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Natural partial recreation of myelin sheaths in the brain
Remyelination is the process of propagating oligodendrocyte precursor cells to form oligodendrocytes to create new myelin sheaths on demyelinated axons
Remyelination
Subtype of glial cell in the central nervous system
morphological abnormalities, however, remyelination does restore normal conduction. In addition, spontaneous remyelination does not appear to be rare, at least
Oligodendrocyte progenitor cell
Oligodendrocyte_progenitor_cell
Autoimmune disease
longer effectively conduct electrical signals. A repair process, called remyelination, takes place in the early phases of the disease, but the oligodendrocytes
Multiple_sclerosis
Any neurological disease in which the myelin sheath of neurons is damaged
in regions of active remyelination and may play an important role in generating a local environment conducive to remyelination. N-cadherin agonists have
Demyelinating_disease
Formation of myelin sheaths in the nervous system
support learning and memory via neural circuit plasticity as well as remyelination following injury. Successful myelination of axons increases action potential
Myelination
Fatty substance insulating nerve cell axons
Schumacher M, Bernard S, Massaad C (March 2012). "Lithium enhances remyelination of peripheral nerves". Proceedings of the National Academy of Sciences
Myelin
Protein-coding gene in humans
inhibition of EBP promotes oligodendrocyte formation, which may help remyelination and thus limit multiple sclerosis development. Isolation, replication
Emopamil_binding_protein
Neural cell type
PMID 8439409. Franklin RJ, Ffrench-Constant C (November 2008). "Remyelination in the CNS: from biology to therapy". Nature Reviews. Neuroscience.
Oligodendrocyte
therapies on oligodendroglial lineage cells, myelin maintenance, and remyelination". She then carried out her postdoctoral studies at the Centre for Regeneration
Véronique_Miron
Solid, crystalline form of cholesterol
macrophages is believed to be associated with multiple sclerosis, and this remyelination failure is particularly impaired in the elderly. Dowling RH (2000).
Cholesterol_crystal
Renewal or physiological repair of damaged nerve tissue
scars rapidly form, and the glia actually produce factors that inhibit remyelination and axon repair; for instance, NOGO and NI-35. The axons themselves
Neuroregeneration
Neurological injury sustained by athletes
function involves demyelination. Axonal integrity is preserved, and remyelination occurs within days or weeks. Grade II is categorized by axonotmesis
Stinger_(medicine)
University of Cambridge in 1992. Franklin is a pioneer in the biology of remyelination, an area where he has made many seminal contributions. These include
Robin_Franklin
Subfamily of viruses in the family Coronaviridae
Whitman L, Lane TE (July 2010). "Cell replacement therapies to promote remyelination in a viral model of demyelination". Journal of Neuroimmunology. 224
Coronavirus
Cellular response to brain injury involving glial cells
precursor cells are also recruited to the site and may contribute to remyelination. The final component of gliosis is astrogliosis, the proliferation of
Gliosis
Central nervous system disease
PMC 6915812. PMID 31885862. Irvine, K. A.; Blakemore, W. F. (2008). "Remyelination protects axons from demyelination-associated axon degeneration". Brain
Neurodegenerative_disease
Pharmaceutical compound
receptor M1. It has been investigated for potential application in the remyelination of nerve sheaths Schrader TO, Xiong Y, Lorenzana AO, Broadhead A, Stebbins
PIPE-359
Protein family and hormone
VW, Weiss S (February 2007). "White matter plasticity and enhanced remyelination in the maternal CNS". The Journal of Neuroscience. 27 (8): 1812–23.
