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Class of enzyme that catalyzes the degradation of RNA
Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided
Ribonuclease
Enzyme family
Ribonuclease H (abbreviated RNase H or RNH) is a family of non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate
Ribonuclease_H
Index of enzymes associated with the same name
Ribonuclease II may refer to one of two enzymes: Ribonuclease T2 Exoribonuclease II This set index page lists enzyme articles associated with the same
Ribonuclease_II
Class of enzymes
Ribonuclease P (EC 3.1.26.5, RNase P) is a type of ribonuclease which cleaves RNA. RNase P is unique from other RNases in that it is a ribozyme – a ribonucleic
Ribonuclease_P
Enterobacter ribonuclease (EC 3.1.27.6) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic cleavage to nucleoside 3'-phosphates
Enterobacter_ribonuclease
Yeast ribonuclease (EC 3.1.14.1) is an enzyme. This enzyme catalyses the following chemical reaction Exonucleolytic cleavage to nucleoside 3'-phosphates
Yeast_ribonuclease
Class of enzymes
Ribonuclease T2 (EC 3.1.27.1, acid ribonuclease, acid RNase, base-non-specific ribonuclease, Escherichia coli ribonuclease I' ribonuclease PP2, Escherichia
Ribonuclease_T2
Protein family
Ribonuclease inhibitor (RI) is a large (~450 residues, ~49 kDa), acidic (pI ~4.7), leucine-rich repeat protein that forms extremely tight complexes with
Ribonuclease_inhibitor
Class of enzymes
Ribonuclease III (RNase III or RNase C) (BRENDA 3.1.26.3) is a type of ribonuclease that recognizes dsRNA and cleaves it at specific targeted locations
Ribonuclease_III
Ribonuclease F (EC 3.1.27.7, ribonuclease F (E. coli)) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic cleavage of
Ribonuclease_F
RNA-cleaving enzyme
Bovine pancreatic ribonuclease, also often referred to as bovine pancreatic ribonuclease A or simply RNase A, is a pancreatic ribonuclease enzyme that cleaves
Bovine pancreatic ribonuclease
Bovine_pancreatic_ribonuclease
Bacillus subtilis ribonuclease (EC 3.1.27.2, Proteus mirabilis RNase, ribonucleate nucleotido-2'-transferase (cyclizing)) is an enzyme. This enzyme catalyses
Bacillus subtilis ribonuclease
Bacillus_subtilis_ribonuclease
American biochemist and biophysicist (1925–2009)
biophysicist known for solving the pioneering crystal structure of the ribonuclease S enzyme in 1967 and for defining the concept of solvent-accessible surface
Frederic_M._Richards
Ribonuclease (poly-(U)-specific) (EC 3.1.26.9, ribonuclease (uracil-specific), uracil-specific endoribonuclease, uracil-specific RNase) is an enzyme.
