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Protein which after translation is cleaved into one or more smaller proteins
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational
Protein_precursor
Mammalian protein found in humans
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions
Amyloid-beta precursor protein
Amyloid-beta_precursor_protein
Compound that participates in a chemical reaction that produces another compound
chemical compound preceding another in a metabolic pathway, such as a protein precursor. In 1988, the United Nations Convention Against Illicit Traffic in
Precursor_(chemistry)
Group of peptides
with Alzheimer's disease. The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield
Amyloid_beta
protease cleaves viral precursor proteins pTP, pVI, pVII, pVIII, and IIIa to produce the mature viral proteins. Control protein E1A activates transcription
Adenovirus_genome
processing enhancing peptidase (for one of two subunits), mitochondrial protein precursor-processing proteinase, matrix peptidase, matrix processing peptidase
Mitochondrial processing peptidase
Mitochondrial_processing_peptidase
Type of enzyme
a longer protein that is embedded in the cell membrane. Among other roles in the cell, secretases act on the amyloid-beta precursor protein (APP) to cleave
Amyloid-beta precursor protein secretase
Amyloid-beta_precursor_protein_secretase
Metabolic disease involving abnormal deposited amyloid proteins
mutations in the precursor protein.[medical citation needed] Other forms are due to different diseases causing overabundant or abnormal protein production –
Amyloidosis
Post-translational removal of peptide sequences from a protein sequence
(called an intein) is removed from a precursor protein with a ligation of C-terminal and N-terminal external proteins (called exteins) on both sides. The
Protein_splicing
Part of the immune system that enhances the ability of antibodies and phagocytic cells
synthesized protein precursors circulating in the blood. When stimulated by one of several triggers, proteases in the system cleave specific proteins to release
Complement_system
Precursor of a hormone
supplements. Androgen prohormone Prehormone Preprohormone Prodrug Protein precursor Friedman, Theodore C.; Cool, David R. (2004-01-01), "Prohormones"
Prohormone
Medical condition
amyloidosis is the misfolding of a specific protein precursor depending on the amyloidosis type. Protein precursors include immunoglobulin-derived light chains
Cardiac_amyloidosis
Protein-coding gene in the species Homo sapiens
also known as PSAP, is a protein which in humans is encoded by the PSAP gene. This highly conserved glycoprotein is a precursor for 4 cleavage products:
Prosaposin
kallidin (lysyl-bradykinin, a bioactive kinin) from kininogen (a kinin protein precursor). Fiedler F, Fink E, Tschesche H, Fritz H (1981). "Porcine glandular
Renal_tissue_kallikrein
Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is
Neuropeptide_VF_precursor
family N9 and for several inteins from family N10. Asparagine Lyase Protein precursor Proteolysis Nucleophilic substitution Protease cysteine- serine- threonine-
Asparagine_peptide_lyase
Class of antiviral drugs used to treat HIV/AIDS and hepatitis C
proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles
Protease inhibitor (pharmacology)
Protease_inhibitor_(pharmacology)
Family of proteins
651. PMID 1755958. "SAA1 - Serum amyloid A-1 protein precursor - Homo sapiens (Human) - SAA1 gene & protein". "SAA4". Abcam. Retrieved 2024-11-16. Pincus
Serum_amyloid_A
Attachment of an oligosaccharide to a nitrogen atom
steps: Synthesis of dolichol-linked precursor oligosaccharide En bloc transfer of precursor oligosaccharide to protein Processing of the oligosaccharide
N-linked_glycosylation
Complex that catalyzes conversion of prothrombin to thrombin
enzyme complex consists of factor Xa (a serine protease) and factor Va (a protein cofactor). The complex assembles on negatively charged phospholipid membranes
Prothrombinase
Protein-coding gene in the species Homo sapiens
Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in humans. APLP1 along with APLP2 are important modulators
APLP1
Protein-coding gene in humans
disease. CLSTN1 has been shown to interact with APBA2 and Amyloid precursor protein. GRCh38: Ensembl release 89: ENSG00000171603 – Ensembl, May 2017 GRCm38:
CLSTN1
Protein-coding gene in the species Homo sapiens
lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which
Cathepsin_H
Protein-coding gene in the species Homo sapiens
disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed
Cathepsin_D
Nutrient for the human body
