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Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin
Neuronal_calcium_sensor
Neuronal calcium sensory protein
Neuronal calcium sensor-1 (NCS-1) also known as frequenin homolog (Drosophila) (freq) is a protein that is encoded by the FREQ gene in humans. NCS-1 is
Neuronal_calcium_sensor-1
Protein found in humans
encoded by the HPCA gene. Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed
Hippocalcin
Mammalian protein found in Homo sapiens
delta is a neuronal calcium-binding protein which in humans is encoded by the NCALD gene. Neurocalcin belongs to the neuronal calcium sensor (NCS) family
Neurocalcin
Protein-coding gene in the species Homo sapiens
gene. This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule
Visinin-like_protein_1
Intracellular calcium-sensing proteins are proteins that act in the second messenger system. Examples include: calmodulin calnexin calreticulin gelsolin
Intracellular calcium-sensing proteins
Intracellular_calcium-sensing_proteins
Topics referred to by the same term
the free dictionary. Freq may refer to: Frequency (abbreviation) Neuronal calcium sensor-1, protein also known as frequenin homolog or freq Freq (album)
Freq
Protein-coding gene in the species Homo sapiens
hippocalcin-like 1". Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3):
Hippocalcin-like_protein_1
Primary cell of the nervous system
the axon terminal, it opens voltage-gated calcium channels, allowing calcium ions to enter the terminal. Calcium causes synaptic vesicles filled with neurotransmitter
Neuron
Scientific method
Hasseman JP, et al. (July 2019). "High-performance calcium sensors for imaging activity in neuronal populations and microcompartments". Nature Methods
Calcium_imaging
Genetically encoded calcium indicator
Hasseman JP, et al. (July 2019). "High-performance calcium sensors for imaging activity in neuronal populations and microcompartments". Nature Methods
GCaMP
Calcium-binding proteins are proteins that participate in calcium cell signaling pathways by binding to Ca2+, the calcium ion that plays an important
Calcium-binding_protein
Intracellular communication process
mediators of ICRAC. Calcium is a ubiquitous second messenger with wide-ranging physiological roles. These include muscle contraction, neuronal transmission (as
Calcium_signaling
Protein 7B2 Neurofilament Proteins Neurogranin Neuronal Apoptosis-Inhibitory Protein Neuronal Calcium-Sensor Proteins Neuropeptides Olfactory Marker Protein
Nerve_tissue_protein
Biological process
Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca2+ stores
Calcium-induced calcium release
Calcium-induced_calcium_release
British physiologist and neuroscientist
1152/physrev.00031.2002. Burgoyne, R. D. (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews Neuroscience
Robert_D._Burgoyne
Protein found in humans
Calcium binding protein 1". McCue HV, Haynes LP, Burgoyne RD (August 2010). "The diversity of calcium sensor proteins in the regulation of neuronal function"
Calcium-binding_protein_1
Protein found in humans
hippocalcin like 4". Burgoyne RD (March 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience
Hippocalcin-like_protein_4
Protein
pathway is suggested to be involved on this regulation. Also, neuronal calcium sensor-1 was suggested to modulate the expression of DARPP-32. PPP1R1B
PPP1R1B
State of steady internal conditions maintained by living things
effectively. The plasma ionized calcium (Ca2+) concentration is very tightly controlled by a pair of homeostatic mechanisms. The sensor for the first one is situated
Homeostasis
Family of vertebrate proteins involved in cell division and inflammation
low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation
S100_protein
Chemical compound
PMC 6671165. PMID 18171931. Bezprozvanny, I.; Hayden, M.R. (2004). "Deranged neuronal calcium signaling and Huntington disease". Biochemical and Biophysical Research
Inositol_trisphosphate
Family of transport proteins
calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium
L-type_calcium_channel
Topics referred to by the same term
complex syndrome Nerve conduction study, a medical diagnostic test Neuronal calcium sensor, a family of proteins Thiocyanate, a compound in the cyanate family
NCS
Protein-coding gene in the species Homo sapiens
in humans is encoded by the gene RCVRN. It is a 23 kilodalton (kDa) neuronal calcium-binding protein that is primarily detected in the photoreceptor cells
Recoverin
Antiporter membrane protein that removes calcium from cells
gradients. This effect may prolong calcium transients following bursts of neuronal activity, thus influencing neuronal information processing. The ability
Sodium-calcium_exchanger
Protein
calcium-binding domains, and 2 modified domains that have lost their calcium-binding capacity. Calbindin acts as a calcium buffer and calcium sensor and