Ribonuclease (poly-(U)-specific)
Ribonuclease_(poly-(U)-specific)
Ribonuclease alpha (EC 3.1.26.2, 2'-O-methyl RNase) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic cleavage to 5'-phosphomonoester
Ribonuclease_alpha
Physarum polycephalum ribonuclease (EC 3.1.26.1) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic cleavage to 5'-phosphomonoester
Physarum polycephalum ribonuclease
Physarum_polycephalum_ribonuclease
Ribonuclease U2 (EC 3.1.27.4, purine specific endoribonuclease, ribonuclease U3, RNase U3, RNase U2, purine-specific ribonuclease, purine-specific RNase
Ribonuclease_U2
Mammalian protein found in Homo sapiens
Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic
Eosinophil_cationic_protein
Class of enzymes
Ribonuclease T (RNase T, exonuclease T, exo T) is a ribonuclease enzyme involved in the maturation of transfer RNA and ribosomal RNA in bacteria, as well
Ribonuclease_T
Enzyme found in humans
Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon
Ribonuclease_L
Physical interactions and constructions between multiple proteins
The horseshoe shaped ribonuclease inhibitor (shown as wireframe) forms a protein–protein interaction with the ribonuclease protein. The contacts between
Protein–protein_interaction
Class of enzymes
Pancreatic ribonuclease family (EC 4.6.1.18, RNase, RNase I, RNase A, pancreatic RNase, ribonuclease I, endoribonuclease I, ribonucleic phosphatase, alkaline
Pancreatic ribonuclease family
Pancreatic_ribonuclease_family
Molecular biology hypothesis
Prize Laureate Christian B. Anfinsen from his research on the folding of ribonuclease A. His research was based on previous studies by biochemist Lisa Steiner
Anfinsen's_dogma
Ribonuclease IV (EC 3.1.26.6, endoribonuclease IV, poly(A)-specific ribonuclease) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic
Ribonuclease_IV
Protein-coding gene in the species Homo sapiens
Ribonuclease 4 is an enzyme that in humans is encoded by the RNASE4 gene. The protein encoded by this gene belongs to the pancreatic ribonuclease family
Ribonuclease_4
Ribonuclease V (EC 3.1.27.8, endoribonuclease V) is an enzyme. This enzyme catalyses the following chemical reaction Hydrolysis of poly(A), forming oligoribonucleotides
Ribonuclease_V
Ribonuclease M5 (EC 3.1.26.8, RNase M5, 5S ribosomal maturation nuclease, 5S ribosomal RNA maturation endonuclease) is an enzyme. This enzyme catalyses
Ribonuclease_M5
Class of enzymes
ribonuclease N3, ribonuclease U1, ribonuclease F1, ribonuclease Ch, ribonuclease PP1, ribonuclease SA, RNase F1, ribonuclease C2, binase, RNase Sa, guanyl-specific
Ribonuclease_T1
American biochemist (1930–1982)
enzyme ribonuclease and for contributing to the understanding of the connection between the chemical structure and catalytic activity of the ribonuclease molecule
Stanford_Moore
Enzyme that cleaves double-stranded RNA (dsRNA) into short dsRNA fragments
functioning. Human Dicer (also known as hsDicer or DICER1) is classified a Ribonuclease III because it cleaves double-stranded RNA. In addition to two RNaseIII
Dicer
Interactive graphic scientific illustration
Ribonuclease A ribbons, from a kinemage displayed in Mage: β-strands are green, helices gold, and active-site His sidechains blue.
Kinemage
Bacterial ribonuclease
Ribonuclease E is a bacterial ribonuclease that participates in the processing of ribosomal RNA (9S to 5S rRNA) and the chemical degradation of bulk cellular
Ribonuclease_E
Exoribonuclease II (EC 3.1.13.1, ribonuclease II, ribonuclease Q, BN ribonuclease, Escherichia coli exo-RNase II, RNase II, exoribonuclease (misleading)
Exoribonuclease_II
Retroviral ribonuclease H (retroviral RNase H) is a catalytic domain of the retroviral reverse transcriptase (RT) enzyme. The RT enzyme is used to generate
Retroviral_ribonuclease_H
Form of treatment for genetic disorders and other illnesses
altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content
Antisense_therapy
Class of enzymes
TRNase Z (EC 3.1.26.11, 3 tRNase, tRNA 3 endonuclease, RNase Z, 3' tRNase) is an enzyme that, among other things, catalyses the reactions involved in the
Ribonuclease_Z
