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Protein-coding gene in the species Homo sapiens
family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene. Ikaros is a transcription factor that is encoded by the IKZF genes
IKZF1
Pair of enantiomers
in the rapid degradation of several disease-related proteins including IKZF1, IKZF3, and CSNK1A1. Lenalidomide was approved for medical use in the United
Lenalidomide
Class of protein inhibiting drugs
(CC-220) CRBN modulator, IKZF1/IKZF3 degrader Multiple myeloma, lupus Phase III NCT04975997 Mezigdomide (CC-92480) CRBN modulator, IKZF1/3 degrader Relapsed
Targeted_protein_degradation
Topics referred to by the same term
Heaven's Lost Property Ikaros, a transcription factor encoded by the human IKZF1 gene Icarus (disambiguation) This disambiguation page lists articles associated
Ikaros
Pharmaceutical compound
tyrosine kinase (BTK) along with the immunomodulatory proteins Ikaros (IKZF1) and Aiolos (IKZF3). Salvaris RT, Brennan J, Lewis KL (February 2025). "BTK
Zelebrudomide
Rare type of blood cancer
relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1". Leukemia. 24 (6): 1128–1138. doi:10.1038/leu.2010.69. PMC 3035972. PMID 20428194
Primary_myelofibrosis
Protein-coding gene in the species Homo sapiens
This family of transcription factors consists of five members: Ikaros (Ikzf1), Helios (Ikzf2), Aiolos (Ikzf3), Eos (Ikzf4), and Pegasus (Ikzf5). The
IKZF2
Blood cancer characterized by overproduction of lymphoblasts
Common inherited risk factors include mutations in ARID5B, CDKN2A/2B, CEBPE, IKZF1, GATA3, PIP4K2A and, more rarely, TP53. These genes play important roles
Acute_lymphoblastic_leukemia
Class of chemical compounds
cereblon (CRBN) and reprograms it to degrade transcription factors like IKZF1/IKZF3 in multiple myeloma. Other examples include tafamidis that stabilizes
Molecular_glue
ENSG00000169953 HSF Known motif – High-throughput in vitro [418] DTCGAAHSNWTCGAW IKZF1 ENSG00000185811 C2H2 ZF Known motif – In vivo/Misc source [419] BTGGGARD
List of human transcription factors
List_of_human_transcription_factors
Molecular geneticist
disease. In patients with alopecia, one of the genes that are hyperactive is IKZF1, which results in overproduction of immune cells that subsequently attack
Angela_Christiano
Human gene
development.[supplied by OMIM] IKZF4 has been shown to interact with CTBP1 and IKZF1. GRCh38: Ensembl release 89: ENSG00000123411 – Ensembl, May 2017 GRCm38:
IKZF4
Protein-coding gene in the species Homo sapiens
relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1". Leukemia. 24 (6): 1128–1138. doi:10.1038/leu.2010.69. PMC 3035972. PMID 20428194
Thrombopoietin_receptor
Chinese-American physician-scientist
(1): e1007129. Hoshino, A; Boutboul, D; et al. (2022). "Gain-of-function IKZF1 variants in humans cause immune dysregulation with inflammation, autoimmunity
Xiao_P._Peng
Protein found in humans
reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are not normally targeted by CRL4
Cullin-4A
Protein found in humans
of: Cdt1 p21 PR-Set7/SET8 p12 subunit of DNA polymerase δ SAMHD1† UNG2† IKZF1§ IKZF3§ †protein is a CRL4 substrate only when directed by viral proteins
Cullin-4B
Protein found in humans
with other transcription factors (viz., RUNX1, SCL/TAL1, GFI1, GFI1b, MYB, IKZF1, Transcription factor PU.1, LYL1) and cellular receptors (viz., MPL, GPR56)
GATA2
Maternal effect gene and gap gene