Proteins are essential nutrients for the human body. They are one of the constituents of body tissue and also serve as a fuel source. As fuel, proteins
Protein_(nutrient)
Protein family
with most active peptides, both hormones are synthesised as larger protein precursors that are enzymatically converted to their mature forms. Members of
Neurohypophysial_hormone
Family of viruses
encodes protein B2, an RNA silencing inhibitor. RNA2 encodes protein α, a viral capsid protein precursor, which is auto-cleaved into two mature proteins, a
Nodaviridae
American geneticist (born 1958)
the discovery and isolation of the gene that encodes amyloid precursor protein, the precursor to beta-amyloid which is a pathological hallmark of Alzheimer's
Rudolph_E._Tanzi
Protein found in humans
(plus) strand. The CCL2 gene has three exons and two introns. The CCL2 protein precursor contains a signal peptide of 23 amino acids. In turn, the mature CCL2
CCL2
Protein produced by the endocrine pancreas
tumours. The PPY gene encodes an unusually short protein precursor of 95 amino acids in length. This precursor is cleaved to produce the signal peptide, the
Pancreatic_polypeptide
inactive form and requires modification (e.g. cleavage) for activation. Protein precursor Zymogen Braun P, de Groot A, Bitter W, Tommassen J (1988). "Secretion
Preproenzyme
Protein-coding gene in the species Homo sapiens
Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene. The protein encoded by this gene
APBB1
Protein found in humans
units are post-translationally hydrolyzed from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin
Filaggrin
Protein-coding gene in the species Homo sapiens
Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene. This protein has phosphotyrosine-binding
APBA2
Start of a polypeptide
N-formylmethionine, fMet). However, some proteins are modified posttranslationally, for example, by cleavage from a protein precursor, and therefore may have different
N-terminus
receptor proteins Tom70 and Tom20 recognize incoming precursor proteins, in which Tom70 is responsible for docking of precursors of hydrophobic proteins accompanied
Mitochondrial membrane transport protein
Mitochondrial_membrane_transport_protein
Group of transport proteins
function was affected by an implantation-associated protein precursor. They designated this protein, MagT1. MagT1 is expressed as a 335 amino acid polypeptide
Magnesium_transporter1_family
Class of proteins
Kininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction,
Kininogen
Mammalian protein found in humans
commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46%
CCL14
Inactive precursor to an enzyme
(/ˈzaɪmədʒən, -moʊ-/), also called a proenzyme (/ˌproʊˈɛnzaɪm/), is an inactive precursor of an enzyme. A zymogen requires a biochemical change (such as a hydrolysis
Zymogen
Part of a cell
membrane (TIM). The IMS is involved in the mitochondrial protein translocation. The precursor proteins called small TIM chaperones which are hexameric complexes
Intermembrane_space
Physiological state of dormant inactivity in order to pass the winter season
the protein precursors were identified to play a role in the preservation of veterinary organ function. Recent advances in recombinant protein technology
Hibernation
Protein
the uncleaved precursor of haptoglobin 2. Later studies demonstrated that zonulin is not a single molecule but rather a family of proteins sharing structural
Zonulin
Protein family
VG) (from Latin vitellus, yolk, and genero, I produce) is a precursor of the egg yolk proteins. It is synthesized and secreted by the liver of vertebrates
Vitellogenin
Protein used by single-celled organisms
extracellular-facing, two-stranded beta sheet. Bacteriorhodopsin is synthesized as a protein precursor, known as bacterio-opsin, which is extensively modified after translation
Bacteriorhodopsin
Species of spider
wrapping silk fibre architecture arising from its modular soluble protein precursor". Scientific Reports. 5 (1) 11502. Bibcode:2015NatSR...511502T. doi:10
Cyrtophora_citricola
Protein-coding gene in the species Homo sapiens
important role in generation of amyloid beta (Aβ) from amyloid-beta precursor protein (APP). Accumulation of amyloid beta is associated with the onset of
Presenilin-1
Protein-coding gene in humans
Granulin is a protein that in humans is encoded by the GRN gene. Each granulin protein is cleaved from the precursor progranulin, a 593 amino-acid-long
Granulin
Protein-coding gene in the species Homo sapiens
mammalian homolog of CDC48 (valosin) revealed a 97 kDa protein precursor named "valosin-containing protein (VCP)" or p97, and also showed that it was only generated
Valosin-containing_protein
Family of transport proteins
