1 S100 calcium-binding protein A1 TATA-binding protein Actin-binding protein Most actin binding proteins bind on
Binding_protein
Medical condition
different histologic appearance, neurothekeomas do not respond with the S100 protein while nerve sheath myxoma do (myxoid, mixed, or cellular). A rare neuro-ectodermal
Neurothekeoma
Cells covering neuron soma in PNS ganglia
PMID 20566001. Ichikawa H; Jacobowitz DM; Sugimoto T (February 1997). "S100 protein-immunoreactive primary sensory neurons in the trigeminal and dorsal root
Satellite_glial_cell
Cell surface receptor found in humans
molecular patterns (DAMPs), including high mobility group box protein 1 (HMGB1), S100 proteins, or histones. These compounds are released during tissue injury
Toll-like_receptor_4
Abnormal proliferation of Langerhans cells
M (May 1998). "Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive Langerhans cells in endometrial carcinoma". Human Pathology
Langerhans_cell_histiocytosis
Protein-coding gene in the species Homo sapiens
"Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458
Protein_ecdysoneless_homolog
Type of abnormal growth in the body
other tumor types contain cells that express S100 protein in most or all cases (see Pathology of S100 protein). The cytogenetics of this tumor reside in
Extraskeletal myxoid chondrosarcoma
Extraskeletal_myxoid_chondrosarcoma
Medical condition
bright blue. The glial tissue is highlighted with S100 protein and with glial fibrillary acidic protein, although the latter is much more sensitive for
Nasal_glial_heterotopia
Tumor of the adrenal medulla which secretes adrenal hormones
sympathoadrenal lineage tumors. Sustentacular cells express SOX10 and S100, with S100 protein being more widely distributed but less specific. Loss of sustentacular
Pheochromocytoma
Medical condition
neoplastic cells are S100 protein positive (approximately 80%), and show membrane and vacuole CD31 immunoreactivity. Uncoupling protein 1 (UCP1), a unique
Hibernoma
Neuronal Apoptosis-Inhibitory Protein Neuronal Calcium-Sensor Proteins Neuropeptides Olfactory Marker Protein S100 Proteins Synapsins Synaptophysin Synucleins
Nerve_tissue_protein
Topics referred to by the same term
by-product of the production of coke and coal gas from coal. S100A7, S100 calcium-binding protein A7. This disambiguation page lists articles associated with the
Psoriasin
Protein family
antifungal protein S100A7, which is not a member of this protein family. Instead, S100A7 belongs in the S100 protein family. The proteins kill fungi by
Antifungal_protein_family
Tumor of the external ear
positive with CK7; only the basal cells are positive with CK5/6, p63, S100 protein. CD117 can be positive in either population. The cells are negative with
Ceruminous_adenoma
large quantities of the enzyme glutamine synthetase also express the S100 protein which is the marker for folliculostellate cells. After exogenous glucocorticoid
Folliculostellate_cell
Protein found in humans
Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. Annexin 2 is involved in diverse cellular processes such
Annexin_A2
Medical condition
cells express CD34 protein in 92% to 100% of cases, nestin protein in 95% of cases, and S100 protein and melanocyte protein PMEL protein in some cases. DFSP-FS
Dermatofibrosarcoma protuberans, fibrosarcomatous
Dermatofibrosarcoma_protuberans,_fibrosarcomatous
Mammalian protein found in Homo sapiens
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ATP2A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings
ATP2A2
Rare form of breast cancer
cases express HER2/neu receptors; and in most cases express S100 protein, mammaglobin protein, and cytokeratin 5 or 6 (as detected using cytokeratin 5/6
Mammary_secretory_carcinoma
Medical condition
staining. Markers like S100, MelanA, HMB-45, tyrosinase, MITF, and Ki-67 are often used. The most sensitive marker is S100 protein staining; other markers
Amelanotic_melanoma
Medical condition
Luminal cells: positive with CK7 and CD117 Basal cells: positive with p63, S100 protein and CK5/6 It is important to exclude a tumor which is directly extending
Ceruminous_adenocarcinoma
Protein
