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Protein domain
Fibulin (FY-beau-lin) (now known as Fibulin-1 FBLN1) is the prototypic member of a multigene family, currently with seven members. Fibulin-1 is a calcium-binding
Fibulin
Protein-coding gene in the species Homo sapiens
FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein. Fibulin-1 is a secreted glycoprotein that is found in association with
FBLN1
Type of connective tissue in animals
a highly complex process involving several key proteins including fibulin-4, fibulin-5, latent transforming growth factor β binding protein 4, and microfibril
Elastic_fiber
Protein-coding gene in the species Homo sapiens
EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene. A large number of extracellular
EFEMP2
Vision loss due to damage to the macula of the eye
also cause hereditary angioedema. Fibulin-5 mutation: Rare forms of the disease are caused by genetic defects in fibulin-5, in an autosomal dominant manner
Macular_degeneration
nevus Fibulin-1 Fibulin-1 Marfan syndrome Fibulin-2 Fibulin-2 Congenital contractural arachnodactyly Fibulin-4 Fibulin-4 Cutis laxa Fibulin-5 Fibulin-5 Cutis
List of genes mutated in cutaneous conditions
List_of_genes_mutated_in_cutaneous_conditions
Protein-coding gene in the species Homo sapiens
Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene. This gene encodes an extracellular matrix protein, which belongs to the fibulin family
FBLN2
Protein-coding gene in the species Homo sapiens
EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene. This gene encodes a member of the fibulin family
EFEMP1
Skin which is abnormally inelastic and hangs loosely
macrophages. It has also been considered that mutations in elastin (ELN) and fibulin-5 (FBLN5) genes can increase susceptibility of elastic fibres to inflammatory
Cutis_laxa
Metabolic disease involving abnormal deposited amyloid proteins
seminalis L A ACatKe Cathepsin K Tumour associated L A AEFEMP1e EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) Portal veins, Aging associated
Amyloidosis
Protein allowing tissue in the body to resume shape after stretching
coacervation before being deposited onto microfibrils. Proteins including fibulin-4, fibulin-5, and latent transforming growth factor beta-binding protein 4 participate
Elastin
Most abundant structural protein in animals
membranes via several types of protein, including fibronectin, laminin, fibulin, and integrin. A single collagen molecule, tropocollagen, is used to make
Collagen
Protein found in humans
Wiedemann H, Chu ML, Timpl R, Kostka G (September 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array
Nidogen-1
Protein-coding gene in the species Homo sapiens
Fibulin-5 (also known as DANCE (developmental arteries and neural crest epidermal growth factor (EGF)-like)) is a protein that in humans is encoded by
FBLN5
is lost when in reduction. Proteins such as Fibulin-5 keep elastic fibers organized and functional. Fibulin-5 levels can drop due to normal aging or damage
Elaunin
Protein-coding gene in the species Homo sapiens
PMID 12477932. Debeer P, Schoenmakers EF, Twal WO, et al. (2002). "The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type
RASSF8
Class of intracellular transport proteins
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Ryanodine_receptor
Mass formed in response to injury to the nervous system
structural support. Other molecular components of the basal membrane include fibulin-1, fibronectin, entactin, and heparin sulfate proteoglycan perlecan. Ultimately
Glial_scar
family of proteins (also known as CCN intercellular signaling protein), fibulins, osteopontin, periostin, SPARC family members, tenascin(s), and thrombospondins
Matricellular_protein
Protein family
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Synaptotagmin
French cancer physician
receptors (including estrogen beta receptor) in pre-cancerous breast lesions. Fibulin 1, induced by estrogens, is secreted in excess by ovarian cancer cells
Henri_Rochefort_(physician)
Biological process
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calcium-induced calcium release
Calcium-induced_calcium_release
Protein-coding gene in the species Homo sapiens
binding to integrin receptors, as well as other receptors such as NOTCH1 and fibulin 1c (FBLN1). NOV is expressed during wound healing and induces angiogenesis
CCN_family_member_3
Mammalian protein found in Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Osteonectin
Protein found in humans
interacts with members of the TGF-β superfamily, fibronectin, perlecan, fibulin-1, slit, and mucins. Knockout mice with the Ctgf gene disrupted die at
CCN_family_member_2
Disorders of the lung and pleura caused by the inhalation of asbestos fibres
ccr-08-0360. PMID 19174489. Pass HI, Levin SM, Harbut MR, et al. (2012). "Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma". The New
Asbestos-related_diseases
Protein found in humans
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Annexin_A2
Protein-coding gene in the species Homo sapiens
LAMA1 laminin, alpha 1". Utani A, Nomizu M, Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino
Laminin_subunit_alpha-1
Database of human proteins
Uhlén M, Schwenk JM, Nilsson P (Nov 2011). "Plasma profiling reveals human fibulin-1 as candidate marker for renal impairment". Journal of Proteome Research
Human_Protein_Atlas
Protein-coding gene in the species Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Sarcalumenin
Protein-coding gene in the species Homo sapiens
(January 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry
Tenascin-R
Mammalian protein found in humans
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Osteocalcin
