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Class of enzymes
Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid. Karl Meyer classified these enzymes in 1971, into three distinct
Hyaluronidase
Combination medication
Efgartigimod alfa/hyaluronidase, sold under the brand name Vyvgart Hytrulo, is a coformulation medication used for the treatment of generalized myasthenia
Efgartigimod alfa/hyaluronidase
Efgartigimod_alfa/hyaluronidase
Biopharmaceutical drug
macroglobulinemia, a type of non-Hodgkin lymphoma. Rituximab in combination with hyaluronidase human, sold under the brand names MabThera SC and Rituxan Hycela, is
Rituximab
Combination medication
Ocrelizumab/hyaluronidase, sold under the brand name Ocrevus Zunovo, is a fixed-dose combination medication used for the treatment of multiple sclerosis
Ocrelizumab/hyaluronidase
Medication
Nivolumab/hyaluronidase, sold under the brand name Opdivo Qvantig, is a fixed-dose combination anti-cancer medication used for the treatment of various
Nivolumab/hyaluronidase
Combination drug
Daratumumab/hyaluronidase, sold under the brand name Darzalex Faspro, is a fixed-dose combination medication for the treatment of adults with newly diagnosed
Daratumumab/hyaluronidase
Biotechnology company
primarily focused on its proprietary and patented recombinant human hyaluronidase enzyme, rHuPH20. The company's development pipeline is concentrated
Halozyme
Combination drug
Pertuzumab/trastuzumab/hyaluronidase, sold under the brand name Phesgo, is a fixed-dose combination medication to treat adults with HER2-positive breast
Pertuzumab/trastuzumab/hyaluronidase
Pertuzumab/trastuzumab/hyaluronidase
Combination medication
Atezolizumab/hyaluronidase, sold under the brand name Tecentriq Hybreza, is a fixed-dose combination medication used for the treatment of non-small cell
Atezolizumab/hyaluronidase
Medical condition
Hyaluronidase deficiency, also known as Mucopolysaccharidosis type IX or MPS IX, is a condition caused by mutations in the HYAL1 gene, and is characterized
Hyaluronidase_deficiency
Pharmaceutical drug
Trastuzumab/hyaluronidase, sold under the brand name Herceptin SC among others, is a fixed-dose combination medication for the treatment of HER2-overexpressing
Trastuzumab/hyaluronidase
Protein-coding gene in the species Homo sapiens
Hyaluronidase-1 is an enzyme that in humans is encoded by the HYAL1 gene. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly
HYAL1
Medical condition
acid)). Two published medical journals appear to show Hyaluronidase injections (Hyaluronidase is an enzyme used to dissolve hyaluronic acid which is
Cutis_verticis_gyrata
Medication
Amivantamab/hyaluronidase, sold under the brand name Rybrevant Faspro, is a fixed-dose combination medication used for the treatment of non-small cell
Amivantamab/hyaluronidase
Species of bacterium
PMID 22050223. S2CID 207441558. Starr CR, Engleberg NC (January 2006). "Role of hyaluronidase in subcutaneous spread and growth of group A streptococcus". Infection
Streptococcus_pyogenes
Puncture wound caused by a bee's stinger
phospholipase A2, hyaluronidase and acid phosphatase. The three proteins in honeybee venom that are important allergens are phospholipase A2, hyaluronidase and acid
Bee_sting
Limbless, scaly, elongate reptile
affect the body in different ways. Almost all snake venom contains hyaluronidase, an enzyme that ensures rapid diffusion of the venom. Venomous snakes
Snake
Monoclonal antibody
mantle cell lymphoma. It is available in combination with hyaluronidase as daratumumab/hyaluronidase (brand name Darzalex Faspro). In May 2018, the US Food
Daratumumab
Artificial stimulation of the immune system to treat cancer
atezolizumab and hyaluronidase-tqjs injection". DailyMed. 25 September 2024. Retrieved 5 October 2024. "FDA approves atezolizumab and hyaluronidase-tqjs". U.S
Cancer_immunotherapy
Carbohydrate-rich layer at the periphery of a cell
sulphate and hyaluronan can be shed of the endothelial layer by enzymes. Hyaluronidase, hepararanse/heparinase, matrix and membrane-type matrix metalloproteases
Glycocalyx
Medication
myeloid: CD33 (Gemtuzumab ozogamicin) Other Amivantamab (+hyaluronidase) Atezolizumab (+hyaluronidase) Avelumab Axatilimab Belantamab mafodotin Bermekimab
Elranatamab
Disease that damages the myelin sheaths around nerves
relapsing MS, and SPMS in the U.S., and RRMS in Europe. Ocrelizumab/hyaluronidase was approved for medical use in the United States in September 2024
Multiple_sclerosis
Monoclonal antibody
myeloid: CD33 (Gemtuzumab ozogamicin) Other Amivantamab (+hyaluronidase) Atezolizumab (+hyaluronidase) Avelumab Axatilimab Belantamab mafodotin Bermekimab
Mosunetuzumab
Union of opposite-sex gametes in sexual reproduction to form a zygote
the GalT initiates the acrosome reaction. This process releases the hyaluronidase that digests the matrix of hyaluronic acid in the vestments around the
Fertilisation
Cellular mantle around egg cell
Graafian follicle. For fertilization to occur, sperm cells rely on hyaluronidase (an enzyme found in the acrosome of spermatozoa) to disperse the corona
Corona_radiata_(embryology)
Combination medication
(PD-1) blocking antibody; and berahyaluronidase alfa, a variant of hyaluronidase. It is given by injection under the skin (subcutaneous).
