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Class of short biopolymers
Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics. Commonly
Oligonucleotide
Chemical synthesis of nucleic acids
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure (sequence). The technique
Oligonucleotide_synthesis
Form of treatment for genetic disorders and other illnesses
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA
Antisense_therapy
Antibody–oligonucleotide conjugates or AOCs belong to a class of chimeric molecules combining in their structure two important families of biomolecules:
Antibody–oligonucleotide conjugate
Antibody–oligonucleotide_conjugate
making them thiophosphate groups instead. Oligonucleotide phosphorothioates (OPS) are modified oligonucleotides where one of the oxygen atoms in the phosphate
Phosphorothioate_nucleic_acid
Short piece of synthetic DNA
An anti-sense oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe for the
Allele-specific oligonucleotide
Allele-specific_oligonucleotide
Technique used to map epigenetic methylations in cancer DNA
Methylation specific oligonucleotide microarray, also known as MSO microarray, was developed as a technique to map epigenetic methylation changes in DNA
Methylation specific oligonucleotide microarray
Methylation_specific_oligonucleotide_microarray
Collection of microscopic DNA spots attached to a solid surface
open reading frames. Although oligonucleotide probes are often used in "spotted" microarrays, the term "oligonucleotide array" most often refers to a
DNA_microarray
Succession of nucleotides in a nucleic acid
A nucleic acid sequence is a succession of bases within the nucleotides forming alleles within a DNA (using GACT) or RNA (GACU) molecule. This succession
Nucleic_acid_sequence
Zimmermann S, Albrecht I, Heeg K (May 2002). "Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve
CpG_oligodeoxynucleotide
Technique for producing oligonucleotides that specifically bind to a target
combinatorial chemistry technique in molecular biology for producing oligonucleotides of either single-stranded DNA or RNA that specifically bind to a target
Systematic evolution of ligands by exponential enrichment
Systematic_evolution_of_ligands_by_exponential_enrichment
Genetic testing technique
Each probe for the detection of mRNA and lncRNA is composed of ~20-50 oligonucleotide pairs, each pair covering a space of 40–50 bp. The specifics depend
Fluorescence in situ hybridization
Fluorescence_in_situ_hybridization
American biotechnology company
IDT's primary business is the manufacturing of custom DNA and RNA oligonucleotides (oligos) for research applications. Joseph A. Walder, M.D., Ph.D. (Northwestern
Integrated_DNA_Technologies
Group of methods in synthetic biology
produces oligonucleotide fragments that are generally under 200 base pairs. The second step then involves connecting these oligonucleotide fragments
Artificial_gene_synthesis
of Nitto Denko Inc., is a private biotechnology company focused on oligonucleotide production. Avecia has two facilities, one near Boston, MA, and the
Avecia
Representational oligonucleotide microarray analysis (ROMA) is a technique that was developed by Michael Wigler and Rob Lucito at the Cold Spring Harbor
Representational oligonucleotide microarray analysis
Representational_oligonucleotide_microarray_analysis
Species of bacterium
The 105 regions with atypical oligonucleotide composition can be differentiated by their patterns of oligonucleotide usage into categories of horizontally
Pseudomonas_putida
Experimental antisense oligonucleotide drug for lowering lipoprotein(a)
Pelacarsen is an experimental antisense oligonucleotide drug designed to lower lipoprotein(a) (Lp(a)) levels in patients with cardiovascular disease.
