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Protein-coding gene in the species Homo sapiens
Rev-Erb beta (Rev-Erbβ), also known as nuclear receptor subfamily 1 group D member 2 (NR1D2), is a member of the Rev-Erb protein family. Rev-Erbβ, like
Rev-ErbA_beta
Type of protein
classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-Erbα), which in
Rev-Erb
Biological mechanism that controls circadian rhythm
example, when Bmal1 was knocked down in a dose-dependent manner, Rev-ErbA alpha and Rev-ErbA beta mRNA levels were shown to decrease in a linear, proportional
Circadian_clock
Gene of the species Homo sapiens
encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and
NCOA5
Nuclear receptor protein found in humans
Peroxisome proliferator-activated receptor delta (PPAR-delta), or (PPAR-beta), also known as Nuclear hormone receptor 1 (NUC1) is a nuclear receptor that
Peroxisome proliferator-activated receptor delta
Peroxisome_proliferator-activated_receptor_delta
Protein-coding gene in the species Homo sapiens
Usala SJ (1992). "An arginine to histidine mutation in codon 315 of the c-erbA beta thyroid hormone receptor in a kindred with generalized resistance to thyroid
Thyroid_hormone_receptor_beta
Protein-coding gene in the species Homo sapiens
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear
Estrogen_receptor_beta
Protein-coding gene in the species Homo sapiens
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans
RAR-related orphan receptor beta
RAR-related_orphan_receptor_beta
Protein-coding gene in the species Homo sapiens
Retinoic acid receptor beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor that in humans is encoded
Retinoic_acid_receptor_beta
Protein-coding gene in the species Homo sapiens
of other nuclear receptors. V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ENSG00000160113
V-erbA-related_gene
Protein-coding gene in the species Homo sapiens
Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans
Estrogen-related receptor beta
Estrogen-related_receptor_beta
Protein found in humans
1159/000057359. PMID 9525694. S2CID 84458561. Massagué J (1998). "TGF-beta signal transduction". Annu. Rev. Biochem. 67: 753–91. doi:10.1146/annurev.biochem.67.1.753
SMAD2
Protein-coding gene in the species Homo sapiens
Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor
Liver_X_receptor_beta
Swiss chronobiologist
Chronobiology University of Geneva Circadian rhythm suprachiasmatic nucleus Rev-ErbA alpha PER CRY BMAL1 alpha-amylase CRE Louis-Jeantet Prize Archived 2019-01-23
Ueli_Schibler
Phosphorylation of peptidyl-tyrosine
1080/147342202753671231. PMID 12882359. S2CID 9909209. Di Stefano P, Cabodi S, Boeri Erba E, Margaria V, Bergatto E, Giuffrida MG, et al. (2004). "P130Cas-associated
Tyrosine_phosphorylation
Protein-coding gene in humans
factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling
SMAD3
Group of nuclear receptor proteins
alpha, gamma, and delta (beta): α (alpha) - expressed in liver, kidney, heart, muscle, adipose tissue, and others β/δ (beta/delta) - expressed in many
Peroxisome proliferator-activated receptor
Peroxisome_proliferator-activated_receptor
Transcription factor activated by vitamin D
alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor". Pharmacol. Rev. 58 (4): 742–59. doi:10.1124/pr
Vitamin_D_receptor
Protein-coding gene in the species Homo sapiens
Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded
Retinoid_X_receptor_beta
Protein-coding gene in humans
CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene. The protein encoded by this intronless gene is a bZIP transcription
CEBPB
Protein-coding gene in humans
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
MYB_(gene)
Family of proteins
main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development
SMAD_(protein)
Protein structural motif
(October 2005). "Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization". J. Mol. Biol. 353 (3):
Basic_helix–loop–helix
Protein-coding gene in the species Homo sapiens
proteins in the nucleus of transforming growth factor-beta activated cells". Cytokine Growth Factor Rev. 10 (3–4): 187–99. doi:10.1016/S1359-6101(99)00012-X
SMAD7
Transcription factor and coding gene in humans
nucleus. These processes are dependent on cytokines like interferon alpha or beta, interferon gamma or interleukin 27. As mentioned above, low levels of interleukin
STAT1
Proteins activated by the hormone estrogen