Prolactin
Medication used for cancer
increase the number of microtubules in the cell. Paclitaxel induces remyelination in a demyelinating mouse in vivo and inhibits human peptidylarginine
Paclitaxel
Hospital in Manhattan, New York
disease course. Conversely, remyelination is associated with return of conduction and clinical recovery, but remyelination often fails as the disease progresses
Corinne Goldsmith Dickinson Center for Multiple Sclerosis
Corinne_Goldsmith_Dickinson_Center_for_Multiple_Sclerosis
Compression of the median nerve in the wrist
the pressure is relieved leading to persistent sensory symptoms until remyelination can occur. If the compression continues and is severe enough, axons
Carpal_tunnel_syndrome
Experimental drug for neurodegenerative disorders
Granatov EV, Shakirzianova SR (2016). "[Effect of cerebrolysin on remyelination processes in multiple sclerosis patients in stage of relapse regression]"
Cerebrolysin
Support-cells in the nervous system
(2020-07-09). "Macroglial diversity: white and grey areas and relevance to remyelination". Cellular and Molecular Life Sciences. 78 (1): 143–71. doi:10.1007/s00018-020-03586-9
Glia
Glial cell type
studies since 2001 have implanted Schwann cells in an attempt to induce remyelination in multiple sclerosis-afflicted patients. In the past two decades, many
Schwann_cell
Class of chemical compounds
Morell P (May 2001). "Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain". Journal of Neurochemistry
Glycolipid
Damage to nervous tissue
to a temporary loss of motor coordination and sensory function until remyelination occurs. Axonotmesis is a more severe nerve injury with disruption of
Nerve_injury
Use of stem cells to treat or prevent a disease or condition
Positive migration of the injected cells to the site of lesion, increased remyelination detected by Myelin Basic Proteins, positive differentiation into Olig2
Stem-cell_therapy
Laboratory technique to study physiology
(CNS). Julia Ruckh and fellow researchers have used parabiosis to study remyelination from adult stem cells to see if conjoining young with older mice could
Parabiosis
Pentacyclic chemical compound found in fruits
treatment of multiple sclerosis through both immunomodulation and direct remyelination". Proceedings of the National Academy of Sciences. 117 (16): 9082–9093
Ursolic_acid
Pharmaceutical compound
Louapre C, Beigneux Y, Maestri F, Meyniel C, Touitou V (May 2026). "Remyelination and neuroprotection translational trials: Lessons from optic neuritis"
Privosegtor
Vitamin
demyelinating autoimmune disease. The hypothesis is that biotin may promote remyelination of the myelin sheath of nerve cells, slowing or even reversing neurodegeneration
Biotin
Allergy medication
remyelination and myelin repair in condition like multiple sclerosis (MS). Early phase II clinical trials showed promise for promoting remyelination in
Clemastine
Protein receptor active in neurons
processes, such as axon guidance and angiogenesis, the immune response and remyelination. Therefore, dysregulation of NRP activity has been implicated in many
Neuropilin
Lipid classification
Cerebroside synthesis can therefore give a measurement of myelin formation or remyelination. The sugar moiety is linked glycosidically to the C-1 hydroxyl group
Cerebroside
Protein-coding gene in the species Homo sapiens
receptor, NgR. MAG is believed to be involved in myelination during remyelination (nerve regeneration) in the peripheral nervous system (PNS) and is vital
Myelin-associated glycoprotein
Myelin-associated_glycoprotein
Protein-coding gene in the species Homo sapiens, named for ketazocine
Yong VW, et al. (February 2007). "White matter plasticity and enhanced remyelination in the maternal CNS". The Journal of Neuroscience. 27 (8): 1812–1823
Κ-opioid_receptor
Italian biologist
Cure to study the potential of subpopulations of stem cells to promote remyelination and phenotypic rescue in animal models of white matter disease, including
Paola_Leone
Inflammation of the spinal cord
inflammation, to modulate the immune system, and to enhance regeneration and remyelination of axons. Neural stem cells (NSC) have the potential to integrate with
Myelitis
Cytokine protein
neurons and, hence, may be important in nerve regeneration through remyelination. Interleukin-6 has been shown to interact with interleukin-6 receptor
Interleukin_6
Medical condition
cause inhibition of oligodendrocyte progenitor cell maturation and remyelination through reactive astrocytes mechanism. As mentioned at the beginning
CARASAL
Cytokine
growth. Hence, the decreased TGF-β levels during MS may also prevent remyelination of neurons. Higher concentrations of TGF-β are found in the blood and
Transforming growth factor beta
Transforming_growth_factor_beta
Canadian biologist (born 1971)
Franklin, Robin J.M. (2001). "Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination". Glia. 35 (3): 204–212
Mark_Kotter
Protein-coding gene in humans
TCF7L2 is unregulated during early remyelination, leading scientists to believe that it is involved in remyelination. TCF7L2 could act in dependence or