Calbindin
Protein family
domains of certain synaptotagmins bound to calcium, synaptotagmins were proposed to function as calcium sensors in the regulation of neurotransmitter release
Synaptotagmin
Topics referred to by the same term
NCS1 may refer to: National Comorbidity Survey Neuronal calcium sensor-1, encoded by the NCS1 gene Nucleobase cation symporter-1 This disambiguation page
NCS1
Main receptor for most antipsychotic drugs
activity. In mice, regulation of D2R surface expression by the neuronal calcium sensor-1 (NCS-1) in the dentate gyrus is involved in exploration, synaptic
Dopamine_receptor_D2
Messenger protein
unable to bind calcium themselves, and use calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the calcium stores in the
Calmodulin
Chemical element with atomic number 30 (Zn)
Golovin, AV; Permyakov, SE; Zernii, EY (2018). "Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding". Frontiers in Molecular Neuroscience
Zinc
Protein family
it has to be capable of binding negatively charged phospholipids in a calcium-dependent manner and must contain a 70 amino acid repeat sequence called
Annexin
Biochemist
Viviana (June 29, 2018). "Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors". Science. 360 (6396). doi:10.1126/science
Lin_Tian
Protein found in humans
channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. Members of this family are small calcium binding proteins containing EF-hand-like
Calsenilin
Co- & Post-translational modification
N-terminus myristoylation aids in membrane association Hippocalcin Neuronal calcium sensor Contains a Ca2+/myristoyl switch FSP1 Apoptosis-inducing factor
Myristoylation
the term optogenetics. Genetically encoded calcium indicators (GECIs) are used frequently to monitor neuronal activity, but other cellular parameters such
Optogenetic methods to record cellular activity
Optogenetic_methods_to_record_cellular_activity
Protein-coding gene in the species Homo sapiens
"The calcium binding sites in human annexin V by crystal structure analysis at 2.0 A resolution. Implications for membrane binding and calcium channel
Annexin_A5
Neuron communication by electric impulses
the other by voltage-gated calcium channels. Sodium-based action potentials usually last for under one millisecond, but calcium-based action potentials may
Action_potential
Class of intracellular transport proteins
Ryanodine receptors (RyR) are classified as high-conductance, intracellular calcium release channels, typically present in the membrane of the sarcoplasmic
Ryanodine_receptor
Calcium imaging technique
Fiber photometry is a calcium imaging technique that captures 'bulk' or population-level calcium (Ca2+) activity from specific cell-types within a brain
Fiber_photometry
American biochemist (1938–2024)
Molecular mechanics of calcium-myristoyl switches. Nature 389:198-202 Burgoyne, R.D.; Weiss, J.L. (2001). "The neuronal calcium sensor family of Ca2+-binding
Lubert_Stryer
Shevelyova MP, Vladimirov VI, et al. (2018). "Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding". Frontiers in Molecular Neuroscience
Zinc_in_biology
Protein domain
member of a multigene family, currently with seven members. Fibulin-1 is a calcium-binding glycoprotein. In vertebrates, fibulin-1 is found in blood and extracellular
Fibulin
mitochondrial matrix free calcium concentration rises to the tens of micromolar levels in situ during neuronal activity. The effects of calcium on human cells are
Calcium_in_biology
Mammalian protein found in humans
noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. Because osteocalcin has gla domains, its synthesis is
Osteocalcin
Family of transport proteins
increase in calcium levels. Structurally, BK channels are homologous to voltage- and ligand-gated potassium channels, having a voltage sensor and pore as
BK_channel
Protein-coding gene in the species Homo sapiens
interacting protein 1". Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3):
KCNIP1
Mammalian protein found in Homo sapiens
Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca2+) pump in cardiac muscle cells. This protein is found as a pentamer
Phospholamban
Biological study Of bipolar disorder
(IP3) caused by hyperactive neuronal calcium sensor 1 causes excessive calcium release. Serum levels of S100B (a calcium binding protein) are elevated
Biology_of_bipolar_disorder
Organelle in eukaryotic cells responsible for respiration
and mitochondrial calcium act to synchronize neuronal activity with mitochondrial energy metabolism. Mitochondrial matrix calcium levels can reach the
Mitochondria
Family of transport proteins
many neuronal cells within the central nervous system. Different experimental studies within the 1970s allowed for the distinction of T-type calcium channels
T-type_calcium_channel
Protein-coding gene in the species Homo sapiens