Pembrolizumab/berahyaluronidase alfa
Pembrolizumab/berahyaluronidase_alfa
Protein-coding gene in the species Homo sapiens
Hyaluronidase-2 is a multifunctional protein, previously thought to only possess acid-active hyaluronan-degrading enzymatic function. In humans it is
HYAL2
Physiological molecule and therapeutic drug
degraded by a family of enzymes called hyaluronidases. In humans, there are at least seven types of hyaluronidase-like enzymes, several of which are tumor
Hyaluronic_acid
Protein family
peptides and two enzymes, one of which is a hyaluronidase. The amino acid sequence of bee venom hyaluronidase contains 349 amino acids, and includes four
Glycoside_hydrolase_family_56
Enzyme
Hyaluronidase PH-20 is an enzyme that in humans is encoded by the SPAM1 gene. Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan
SPAM1
Medication
under the brand name Longidaze, is a conjugate of proteolytic enzyme hyaluronidase with high- molecular weight copolymer that forms a component of combination
Bovhyaluronidase_azoximer
Protein-coding gene in the species Homo sapiens
Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene. This gene encodes a protein which is similar in structure to hyaluronidases
HYAL3
Species of Gram-positive bacterium
fibrinogen to fibrin to cause clots, which is important in skin infections. Hyaluronidase (also known as spreading factor) breaks down hyaluronic acid and helps
Staphylococcus_aureus
Medication
present in myasthenia gravis. It is also available coformulated with hyaluronidase. The most common side effects include respiratory tract infections,
Efgartigimod_alfa
Organelle of sperm cells
placental mammals, the acrosome contains degradative enzymes (including hyaluronidase and acrosin). These enzymes break down the outer membrane of the ovum
Acrosome
Anti-CD20 monoclonal antibody
administered by intravenous infusion. The fixed-dose combination ocrelizumab/hyaluronidase is administered by subcutaneous injection. It was approved by the US
Ocrelizumab
Largest species of lizard in the United States
substances have been isolated from the Gila monster's venom, including hyaluronidase, serotonin, phospholipase A2, and several kallikrein-like glycoproteins
Gila_monster
Genus of social wasps
subgenus of Vespula The venom of Vespula is mostly composed of antigen 5, hyaluronidase, and phospholipase. A high degree of similarity occurs between immunogenic
Vespula
Pentacyclic chemical compound in plant leaves and fruit
female rats. Oleanolic acid is also used as standard for comparison of hyaluronidase, elastase and matrix-metalloproteinase-1 inhibition of other substances
Oleanolic_acid
Chemical compound
family of antibiotics that inhibits the hydrolysis of hyaluronic acid by hyaluronidase. It has been isolated from cultures of Streptomyces hyaluromycini. Harunari
Hyaluromycin
Monoclonal antibody
Monoclonal antibodies for tumors Tumor Human Adecatumumab§ Amivantamab (+hyaluronidase) Ascrinvacumab§ Balstilimab† Botensilimab Cixutumumab§ Conatumumab§
Minretumomab
Chemical compound
in combination with atezolizumab or in combination with atezolizumab/hyaluronidase for the maintenance treatment of adults with extensive-stage small cell
Lurbinectedin
Class of enzymes
Hyaluronoglucuronidase (EC 3.2.1.36, hyaluronidase, glucuronoglucosaminoglycan hyaluronate lyase, orgelase) is an enzyme with systematic name hyaluronate
Hyaluronoglucuronidase
Any type of epithelial lung cancer other than small-cell lung carcinoma
approved for medical use in the United States in August 2024. Amivantamab/hyaluronidase (Rybrevant Faspro) was approved for medical use in the United States
Non-small-cell_lung_cancer
Enzyme that functions outside the cell it is secreted from
diffuse into the host at the correct time. Similar to collagenase, hyaluronidase enables a pathogen to penetrate deep into tissues. Bacteria such as
Exoenzyme
Insertion of medication under the skin
bruised. Hyaluronic acid "bruising" may be treated using injections of hyaluronidase enzyme around the location. Other common medication-specific side effects