Pelacarsen
Chemical compound
protection of the 5'-hydroxy group in nucleosides, particularly in oligonucleotide synthesis. It is usually bound to a molecule, but can exist as a stable
Dimethoxytrityl
Medication
is an apolipoprotein C-III-directed antisense oligonucleotide. Olezarsen is an antisense oligonucleotide which inhibits the formation of apolipoprotein
Olezarsen
Protein superfamily
OB-fold (oligonucleotide/oligosaccharide-binding fold) is a small protein structural motif observed in different proteins that bind oligonucleotides or oligosaccharides
OB-fold
Technology for screening small molecule compounds
link each molecule of a chemically synthesized entity to a particular oligonucleotide sequence constructed in parallel and to use this encoding genetic tag
DNA-encoded_chemical_library
DNA structure
(also known as H-DNA or Triplex-DNA) is a DNA structure in which three oligonucleotides wind around each other and form a triple helix. In triple-stranded
Triple-stranded_DNA
Synthetic equivalents of fluorescein dye used in oligonucleotide synthesis
fluorescein dye used in oligonucleotide synthesis and molecular biology. FAM is used in the preparation of fluorescein-labeled oligonucleotide probes for the detection
Fluorescein_amidite
Technique in molecular biology
or to its gene products. Also called site-specific mutagenesis or oligonucleotide-directed mutagenesis, it is widely used for investigating the structure
Site-directed_mutagenesis
Pharmaceutical drug
Bepirovirsen (GSK3228836) is an antisense oligonucleotide gapmer developed to treat hepatitis B infection. Mak, Lung-Yi; Hui, Rex Wan-Hin; Fung, James;
Bepirovirsen
Enzyme
Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and
PDE1
SOAP (Short Oligonucleotide Analysis Package) is a suite of bioinformatics software tools from the BGI Bioinformatics department enabling the assembly
Short Oligonucleotide Analysis Package
Short_Oligonucleotide_Analysis_Package
Group of atoms introduced into a compound to prevent subsequent reactions
tetrabutylammonium fluoride in THF. Commonly protects 2'-hydroxy function in oligonucleotide synthesis. Triisopropylsilyl (TIPS) — Similar conditions to TBS but
Protecting_group
Genetic disorder caused by a mutation of chromosome 15
phase. Tangelo (phase 1): Roche is testing the safety of an antisense oligonucleotide, RO7248824, administered via intrathecal injection. This drug works
Angelman_syndrome
Medication
hereditary angioedema. Donidalorsen is a prekallikrein-directed antisense oligonucleotide. It is given by injection under the skin (subcutaneous). Donidalorsen
Donidalorsen
Medication
Casimersen, sold under the brand name Amondys 45, is an antisense oligonucleotide medication used for the treatment of Duchenne muscular dystrophy (DMD)
Casimersen
Derivatives of nucleosides
derivatives of natural or synthetic nucleosides. They are used to synthesize oligonucleotides, relatively short fragments of nucleic acid and their analogs. Nucleoside
Nucleoside_phosphoramidite
Biotechnology company
had proprietary technologies for laser based in-situ synthesis of oligonucleotides and other biomolecules. On 21 December 2015, Flexgen Bv in Leiden (South
FlexGen_B.V.
American biotechnology company
organization (CDMO) that specializes in the production of peptides and oligonucleotides. The company provides custom synthesis, process development, and manufacturing
CPC_Scientific
Antisense oligonucleotide
second-generation 2'-O-methoxyethyl (2'-MOE) antisense therapeutic oligonucleotide (ASO) that targets the messenger RNA for apolipoprotein C3 (apo-CIII)
Volanesorsen
Medication
myelodysplastic syndromes with transfusion-dependent anemia. Imetelstat is an oligonucleotide telomerase inhibitor. By blocking telomerase activity, imetelstat causes
Imetelstat
Spectroscopic technique
Surface-enhanced Raman spectroscopy or surface-enhanced Raman scattering (SERS) is a surface-sensitive technique that enhances Raman scattering by molecules
Surface-enhanced Raman spectroscopy
Surface-enhanced_Raman_spectroscopy
afford a 2', 4'-BNA monomer. The monomers can be incorporated into oligonucleotide polymeric structures using standard phosphoramidite chemistry. BNAs
Bridged_nucleic_acid
Branch of biology that studies biological systems at the molecular level