Ribonuclease D Structure of the RNase D protein Identifiers Symbol RNASED Other data EC number 3.1.13.5
RNase_D
Gene regulation in single-cell organisms
One main ribonuclease in prokaryotes is called ribonuclease E, and another ribonuclease that degrades RNA in prokaryotes is called ribonuclease G. It is
Prokaryotic_mRNA_degradation
Ribonuclease III enzyme
Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA (formerly RNASEN) gene. It is the primary nuclease that executes the
Drosha
Indian computational biologist
The horseshoe shaped ribonuclease inhibitor (shown as wireframe) forms a protein–protein interaction with the ribonuclease protein
R._Sankararamakrishnan
American biochemist (1916–1995)
in Chemistry with Stanford Moore and William Howard Stein for work on ribonuclease, especially concerning the connection between the amino acid sequence
Christian_B._Anfinsen
Ribonuclease enzyme found in the venom of the Caspian cobra
Ribonuclease V1 (RNase V1) is a ribonuclease enzyme found in the venom of the Caspian cobra (Naja oxiana). It cleaves double-stranded RNA in a non-sequence-specific
Ribonuclease_V1
Ribonuclease IX (EC 3.1.26.10, poly(U)- and poly(C)-specific endoribonuclease) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic
Ribonuclease_IX
American biochemist
that was responsible for the first organic synthesis of an enzyme, a ribonuclease. Born on May 6, 1922, in Fürth, he emigrated from Nazi Germany in 1936
Ralph_F._Hirschmann
Protein-coding gene in the species Homo sapiens
Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator
Angiogenin
Model of enzyme kinetics
Pepsin 3.0 × 10−4 0.50 1.7 × 103 tRNA synthetase 9.0 × 10−4 7.6 8.4 × 103 Ribonuclease 7.9 × 10−3 7.9 × 102 1.0 × 105 Carbonic anhydrase 2.6 × 10−2 4.0 × 105
Michaelis–Menten_kinetics
Biomolecule consisting of chains of amino acid residues
purified 1 kg of bovine pancreatic ribonuclease A and made it freely available to scientists. This gesture helped ribonuclease A become a major target for biochemical
Protein
Species of filamentous fungi
secretes high quantities of a number of varied enzymes. Crystals of ribonuclease Rh were crystallized via a vapor diffusion technique from Rhizopus niveus
Rhizopus_niveus
Hoofed herbivorous grazing or browsing mammals
facilitate digestion of bacteria in the ruminant abomasum. Pancreatic ribonuclease also degrades bacterial RNA in the ruminant small intestine as a source
Ruminant
Type of stable macromolecular complex
The Bacillus amyloliquefaciens ribonuclease barnase (colored) and its inhibitor (blue) in a complex
Protein_complex
Protein-coding gene in the species Homo sapiens
Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is
Poly(A)-specific_ribonuclease
Ribonuclease P4 (EC 3.1.26.7) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic cleavage of RNA, removing 3'-extranucleotides
Ribonuclease_P4
Protein-coding gene in the species Homo sapiens
Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene. ENSG00000023191 GRCh38: Ensembl release 89: ENSG00000276230, ENSG00000023191
RNH1
Medical condition
namely: TREX1, RNASEH2A, RNASEH2B, RNASEH2C (which together encode the ribonuclease H2 enzyme complex), SAMHD1, ADAR1, and IFIH1 (coding for MDA5). This
Aicardi–Goutières_syndrome
Protein-coding gene in the species Homo sapiens
Ribonuclease P protein subunit p20 is an enzyme that in humans is encoded by the POP7 gene. GRCh38: Ensembl release 89: ENSG00000172336 – Ensembl, May
POP7
consensus. › S-tag is the name of an oligopeptide derived from pancreatic ribonuclease A (RNase A). If RNase A is digested with subtilisin, a single peptide
S-tag
collection and microcrystals for micro electron diffraction. 1967 – Ribonuclease A (PDB file 2RSA) is an RNA-cleaving enzyme stabilized by 4 disulfide
List of biophysically important macromolecular crystal structures
List_of_biophysically_important_macromolecular_crystal_structures
American biochemist (1911–1980)
an American biochemist who collaborated in the determination of the ribonuclease sequence, as well as how its structure relates to catalytic activity
William_Howard_Stein
Bacterial ribonuclease protein