Subcutaneous_administration
Species of bacterium
Acetoin Negative Acid Phosphatase Variable Alkaline Phosphatase Positive Hyaluronidase Negative β-D-glucosidase Positive Leucine aminopeptidase Positive Neuraminidase
Streptococcus_mitis
Species of snake
failure or cardiac arrest. The venom components include enzymes such as hyaluronidase that cause lysis and increase the spread of the venom. Envenomation
Indian_cobra
Medication administered into a vein
the affected limb so the collected fluids drain away. Injections of hyaluronidase around the area can be used to speed the dispersal of the fluid/drug
Intravenous_therapy
Highly modified saliva containing zootoxins
is responsible for the yellow colour of the venom of some species. Hyaluronidase increases tissue permeability to accelerate the absorption of other
Snake_venom
Danish healthcare company
Darzalex (IV) (daratumumab) / Darzalex Faspro (SC) (daratumumab and hyaluronidase) for the treatment of all stages of multiple myeloma as combination
Genmab
American multinational pharmaceutical and medical device company
for multiple myeloma (2.0% of revenues); DARZALEX (daratumumab and hyaluronidase-fihj), also for multiple myeloma (15.2% of revenues); ERLEADA (apalutamide)
Johnson_&_Johnson
Male reproductive cell
modification of the Golgi body, which contains enzymes such as spermlysin (hyaluronidase, corona-penetrating enzyme, zona lysin, or acrosin) used for penetrating
Sperm
Species of reptile
consists of a number of components, including L-amino acid oxidase, hyaluronidase, phospholipase A, serotonin, and highly active kallikreins that release
Mexican_beaded_lizard
Venom made by bees
peptides. Further protein components include apamin (2%), a neurotoxin, hyaluronidase (2%), which dilates blood vessels, increasing their permeability and
Apitoxin
Autoimmune disease resulting in skeletal muscle weakness
medical use in the United States in December 2021. Efgartigimod alfa/hyaluronidase (Vyvgart Hytrulo) was approved for medical use in the United States
Myasthenia_gravis
Aspect of anatomy
pathogenic bacterial release of enzymes which cause tissue lysis (e.g. hyaluronidase and collagenase). The spaces filled with loose areolar connective tissue
Fascial spaces of the head and neck
Fascial_spaces_of_the_head_and_neck
Medical intervention
reversed even if injected into a blood vessel with an enzyme called hyaluronidase, which can be also injected like fillers. Originally developed at the
Non-surgical_rhinoplasty
Process by which a gene can code for multiple proteins
instance, the figure to the right shows three spliceforms from the mouse hyaluronidase 3 gene. Comparing the exonic structure shown in the first line (green)
Alternative_splicing
Sperm-meets-egg process
sperm on the egg's surface. In mammals, the acrosome reaction releases hyaluronidase and acrosin; their role in fertilization is not yet clear. The acrosomal
Acrosome_reaction
Extremely venomous snake native to Australia
possibly haemorrhagins, which damage the vascular endothelium; the enzyme hyaluronidase, which facilitates rapid spread of venom through tissues. Paradoxin
Inland_taipan
Genus of bacteria
growth of the latter. Some clostridia that cause gas gangrene produce hyaluronidase, deoxyribonuclease, lecithinase, leukocidin, protease, lipase, and hemolysin
Clostridium
Pharmaceutical compound
Monoclonal antibodies for tumors Tumor Human Adecatumumab§ Amivantamab (+hyaluronidase) Ascrinvacumab§ Balstilimab† Botensilimab Cixutumumab§ Conatumumab§
Indium (111In) altumomab pentetate
Indium_(111In)_altumomab_pentetate
British pharmaceutical and biotechnology company
Tesaro to acquire world-wide rights to use ALT-B4, Alteogen's novel hyaluronidase utilising Hybrozyme technology, for the development and commercialisation
GSK_plc
Medical treatment
human) Hyqvia (immune globulin 10 percent – human with recombinant human hyaluronidase) Octagam (immune globulin intravenous, human) Panzyga (immune globulin
Immunoglobulin_therapy
Species of wasp