microscope slide where each spot contains one or more single-stranded DNA oligonucleotide fragments. Arrays make it possible to put down large quantities of
Molecular_biology
Molecule that carries genetic information
DNA and other nucleic acids are the basis of aptamers, synthetic oligonucleotide ligands for specific target molecules used in a range of biotechnology
DNA
Chemical compound
ion-pairing reagent in high-performance liquid chromatography separations of oligonucleotides. "Triethylammonium Acetate, 1 M Solution - CAS 5204-74-0 - Calbiochem
Triethylammonium_acetate
RNA-like molecule
from L-ribose units. It is an artificial oligonucleotide named for being a mirror image of natural oligonucleotides. L-RNA aptamers are a form of aptamers
L-Ribonucleic_acid_aptamer
Medication
treatment of amyotrophic lateral sclerosis (ALS). Tofersen is an antisense oligonucleotide that targets the production of superoxide dismutase 1, an enzyme whose
Tofersen
Pharmaceutical compound
IONIS-AGT-LRx), usually supplied as its sodium salt, is an antisense gapmer oligonucleotide designed to inhibit angiotensinogen as an alternative to other mechanisms
Evazarsen
Chemical compound
of 5-methoxysalicylic acid and spermine can be used as a matrix for oligonucleotides analysis in MALDI mass spectrometry. It is an isomer of vanillic acid
5-Methoxysalicylic_acid
Anti-miRNA oligonucleotides (also known as AMOs) have many uses in cellular mechanics. These synthetically designed molecules are used to neutralize microRNA
Anti-miRNA_oligonucleotides
Percentage of guanine and cytosine in DNA or RNA molecules
group of genes or gene clusters, a non-coding region, or a synthetic oligonucleotide such as a primer. Qualitatively, guanine (G) and cytosine (C) undergo
GC-content
Chemical compound
is an organophosphorus compound. It has commercial application in oligonucleotide synthesis, but is most notable as being a precursor to several chemical
Methylphosphonyl_dichloride
Biotech company
organization facilities in Belgium which produce custom biologic and oligonucleotide products mainly for European pharmaceutical companies, but also holds
Eurogentec
Short strand of RNA or DNA that serves as a starting point for DNA synthesis
of DNA synthesis. A synthetic primer is a type of oligo, short for oligonucleotide. DNA polymerases (responsible for DNA replication) are only capable
Primer_(molecular_biology)
Molecular beacons, or molecular beacon probes, are oligonucleotide hybridization probes that can report the presence of specific nucleic acids in homogenous
Molecular_beacon
Property of nucleic acid strands with respect to their translatability into protein
been targeted using antisense oligonucleotides to inhibit their replication in host cells. If the antisense oligonucleotide contains a stretch of DNA or
Sense_(molecular_biology)
Chemical compound
macromolecules, such as proteins, DNA, and RNA. TCA is used during oligonucleotide synthesis during the "deblocking" step to remove the dimethoxytrityl
Trichloroacetic_acid
DNA structure
Gapmers are short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence. These linear pieces of genetic information
Gapmer
biology, is designed to uniquely and globally identify oligonucleotide microarray probes. Oligonucleotide probes of microarrays that are sequence identical
Nucleotide universal IDentifier
Nucleotide_universal_IDentifier
Medication
transthyretin-mediated amyloidosis. It is a transthyretin-directed antisense oligonucleotide. It was developed to treat hereditary transthyretin amyloidosis by
Eplontersen
Technique for the investigation of nucleic acids and its modifications
that started the concept of NAIL-MS. NAIL-MS can also be applied to oligonucleotide analysis by mass spectrometry. This is useful when the sequence information
NAIL-MS
Class of enzymes
ribonuclease N2, ribonuclease PP3, ribonuclease U4, ribonucleate 3'-oligonucleotide hydrolase, ribonucleate nucleotido-2'-transferase (cyclizing), RNAase
Ribonuclease_T2
Family of RNA-binding proteins
oligonucleotides that vary in binding strength from very stable complexes (such as the Sm class snRNPs) to transient complexes. RNA oligonucleotides generally
LSm
Antiviral drug