six. Unlike calbindin 1 and 2, S100G is a member of the S100 family of calcium-binding proteins. S100G mediates the transport of calcium across the enterocytes
Calbindin
Malignant tumor of oil glands in the skin
for carcinoembryonic antigen (CEA), gross cystic disease fluid protein, and S100 protein, helping differentiate SGc from SCC and BCC. Immunohistochemistry
Sebaceous_carcinoma
Benign childhood tumor
actin proteins by the cells located primarily in fibroblast/myofibroblast zones and occasionally by the cells located in myxoid zones; the S100 protein was
Fibrous_hamartoma_of_infancy
Soft tissue tumor
GFAP, or S100 proteins. Earlier studies had reported that these cells express vimentin, periodic acid-Schiff, CD34, CD68, and S100 proteins in many cases
Acral myxoinflammatory fibroblastic sarcoma
Acral_myxoinflammatory_fibroblastic_sarcoma
Protein-coding gene in the species Homo sapiens
signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast
Fibroblast_growth_factor_1
Protein-coding gene in humans
a protein that in humans is encoded by the KCNK3 gene. This gene encodes K2P3.1, one of the members of the superfamily of potassium channel proteins containing
KCNK3
Mammalian protein found in Homo sapiens
(ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by
Osteonectin
Benign salivary gland tumor
immunohistochemistry studies, with the cells reacting with pancytokeratin, S100 protein and SOX10, with a delicate GFAP reaction around the periphery. Although
Canalicular_adenoma
Medical condition
not express GATA3 or alpha-methylacyl-CoA racemase but do express the S100 protein. PACB tumors have commonly been treated with regimens similar to those
Pure apocrine carcinoma of the breast
Pure_apocrine_carcinoma_of_the_breast
Protein family
A-II can also use its long N-terminal to form a heterotrimer between a S100 protein and two peripheral annexins. The structural diversity of annexins is
Annexin
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene
IQGAP1
Any type of cell death eliciting an immune response
distribution of further immunogenic molecules. Among these, HMGB1, S100 proteins and IL-1α are important DAMPs. Pyroptosis has some characteristics similar
Immunogenic_cell_death
Medical condition
Synaptophysin, GFAP, NSE, CD57 There is usually a variable expression of EMA and S100 protein. It is important in this age group to exclude other tumors that can have
Melanotic neuroectodermal tumor of infancy
Melanotic_neuroectodermal_tumor_of_infancy
Australian immunologist
migration inhibitor factor and major contributions to our understanding of S100 proteins in inflammatory diseases. 2024, Member of the Order of Australia (AM)
Carolyn_Geczy
National Library of Medicine (NLM). This list covers carrier proteins. For other protein-related codes, see List of MeSH codes (D12.776). Codes before
List of MeSH codes (D12.776.157)
List_of_MeSH_codes_(D12.776.157)
Benign small tumor on the finger or toe of an infant
α-smooth muscle actin, calponin, desmin, and CD99 proteins but not S100 protein or glial fibrillary acidic protein. The diagnosis of IDF is usually based on its
Infantile digital fibromatosis
Infantile_digital_fibromatosis
Protein-coding gene in the species Homo sapiens
extracellular matrix protein expressed in the epidermis. In humans it is encoded by the RPTN gene. Repetin is part of the S100 fused-type protein family and contains
Repetin
Medical condition often associated with monoclonal gammopathies
crystals which are eosinophilic. The macrophages tend to be negative for S100 protein, CD1a, Langerin, and cytokeratin when immunohistochemically tested, but
Crystal-storing_histiocytosis
Type of brain tumor
stippled chromatin. The cytoplasmic and often nuclear expression of S100 protein is present in nearly all tumor cells, and vimentin typically stains tumor
Papillary tumors of the pineal region
Papillary_tumors_of_the_pineal_region
Protein-coding gene in humans
2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". The Journal of Biological Chemistry. 277 (32):
CACYBP
Protein-coding gene in humans
Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene. AHNAK was originally
AHNAK
Protein-coding gene in the species Homo sapiens