noradrenaline neurotoxin apamin, as well as enzymes phospholipase A and hyaluronidase, and proteins melittin and bradykinin. These compounds have been shown
European_hornet
Injectable drug
degrade cartilage matrix proteins; collagenases such as cathepsin B1; and hyaluronidase. PSGAG inhibits the synthesis of prostaglandin E2, which is released
Polysulfated glycosaminoglycan
Polysulfated_glycosaminoglycan
Hy-Phen Hyalgan hyalosidase (INN) hyaluronidase (INN) hyaluronidase-fihj hyaluronidase-nvhy hyaluronidase-oysk hyaluronidase-zzxf hybufocon A (USAN) Hycamtin
List_of_drugs:_Hf–Hz
Injectable cosmetic filler
granulomas. These side effects can be easily reversed with a treatment of hyaluronidase, which is an enzyme that speeds up the natural degradation of the injected
Restylane
Poison of the stonefish
destructive ability. Besides stonustoxin, it also contains hyaluronidase and cardioleputin. Hyaluronidase damages the tissue surrounding the sting, causing a
Stonustoxin
Chemical compound
phagocytosis in both in vitro and in vivo studies, to inhibit the function of hyaluronidase (an enzyme that breaks down hyaluronic acid in the human body), to protect
Chicoric_acid
Species of lizard
disorders, but also helps to digest food through breaking down proteins. Hyaluronidase within the venom has a similar digestive effect, increasing the production
Desert_monitor
Pharmaceutical bromfenac Xibrom Ocular inflammation Ista Pharmaceutical hyaluronidase Vitrase Spreading agent Ista Pharmaceutica rivaroxaban Xarelto Deep
Annual pharmaceutical drug sales
Annual_pharmaceutical_drug_sales
Species of bacterium
production Human strains (S. dysgalactiae) Animal strains (S. canis) Hyaluronidase + – Fibrinolysin + – α-Galactosidase – + β-Galactosidase – + β-Glucuronidase
Streptococcus_canis
Species of virus
cellular receptor for JSRV is hyaluronidase 2 (Hyal2), a glycophosphatidylinol(GPI)-anchored protein belonging to the hyaluronidase family. Generally, oncogenic
Jaagsiekte_sheep_retrovirus
Medical condition
another three were reported in the same year. The disorder results from hyaluronidase deficiency. Symptoms included nodular soft-tissue masses located around
Mucopolysaccharidosis
Species of bacteria
adhesion factor that mediates the binding to human colonic cells and a hyaluronidase. The bacterium also produces the chemical para-cresol, which inhibits
Clostridioides_difficile
Monoclonal anti-PD-L1 antibody
Union. In October 2025, the FDA approved a combination of atezolizumab, hyaluronidase, and lurbinectedin for the treatment of adults with extensive-stage
Atezolizumab
Genus of bacteria
involved in comedome rupturing by producing factors such as proteases, hyaluronidases and neuraminidases which might be involved in thinning of the epithelium
Propionibacterium
Species of bacterium
Beta-N-acetylglucosaminidase - - + Beta-N-galactosaminidase - - + Sialidase - - + Beta-galactosidase - - + Beta-glucosidase - + +/- Hyaluronidase + - +
Streptococcus_constellatus
Venom and aggression rankings
molecular weight, low viscosity, and the venom's high activity in terms of hyaluronidases, which is also essential in facilitating dispersion of venom toxins
List_of_dangerous_snakes
Metabolic disorders affecting a cell's lysosomes
Type VI (Maroteaux–Lamy syndrome) Type VII (Sly syndrome) Type IX (hyaluronidase deficiency) Mucolipidosis Type I (sialidosis) Type II (I-cell disease)
Lysosomal_storage_disease
Species of king crab
complex of enzymes with various activities: collagenase, protease, hyaluronidase, lipase, nuclease, etc. The complex of proteolytic enzymes of the red
Red_king_crab
Mammalian protein found in humans
N, Heath J, Schultz L, Sleve D, Carey GB, et al. (February 2001). "Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor
P53
Scottish physician
and Surgeons in Glasgow. In 1966, Cameron published his first book, Hyaluronidase and Cancer. In 1971, Cameron began corresponding with Dr. Linus Pauling
Ewan_Cameron
Medical condition
to four hours for three to four weeks 0.5 ml intralesional injection Hyaluronidase 1500 IU mixed in 1 ml of Lignocaine into each buccal mucosa once a week
