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Lipid-lowering medication
Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and
Simvastatin
Drug combination used for the treatment of dyslipidemia
Ezetimibe/simvastatin is a drug combination used for the treatment of dyslipidemia. It is a combination of ezetimibe (known as Zetia in the United States)
Ezetimibe/simvastatin
Combination drug
Sitagliptin/simvastatin, sold under the brand name Juvisync, is a fixed-dose combination anti-diabetic medication used to treat type 2 diabetes and hypercholesterolemia
Sitagliptin/simvastatin
Combination drug
Niacin/simvastatin (trade name Simcor, by Abbott) is a combination drug consisting of an extended release form of the lipid-lowering drug niacin and the
Niacin/simvastatin
Class of drugs to lower cholesterol
pravastatin, rosuvastatin, and simvastatin. Combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. The class
Statin
Multicenter clinical trial that was performed in 1990s in Scandinavia
The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial
Scandinavian Simvastatin Survival Study
Scandinavian_Simvastatin_Survival_Study
Medication against high blood pressure
of simvastatin, a lipid-lowering agent, are given with amlodipine, the risk of myopathy increases. The FDA issued a warning to limit simvastatin to a
Amlodipine
Combination drug
Fenofibrate/simvastatin, sold under the brand name Cholib, is a fixed-dose combination medication used to treat abnormal blood lipid levels when used
Fenofibrate/simvastatin
Statin medication
milligram-equivalent doses of atorvastatin and milligram-equivalent or higher doses of simvastatin and pravastatin. A meta-analysis showed that rosuvastatin can modestly
Rosuvastatin
Medication used to treat high cholesterol
mouth. It is also available in the fixed-dose combinations ezetimibe/simvastatin, ezetimibe/atorvastatin, ezetimibe/rosuvastatin, and ezetimibe/bempedoic
Ezetimibe
Antiarrhythmic medication
kidney failure or death, when simvastatin is used with amiodarone. This interaction is dose-dependent with simvastatin doses exceeding 20 mg. This drug
Amiodarone
Recessive genetic condition
increased cholesterol levels are due to simvastatin's effect on the expression of different genes. Simvastatin increases the expression of DHCR7, likely
Smith–Lemli–Opitz_syndrome
Indian multinational pharmaceutical company
drug simvastatin (Zocor) in the USA. Since Dr. Reddy's has a licence from Merck, it was not subject to the exclusivity period on generic simvastatin, which
Dr._Reddy's_Laboratories
Cholesterol-lowering medication
treatment or placebo at reducing the risk of CI-AKI. Statins (predominantly simvastatin) have been evaluated in clinical trials in combination with fibrates
Atorvastatin
Formulary by the World Health Organization
ramipril) Acetylsalicylic acid/simvastatin/ramipril/atenolol/hydrochlorothiazide (acetylsalicylic acid + simvastatin + ramipril + atenolol + hydrochlorothiazide)
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Antibiotic medication
A noted drug interaction involves erythromycin and simvastatin, resulting in increased simvastatin levels and the potential for rhabdomyolysis. Another
Erythromycin
Benzodiazepine
via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit
Mexazolam
Pharmaceutical clinical trial
normal low-density lipoprotein (LDL). The study compared a combination of simvastatin and niacin with antioxidant vitamin therapy. Using angiography, coronary
HDL-Atherosclerosis Treatment Study
HDL-Atherosclerosis_Treatment_Study
Antiretroviral medication
may occur with a number of other medications including amiodarone and simvastatin. At low doses, it is considered to be acceptable for use during pregnancy
Ritonavir
Abnormal amount of lipids in the blood
Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute
Dyslipidemia
Mammalian protein found in Homo sapiens
pravastatin (Pravachol), fluvastatin (Lescol), pitavastatin (Livalo), and simvastatin (Zocor). Red yeast rice extract, one of the fungal sources from which
HMG-CoA_reductase
Loss of all body hair
(September 2007). "Alopecia Universalis: Hair Growth following Initiation of Simvastatin and Ezetimibe Therapy". Journal of Drugs in Dermatology. 6 (9): 946–7
Alopecia_universalis
Diabetes medication
combinations of sitagliptin/metformin (Janumet, Janumet XR) and sitagliptin/simvastatin (Juvisync). Sitagliptin should not be used to treat type 1 diabetes.