TCF7L2
Protein-coding gene in humans
Vinters HV, et al. (December 2016). "Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery
Reticulon_4
Chemical compound
by the University of Cambridge, have shown that the drug can cause remyelination, but will not lead to the drug being used as a therapy, due to its risk
Bexarotene
Academic medical research institute in Toronto
"Delayed Transplantation of Adult Neural Precursor Cells Promotes Remyelination and Functional Neurological Recovery after Spinal Cord Injury". Journal
Krembil_Research_Institute
Italian researcher
neuroprotection and therapeutic intervention. Showing that iNSCs promote remyelination in chronic MS-like lesions by supporting endogenous repair mechanisms
Stefano_Pluchino
Protein domain
proteins as key players in cancer biology, as well as inflammation and remyelination in multiple sclerosis. Members of the BET family have been implicated
Bromodomain
Chemical compound
C, et al. (September 2020). "Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis". Neurobiology of Disease. 143
Etrinabdione
Neuron membrane protein
influx. The experiments showed improved oligodendrocyte survival, and remyelination increased. Furthermore, CNS inflammation, apoptosis, and axonal damage
Glutamate_receptor
in sleep, cognition, synaptic function and plasticity, and promote remyelination and regeneration of injured nervous tissue. Other functions include
Gliotransmitter
Mammalian protein found in humans
Santambrogio L, Lira SA, Raine CS (January 2009). "Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1"
CXCL1
Protein found in humans
Multiple sclerosis (MS): is one of the diseases, in which a failure of remyelination can provoke lasting axonal damage and an irreversible loss of function
Cyclin-dependent_kinase_5
Medical condition
TREM2 cannot remove myelin debris, eventually leading to the lack of remyelination. The disease ultimately causes robust loss of white matter and axons
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
Polycystic_lipomembranous_osteodysplasia_with_sclerosing_leukoencephalopathy
Chemical compound containing the element cobalt
Almog, Ronit; Galboiz, Yanina (2005). "Vitamin B12, demyelination, remyelination and repair in multiple sclerosis". Journal of the Neurological Sciences
Cobalt_compounds
neural stem cells in repairing/regenerating injured spinal cords through remyelination of axons. This finding has been key in leading clinical translational
Michael_Fehlings
American biotechnology company
that is designed to treat specific forms of spinal cord injury through remyelination of damaged axons. This trial does not involve direct use of stem cells
Geron_Corporation
Pharmaceutical compound
autoimmune encephalomyelitis: Inhibiting neuroinflammation and promoting remyelination". Biochemical Pharmacology. 243 (Pt 1) 117514. doi:10.1016/j.bcp.2025
Tertomotide
Class of kinase enzymes
is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS". Neuron. 85 (6): 1227–43. doi:10.1016/j.neuron.2015.02.024
Phosphatidylinositol-4-phosphate 5-kinase
Phosphatidylinositol-4-phosphate_5-kinase
Type III intermediate filament protein
S2CID 1411700. Bunge MB, Bunge RP, Ris H (May 1961). "Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord". The Journal of
Glial fibrillary acidic protein
Glial_fibrillary_acidic_protein
CNS. Microglia and macrophages together help in the oligodendrocyte remyelination. Intestinal injury of the epithelia activates macrophages that secrete
Immune system contribution to regeneration
Immune_system_contribution_to_regeneration
Integral membrane protein G protein-coupled receptor
PMID 27863043. S2CID 10935349. Fumagalli M, Lecca D, Abbracchio MP (2016). "CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles
Eicosanoid_receptor
Mechanisms that form the human nervous system
Neurodevelopment in the adult nervous system includes mechanisms such as remyelination, generation of new neurons, glia, axons, myelin or synapses. Neuroregeneration
Development of the nervous system in humans
Development_of_the_nervous_system_in_humans
Pharmaceutical compound
functional recovery in an extended treatment window via facilitating remyelination". Med. 5 (6): 622–644.e8. doi:10.1016/j.medj.2024.03.018. PMID 38663402
SN-011
Mammalian protein found in Homo sapiens
in the myelin sheath. Further, the activity of MYRF increases during remyelination, suggesting it has a critical role in this process. Animals with repressed
Myelin_regulatory_factor
Chemical compound
avulsion injury. In addition C286 has shown a novel function for RARβ in remyelination after peripheral nervous system / central nervous system injury, and
KCL-286
Group of immune cells in the bone marrow
Castro, Fernando (April 2021). "Myeloid-derived suppressor cells support remyelination in a murine model of multiple sclerosis by promoting oligodendrocyte
Myeloid-derived suppressor cell
Myeloid-derived_suppressor_cell
American developmental biologist
"Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo". Nature. 522 (7555): 216–220. Bibcode:2015Natur.522..216N.
