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Protein family
tissues. The pleckstrin homology domain (PH domain) was named after pleckstrin-1. Both pleckstrin-1 and pleckstrin-2 contain two pleckstrin homology domains
Pleckstrin
Clinical Significance
Pleckstrin homology domain (PH domain) or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved
Pleckstrin_homology_domain
Protein-coding gene in the species Homo sapiens
Pleckstrin homology domain containing A4 is a protein that in humans is encoded by the PLEKHA4 gene. This gene encodes a pleckstrin homology (PH) domain-containing
Pleckstrin homology domain containing A4
Pleckstrin_homology_domain_containing_A4
Protein-coding gene in the species Homo sapiens
Pleckstrin homology and RhoGEF domain containing G3 is a protein that in humans is encoded by the PLEKHG3 gene. Pleckstrin homology domain RhoGEF domain
Pleckstrin homology and RhoGEF domain containing G3
Pleckstrin_homology_and_RhoGEF_domain_containing_G3
Protein-coding gene in the species Homo sapiens
Pleckstrin homology domain containing S1 is a protein that in humans is encoded by the PLEKHS1 gene. GRCh38: Ensembl release 89: ENSG00000148735 – Ensembl
Pleckstrin homology domain containing S1
Pleckstrin_homology_domain_containing_S1
Protein-coding gene in the species Homo sapiens
a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members
CYTH3
Protein family
The oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of lipid transfer proteins (LTPs). Concretely, they constitute a family of sterol
Oxysterol-binding_protein
Protein-coding gene in the species Homo sapiens
PLEKHA7 (Pleckstrin homology domain-containing family A member 7) is an adherens junction (AJ) protein, involved in the junction's integrity and stability
PLEKHA7
Protein-coding gene in the species Homo sapiens
Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B
PLEK2
Protein found in humans
Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants
PLEKHG5
Protein-coding gene in humans
Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene. PLEKHO1 has been shown to interact
PLEKHO1
Protein found in humans
encoded by the CERT1 gene (previously COL4A3BP). The protein contains a pleckstrin homology domain at its amino terminus and a START domain towards the end
Ceramide_transfer_protein
Protein-coding gene in humans
Pleckstrin homology domain-containing family A member 6 is a protein that in humans is encoded by the PLEKHA6 gene. GRCh38: Ensembl release 89: ENSG00000143850
PLEKHA6
Protein found in humans
protein with amino acid sequence of 1242 residues. It contains a single pleckstrin homology (PH) domain at the N-terminus and a PTB domain ca. 40 residues
Insulin_receptor_substrate_1
Protein domain
"Dbl-homology" (DH) domain, which almost always is found together with a pleckstrin-homology (PH) domain to form a combined DH/PH domain structure. A distinct
RhoGEF_domain
Protein-coding gene in the species Homo sapiens
Pleckstrin homology domain-containing family M member 1 also known as PLEKHM1 is a protein that in humans is encoded by the PLEKHM1 gene. PLEKHM1 may have
PLEKHM1
Set of three serine threonine-specific protein kinases
possess a protein domain known as a PH domain, or pleckstrin homology domain, named after pleckstrin, the protein in which it was first discovered. This
Protein_kinase_B
Protein-coding gene in humans
can be found within this gene's sequence: DEP (Dishevelled, Egl-10, and Pleckstrin) domain and RhoGAP domain. Transcription produces 4 alternatively spliced
DEPDC7
Class of enzymes
which an assorted group of signalling proteins, containing PX domains, pleckstrin homology domains (PH domains), FYVE domains or other phosphoinositide-binding
Phosphoinositide_3-kinase
Protein family
In molecular biology, the DEP domain (Dishevelled, Egl-10 and Pleckstrin domain) is a globular protein domain of about 80 amino acids that is found in
DEP_domain
Protein of the immune system
PIK3R2 and PIP5K1A are two kinases that create substrates for PSD4. PSD4 (Pleckstrin and Sec7 Domain containing 4) is a GEF (Guanine nucleotide Exchange Factor)
MHC_class_II
Protein-coding gene in the species Homo sapiens
the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology
SOS1
Protein-coding gene in humans
gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized
DGKQ
Most common type of skin cancer
differentiation, and cut artefacts. Cytokeratin (CK)20+, p75+, Pleckstrin homology-like domain family A member 1 + (PHLDA1+), common acute lymphoblastic
Basal-cell_carcinoma
Cascade of intracellular and molecular events for transmission/amplification of signals
calmodulin-dependent kinase. PIP3 and other phosphoinositides do the same thing to the Pleckstrin homology domains of proteins such as the kinase protein AKT. G protein–coupled