Calcium-binding protein
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calsequestrin
Protease enzyme present in mammals and other organisms
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calpain
Mammalian protein found in humans
APBA2, APBA3, APBB1, APPBP1, APPBP2, BCAP31, BLMH CLSTN1, CAV1, COL25A1, Fibulin-1, GSN, HSD17B10, and SHC-transforming protein 1. APP interacts with reelin
Amyloid-beta precursor protein
Amyloid-beta_precursor_protein
Mammalian protein found in Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Phospholamban
Family of vertebrate proteins involved in cell division and inflammation
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
S100_protein
Protein found in humans
(Jan 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry
Brevican
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calcium-binding_protein
Range of genetic disorders which cause a person to appear to grow older faster
org. Retrieved 2016-12-06. Hirai, M; Ohbayashi, T; Horiguchi, M (2007). "Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic
Progeroid_syndromes
Protein family
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Annexin
Protein-coding gene in the species Homo sapiens
glypican proteoglycan families. Versican’s C-terminal domain interacts with fibulin-2, a protein whose expression is associated with that of versican in the
Versican
Extracellular proteoglycan
Mann K, Timpl R (August 2001). "Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan". Journal
Perlecan
Mammalian protein found in humans
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calnexin
Messenger protein
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calmodulin
Protein involved in cell adhesion, cell growth, cell migration and differentiation
contains domains for fibrin-binding (I1–5, I10–12), collagen-binding (I6–9), fibulin-1-binding (III13–14), heparin-binding and syndecan-binding (III12–14).
Fibronectin
Protein
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calgranulin
Chemical compound
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Inositol_trisphosphate
Protein-coding gene in the species Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Recoverin
Intracellular communication process
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calcium_signaling
Chemical compound
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Nicotinic acid adenine dinucleotide phosphate
Nicotinic_acid_adenine_dinucleotide_phosphate
Mammalian protein found in Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Neurocalcin
Protein-coding gene in the species Homo sapiens
Eidels L (2002). "Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like
LTBP3
Soluble protein
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calreticulin
Mammalian protein found in humans
Sasaki T, Göhring W, Pan TC, et al. (1996). "Binding of mouse and human fibulin-2 to extracellular matrix ligands". J. Mol. Biol. 254 (5): 892–9. doi:10
Collagen,_type_IV,_alpha_6
Protein
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calbindin
Protein family
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Troponin_C
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Neuronal_calcium_sensor
Mammalian protein found in Mus musculus
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Oncomodulin
Medical condition
elastin (which is normally non-glycosylated) and glycosylated proteins (fibulin, fibronectin, and collagen). It is speculated that either abnormal glycosylation
Wrinkly_skin_syndrome
Protein found in humans
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Hippocalcin
Protein-coding gene in the species Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Annexin_A1
Protein found in humans
Fritsche LG, et al. (2007). "Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD)"
Hemicentin_1
Mammalian protein found in Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Gelsolin
Calcium-binding protein
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calexcitin
Protein found in humans
Components of Connective Tissues and Extracellular Matrix: Elastin, Fibrillin, Fibulins, Fibrinogen, Fibronectin, Laminin, Tenascins and Thrombospondins". Progress
Cartilage oligomeric matrix protein
Cartilage_oligomeric_matrix_protein
Chemical compound
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Cyclic_ADP-ribose
sequences of many bovine extracellular proteins, like fibronectin and fibulin-1, are similar to the human protein sequences. To remove these contaminants
Secretomics
Protein-coding gene in the species Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Annexin_A5
Protein-coding gene in the species Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Regucalcin
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Intracellular calcium-sensing proteins
Intracellular_calcium-sensing_proteins
Protein-coding gene in the species Homo sapiens
1074/jbc.M208731200. PMID 12244066. Utani A, Nomizu M, Yamada Y (Jan 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino
Laminin,_alpha_5
Protein-coding gene in the species Homo sapiens
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
S100G
Protein found in humans
Vitamin D Vitamin K Extracellular chelators Extracellular matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin
Calretinin
Protein-coding gene in the species Homo sapiens
Abrams WR, Rosenbloom J, Timpl R (Oct 1999). "Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins". FEBS Letters. 460
Nidogen-2
Protein found in humans
Sasaki T, Göhring W, Miosge N, et al. (1999). "Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins". FEBS Lett. 460 (2):
Collagen,_type_XVIII,_alpha_1
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