Manahan-Vaughan D, Braunewell KH (2004). "MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc
Activity-regulated cytoskeleton-associated protein
Activity-regulated_cytoskeleton-associated_protein
Protease enzyme present in mammals and other organisms
(/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed
Calpain
Soluble protein
receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of
Calreticulin
Mammalian protein found in humans
endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues)
Calnexin
Protein-coding gene in the species Homo sapiens
interacting protein 4". Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3):
KCNIP4
Protein family
N-type calcium channels, also called Cav2.2 channels, are voltage gated calcium channels that are localized primarily on the nerve terminals and dendrites
N-type_calcium_channel
Protein-coding gene in the species Homo sapiens
PMID 1602151. Ando Y, Imamura S, Owada MK, Kannagi R (January 1991). "Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase
Annexin_A1
Protein-coding gene in the species Homo sapiens
2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and
TUBB
Protein family
191039) It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is
Troponin_C
Family of transport proteins
P-type calcium channels play a similar role to the N-type calcium channel in neurotransmitter release at the presynaptic terminal and in neuronal integration
P-type_calcium_channel
Calcium-binding protein
Calsequestrin is a calcium-binding protein that acts as a calcium buffer within the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna
Calsequestrin
Protein found in humans
fibrinolysis, ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize
Annexin_A2
Chemical compound
messenger system. cADPR is a cellular messenger for calcium signaling. It stimulates calcium-induced calcium release at lower cytosolic concentrations of Ca2+
Cyclic_ADP-ribose
Active transport and bulk transport in which a cell transports molecules out of the cell
membrane. Exocytosis in neuronal chemical synapses is Ca2+ triggered and serves interneuronal signalling. The calcium sensors that trigger exocytosis
Exocytosis
Mammalian protein found in Homo sapiens
by the SPARC gene. Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization
Osteonectin
Protein-coding gene in the species Homo sapiens
interacting protein 2". Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience
KCNIP2
Protein-coding gene in the species Homo sapiens
role in dark adaptation. Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability
GUCA1B
Protein found in humans
similar vitamin D-dependent calcium-binding protein, calbindin-28kDa. Calretinin has an important role as a modulator of neuronal excitability including the
Calretinin
Class of enzymes
2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and
Purine nucleoside phosphorylase
Purine_nucleoside_phosphorylase
bind to a protein called synaptotagmin, which acts as a calcium sensor. Once bound to calcium, synaptotagmin interacts with the SNARE complex, a group
Quantal neurotransmitter release
Quantal_neurotransmitter_release
Protein-coding gene in the species Homo sapiens
protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis". Hum. Mol. Genet. 12 (12): 1415–25
IL1RAPL1
Protein-coding gene in humans
Lin R, Goldman-Rakic P, Levenson R (2002). "Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor". J
Dopamine_receptor_D5
Protein-coding gene in the species Homo sapiens
PMID 12390029. Hwang JY, Koch KW (2002). "The myristoylation of the neuronal Ca2+ -sensors guanylate cyclase-activating protein 1 and 2". Biochim. Biophys
GUCA1A
Type of brain cell
Recent data show that astrocytes function as glucose sensors and exert a commanding influence upon neuronal reactivity to changes in extracellular glucose.
Astrocyte
Mammalian protein found in Homo sapiens
moves like a latch depending on the concentration of calcium ions. The C-terminal end detects the calcium concentration within the cell. When there is no Ca2+
Gelsolin
Index of articles associated with the same name
by the KCNIP4 gene. Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3):
Kv channel interacting protein
Kv_channel_interacting_protein
Calcium-binding protein
Calexcitin is a calcium-binding protein first isolated from the sea snail Hermissenda crassicornis. It is upregulated following Pavlovian conditioning
Calexcitin
Protein-coding gene in the species Homo sapiens
Retrieved 5 May 2013. Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience
ARMH3
Toxin found in scorpion venom
transvaalicus. It affects the gating of voltage-gated sodium channels and calcium channels. Many venoms are evolved among animals, and most of them are a
Kurtoxin
Protein-coding gene in humans
LP, Burgoyne RD (August 2010). "The diversity of calcium sensor proteins in the regulation of neuronal function". Cold Spring Harbor Perspectives in Biology
CALN1