Sitagliptin
Chemical compound
is a statin compound produced by red yeast rice. It is a precursor to simvastatin, and has potential neuroprotective activities.[unreliable medical source
Monacolin_J
Pharmaceutical drug classification
codes not present in this list, which follows the WHO version. C10AA01 Simvastatin C10AA02 Lovastatin C10AA03 Pravastatin C10AA04 Fluvastatin C10AA05 Atorvastatin
ATC_code_C10
Gastrointestinal peptide hormone involved in glucose homeostasis
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Glucagon-like_peptide-1
British clinical trial
United Kingdom. It studied the use of the cholesterol lowering drug, simvastatin 40 mg and vitamin supplementation (vitamin E, vitamin C and beta carotene)
Heart_Protection_Study
Dutch pharmaceutical company
company is headquartered in Nijmegen. Medications made by Synthon include: Simvastatin (A statin) Tamsulosin (An alpha blocker for the symptomatic treatment
Synthon_(company)
Opioid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Fentanyl
Muscular disease in which the muscle fibers do not function correctly
Administration is recommending that physicians restrict prescribing high-dose simvastatin (Zocor, Merck) to patients, given an increased risk of muscle damage
Myopathy
Drug interactions with grapefruit juice
statins, including atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor, Simlup, Simcor, Simvacor) In contrast, pravastatin (Pravachol)
Grapefruit–drug_interactions
Cholesterol lowering medication in the statin class
"Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics
Pravastatin
Statins that belong to this group are: Lovastatin (Figure 2) Pravastatin Simvastatin Type 2 statins Statins that are fully synthetic and have larger groups
Discovery and development of statins
Discovery_and_development_of_statins
Diabetes medication
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Empagliflozin
Presence of excess fat in feces
and absorbed, sometimes causing oily anal leakage. Vytorin (ezetimibe/simvastatin) tablets can cause steatorrhea in some people. Some studies have shown
Steatorrhea
Chemical compound
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Retatrutide
National medical research agency
Heart Protection Study, showing benefits of primary prevention with simvastatin in patients at high risk for cardiovascular disease; Dr Venki Ramakrishnan
Medical Research Council (United Kingdom)
Medical_Research_Council_(United_Kingdom)
Medication used to treat diabetes
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Metformin
with coronary heart disease: the Scandinavian Simvastatin Survival Study Authors: The Scandinavian Simvastatin Survival Study Group. Publication data: Lancet
List of publications in medicine
List_of_publications_in_medicine
Chemical compound
with liver disease should not take lovastatin. As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice
Lovastatin
Chemical compound
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Pioglitazone
Chemical compound
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Danuglipron
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Meclizine
Vitamer of Vitamin B3
release nicotinic acid was combined with lovastatin (Advicor), and with simvastatin (Simcor), as prescription drug combinations. The combination niacin/lovastatin
Nicotinic_acid
Pharmaceutical drug
with a number of drugs that are known for their interaction potential (simvastatin, warfarin, digoxin, and oral contraceptives). Nonetheless, since albiglutide
Albiglutide
Medication to treat gastroesophageal reflux disease and other conditions
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Omeprazole
Long-acting form of insulin
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Ultralente_insulin
Peptide drug
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Survodutide
Study (1951 to 2001) into smoking and lung cancer
more recent Heart Protection Study. Framingham Heart Study Scandinavian Simvastatin Survival Study Nurses' Health Study Smoking in the United Kingdom History
British_Doctors_Study
Systematic naming of drugs
HMG-CoA reductase inhibitor (or statins) Vascular + -statin Atorvastatin Simvastatin -prazole Proton-pump inhibitors (PPIs) Timoprazole Omeprazole Pantoprazole
Drug_nomenclature
Anti-obesity medication
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Orforglipron
Anti-diabetic and anti-obesity medication
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Semaglutide
Drug for erectile dysfunction and hypertension
paraxanthine) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil) Statins (e.g., simvastatin) See also: Receptor/signaling modulators
Sildenafil
Group of drugs used against malaria
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Artemisinin
Combination drug
Journal of Medicine. Polycap combines 100 milligrams of aspirin, with simvastatin (a generic version of Zocor, the cholesterol-lowering statin; 20 mg)
Polycap
Laxatives/stool softeners
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Docusate
Medication
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Insulin_efsitora_alfa
Pharmaceutical clinical trial
Scientific Session in 2004. Heart Protection Study (HPS) Scandinavian Simvastatin Survival Study (4S) West of Scotland Coronary Prevention Study (WOSCOPS)
PROVE-IT_TIMI_22
American cardiologist (born 1951)
the efficacy of the cholesterol-lowering drug combination ezetimibe/simvastatin. As of 2015, he was vice-chancellor of clinical and translational research
Robert_Califf
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Clotrimazole
Use of insulin protein and analogs as medical treatment
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Insulin_(medication)
Species of fungus
PMC 317299. PMID 14969594. Becker DJ, Gordon RY, Morris PB, et al. (2008). "Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary
Monascus_purpureus
Chemical compound
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Retagliptin
Substance used to diagnose, cure, treat, or prevent disease
the second available in the United States, and the release of Zocor (simvastatin) made Mevacor no longer the only statin on the market. In 1998, Viagra
Medication
Diabetes medication
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Dulaglutide
Combination medication
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Insulin degludec/insulin aspart
Insulin_degludec/insulin_aspart
Israeli pharmaceutical company
2006, Teva received from the FDA a 180-day exclusivity period to sell simvastatin (Zocor) in the U.S. as a generic drug in all strengths except 80 mg.