the number of cases of CMV. It is an antisense oligonucleotide -- a synthetic 21 member oligonucleotide with phosphorothioate linkages (which are resistant
Fomivirsen
The Universal PBM Resource for Oligonucleotide-Binding Evaluation (UniPROBE) is database of DNA-binding proteins determined by protein-binding microarrays
UniPROBE
Biotechnology company
the body. Different methodologies (RNA interference, micro-RNA, and oligonucleotides) are used to modify RNA for different applications. For example, an
Ionis_Pharmaceuticals
allows the synthesis of oligonucleotides with a methacryl group at the 5' end (less commonly 3' or internal). Acryl oligonucleotides have been tested, but
Acrydite
Pharmaceutical drug
brand name Tegsedi, is a 2'-O-(2-methoxyethyl) (2'-MOE) antisense oligonucleotide medication used for the treatment of nerve damage in adults with hereditary
Inotersen
Study of how temperature affects the nucleic acid structure
complex, which in the case of two strands is referred to as a duplex. Oligonucleotides, DNA, or RNA will bind to their complement under normal conditions
Nucleic_acid_thermodynamics
Single stranded RNA
antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding
Antisense_RNA
Synthetic organic compound used as dye and fluorescent tracer
labeled oligonucleotides for the same purpose. Another technique, termed molecular beacons, makes use of synthetic fluorescein-labeled oligonucleotides. Fluorescein-labelled
Fluorescein
Genetic modification technique
modification or by treatment with a reagent such as a short DNA or RNA oligonucleotide that has a sequence complementary to either gene or an mRNA transcript
Gene_knockdown
American prion researcher
and cure. In 2023, she earned the Paper of the Year Award from the Oligonucleotide Therapeutics Society. As of 2026, prion diseases remain invariably
Sonia_M._Vallabh
Measurement of genetic variations
makes use of a specifically engineered single-stranded oligonucleotide probe. The oligonucleotide is designed such that there are complementary regions
SNP_genotyping
Drug used to treat allergic diseases
YM-90709 Antibodies: Benralizumab Mepolizumab Reslizumab Antisense oligonucleotides: TPI ASM8 IL-6 Agonists: Atexakin alfa Interleukin 6 Antibodies: ARGX-109
Dupilumab
Cellular biology lab technique
antibody-oligonucleotide conjugates to enable sample multiplexing for scRNA-seq. This technique called, Cell Hashing, uses oligonucleotide-labelled antibodies
CITE-Seq
Class of drugs
Somavubove Somidobove Antagonists: G120K-hGH Pegvisomant Antisense oligonucleotides: Atesidorsen Binding proteins: GHBPTooltip Growth hormone-binding protein
Growth_hormone_secretagogue
Peptide hormone that regulates the endocrine system
Somavubove Somidobove Antagonists: G120K-hGH Pegvisomant Antisense oligonucleotides: Atesidorsen Binding proteins: GHBPTooltip Growth hormone-binding protein
Somatostatin
chemistry [...] for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies"
1993_Nobel_Prizes
Method of DNA amplification
prevent ligation. By performing the ligation right at the Tm of the oligonucleotide probe, only perfectly matched primer:template duplexes will be tolerated
Ligase_chain_reaction
Molecule composed of copies of a small unit
oligosaccharide is an oligomer of monosaccharides (simple sugars). An oligonucleotide is a short single-stranded fragment of nucleic acid such as DNA or
Oligomer
Medication
repeated exposure to miravirsen. Miravirsen is a modified antisense oligonucleotide consisting of a chain of 15 nucleotides, the base sequence of which
Miravirsen
Type of muscular dystrophy
(Translarna) is approved for use in the European Union. The antisense oligonucleotide golodirsen (Vyondys 53) was approved for medical use in the United
Duchenne_muscular_dystrophy
Pharmaceutical drug
Duchenne muscular dystrophy (DMD). Viltolarsen is a Morpholino antisense oligonucleotide. The most common side effects include upper respiratory tract infection
Viltolarsen
Method of synthesizing complex molecules
fragments of DNA, RNA, and modified oligonucleotides are also synthesised by the solid-phase method. Although oligonucleotides can be synthesised in a flask
Solid-phase_synthesis
Monoclonal antibody
YM-90709 Antibodies: Benralizumab Mepolizumab Reslizumab Antisense oligonucleotides: TPI ASM8 IL-6 Agonists: Atexakin alfa Interleukin 6 Antibodies: ARGX-109