Signal_transduction
Family of proteins
Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh (Dvl in mammals) is a cytoplasmic phosphoprotein
Dishevelled
Protein domain
domain of tensin. Insulin receptor substrate-1 proteins contain both a pleckstrin homology domain and a phosphotyrosine binding (PTB) domain. The PTB domains
Phosphotyrosine-binding domain
Phosphotyrosine-binding_domain
Protein-coding gene in the species Homo sapiens
Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans
FERMT2
Chemical compound
PI3K/AKT/mTOR pathway by acting as an allosteric AKT inhibitor targeting the pleckstrin homology domain of AKT. It was being developed by Keryx Biopharmaceuticals
Perifosine
Protein-coding gene in humans
Pleckstrin homology domain-containing family M member 2 is a protein that in humans is encoded by the PLEKHM2 gene. GRCh38: Ensembl release 89: ENSG00000116786
PLEKHM2
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
using a Yeast-2-hybrid screen. Ubiquitin binding to Rpn13 is through the pleckstrin-like receptor for the Ub (PRU) domain. and mutations to the PRU block
Proteasome
Protein-coding gene in the species Homo sapiens
various signaling molecules. Alpha-1 syntrophin contains a PDZ domain, two Pleckstrin homology domain and a 'syntrophin unique' domain. Dystrophin is a large
Syntrophin,_alpha_1
Protein-coding gene in the species Homo sapiens
PMID 11278382. Yang XL, Zhang YL, Lai ZS, Xing FY, Liu YH (April 2003). "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and
Protein_kinase_C_beta_type
Protein-coding gene in the species Homo sapiens
protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the KALRN gene
Kalirin
Form of programmed cell death
2005). "The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family
Apoptosis
Topics referred to by the same term
highly-stable and aromatic hydrocarbon unit found in many organic compounds Pleckstrin homology domain, a part of many proteins which bind phosphoinositides
PH_(disambiguation)
Protein-coding gene in the species Homo sapiens
of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding
OSBPL1A
Protein-coding gene in the species Homo sapiens
Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene. PHLDB2 has been shown to interact with FLNC
PHLDB2
Protein family
Mammalian ROCK consists of a kinase domain, a coiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an
Rho-associated_protein_kinase
Protein-coding gene in the species Homo sapiens
Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene. The first PHLDB1 cDNA was cloned from a rat
PHLDB1
Protein-coding gene in the species Homo sapiens
Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene. This gene encodes an evolutionarily
PHLDA1
Protein found in humans
DOCK-A/B/C proteins DOCK-D proteins (including Dock9) contain an N-terminal pleckstrin homology (PH) domain that mediates their recruitment to the membrane.
Dedicator of cytokinesis protein 9
Dedicator_of_cytokinesis_protein_9
for the formation of neuromuscular synapses. Further, Dok-7 contains pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains that are critical
Dok-7
Transmembrane protein on the surface of a B cell
PI3K leads to PIP2 phosphorylation, forming PIP3. Proteins that have a Pleckstrin homology domain can bind to the newly created PIP3, which activates them
B-cell_receptor
Protein-coding gene in the species Homo sapiens
(2000). "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains". Mol. Cell. 6 (2): 373–84. doi:10.1016/S1097-2765(00)00037-X
DAPP1
Protein-coding gene in the species Homo sapiens
FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene. This gene was originally isolated through
FARP1
Protein-coding gene in the species Homo sapiens
"Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun
T-cell lymphoma invasion and metastasis-inducing protein 1
T-cell_lymphoma_invasion_and_metastasis-inducing_protein_1
Protein-coding gene in the species Homo sapiens
domain membrane-association domain-1 self-association domain C-terminal pleckstrin homology domain. Based on these structural features it is thought that
SPTBN5
Series of biochemical reactions
membrane, where they can directly bind intracellular proteins containing a pleckstrin homology (PH) or FYVE domain. For example, the triphosphate form (PI(3
Akt/PKB_signaling_pathway
Medical condition
involved in juvenile granulosa cell tumours. In-frame duplications in the pleckstrin-homology domain of the protein were found in more than 60% of juvenile
Granulosa_cell_tumour
Belizean-born American scientist (born 1964)
of Inducible T cell Kinase (ITK) requires PI3 kinase activity and the Pleckstrin Homology domain of inducible T cell kinase." (1997) Proc. Natl. Acad.