ERβ (ββ) homodimers or ERαβ (αβ) heterodimers. Estrogen receptor alpha and beta show significant overall sequence homology, and both are composed of five
Estrogen_receptor
Transcription factor gene of the SOX family
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
SOX9
Protein-coding gene in humans
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
PAX1
Protein-coding gene in the species Homo sapiens
proteins in the nucleus of transforming growth factor-beta activated cells". Cytokine Growth Factor Rev. 10 (3–4): 187–99. doi:10.1016/S1359-6101(99)00012-X
SMAD6
Transcription factor
RNA polymerase. This model has been suggested in pioneering works on the beta-globin locus. CTCF is conserved across eumetazoans, including cnidarians
CTCF
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
suggested involvement in the cell cycle. The growth factors TGF alpha, TGF beta, and IL2 have all been shown to stimulate c-Fos, and thereby stimulate cellular
AP-1_transcription_factor
Nuclear protein
splicing. Genes on chromosomes 3 and 17 are transcribed and translated into c-erbA gene products. Splicing of these gene products leads to the production of
Thyroid_hormone_receptor
Protein-coding gene in the species Homo sapiens
Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene. The protein encoded by this gene is one subunit of
NFYB
Protein-coding gene in the species Homo sapiens
is regulated through the upstream ROR/REV-ERB Response Element (RRE) in the Bmal1 promoter, to which RORα and REV-ERBα bind. This stabilizing regulatory
RAR-related orphan receptor alpha
RAR-related_orphan_receptor_alpha
Inhibitory SMAD proteins
SMADs that are involved in the modulation of transforming growth factor beta ligands. This class includes SMAD6 and SMAD7. They compete with SMAD4 and
I-SMAD
Protein found in humans
corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the
Nuclear receptor co-repressor 1
Nuclear_receptor_co-repressor_1
Protein-coding gene in humans
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
IFI16
Protein-coding gene in the species Homo sapiens
subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene. This gene encodes the GA-binding protein transcription factor, beta subunit
GABPB1
Protein-coding gene in the species Homo sapiens
(GTF2E2), also known as transcription initiation factor IIE subunit beta (TFIIE-beta), is a protein that in humans is encoded by the GTF2E2 gene. Transcription
GTF2E2
Mammalian protein found in Homo sapiens
Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development
FOXA2
Protein found in humans
transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor". The EMBO Journal. 11
Retinoic_acid_receptor_alpha
Class of protein transcription factors
subunits: the sigma subunit-in addition to the two alpha (α), one beta (β), one beta prime (β'), and one omega (ω) subunits that make up the core enzyme(~450
General_transcription_factor
Protein-coding gene in the species Homo sapiens
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
Retinoid_X_receptor_alpha
Transcription factors
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
Hepatocyte_nuclear_factors
Transcription factor
polymerase II preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus
Transcription_factor_II_E
Class of enzymes
contributes to the therapeutic effect. Inhibition of GSK-3 also destabilises Rev-ErbA alpha transcriptional repressor, which has a significant role in the circadian
GSK-3
Protein-coding gene in humans
Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (October 2002). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type
NFKB1
Protein-coding gene in humans
GA-binding protein subunit beta-2 is a protein that in humans is encoded by the GABPB2 gene. Not much has been reported about the function of this protein
GABPB2
Nuclear receptor that mediates the effects of the mineralocorticoid hormone Aldosterone
occurs because mineralocorticoid-responsive cells express Corticosteroid 11-beta-dehydrogenase isozyme 2, an enzyme which selectively inactivates glucocorticoids
Mineralocorticoid_receptor
Vertebrate receptor protein and transcription factor
role in the regulation of the expression of some transforming growth factor-beta (TGF-b) isoforms. This is not to say that ligand-dependent AhR activation
Aryl_hydrocarbon_receptor
Mammalian protein found in Homo sapiens