translocation of lipid-linked murein (aka peptidoglycan) precursors. A representative list of proteins belonging to the MPE family can be found in the Transporter
Bacterial murein precursor exporter
Bacterial_murein_precursor_exporter
Genus of viruses
an envelope. Tenuivirus encodes a membrane protein precursor that is homologue to the virion envelope protein of Tospoviridae, although no envelope was
Tenuivirus
Protein that is a precursor of glucagon
Proglucagon is a protein that is a precursor of glucagon and several other components. It is cleaved from preproglucagon. Proglucagon is generated in
Proglucagon
Type of cows' milk
of BCM-7 (beta-casomorphin-7), related peptides or their possible protein precursors and non-communicable diseases". Commercial development proceeded,
A2_milk
Natural polymeric materials that act as adhesives
43 (4), 448-450 Monahan, J.; Wilker, J.J. (2004) Cross-linking the protein precursor of marine mussel adhesives: bulk measurements and reagents for curing
Bioadhesive
Assembly of proteins inside biological cells
Protein biosynthesis or protein synthesis (also known as proteosynthesis) is a core biological process, occurring inside cells, balancing the loss of
Protein_biosynthesis
Protein-coding gene in humans
York: WH Freeman and Company. "Conserved domains on uncharacterized protein precursor C1orf127". National Center for Biotechnology Information. "PSORT II"
CIROZ
Type of protein
extension (26 residues). The precursor and mature forms of MBP do not contain any cysteine residues. MBP is a monomeric protein. Crystal structures have shown
Maltose-binding_protein
Mammalian protein found in humans
binding to the chemokine receptor CCR9. Human CCL25 is produced as a protein precursor containing 151 amino acids. The gene for CCL25 (scya25) is located
CCL25
Amino acid having an aromatic ring
portions of protein-protein or protein-ligand interaction interfaces on the protein surface. Aromatic amino acids often serve as the precursors to important
Aromatic_amino_acid
Class of enzymes
well-known PPCs is furin. Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and
Proprotein_convertase
Protein-coding gene in the species Homo sapiens
is a calcium-binding EF-hand protein.[supplied by OMIM] NUCB2 is protein precursor of nesfatin-1 In the study of the evolution of nervous systems, NUCB2
Nucleobindin_2
Proteins present in blood serum
the immune system. Other blood proteins act as enzymes, complement, components, protease inhibitors or kinin precursors. Contrary to popular belief, haemoglobin
Plasma_protein
Human disease
however, it may play a role in protein folding or cellular transport. In the pancreas, wolframin may help fold a protein precursor of insulin (called proinsulin)
Wolfram_syndrome
Species of mosquito
mosquitoes, females were unable to synthesize vitellogenin, a yolk-protein precursor, unless given a donor ovary from a sugar-fed or blood-fed mosquito
Aedes_taeniorhynchus
Protein found in humans
protein precursor, pro-GDNF. The pre-sequence leads the protein to the endoplasmic reticulum for secretion. While secretion takes place, the protein precursor
Glial cell line-derived neurotrophic factor
Glial_cell_line-derived_neurotrophic_factor
Mammalian protein found in Homo sapiens
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from
Proopiomelanocortin
Protein family
within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member
Growth_factor-like_domain
Immune system protein
envelope glycoprotein structure consists of two protein subunits cleaved from a Gp160 protein precursor encoded for by the HIV-1 env gene: the Gp120 external
CCR5
viral and cellular membranes. This class I fusion protein is synthesized as an inactive precursor (F0), which undergoes cleavage to form two disulfide
Respiratory syncytial virus F protein
Respiratory_syncytial_virus_F_protein
Family of globular proteins found in leguminous seeds
bridge is formed between the α and β chains to form prolegumin, a protein precursor. Three of these subunits come together to form a trimer in the ER
Legumin
Protein-coding gene in the species Homo sapiens
proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene. The protein encoded by this gene is a proline-rich salivary protein. This gene
PRB4
Precursor protein to one or more prohormones
preprohormone is the precursor protein to one or more prohormones, which are in turn precursors to peptide hormones. In general, the protein consists of the
Preprohormone
Protein-coding gene in humans
cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase. GRCh38: Ensembl
CILP
Protein-coding gene in humans
protein that in humans is encoded by the NAE1 gene (previously APPBP1). The protein encoded by this gene binds to the beta-amyloid precursor protein.