Avery_August
Protein-coding gene in the species Homo sapiens
receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding
OSBPL8
Protein domain
WH1 domain of the Mena protein revealed structure similarities with the pleckstrin (PH) domain. The overall fold consists of a compact parallel beta-sandwich
WH1_domain
Protein-coding gene in humans
domain (with guanine nucleotide exchange factor activity) PH domain (pleckstrin homology domain) GRCh38: Ensembl release 89: ENSG00000139132 – Ensembl
FGD4
Protein-coding gene in the species Homo sapiens
FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene. FARP2 has been shown to interact with
FARP2
Vesicle formation GTPase family
opposite end of the stalk domain is a loop that links to a membrane-binding Pleckstrin homology domain. The protein strand then loops back towards the GTPase
Dynamin
Enzyme
regulatory domains of GRK2 (particularly overexpressing the carboxy terminal pleckstrin-homology (PH) domain that binds the G protein βγ-subunit complex and inhibits
G protein-coupled receptor kinase 2
G_protein-coupled_receptor_kinase_2
Protein-coding gene in the species Homo sapiens
OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1,3,4,5)-TETRAKISPHOSPHATE 1w1g: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH)
Phosphoinositide-dependent kinase-1
Phosphoinositide-dependent_kinase-1
Physical interactions and constructions between multiple proteins
are mainly present in cytoskeletal proteins as parvin. Pleckstrin homology domain Pleckstrin homology domains bind to phosphoinositides and acid domains
Protein–protein_interaction
Protein-coding gene in the species Homo sapiens
contains 3 functional domains: a C-terminal Src homology 2 (SH2) domain, a pleckstrin homology (PH) domain, and a dimerization domain. The SH2 domain spans
SH2B3
Membrane proteins that adhere temporarily to membranes with which they are associated
phosphatidylserine, phosphatidylcholine or PtdIns(3,4)P2 or PtdIns(4,5)P2. Pleckstrin homology domains, PX domains, and Tubby domains bind different phosphoinositides
Peripheral_membrane_protein
Proteins which remove GDP from GTPases
number in Metazoa varies in proportion of cell signaling complexity. Pleckstrin homology domains (PH domains) are associated in tandem with DH domains
Guanine nucleotide exchange factor
Guanine_nucleotide_exchange_factor
Protein-coding gene in the species Homo sapiens
encoded by the APPL1 gene. APPL1 contains several key interactory domains: pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain and Bin–Amphiphysin–Rvs
APPL1
Protein-coding gene in the species Homo sapiens
Pleckstrin homology domain-containing family A member 5 is a protein that in humans is encoded by the PLEKHA5 gene. GRCh38: Ensembl release 89: ENSG00000052126
PLEKHA5
Protein-coding gene in the species Homo sapiens
Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene. GRCh38: Ensembl release 89: ENSG00000115762
PLEKHB2
Protein-coding gene in the species Homo sapiens
central ELMO (Engulfment and Cell Motility) domain (301-492) C-terminal pleckstrin homology domain (residues 527-674) ELMO1 also has a pro-rich motif at
ELMO1
required for the attachment of Ste5 to the membrane, which depends on a pleckstrin homology domain as well as an amphipathic alpha-helical domain in the
Ste5
Protein-coding gene in the species Homo sapiens
1btn: STRUCTURE OF THE BINDING SITE FOR INOSITOL PHOSPHATES IN A PH DOMAIN 1mph: PLECKSTRIN HOMOLOGY DOMAIN FROM MOUSE BETA-SPECTRIN, NMR, 50 STRUCTURES
SPTBN1
Protein found in humans
Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: PSD3 pleckstrin and Sec7 domain containing 3". Nakajima D, Okazaki N, Yamakawa H, et al
PSD3
Protein-coding gene in the species Homo sapiens
of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding
OSBPL5
Protein-coding gene in the species Homo sapiens
Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene. Cytohesin-1
CYTH1
sequence homology with sphingosine kinase type I, including an N-terminal pleckstrin homology (PH) domain and a diacylglycerol kinase domain. BLAST searches
Ceramide_kinase
Protein-coding gene in the species Homo sapiens
Pleckstrin homology domain containing A8 is a protein that in humans is encoded by the PLEKHA8 gene. GRCh38: Ensembl release 89: ENSG00000106086 – Ensembl
PLEKHA8
Protein-coding gene in the species Homo sapiens
Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene. PLEKHA1 has been shown to interact
PLEKHA1
Self-stable region of a protein's chain that folds independently from the rest