Oral_submucous_fibrosis
Drug used to treat allergic diseases
disclosed that Sanofi had been utilizing its ALT-B4 recombinant human hyaluronidase platform since 2019 to develop a high-dose subcutaneous formulation
Dupilumab
Leakage of intravenously-infused medications into surrounding tissue
substance-specific measures apply, carry them out (e.g. topical cooling, DMSO, hyaluronidase or dexrazoxane may be appropriate). Recent clinical trials have shown
Extravasation_(intravenous)
gonadotropin (hCG) Human growth hormone Hyaluronate Hyaluronic acid Hyaluronidase Hydrogen peroxide 5-Hydroxymethylcytosine Hydroxyproline 5-Hydroxytryptamine
List_of_biomolecules
Type of molecules produced by a pathogen that might cause potential harmful effects
variety of enzymes which cause damage to host tissues. Enzymes include hyaluronidase, which breaks down the connective tissue component hyaluronic acid;
Virulence_factor
Class of enzymes which break glycosidic bonds via hydrolysis
lactase, amylase, chitinase, sucrase, maltase, neuraminidase, invertase, hyaluronidase and lysozyme. Glycoside hydrolases are predicted to gain increasing
Glycoside_hydrolase
Cell membrane engulfing a large particle
provide unfavourable growth conditions for bacteria. Other enzymes like hyaluronidase, lipase, collagenase, elastase, ribonuclease, deoxyribonuclease also
Phagocytosis
Surgery to remove unwanted fat
"wet" technique in which the fat tissue was injected with saline and hyaluronidase, which helped dissolve tissue holding the fat, prior to suctioning.
Liposuction
Pharmaceutical drug
prompt elevation of the part, warmth and local injection of lidocaine or hyaluronidase. Norepinephrine and dobutamine cannot be used as additives in an intravenous
Intravenous sodium bicarbonate
Intravenous_sodium_bicarbonate
Protein-coding gene in the species Homo sapiens
hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. Such function has also been validated in mice. CEMIP is associated
CEMIP
Species of bacterium
nitrate to nitrite. It is negative for clumping factor, coagulase, hyaluronidase, arginine dihydrolase, ornithine decarboxylase, acetoin, arginine arylamidase
Staphylococcus_nepalensis
considered a promising target for cancer therapy. Hyaluronan synthase Hyaluronidase Toole, B.P. (October 1990). "Hyaluronan and its binding proteins, the
Hyaladherin
Request US FDA approve new medications
including biosynthetic insulin, growth hormone, glucagon, calcitonin, and hyaluronidase are grandfathered under governance of the Federal Food Drug and Cosmetics
New_Drug_Application
Genus of snakes
Yingprasertchai, Senee; Bunyasrisawat, Srisurat; Ratanabanangkoon, Kavi (2003). "Hyaluronidase inhibitors (sodium cromoglycate and sodium auro-thiomalate) reduce the
Calloselasma
Class of prescription drugs in India
HYDROXYQUINOLINES 237. HALOPERIDOL 238. HEPARIN 239. HEPATITIS B. VACCINE 240. HYALURONIDASE 241. HYDROCORISONE 17-BUTYRATE 242. HYDROTALCITE 243. HYDROXIZINE 244
Schedule_H
HYALURONIDASE
HYALURONIDASE
HYALURONIDASE
HYALURONIDASE
Boy/Male
Indian
Wish; Good
Male
French
French form of Roman Latin Urbanus, URBAIN means "of the city."
Boy/Male
Tamil
A carpenter, Another name of the divine architect Vishvakarma
Girl/Female
Indian, Telugu
Season
Boy/Male
American, Australian, Hawaiian, Hebrew
Grandfather
Girl/Female
French English Teutonic
Boy/Male
Australian, Finnish, French, German, Irish, Swedish
Brave Adviser; Strong; Wild; Steadfast; Brave; Strong Willed; Wise; Constant; Diminutive of Conrad
Boy/Male
Muslim/Islamic
Name of an authority of Hadith
Female
English
Modern English name derived from the country name which was derived from the name of a mountain, probably from Kiinyaa, the Wakamba tribe's name for the mountain, KENYA means "mountain of the ostrich," because the mountain is said to have certain features of the ostrich when it is snow-covered. Compare with masculine Kenya.
Girl/Female
Arabic
Sharp; Intellectual; Pure; Pious
HYALURONIDASE
HYALURONIDASE
HYALURONIDASE
HYALURONIDASE
HYALURONIDASE