NAE1
Species of coral
Vitellogenin (Vg [a major egg yolk protein precursor]) has been identified in Fimbriaphyllia ancora. Ep (another novel yolk protein) was also found in to be E
Fimbriaphyllia_ancora
Mammalian protein found in Homo sapiens
tax gene & protein". www.uniprot.org. Retrieved 2020-05-03. "PRNP - Major prion protein precursor - Homo sapiens (Human) - PRNP gene & protein". www.uniprot
Cholesin
Serum albumin protein derived from cows
full-length BSA precursor polypeptide is 607 amino acids (AAs) in length. An N-terminal 18-residue signal peptide is cut off from the precursor protein upon secretion
Bovine_serum_albumin
Enzyme found in humans
generated as the result of proteolytic processing of the amyloid precursor protein (APP) by proteases referred to as the β and γ secretases. The physiological
Insulin-degrading_enzyme
Protein-coding gene in the species Homo sapiens
Protein AMBP is a protein that in humans is encoded by the AMBP gene. Alpha-1-microglobulin/bikunin precursor has been shown to interact with CD79A. Inter-alpha-trypsin
Alpha-1-microglobulin/bikunin precursor
Alpha-1-microglobulin/bikunin_precursor
protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - protein targeting - protein translocation
Index of biochemistry articles
Index_of_biochemistry_articles
Egyptian-American plant pathologist
transgenic soybean lines expressing the bean pod mottle virus coat protein precursor gene", Plant Cell Reports, 15 (10): 746–50, Bibcode:1996PCelR..15
Said_Ghabrial
Protein-coding gene in the species Homo sapiens
PMID 11861531. "Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor". Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D
Parathyroid_hormone_2
Protein family
peptides, like many other active peptides, are synthesized as larger protein precursors that are enzymatically converted to their mature forms. The final
Bombesin-like_peptides
Protein-coding gene in humans
(abbreviated PPT-1, PPT-I, or PPT-A), is a precursor protein that in humans is encoded by the TAC1 gene. The protein has four isoforms—alpha-, beta-, gamma-
TAC1
Protein-coding gene in the species Homo sapiens
known as ISLR 2 and two paralogous domains: LRRN4 (protein precursor 4) and LRRN4CL (protein precursor 4 C-terminal like). As of August 2020, there above
ISLR
Control of DNA to RNA conversion in cells
S2CID 34940548. "malE - Maltose-binding periplasmic protein precursor - Escherichia coli (strain K12) - malE gene & protein". www.uniprot.org. Retrieved 20 November
Transcriptional_regulation
name: Major hevein, gene name: HEV1) is a wound-induced and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation
Pro-hevein
Selenium responsive proteins within human biology, are the class of proteins sensitive to selenium, in healthy human beings, in cancer patients, in in-vivo
Selenium_responsive_proteins
Protein family
system. Like many other active peptides they are synthesized as larger protein precursors that are then enzymatically converted into their mature forms. They
Gastrin_family
Protein-coding gene in the species Homo sapiens
a protein with a molecular mass of 25 kilodaltons with a potential role in wound healing. It was later characterized as a large protein precursor (containing
TGF_beta_1
Mammalian protein found in humans
several AT-rich sequences. The CCL4 protein precursor consist of 92 amino acids. In turn, the mature CCL4 protein is 69 amino acids long. The CCL4 predicted
CCL4
Protein-coding gene in humans
chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. Cleavage
Cathepsin_L1
Organic compounds containing amine and carboxylic groups
photoleucine (pLeu) and photomethionine (pMet). Amino acids are the precursors to proteins. They join by condensation reactions to form short polymer chains
Amino_acid
Soluble protein complex in blood plasma and involved in clot formation
certain liver and kidney diseases. Fibrinogen is a "positive" acute-phase protein, i.e. its blood levels rise in response to systemic inflammation, tissue
Fibrinogen
Protein type
cancers. Entrez protein entry for trophoblast glycoprotein precursor 37 kiloDalton oncofetal antigen protein and immature laminin receptor protein are identical
Oncofetal_antigen
Protein-coding gene in the species Homo sapiens
Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor NPPC protein is cleaved to the
Natriuretic peptide precursor C
Natriuretic_peptide_precursor_C
American neuroscientist
(1990-08-01). "Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation". Proceedings of the National
Joseph_Buxbaum
an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor protein (APP), whose function is unclear but thought to be involved
Biochemistry of Alzheimer's disease
Biochemistry_of_Alzheimer's_disease
Precursor protein for other proteins found in the teeth
Dentin sialophosphoprotein is a precursor protein for other proteins found in the teeth. It is produced by cells (odontoblasts) inside the teeth (dental
Dentin_sialophosphoprotein
Protein-coding gene in the species Homo sapiens
Spermatogenesis-associated protein 31H1 is a protein which in humans is encoded by the gene SPATA31H1 (previously C2orf16) Not much has been reported
SPATA31H1
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PROTEIN PRECURSOR
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PROTEIN PRECURSOR
PROTEIN PRECURSOR
PROTEIN PRECURSOR
PROTEIN PRECURSOR
PROTEIN PRECURSOR
PROTEIN PRECURSOR
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