portmanteau of "BActerial" "RiboNucleASE") is a bacterial protein that consists of 110 amino acids and has ribonuclease activity. It is synthesized and
Barnase
Enzyme which generates DNA
sequential biochemical activities: RNA-dependent DNA polymerase activity, ribonuclease H (RNase H), and DNA-dependent DNA polymerase activity. Collectively
Reverse_transcriptase
Protein-coding gene in the species Homo sapiens
Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene. According to the US National Library of Medicine, "This gene encodes
RNASE1
Type of white blood cells
which contain many chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic
Eosinophil
DNA oligonucleotides that can perform a specific chemical reaction
deoxyribozymes was released. The most abundant class of deoxyribozymes are ribonucleases, which catalyze the cleavage of a ribonucleotide phosphodiester bond
Deoxyribozyme
Protein-coding gene in the species Homo sapiens
Ribonuclease A family member k6 is a protein that in humans is encoded by the RNASE6 gene. The protein encoded by this gene is a member of the ribonuclease
RNASE6
Protein-coding gene in the species Homo sapiens
gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2
Eosinophil-derived_neurotoxin
Protein-coding gene in the species Homo sapiens
Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene. It is a type of endoribonuclease. This ribonuclease gene is a novel member
RNASET2
Protein involved in processing RNA in animal cells
interference (RNAi) in animal cells. The complex is minimally composed of the ribonuclease enzyme Drosha and the dimeric RNA-binding protein DGCR8 (also known as
Microprocessor_complex
Protein-coding gene in the species Homo sapiens
Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene. POP1 is a protein subunit of two different small nucleolar
Ribonucleases P/MRP protein subunit POP1
Ribonucleases_P/MRP_protein_subunit_POP1
British biochemist (born 1958)
Alexander Steven (1985). The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus. jisc.ac.uk (PhD thesis). University
Neil_Brockdorff
Topics referred to by the same term
PP-1 (Rawalpindi-I) a Constituency of Provincial Assembly of Punjab Ribonuclease PP1 1-PP 1PP This disambiguation page lists articles associated with
Pp1
Gene which maintains basic cellular functions
NM_006247 PPP6C NM_002721 PPP6R2 NM_014678 PPP6R3 NM_018312 RAD1Homo sapiens ribonuclease/angiogenin inhibitor (RNH), mRNA RAD17 NM_002869 Essential for sustained
Housekeeping_gene
Protein-coding gene in the species Homo sapiens
Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene. RPP38 has been shown to interact with POP4. GRCh38: Ensembl
RPP38
Small non-coding ribonucleic acid molecule
processing (for example, of pri-miR-142, leading to degradation by the ribonuclease Tudor-SN) and alter downstream processes including cytoplasmic miRNA
MicroRNA
American biologist
doctoral research looked to understand the cytotoxicity mechanisms of a ribonuclease. She learned a lot about protein folding and Sirtuin 1. She was a postdoctoral
Marcia_Haigis
Protein-coding gene in the species Homo sapiens
PAB-dependent poly(A)-specific ribonuclease subunit 2 is an enzyme that in humans is encoded by the PAN2 gene (previously USP52). PAN2 is involved in the
PAN2
Chemical compound
isolation procedures to eliminate ribonuclease released during cell lysis. Numerous disulfide bonds make ribonucleases very stable enzymes, so 2-mercaptoethanol
2-Mercaptoethanol
American biophysicist (born 1940)
University Spouse Robert Hearn (m. 1960) Children 2 Scientific career Fields Biophysics Thesis Thermodynamic Parameters in the Ribonuclease-S System (1969)
Ruby_Puryear_Hearn
nucleotide modification Kinetoplastid mitochondria Ribonuclease P RNase P tRNA maturation All organisms Ribonuclease MRP RNase MRP rRNA maturation, DNA replication
List_of_RNAs
Protein-coding gene in the species Homo sapiens
Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene. GRCh38: Ensembl release 89: ENSG00000167272 – Ensembl
POP5
Protein family
bacterium Bacillus amyloliquefaciens. Its function is to inhibit the ribonuclease activity of its binding partner barnase, with which it forms an extraordinarily