Pacibekitug
The genomic signature refers to the characteristic frequency of oligonucleotides in a genome or sequence. It has been observed that the genomic signature
Genomic_signature
Molecular biology technique
microsatellite sequences in a DNA sample. This can be achieved by designing oligonucleotide probes that hybridize with the repeats in the microsatellites and then
Microsatellite_enrichment
Microtechnology
during bio-MEMS development of the 1990s include: In 1991, the first oligonucleotide chip was developed In 1998, the first solid microneedles were developed
Bio-MEMS
Type of corticosteroid medication
Tibolone Toripristone Ulipristal acetate Zavacorilant Others Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115) See also Receptor/signaling modulators
Budesonide
Prokaryotic elongation factor
consists of three structural domains: a GTP-binding domain and two oligonucleotide-binding domains, often referred to as domain 2 and domain 3. The N-terminal
EF-Tu
Class of enzymes
(The mice did not change their eating or exercise habits). Antisense oligonucleotide (ASO) technology can be used to silence the expression of the NNMT
Nicotinamide N-methyltransferase
Nicotinamide_N-methyltransferase
American pharmacologist
collaborator Adrian R. Krainer for the development of an effective antisense oligonucleotide therapy for children with the neurodegenerative disease spinal muscular
C._Frank_Bennett
Chemical compound
Tibolone Toripristone Ulipristal acetate Zavacorilant Others Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115) See also Receptor/signaling modulators
Miricorilant
American pharmaceutical company
company under the name Oligogen. The original name was a reference to oligonucleotides, small strands of DNA used to target genetic sequences. Gilead held
Gilead_Sciences
Protocols for reporting qPCR experiments
used and the total volume of the reaction, give information on the oligonucleotide used as a primer and its concentration, the concentration and type
MIQE
Topics referred to by the same term
Oligomer, as an abbreviation for the general term, or specifically for oligonucleotide, oligopeptide, oligosaccharide, or oligoester. OLIGO Primer Analysis
Oligo
Biological molecule
monomer or a constituent of an oligonucleotide. LNA nucleotides can be mixed with DNA or RNA residues in a oligonucleotide. LNA is one type of bridged nucleic
Locked_nucleic_acid
Laboratory technique to multiply an RNA sample for study
Transfer (FRET) coupling of the dye molecule and a quencher moiety to the oligonucleotide substrates. SYBR Green When the SYBR Green binds to the double-stranded
Reverse transcription polymerase chain reaction
Reverse_transcription_polymerase_chain_reaction
Pharmaceutical compound
Lampignano L, et al. (May 2023). "The development of peptide- and oligonucleotide-based drugs to prevent the formation of abnormal tau in tauopathies"
Peptide_021
Oligonucleotides which recognize the exosites of human thrombin
Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA
Anti-thrombin_aptamers
Peptide hormone that stimulates growth
Somavubove Somidobove Antagonists: G120K-hGH Pegvisomant Antisense oligonucleotides: Atesidorsen Binding proteins: GHBPTooltip Growth hormone-binding protein
Growth_hormone
Topics referred to by the same term
Japan Coast Guard, named after Mount Aso Allele-specific oligonucleotide Antisense oligonucleotide Anti-streptolysin O Arterial switch operation Arteriosclerosis
ASO
OLIGONUCLEOTIDE
OLIGONUCLEOTIDE
OLIGONUCLEOTIDE
OLIGONUCLEOTIDE
Boy/Male
American, Anglo, Australian, British, Chinese, Christian, Dutch, English, German, Greek, Irish, Italian, Latin, Portuguese, Swedish
Majestic; Dignity; Grandeur; Great; Magnificent; Worthy of Respect; Holy
Male
African
a mongoose or weasel.
Boy/Male
Hindu
Arrow like
Boy/Male
Indian, Tamil
Who is Guarded
Female
Chinese
clouds.
Girl/Female
Muslim
A star in the constellation Leo
Male
Hindi/Indian
(शंकर) Modern form of Hindi Shankara, SHANKAR means "makes good luck."
Girl/Female
Indian
Young mother, Name of the prophets granddaughter
Boy/Male
Hindu
Sunshine
Girl/Female
Biblical
Pleasant, testifying.
OLIGONUCLEOTIDE
OLIGONUCLEOTIDE
OLIGONUCLEOTIDE
OLIGONUCLEOTIDE
OLIGONUCLEOTIDE