Paul_J._Tesar
Fictional character from the Australian soap opera Neighbours
Kay), who plots to have Clive removed from his job. Clive rejects a remyelination therapy trial for the hospital and backs David for a position on the
Clive_Gibbons
Medical condition
astrocytes within lesions may also contribute to the potential for remyelination, as preserved astrocytic function and support oligodendrocyte precursor
Baló_concentric_sclerosis
Diseases of the brain and spinal cord
plaques or lesions usually reported in MS. A repair process, called remyelination, takes place in early phases of the disease, but the oligodendrocytes
Lesional demyelinations of the central nervous system
Lesional_demyelinations_of_the_central_nervous_system
Pathologic overview
astrogliosis, oligodendrocyte injury, neurodegeneration, axonal loss and remyelination. MS lesions evolve differently during early versus chronic disease phases
Pathology of multiple sclerosis
Pathology_of_multiple_sclerosis
Progestin medication
et al. (October 2011). "Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors". Endocrinology. 152 (10): 3820–3831
Segesterone_acetate
Disease pathology and physiology
Möbius W, Simons M (2018). "Defective cholesterol clearance limits remyelination in the aged central nervous system". Science. 359 (6376): 684–688. Bibcode:2018Sci
Pathophysiology of multiple sclerosis
Pathophysiology_of_multiple_sclerosis
Protein-coding gene in the species Homo sapiens
antibody specific to the lingo-1 protein and is designed to promote remyelination (the formation of new myelin on axons) and neuroprotection. The protein
LINGO1
Physiological changes caused by nerve compression
representing either the late stages of demyelination or early stages of remyelination. The pathology of fascicle to fascicle can vary. For example in some
Pathophysiology of nerve entrapment
Pathophysiology_of_nerve_entrapment
French neurologist and academic
Wikidata Q37183765. Kirby, Tony (2020-08-01). "Catherine Lubetzki—expert on remyelination in multiple sclerosis". The Lancet Neurology. 19 (8): 648. doi:10
Catherine_Lubetzki
Protein found in humans
conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal
SURF1
British biologist (1958–2012)
reproduction. He was attached to the Jessen-Mirsky laboratory and was studying remyelination. Lee had ethical committee approval in Brazil for creating artificial
Sammy_Lee_(scientist)
Protein-coding gene in the species Homo sapiens
protein-coupled receptor 17". Fumagalli M, Lecca D, Abbracchio MP (2016). "CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles
GPR17
Greek neuroimmunologist
Strickland, Sidney (2002-03-14). "Fibrin Inhibits Peripheral Nerve Remyelination by Regulating Schwann Cell Differentiation". Neuron. 33 (6): 861–875
Katerina_Akassoglou
Medical process used to regrow tissue and bone
stem cells and Schwann cells and for promoting axon restoration and remyelination. Olfactory ensheathing cells, stem cells, and other neural progenitor
Nano-scaffold
Protein-coding gene in the species Homo sapiens
oligodendrocyte differentiation, myelination, myelin production, and remyelination following demyelinating injuries. Furthermore, osteocalcin treatment
GPR37
Line of stem cells for research
(2021). "Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System". Frontiers in Cellular Neuroscience.
Myelinoid
axonal loss dominates in the T1 hypointense core, and the effects of de/remyelination may be better detected in the "T2-rim", where there is relative preservation
Biomarkers of multiple sclerosis
Biomarkers_of_multiple_sclerosis
Species of virus
Whitman L, Lane TE (July 2010). "Cell replacement therapies to promote remyelination in a viral model of demyelination". Journal of Neuroimmunology. 224
Murine_coronavirus
Italian neuroscientist
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency (News and Views and Highlights in Nature Neuroscience Reviews)
Patrizia_Casaccia
Overview article
PMC 6100297. PMID 30150982. Neumann B, et al. (2019). "Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells". Cell Stem Cell. 25 (4): 473–485
Multiple sclerosis drug pipeline
Multiple_sclerosis_drug_pipeline
expression in the adult mouse brain is regulated during demyelination and remyelination". Brain Research. 1642: 124–30. doi:10.1016/j.brainres.2016.03.014.
Hes3_signaling_axis
Swiss neurobiologist
Jacob, Claire; Schaeren-Wiemers, Nicole (2022). "Theophylline Induces Remyelination and Functional Recovery in a Mouse Model of Peripheral Neuropathy".
Nicole_Schaeren-Wiemers
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