as SHC and IRS-1 are important for insulin responses of human cells. Pleckstrin homology domain (PH): PH domains bind phosphoinositides with high affinity
Protein_domain
Cell receptor protein found in humans
homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains". The Journal of Biological Chemistry. 273 (12):
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Protein-coding gene in the species Homo sapiens
Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene. This gene is one of several genes in the imprinted
PHLDA2
Class of enzymes
motifs and a recoverin homology domain Type 2 - DGK-δ, DGK-η - contain a pleckstrin homology domain Type 3 - DGK-ε - has specificity for arachidonate-containing
Diacylglycerol_kinase
Protein-coding gene in the species Homo sapiens
related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent
RASA3
Olfactomedin 4 glycoprotein Active 19450592 PHLDA1 DT1P1B11, PHRIP, TDAG51 pleckstrin homology-like domain, family A, member 1 regulation of apoptosis Active
List of intestinal stem cell marker genes
List_of_intestinal_stem_cell_marker_genes
Class of enzymes
domain structure, which includes a putative Ras association domain, a pleckstrin homology domain, a series of leucine-rich repeats, a PP2C phosphatase
PHLPP
British–Kenyan scientist
Blanchard, K. L.; Thomas, J. E. (2007). "A transforming mutation in the pleckstrin homology domain of AKT1 in cancer". Nature. 448 (7152): 439–44. Bibcode:2007Natur
Ketan_J._Patel
Protein-coding gene in the species Homo sapiens
PMID 9512491. Shimohama S, Kamiya S, Fujii M, et al. (1998). "Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated
PLCD1
Type of protein domain
a single helix, as in the ubiquitin-interacting motif); zinc fingers; pleckstrin homology (PH) domains; and domains similar to those in ubiquitin-conjugating
Ubiquitin-binding_domain
Protein-coding gene in the species Homo sapiens
binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538". Biochem. Biophys. Res. Commun
RASA4
Pleckstrin Homology domain containing Family M Member 3, or PLEKHM3, is the hypothetical protein that in humans is encoded by the PLEKHM3 gene. PLEKHM3
PLEKHM3
Type of enzyme
Robinson D, Pretlow TG, Kung HJ (1998). "Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and
BMX_(gene)
Protein-coding gene in the species Homo sapiens
assisting with signal integration. The N-terminal is characterized by a Pleckstrin Homology (PH) domain that is the most highly conserved region between
GAB2
Protein-coding gene in the species Homo sapiens
"Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome". Hum. Mol. Genet. 12 (8): 925–35
FERMT1
Transmembrane protein
terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains". Molecular and Cellular Biology. 18 (2): 771–8. doi:10
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Protein-coding gene in humans
DW (May 2000). "Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase
CSNK2A2
Protein and coding gene in humans
Constitutively Activated RhoA Mutant (Q63L) 1lb1: Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA 1ow3: Crystal Structure of
Transforming_protein_RhoA
Protein-coding gene in humans
of intracellular lipid transfer proteins. ORP9 contains an N-terminal pleckstrin homology domain, a FFAT (two phenylalanines in an acidic tract) motif
OSBPL9
Protein-coding gene in the species Homo sapiens
localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma"
GRB10
Protein-coding gene in the species Homo sapiens
with low expression in other parts of the human body. FAM129C contains pleckstrin homology domain that may cause the protein to associate with the plasma
NIBAN3
Protein family
the src-homology 3 (SH3) domain, the dbl-homology (DH) domain, and the pleckstrin homology (PH) domain. The SH3 domain, located at the N-terminus, binds
Collybistin
Protein-coding gene in humans
interactions can influence accessibility of the DH (Dbl homology domain) to PH (Pleckstrin Homology domain) catalytic module to its RHO family substrates. Direct
GEFT
Yeast protein
PLEKHF1) and Phafin2 (EAPF or PLEKHF2). The phafin proteins each have a PH (pleckstrin homology) domain and FYVE domain. Phafin1 also has a tail motif similar
Pib2
Protein-coding gene in the species Homo sapiens
PMID 12517701. Timm D, Salim K, Gout I, et al. (1995). "Crystal structure of the pleckstrin homology domain from dynamin". Nat. Struct. Biol. 1 (11): 782–8. doi:10
DNM1
and behavioral problems caused by a homozygous deletion of the SPTBN2 pleckstrin homology domain". American Journal of Medical Genetics Part A. 173 (9):
Shapiro–Senapathy_algorithm
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