protein encoded by this gene can be phosphorylated by protein-tyrosine kinase in microvilli and is a member of the ERM protein family. This protein serves
Ezrin
Soluble protein
calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60), is a protein that in humans is encoded by the CALR
Calreticulin
Human protein and coding gene
"Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc
SUGT1
myoepithelial components. Positive: Glial fibrillary acidic protein (GFAP), pancytokeratin, and S100 protein. Smooth muscle actin may be positive in about 50% of
Ectomesenchymal chondromyxoid tumor
Ectomesenchymal_chondromyxoid_tumor
Benign tumor of skeletal muscle
tumor cells are almost always negative with glial fibrillary acidic protein, S100 protein, cytokeratin, epithelial membrane antigen, CD68, FLI1, CD99 and
Fetal_rhabdomyoma
Chemical compound
Ostrand-Rosenberg S, Srikrishna G (October 2008). "Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells". Journal
Tasquinimod
Type of animal embryonic connective tissue
tissues. Embryonic mesenchymal cells express protein S100-A4 (S100A4), also known as fibroblast-specific protein, which is indicative of their shared properties
Mesenchyme
surfactant-associated protein A1 Pyruvate dehydrogenase (lipoamide) alpha 1 RNA binding motif protein, Y-linked, family 1, member A1 Replication protein A1 S100 calcium
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
keratins, CK7 and CK19. Basaloid or myoepithelial cells: positive with S100 protein, muscle specific actin, calponin and p63. The proliferation marker, Ki-67
Sialoblastoma
Protein-coding gene in the species Homo sapiens
human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family". Experimental Dermatology. 21 (9): 643–9
SPRR3
Protein encoded by the TCHH gene in mammals
to other toughened epithelial tissues. Trichohyalin belongs to the S100-fused protein family. It is a monomer, containing 1943 amino acids, and has elongated
Trichohyalin
Substance or process that is indicative of the presence of cancer in the body
PSA (prostate specific antigen) (prostate cancer), S100 (melanoma), and many others. Mutant proteins themselves detected by selected reaction monitoring
Cancer_biomarker
Calcium-binding proteins are proteins that participate in calcium cell signaling pathways by binding to Ca2+, the calcium ion that plays an important
Calcium-binding_protein
Protein found in humans
29 kDa calbindin), is a calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by the CALB2 gene. This gene
Calretinin
Protein helix–loop–helix motif
axis –Z. Pseudo EF-hands exclusively found in the N-termini of S100 and S100-like proteins. The 14-residue pseudo EF-hand loop chelates Ca2+ primarily via
EF_hand
Calcium-binding protein
Calsequestrin is a calcium-binding protein that acts as a calcium buffer within the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna
Calsequestrin
Intracellular communication process
messenger through indirect signal transduction pathways, such as in G protein-coupled receptor pathways. Calcium signaling plays a role in muscle contraction
Calcium_signaling
Messenger protein
(an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It
Calmodulin
Protein-coding gene in the species Homo sapiens
Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability
Annexin_A5
Mammalian protein found in Homo sapiens
is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium
Phospholamban
Protein-coding gene in the species Homo sapiens
Annexin A11 is a protein that in humans is encoded by the ANXA11 gene. This gene encodes a member of the annexin family, a group of calcium-dependent
Annexin_A11
Protein found in humans
F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene. CAPZA1 is a member of the F-actin capping protein alpha subunit
Capping protein (actin filament) muscle Z-line, alpha 1
Capping_protein_(actin_filament)_muscle_Z-line,_alpha_1
Mammalian protein found in Homo sapiens
Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of
Gelsolin
Chemical compound
activation. When a ligand binds to a G protein-coupled receptor (GPCR) that is coupled to a Gq heterotrimeric G protein, the α-subunit of Gq can bind to and
Inositol_trisphosphate
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