Wei; Zhang, Jianan; Li, Jianfeng; Shen, Yang (2023). "Identification of IKZF1 genetic mutations as new molecular subtypes in acute myeloid leukaemia"
Hunchback_(gene)
American oncologist
Ebert's lab found that lenalidomide, a cancer drug, targeted two proteins, IKZF1 and IKZF3, for degradation. This finding and additional studies established
Benjamin_L._Ebert
Topics referred to by the same term
an international project studying the migration routes of flying animals IKZF1, a protein in humans that is encoded by the IKZF genes of the Ikaros family
Icarus_(disambiguation)
Protein-coding gene in the species Homo sapiens
developing eye. The expression of Osr1 is negatively regulated by Runx2 and Ikzf1. These genes are involved in osteoblast and lymphocyte differentiation through
OSR1
Protein-coding gene in the species Homo sapiens
CTBP1 has been shown to interact with: ACTL6B, ARF, EVI1 FOXP2, HDAC1, IKZF1, IKZF4, KLF3, KLF8, Mdm2, MLL, NRIP1, Pinin, RBBP8, and TGIF1. GATA1. GRCh38:
CTBP1
Protein-coding gene found in humans
C17orf78-NUTM1 (C17orf78 is also termed ATAD5), CHD4-NUTM1, RUNX1-NUTM1, IKZF1-NUTM1, and SLC12A6-NUTM1 fusion genes. Individuals with these NUTM1 fusion
Nuclear protein in testis gene
Nuclear_protein_in_testis_gene
Medical condition
with other transcription factors (viz., RUNX1, SCL/TAL1, GFI1, GFI1b, MYB, IKZF1, Transcription factor PU.1, LYL1) and cellular receptors (viz., MPL, GPR56)
GATA2_deficiency
shown to interact with: BCL6, Endothelin receptor type A, HDAC3, HTATIP, IKZF1, and Nuclear receptor co-repressor 1. Histone deacetylase GRCh38: Ensembl
HDAC7
Protein-coding gene in the species Homo sapiens
Table 6. List of proteins that interact with FAM214B Protein Description IKZF1 DNA-binding protein Ikaros TRIM27 Zinc finger protein RFP FHL5 Four and
ATOSB
Protein-coding gene in the species Homo sapiens
include (but are not limited to) EGR1, p53, E2F3, E2F4, PLAG1, NeuroD2, Myf5, IKZF1, SMAD3, KRAB, MZF1, and c-Myb. Expression of QSER1 is seen at levels lower
QSER1
O14920 7549 IKBKE HGNC:14552; Q14164 7550 IKBKG HGNC:5961; Q9Y6K9 7551 IKZF1 HGNC:13176; Q13422 7552 IKZF2 HGNC:13177; Q9UKS7 7553 IKZF3 HGNC:13178;
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Mitochondrial protein involved in iron–sulfur cluster biosynthesis
ISCU appears to interact with ISCS, NUP62, SDHB, HPRT1, CCDC172, GOLGA2, IKZF1, KRT40, AGTRAP, NECAB2, FAM9B, BANP, LNX1, MID2, GOLGA6L9, ccdc136, KRT34
ISCU
Protein-coding gene in humans
Histone deacetylase 2, Homeobox protein TGIF1, Host cell factor C1, IFRD1, IKZF1, ING1, MBD3, MIER1, MLL, MTA1, MTA2, Mad1, Mdm2, Methyl-CpG-binding domain
HDAC1
Enzyme found in humans
deacetylase 5 has been shown to interact with: BCL6, CBX5, GATA1, HDAC3, IKZF1, MEF2A, NRIP1, NCOR1, NCOR2, YWHAQ, and ZBTB16. Histone deacetylase GRCh38:
Histone_deacetylase_5
Protein-coding gene in the species Homo sapiens
CABIN1 HBP1, HDAC1, HDAC9, Histone deacetylase 2, Host cell factor C1, IKZF1, ING1, KLF11, MNT, MXD1, Methyl-CpG-binding domain protein 2, Nuclear receptor
SIN3A
Protein-coding gene in the species Homo sapiens
with HDAC1, Zinc finger and BTB domain-containing protein 16, SUDS3 and IKZF1. Transcription coregulator GRCh38: Ensembl release 89: ENSG00000127511 –
SIN3B
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IKZF1
IKZF1
IKZF1
IKZF1
IKZF1
IKZF1
IKZF1
IKZF1
IKZF1
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