AI & ChatGPT searches , social queries for SKP2
Search references for SKP2. Phrases containing SKP2
See searches and references containing SKP2!
Search references for SKP2. Phrases containing SKP2
See searches and references containing SKP2!SKP2
Protein-coding gene in the species Homo sapiens
kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene. Skp2 contains 424 residues in total with the ~40 amino acid F-box domain
SKP2
Type of protein
aggregating to target proteins independently of the complex. Each FBP (e.g. Skp2) may recognize several different substrates in a manner that is dependent
SCF_complex
Protein-coding gene in the species Homo sapiens
Chen L, Liu X (August 2003). "A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1". J. Biol. Chem
CKS1B
Protein containing at least one F-box domain
in few positions. It was first identified in cyclin F. The F-box motif of Skp2, consisting of three alpha-helices, interacts directly with the SCF protein
F-box_protein
Protein-coding gene in the species Homo sapiens
CACYBP, CDCA3, CDK9, CUL1, FBXL3, FBXO4, FBXO5, FBXO7, FBXW2, FBXW7, and SKP2. GRCh38: Ensembl release 89: ENSG00000113558 – Ensembl, May 2017 GRCm38:
S-phase kinase-associated protein 1
S-phase_kinase-associated_protein_1
Protein-coding gene in humans
This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1
CUL1
Protein-coding gene in humans
(Skp2). SKP1 and Skp2 degrades p27 after it has been phosphorylated at threonine 187 (Thr187) by either activating cyclin E- or cyclin A-CDK2. Skp2 is
CDKN1B
Regulatory protein found in most eukaryotic tissues
gene amplification is SKP2. SKP2 is an F-box protein with a role in substrate recognition for ubiquitylation and degradation. SKP2 targets p27Kip-1, an
Ubiquitin
Protein
ZK, Gervais JL, Zhang H (Sep 1998). "Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21CIP1/WAF1 and cyclin D proteins". Proceedings of
P21
Protein found in humans
PPP2CA, Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, and SKP2. GRCh38: Ensembl release 89: ENSG00000123374 – Ensembl, May 2017 GRCm38:
Cyclin-dependent_kinase_2
Mammalian protein found in humans
Prohibitin Promyelocytic leukemia protein RBBP4 RBBP7 RBBP8 RBBP9 SNAPC1 SKP2 SNAPC3 SNW1 SUV39H1 TAF1 THOC1 TRAP1 TRIP11 UBTF USP4. Several methods for
Retinoblastoma_protein
Stage in cell cycle
driving the cell cycle to progress from G1 to S phase. E2F also targets Skp2, an F-box protein that targets the CDK inhibitor p27 for degradation, creating
G1/S_transition
Protein found in humans
laevis - CDT1 DNA replication factor CDT1 has been shown to interact with SKP2. Cdt1 is recruited by the origin recognition complex in origin licensing
DNA_replication_factor_CDT1
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
itself is regulated by the APC via ubiquitination of the adaptor protein, Skp2, which prevents SCF activity before the G1-S transition. Individual components
Proteasome
Immune response protein
factor in cancer development. First, FOXP3 represses expression of HER2, Skp2, SATB1 and MYC oncogenes and induces expression of tumour suppressor genes
FOXP3
American biochemist and structural biologist
N., Schulman, B., Song, L. et al. Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex. Nature 416, 703–709 (2002). https://doi.org/10
Ning_Zheng
Protein-coding gene in humans
Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular
CDC34
license DNA for replication in fission yeast Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis Accurate Processing of a
Zoi_Lygerou
Protein complex
phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)". Genes & Development. 16 (22): 2946–57. doi:10.1101/gad.1011202. PMC 187481
DREAM_complex
Chinese-American academic
survival of cancer cells. These substrates include DEPTOR, XRCC4, SHOC2, SKP2, β-Catenin, MSX2, Nf1, c-Jun, IκBα, Erbin, NOXA, ASCT2, and DIRAS-2, as well
Yi_Sun_(academic)
Protein family
PMC 2645405. PMID 18986514. Eukaryotic Linear Motif resource motif class LIG_SCF_Skp2-Cks1_1 SCOP LRR fold CATH Alpha-beta horseshoe architecture LRRML: a conformational
Leucine-rich_repeat
Protein and coding gene in humans
2004). "Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition". The Journal of Biological Chemistry
DIAPH1
Protein-coding gene in humans
Fujita M, Lygerou Z, Nishimoto T (Mar 2006). "Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis". The EMBO Journal. 25 (5):
CUL4B