(August 1998). "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription". Nature. 394 (6696): 909–13. Bibcode:1998Natur.394
Transcription_factor_Jun
Protein that controls rate of transcription of GH genes
in protein-protein interactions. Activity on thyroid stimulating hormone-beta expression is also known for PIT1. Pituitary-specific positive transcription
Pituitary-specific positive transcription factor 1
Pituitary-specific_positive_transcription_factor_1
Protein-coding gene in the species Homo sapiens
Fong A, Sun SC (Jun 2002). "Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa
NFKB2
Human gene and protein
Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene. AP-2 beta is a member of the AP-2 family
TFAP2B
Mammalian protein found in Homo sapiens
(January 2001). "Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the
ATF4
Mammalian protein found in humans
beta-strand and alpha-helix to form a V-shaped monomer topology. The beta-strand contributes to the formation of an antiparallel intermolecular beta-sheet
P53
Protein-coding gene in the species Homo sapiens
factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling". J. Biol. Chem. 276 (32): 30224–30. doi:10.1074/jbc.M102759200
FOXG1
Protein-coding gene in the species Homo sapiens
Kanai T, Watanabe M (January 2007). "Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer". Gastroenterology
ATOH1
Medical condition
E.; Baroncelli, G.I.; Mora, S.; Russo, G.; Baldinotti, F.; Parrini, D.; Erba, P.; Simi, P.; Bertelloni, S. (11 September 2009). "Body composition and
Complete androgen insensitivity syndrome
Complete_androgen_insensitivity_syndrome
Protein-coding gene in the species Homo sapiens
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
MNX1
Protein-coding gene in the species Homo sapiens
Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse". Mol. Cell. Biol. 18
TCF7
Nuclear receptors that bind to retinoids
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
Retinoid_receptor
Family of intracellular transcription factors
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
STAT_protein
Protein-coding gene in humans
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
ZNF451
Protein-coding gene in the species Homo sapiens
"Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal
TFAP2A
Mammalian protein found in Homo sapiens
factor 2 (TCF2), is a human gene. HNF1B encodes hepatocyte nuclear factor 1-beta, a protein of the homeobox-containing basic helix-turn-helix family. The
HNF1B
Structural motif capable of binding DNA
helix-turn-helix (wHTH) motif is formed by a 3-helical bundle and a 3- or 4-strand beta-sheet (wing). The topology of helices and strands in the wHTH motifs may
Helix-turn-helix
Human protein-coding gene
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
ZBTB20
Nuclear receptor protein found in humans
receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate". Molecular Pharmacology. 50 (1): 67–74. doi:10.1016/S0026-895X(25)09162-X
Peroxisome proliferator-activated receptor alpha
Peroxisome_proliferator-activated_receptor_alpha
Protein-coding gene in humans
ectoderm receives a combination of weak Sonic hedgehog (SHH) and strong TGF-Beta signaling gradients. Expression is first seen in the forebrain, hindbrain
PAX6
Protein
prepro-glucagon expression. In pancreatic beta cells FOXO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. When the level of blood glucose
Forkhead_box_protein_O1
Receptor to which cortisol and other glucocorticoids bind
et al. (September 1996). "The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential
Glucocorticoid_receptor
Protein-coding gene in the species Homo sapiens
TA, Hagman DK, Parazzoli SD, Poitout V, et al. (March 2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription"
NEUROD1
Genes on human chromosome 9
acid receptors. There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma, encoded by the RXRA, RXRB, RXRG genes, respectively. RXR
Retinoid_X_receptor
General transcription factors
Richard A. (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823. Dynlacht
Transcription_factor_II_D
Protein-coding gene in the species Homo sapiens
(February 1998). "The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro". Biochemical
Estrogen_receptor_alpha
Protein-coding gene in the species Homo sapiens
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
TCF4
Protein-coding gene in the species Homo sapiens