Teva_Pharmaceuticals
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Pharmacodynamics of progesterone
Pharmacodynamics_of_progesterone
Medication of the barbiturate type
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Phenobarbital
Typical antipsychotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Chlorpromazine
Rapid-acting man-made insulin
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Insulin_aspart
Antibiotic derived from Penicillin
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Flucloxacillin
Medication and insecticide
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Permethrin
Immunosuppressive drug
no certain interactions with other drugs. The blood plasma levels of simvastatin were reduced by 57% after a single dose of tocilizumab, but it is not
Tocilizumab
Antiretroviral drug
nelfinavir reportedly inhibited the metabolism of atorvastatin and simvastatin. Nelfinavir should be taken with food. Taking the drug with food reduces
Nelfinavir
Statistical measure of drug consumption
population may often occur. For example, the Recorded Daily Dose (RDD) of simvastatin in Canada in 1997 was only 8% different to the DDD, but by 2006 it was
Defined_daily_dose
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Fenbendazole
Dutch psychiatrist
Roberto; van Haren, Neeltje E.M.; Sommer, Iris E.C. (2015-07-03). "Simvastatin augmentation for recent-onset psychotic disorder: A study protocol".
René_Kahn
The anion form of nitrogen dioxide
paraxanthine) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil) Statins (e.g., simvastatin) See also: Receptor/signaling modulators
Nitrite
Intermediate acting insulin formulation
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
NPH_insulin
Enzyme blocker and diabetes treatment drug
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Dipeptidyl peptidase-4 inhibitor
Dipeptidyl_peptidase-4_inhibitor
Chemical compound
Phenylpyruvic acid Phloretin Probenecid Pyruvic acid Quercetin Salicylic acid Simvastatin Sodium valproate Valproic acid SMCTsTooltip Sodium-coupled monocarboxylate
T-HCA
One of four stable isomers of butanediol
Phenylpyruvic acid Phloretin Probenecid Pyruvic acid Quercetin Salicylic acid Simvastatin Sodium valproate Valproic acid SMCTsTooltip Sodium-coupled monocarboxylate
1,4-Butanediol
Cholesterol-lowering medication
increases blood levels of statins. The effect is most pronounced with simvastatin and pravastatin, whose AUC is increased about twofold. No other clinically
Bempedoic_acid
Antibiotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Rifaximin
British physician
(2002). "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial"
Rory_Collins
Anti-diabetic and anti-obesity medication
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Tirzepatide
Concept in pharmacology and biochemistry
additive effect for hypercholesterolemia is niacin (vitamin B3) and simvastatin. This drug combination is also known as Simcor commercially. Niacin can
Additive_effect
Topics referred to by the same term
lipid-lowering medication, in the Philippines Bestatin, a trade name of simvastatin, a lipid-lowering medication, in Pakistan and Thailand This disambiguation
Bestatin_(disambiguation)
Antifungal chemical compound
ranolazine, tolvaptan, eplerenone HMG-CoA reductase inhibitors: lovastatin, simvastatin ergot alkaloids: ergotamine, dihydroergotamine, ergometrine, methylergometrine
Ketoconazole
Protein found in humans
gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping
Solute carrier organic anion transporter family member 1B1
Solute_carrier_organic_anion_transporter_family_member_1B1
Type of drugs
Stroke Older than 75 years old Lighter than 60 kg Statins Atorvastatin Simvastatin Rosuvastatin Pravastatin Inhibit HMG-CoA reductase → reduce cholesterol
Commonly_prescribed_drugs
Immunosuppressive drug
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Tacrolimus
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Thonzonium_bromide
Chemical compound
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Linagliptin
Pharmaceutical compound
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Brenipatide
Chemical compound
Sitagliptin/dapagliflozin Sitagliptin/ertugliflozin Sitagliptin/metformin Sitagliptin/simvastatin Vildagliptin/metformin #WHO-EM ‡Withdrawn from market Clinical trials:
Rivoglitazone
derived from a number of ergot alkaloids one of which is lysergic acid and Simvastatin is based on Lovastatin. Diverted total synthesis is a topic in academic
Diverted_total_synthesis
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole
Diclazuril
Medication
paraxanthine) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil) Statins (e.g., simvastatin) See also: Receptor/signaling modulators
Nitroglycerin_(medication)
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SIMVASTATIN
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