Series of biochemical reactions
cells, this maintains tissue stability. S-phase kinase-associated protein 2 (Skp2) - Ser72 phosphorylation enhances E3 ligase activity and cytosolic localisation
Akt/PKB_signaling_pathway
Protein-coding gene in the species Homo sapiens
D, Pagano M (June 2008). "Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer". Nature Reviews. Cancer. 8 (6):
BTRC_(gene)
Protein-coding gene in humans
Ki K, Benkirane M (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol
Cyclin_T1
Medical condition
depletion induces senescence in prostate cancer cells through down-regulation of Skp2". Neoplasia. 13 (6): 526–36. doi:10.1593/neo.11182. PMC 3114246. PMID 21677876
Androgen deprivation-induced senescence
Androgen_deprivation-induced_senescence
Protein-coding gene in the species Homo sapiens
Cyclin A2, GTF2H1, MDM4, NCOA6, NDN, NPDC1, PURA, PHB, RB1, UDG, RBL1, SKP2, SP1, SP2, SP3, SP4, TFDP1 TOPBP1, TP53BP1, and UBC. E2F Retinoblastoma protein
E2F1
P84550 14847 SKOR2 HGNC:32695; Q2VWA4 14848 SKP1 HGNC:10899; P63208 14849 SKP2 HGNC:10901; Q13309 14850 SLA HGNC:10902; Q13239 14851 SLA2 HGNC:17329; Q9H6Q3
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Protein-coding gene in the species Homo sapiens
A2 has been shown to interact with: CDC6, E2F1, FEN1, ITGB3BP, RBL1, and SKP2. Cyclin A2 regulates homologous recombinational DNA repair in human breast
Cyclin_A2
Protein found in humans
Unconjugated ISG15 negatively regulates IFN-I signaling by preventing the SKP2-mediated proteasomal degradation of USP18, a direct inhibitor of the IFN-I
ISG15
Protein-coding gene in humans
cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A". Cell Growth & Differentiation. 9 (6): 435–449. PMID 9663463
CUL3
Post-translational carbohydrate modification of proteins
regulated by FoxM1-dependent expression of the E3 ubiquitin ligase component Skp2), causing G1 cell cycle arrest. This appeared to be dependent on proteasomal
O-GlcNAc
Protein-coding gene in the species Homo sapiens
Ki K, Benkirane M (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol
Cyclin-dependent_kinase_9
Protein found in the human body
of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1)". Biochemical and Biophysical Research Communications.
NEDD8
Protein-coding gene in the species Homo sapiens
Cyclin-dependent kinase 2, MCM2, MCM4, MCM6, MCM7, MYST2, ORC2, ORC4, ORC5, and SKP2. GRCh38: Ensembl release 89: ENSG00000085840 – Ensembl, May 2017 GRCm38:
ORC1
Fungal protein found in Saccharomyces cerevisiae S288c
APCCdh1 target proteins, such as cyclin A and B, the kinase AuroraB, PLK1, Skp2 and Cdc20, another APC/c co- activator. The main function of Cdh1 is to suppress
APC/C_activator_protein_CDH1
Protein-coding gene in humans
Kirschner MW, Kaelin WG (March 2004). "Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex". Nature. 428 (6979):
FZR1
Protein-coding gene in the species Homo sapiens
Frescas D, Pagano M (Jun 2008). "Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer". Nature Reviews. Cancer. 8 (6):
FBXW11
Gene of the species Homo sapiens
Glaise D, Guguen-Guillouzo C (October 1999). "Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats". FEBS Letters
FBXL2
Protein-coding gene in the species Homo sapiens
Harper JW, Pavletich NP (Apr 2002). "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex". Nature. 416 (6882): 703–9. Bibcode:2002Natur
RBX1
Hydrophobic scaffold protein
Harper JW, Pavletich NP (April 2002). "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex". Nature. 416 (6882): 703–9. Bibcode:2002Natur
Cullin
Pagano, Michele (June 2008). "Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer". Nature Reviews. Cancer. 8 (6):
Michele_Pagano_(biochemist)
Protein-coding gene in the species Homo sapiens
induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells". Cell Death & Disease. 5 (11): e1537. doi:10.1038/cddis
YWHAZ
SKP2
SKP2
SKP2
SKP2
Boy/Male
Bengali, Hindu, Indian, Malayalam, Marathi
Ruler of Dwarka; Lord Krishna
Boy/Male
Afghan, Arabic, Indian, Muslim
Conqueror; War Champion; Hero
Boy/Male
Indian
Stream
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Telugu
The Earth
Girl/Female
Hindu, Indian
First; Best; Shreshth
Female
Egyptian
, the mother of prince Namurot.
Boy/Male
Hindu, Indian
Full of Light
Boy/Male
Irish
Wise one.
Girl/Female
Sikh
Knowledge, Learning
Girl/Female
Tamil
Enlightenment
SKP2
SKP2
SKP2
SKP2
SKP2