A (September 1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Molecular and Cellular
Y_box_binding_protein_1
Protein-coding gene in the species Homo sapiens
the nucleus for the transcriptional activation of interferons alpha and beta, and further interferon-induced genes. IRF3 plays an important role in the
IRF3
Protein-coding gene in humans
2000). "Analysis of beta-catenin aggregation and localization using GFP fusion proteins: nuclear import of alpha-catenin by the beta-catenin/Tcf complex"
TCF7L2
Protein-coding gene in the species Homo sapiens
protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Human Molecular Genetics. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785
Zinc_finger_protein_ZPR1
Protein-coding gene in humans
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
FOXO3
Protein that regulates the rate of DNA transcription
factor) domain 3.6.1 Family: TEA (TEAD1, TEAD2, TEAD3, TEAD4) 4 Superclass: beta-Scaffold Factors with Minor Groove Contacts 4.1 Class: RHR (Rel homology
Transcription_factor
Mammalian protein found in humans
involving SMADS is called the SMAD pathway or the transforming growth factor beta (TGF-β) pathway since the sequence starts with the recognition of TGF-β by
SMAD4
Proteins that bind DNA
SP8 sequences in the 50 upstream regions of genes coding for sporamin and beta-amylase from sweet potato. Mol. Gen. Genet. 244, 563–571 Rushton, P.J. et
WRKY_transcription_factor
Protein-coding gene in the species Homo sapiens
Fernandez-Funez P (June 2011). "The ER stress factor XBP1s prevents amyloid-beta neurotoxicity". Human Molecular Genetics. 20 (11): 2144–2160. doi:10.1093/hmg/ddr100
XBP1
Protein-coding gene in the species Homo sapiens
M, Harris SA, Oursler MJ, et al. (1996). "Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts"
KLF10
Protein-coding gene in the species Homo sapiens
RT, Hicks JS, Willerford DM (Jun 2003). "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs". Blood. 101 (11): 4492–9
KLF5
Protein-coding gene in humans
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
MNDA
Protein-coding gene in the species Homo sapiens
LIM homeobox transcription factor 1-beta, also known as LMX1B, is a protein which in humans is encoded by the LMX1B gene. LMX1B is a LIM homeobox transcription
LMX1B
Protein found in humans
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
SMAD1
Protein family
the EDA exon from the mature transcript. All HP1 isoforms (HP1-alpha, HP1-beta, and HP1-gamma) are recruited to DNA at sites of UV-induced damages, at oxidative
Heterochromatin_protein_1
Nuclear receptor protein found in humans
Laudet V, Krey G, Wahli W (1993). "Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated
Peroxisome proliferator-activated receptor gamma
Peroxisome_proliferator-activated_receptor_gamma
oncogene proteins v-abl MeSH D12.776.624.664.520.750.882 – oncogene proteins v-erba MeSH D12.776.624.664.520.750.883 – oncogene proteins v-erbb MeSH D12.776
List_of_MeSH_codes_(D12.776)
Protein-coding gene in the species Homo sapiens
Thyroid hormone α β CAR FXR EcR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular
ZEB1
Protein-coding gene in the species Homo sapiens
transcription factor able to activate expression of the cytokine Interferon beta, IRF-1 was subsequently shown to function as a transcriptional activator
IRF1
Protein-coding gene in the species Homo sapiens
transcription factor, occurs through the direct interaction of importin beta with HLH-Zip". Molecular Biology of the Cell. 10 (7): 2221–33. doi:10.1091/mbc
Sterol regulatory element–binding protein 2
Sterol_regulatory_element–binding_protein_2
Members of the nuclear receptor family of intracellular transcription factors
"All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nature Structural Biology. 10 (10): 820–5. doi:10.1038/nsb979. PMID 12958591
RAR-related_orphan_receptor
Protein-coding gene in the species Homo sapiens
2002). "Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)". Mol. Cell. 9 (1): 133–43
MYC
Protein-coding gene in the species Homo sapiens
cancer, viral infections, or organ transplant. As a potent repressor of beta-interferon (IFN-β), BLIMP-1 competes for interferon regulatory factors (IRF)
PRDM1
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REV ERBA-BETA
REV ERBA-BETA
REV ERBA-BETA
REV ERBA-BETA
REV ERBA-BETA
REV ERBA-BETA
REV ERBA-BETA
REV ERBA-BETA
REV ERBA-BETA
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