776.157.125.412.437 – gelsolin MeSH D12.776.157.125.412.500 – neuronal calcium-sensor proteins MeSH D12.776.157.125.412.500.124 – guanylate cyclase-activating
List of MeSH codes (D12.776.157)
List_of_MeSH_codes_(D12.776.157)
Type of ion channel transmembrane protein
Voltage-gated ion channels have a crucial role in excitable cells such as neuronal and muscle tissues, allowing a rapid and co-ordinated depolarization in
Voltage-gated_ion_channel
of calcium into the cell triggers the completion of the assembly reaction, which is mediated by an interaction between the putative calcium sensor, synaptotagmin
Vesicle_fusion
Transmembrane protein family
those lacking the GluA2 subunit, leads to increased calcium permeability, contributing to neuronal injury and death—a phenomenon known as excitotoxity
AMPA_receptor
Transmembrane protein allowing sodium ions in and out
Manabu; Ren, Dejian (2010-11-04). "Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel
Sodium_channel
Chemical compound
concentration which, in turn, modulates sundry cellular processes (see Calcium signalling). Structurally, it is a dinucleotide that only differs from
Nicotinic acid adenine dinucleotide phosphate
Nicotinic_acid_adenine_dinucleotide_phosphate
Method by which information is represented in the brain
representation) refers to the relationship between a stimulus and its respective neuronal responses, and the signalling relationships among networks of neurons in
Neural_coding
Protein
Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils. The proteins
Calgranulin
Protein-coding gene in the species Homo sapiens
nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules". Journal of Molecular
FBLN1
Self-labeling protein tag
biosensors of neuronal activity. These sensors undergo a conformational change in response to calcium concentration spikes during neuronal firing; this
HaloTag
Protein-coding gene in the species Homo sapiens
extracellular, plasma membrane Encodes a member of the recoverin family of neuronal calcium sensors. May prolong the termination of the phototransduction cascade in
SCRN3
MeSH D12.644.360.381.437 – gelsolin MeSH D12.644.360.381.500 – neuronal calcium-sensor proteins MeSH D12.644.360.381.500.124 – guanylate cyclase-activating
List_of_MeSH_codes_(D12.644)
Central nervous system disease
progressive loss of neurons, in the process known as neurodegeneration. Neuronal damage may also ultimately result in their death. Neurodegenerative diseases
Neurodegenerative_disease
Protein
"High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor". Nat. Neurosci. 17 (6): 884–889. doi:10
Genetically encoded voltage indicator
Genetically_encoded_voltage_indicator
Strontium(II), or Barium(II) have been shown to have agonist to the calcium-sensor synaptotagmin. Other organics have been studied using this cell line
PC12_cell_line
Protein-coding gene in the species Homo sapiens
ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures
FBLN2
Biological junctions through which neurons' signals can be sent
junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons
Chemical_synapse
Junction between motor neuron and muscle fiber
which activates voltage-gated calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmins) on synaptic
Neuromuscular_junction
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NEURONAL CALCIUM-SENSOR
NEURONAL CALCIUM-SENSOR
Boy/Male
Australian, British, Celtic, English, Latin
Dove
Girl/Female
Latin
Mother of Cycnus.
Girl/Female
Christian, Hindu, Indian
Beautiful
Boy/Male
Scottish
Son of Callum.
Boy/Male
Gaelic Irish Scottish
Dove. Can also be a 'Servant/disciple of Columba'.
Boy/Male
American, Australian, Chinese, Christian, Gaelic, Latin, Scottish
Dove; Similar to Malcolm; Servant or Disciple of Columba; Bald Dove
Surname or Lastname
English (of Norman origin)
English (of Norman origin) : habitational name from places in Eure and Seine-Maritime, France, called Cailly, from a Romano-Gallic personal name Callius + the locative suffix -acum.English : habitational name from a minor place called Caley in the parish of Winwick, Lancashire, named with Old English cÄ â€˜jackdaw’ + lÄ“ah ‘woodland clearing’.Irish : reduced and altered form of McCauley.Manx : variant of Callow.
Boy/Male
Irish Celtic Gaelic
a Latin name meaning dove.
Male
Scottish
Variant spelling of Scottish Calum, CALLUM means "dove."
Surname or Lastname
English
English : occupational name from Old French aillier ‘garlic seller’, from ail ‘garlic’ (from Latin allium).Americanized spelling of German Ehler or Öhler (see Ohler).
Male
Scottish
Scottish form of Latin Columba, CALUM means "dove."
Boy/Male
Arthurian Legend
Various names for Arthur's sword.
NEURONAL CALCIUM-SENSOR
NEURONAL CALCIUM-SENSOR
NEURONAL CALCIUM-SENSOR
NEURONAL CALCIUM-SENSOR
NEURONAL CALCIUM-SENSOR
NEURONAL CALCIUM-SENSOR
NEURONAL CALCIUM-SENSOR
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