Barstar
Chemical element with atomic number 1 (H)
Yoshida, M.; Kanaya, S.; Ikehara, M. (1992). "1H NMR studies of deuterated ribonuclease HI selectively labeled with protonated amino acids". Journal of Biomolecular
Hydrogen
Protein-coding gene in the species Homo sapiens
Ribonuclease P protein subunit p30 is an enzyme that in humans is encoded by the RPP30 gene. GRCh38: Ensembl release 89: ENSG00000148688 – Ensembl, May
RPP30
Protein family
well as on inosine-containing RNA. In eukaryotes endoV is primarily a ribonuclease and cleaves single-stranded RNA at the 3' position relative to an inosine
Endonuclease_V
Protein-coding gene in the species Homo sapiens
superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates)
ABCE1
Purification of RNA from biological samples
samples. This procedure is complicated by the ubiquitous presence of ribonuclease enzymes in cells and tissues, which can rapidly degrade RNA. Several
RNA_extraction
Class of enzymes which split esters into an acid and alcohol via hydrolysis
Phosphoric triester hydrolases Exonucleases (deoxyribonucleases and ribonucleases) EC 3.1.11: Exodeoxyribonucleases producing 5'-phosphomonoesters EC
Esterase
Topics referred to by the same term
Navy Ryan Nugent-Hopkins, ice hockey player Ribonuclease H, a family of endonuclease enzymes RNH1, Ribonuclease inhibitor, human gene New Richmond Regional
RNH
Indian crystallographer
origin. In 1967, he determined the molecular structure of the enzyme ribonuclease. Gopinath Kartha was born in Cherthala, near Alappuzha in the state of
Gopinath_Kartha
Protein-coding gene in the species Homo sapiens
protein binding metal ion binding nucleic acid binding poly(A)-specific ribonuclease activity snRNA binding DNA-binding transcription factor activity, RNA
TOE1
Non-coding RNA in the species Homo sapiens
protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA
MicroRNA_548f-4
Hepatitis B viral protein
It is a DNA polymerase that can use either DNA or RNA templates and a ribonuclease H that cuts RNA in the duplex. Both functions are supplied by the reverse
Hepatitis B virus DNA polymerase
Hepatitis_B_virus_DNA_polymerase
Enzyme from the northern leopard frog
is a ribonuclease enzyme found in the oocytes of the northern leopard frog (Rana pipiens). Ranpirnase is a member of the pancreatic ribonuclease (RNase
Ranpirnase
Drug used to treat genetic hypercholesterolemia
lipoprotein (VLDL). As a consequence, the RNA is degraded by the enzyme ribonuclease H, and ApoB-100 is not translated. After subcutaneous injection, mipomersen
Mipomersen
American chemical biologist (born 1958)
Francisco, where he cloned and expressed the gene encoding bovine pancreatic ribonuclease. Raines was a member of the faculty at the University of Wisconsin–Madison
Ronald_T._Raines
Plant gene encoding a Dicer-like protein
DICER-LIKE 5 (DCL5) is a plant Dicer-like endoribonuclease that functions in the biogenesis of 24-nucleotide reproductive phased small interfering RNAs
DCL5
Chemical property
constant of roughly 10−15 M = 1 fM = 0.000001 nM. Ribonuclease inhibitor proteins may also bind to ribonuclease with a similar 10−15 M affinity. The dissociation
Dissociation_constant
Number and arrangement of multiple folded protein subunits in a multi-subunit complex
tight but also only transient complexes. For example, ribonuclease inhibitor binds to ribonuclease A with a roughly 20 fM dissociation constant. Other proteins
Protein_quaternary_structure
Protein-coding gene in the species Homo sapiens
expression data Gene ontology Molecular function primary miRNA binding ribonuclease III activity double-stranded RNA binding protein binding heme binding
Microprocessor complex subunit DGCR8
Microprocessor_complex_subunit_DGCR8
Protein-coding gene in the species Homo sapiens
Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene. The protein encoded by this gene
RNASEH2A
Protein-coding gene in the species Homo sapiens
Ribonuclease P protein subunit p29 is an enzyme that in humans is encoded by the POP4 gene. POP4 has been shown to interact with RPP38 and POP1. GRCh38:
POP4_(gene)
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